Kevin Patrick Becker M.D., Ph.D.

Assistant Professor of Medicine (Medical Oncology)

Research Interests

Primary brain tumors; Immunotherapeutics; Novel drug delivery; Nano-particles in the treatment of glioblastoma


Research Summary

My current research focus is bringing novel treatments and therapeutics to clinical trial for patients with primary brain tumors. Areas currently being developed include immunotherapeutics and novel drug delivery (use of nano-particles) to treat glioblastoma.

Extensive Research Description

Bibliography:

Jenco, J.M., Becker, K.P. and Morris, A.J. (1997). Membrane-binding properties of phospholipase C- ß1 and phospholipase C-ß2: role of the C-terminus effects of polyphosphoinositides, G-proteins and Ca2+. Biochem. J. 327:431- 437

Becker, K.P., Ullian, M., and Halushka, P.V. (1998). Cloning and Characterization of an Endogenous COS-7 Cell Thromboxane A2 Receptor. Biochimica et. Biophysica Acta. 1403:109-114

Becker, K.P., Garnovskaya, M., Gettys, T., and Halushka, P.V. (1999). Coupling of thromboxane A2 receptor isoforms to Ga13) effects on ligand binding and signaling. Biochimica et Biophysica Acta. 1450: 288-296

Feng, X., Becker, K.P., Striblling, D.S., Peters, K.G. and Hannun, Y.A. (2000). Regulation of Receptor-Mediated Protein Kinase C Membrane Trafficking by Autophosphorylation. J.Biol. Chem. 272: 17024-17034

Johnson, K.J., Becker, K.P., Facchinetti, M.M., Hannun, Y.A., and Obeid, L.M. (2002) PKC Dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane.Extracellular Release of Sphingosine-1-Phosphate Induced by Phorbol-12-Myristate-13-Acetate (PMA). J. Biol. Chem. 277: 35257-35262

Johnson, K.R., Johnson, K.Y., Becker, K.P., Bielawski, J., Mao, C., and Obeid, L.M. (2003) Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability J. Biol. Chem. 278: 34541-34547

Mao, C., Xu, R., Szulc, Z., Bielawski, J., Becker, K.P., Bielawski, A., Galadari, S.H., Hu, W., and Obeid, L.M. (2003) Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase: an Enzyme that Preferentially Regulates Metabolism of Very Long Chain Ceramides. J. Biol. Chem. 278: 31184-31191

Becker, K.P., and Hannun, Y.A. (2003) cPKC-Dependent Sequestration of Membrane Recycling Components in a Subset of Recycling Endosomes. J. Biol. Chem. 278: 52747-52754

Becker, K.P., and Hannun, Y.A. (2004) Phospholipase D-dependent Translocation of Protein Kinase C to a Juxtanuclear Compartment. J. Biol. Chem. 279: 28251-28256.

Becker, K.P., Kitani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y.A. (2005) Selective Inhibition of Juxtanuclear Translocation of PKC ßII by a Negative Feedback Mechanism Involving Ceramide Formed From the Salvage Pathway. J. Biol. Chem. 280: 2606-2612

Idkowiak-Baldys, J., Becker, K.P., Kitatani, K., and Hannun, Y.A. (2006) Dynamic sequestration of the recycling compartment by classical Protein Kinase C. J. Biol. Chem.281: 22321-31.

Becker, K.P., Lacy, J., and Baehring, J.M. Diffusion-Weighted Imaging in Patients Treated with Bevacizumab. (in preparation)

2. Case Reports, Technical Notes, Lectures:

Becker, K.P., Huttner, A., and Baehring, J.M. Leptomeningeal Dissemination of Low Grade Brain Tumors: A Report on Four Cases and Review of the Medical Literature (in preparation)

Becker, K.P., Lacy, J., Cooper, D., and Baehring, J.M. Autologous Stem Cell Transplant in Patient with Relapsed Central Nervous System Lymphoma: A Case Series and Review of the Literature (in preparation)

3. Reviews, Chapters, Books

Becker, K.P., and Hannun, Y.A: The Multifaceted Role of Diacylglycerol, in Bioactive Lipids, Vol17, A. Nicolaou and G. Kokotos (eds).England, PJ Barnes and Associates, 2004, pp 37-61

Becker, K.P., Hannun, Y.A. (2005) Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cellular and Molecular Life Sciences 62: 1448-61.

4. Papers in Press

Becker, K.P., and Baehring, J.M. Increased Intracranial Pressure. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).

Becker, K.P., and Baehring, J.M. Spinal Cord Compression. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).


Selected Publications

  • Becker, K.P., and Baehring, J.M. Spinal Cord Compression. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).
  • Becker, K.P., and Baehring, J.M. Increased Intracranial Pressure. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).
  • Becker, K.P., Lacy, J., and Baehring, J.M. Diffusion-Weighted Imaging in Patients Treated with Bevacizumab. (in preparation)
  • Idkowiak-Baldys, J., Becker, K.P., Kitatani, K., and Hannun, Y.A. (2006) Dynamic sequestration of the recycling compartment by classical Protein Kinase C. J. Biol. Chem.281: 22321-31.
  • Becker, K.P., Kitani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y.A. (2005) Selective Inhibition of Juxtanuclear Translocation of PKC ßII by a Negative Feedback Mechanism Involving Ceramide Formed From the Salvage Pathway. J. Biol. Chem. 280: 2606-2612
  • Becker, K.P., and Hannun, Y.A. (2004) Phospholipase D-dependent Translocation of Protein Kinase C to a Juxtanuclear Compartment. J. Biol. Chem. 279: 28251-28256.
  • Becker, K.P., and Hannun, Y.A. (2003) cPKC-Dependent Sequestration of Membrane Recycling Components in a Subset of Recycling Endosomes. J. Biol. Chem. 278: 52747-52754
  • Mao, C., Xu, R., Szulc, Z., Bielawski, J., Becker, K.P., Bielawski, A., Galadari, S.H., Hu, W., and Obeid, L.M. (2003) Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase: an Enzyme that Preferentially Regulates Metabolism of Very Long Chain Ceramides. J. Biol. Chem. 278: 31184-31191
  • Johnson, K.R., Johnson, K.Y., Becker, K.P., Bielawski, J., Mao, C., and Obeid, L.M. (2003) Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability J. Biol. Chem. 278: 34541-34547
  • Johnson, K.J., Becker, K.P., Facchinetti, M.M., Hannun, Y.A., and Obeid, L.M. (2002) PKC Dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane.Extracellular Release of Sphingosine-1-Phosphate Induced by Phorbol-12-Myristate-13-Acetate (PMA). J. Biol. Chem. 277: 35257-35262

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