Kevin Patrick Becker M.D., Ph.D.
Assistant Professor of Neurology
Research Interests
primary brain tumors; immunotherapeutics; novel drug delivery; nano-particles in the treatment of glioblastoma
Research Summary
My current research focus is bringing novel treatments and therapeutics to clinical trial for patients with primary brain tumors. Areas currently being developed include immunotherapeutics and novel drug delivery (use of nano-particles) to treat glioblastoma.
Extensive Research Description
Bibliography:
Jenco, J.M., Becker, K.P. and Morris, A.J. (1997).
Membrane-binding properties of phospholipase C- ß1 and phospholipase C-ß2: role
of the C-terminus effects of polyphosphoinositides, G-proteins and Ca2+. Biochem.
J. 327:431- 437
Becker,
K.P., Ullian, M., and Halushka, P.V. (1998). Cloning and Characterization
of an Endogenous COS-7 Cell Thromboxane A2 Receptor. Biochimica et.
Biophysica Acta. 1403:109-114
Becker,
K.P., Garnovskaya, M., Gettys, T., and Halushka, P.V. (1999). Coupling of
thromboxane A2 receptor isoforms to Ga13) effects on ligand binding and
signaling. Biochimica et Biophysica Acta. 1450: 288-296
Feng, X., Becker, K.P., Striblling, D.S.,
Peters, K.G. and Hannun, Y.A. (2000). Regulation of Receptor-Mediated Protein
Kinase C Membrane Trafficking by Autophosphorylation. J.Biol. Chem. 272: 17024-17034
Johnson, K.J., Becker, K.P., Facchinetti, M.M.,
Hannun, Y.A., and Obeid, L.M. (2002) PKC Dependent Activation of Sphingosine
Kinase 1 and Translocation to the Plasma Membrane.Extracellular Release of
Sphingosine-1-Phosphate Induced by Phorbol-12-Myristate-13-Acetate (PMA). J.
Biol. Chem. 277: 35257-35262
Johnson, K.R., Johnson,
K.Y., Becker, K.P., Bielawski,
J., Mao, C., and Obeid, L.M. (2003) Role of Human Sphingosine-1-phosphate
Phosphatase 1 in the Regulation of Intra- and Extracellular
Sphingosine-1-phosphate Levels and Cell Viability J. Biol. Chem. 278: 34541-34547
Mao, C., Xu, R., Szulc,
Z., Bielawski, J., Becker, K.P.,
Bielawski, A., Galadari, S.H., Hu, W., and Obeid, L.M. (2003) Cloning and
Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase: an
Enzyme that Preferentially Regulates Metabolism of Very Long Chain Ceramides. J.
Biol. Chem. 278: 31184-31191
Becker,
K.P., and Hannun, Y.A. (2003) cPKC-Dependent Sequestration of Membrane
Recycling Components in a Subset of Recycling Endosomes. J. Biol. Chem. 278: 52747-52754
Becker,
K.P., and Hannun, Y.A. (2004) Phospholipase D-dependent Translocation of
Protein Kinase C to a Juxtanuclear Compartment. J. Biol. Chem. 279: 28251-28256.
Becker,
K.P., Kitani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y.A. (2005)
Selective Inhibition of Juxtanuclear Translocation of PKC ßII by a Negative
Feedback Mechanism Involving Ceramide Formed From the Salvage Pathway. J.
Biol. Chem. 280: 2606-2612
Idkowiak-Baldys, J., Becker, K.P., Kitatani, K., and
Hannun, Y.A. (2006) Dynamic sequestration of the recycling compartment by
classical Protein Kinase C. J. Biol. Chem.281: 22321-31.
Becker, K.P., Lacy, J.,
and Baehring, J.M. Diffusion-Weighted Imaging in Patients Treated with
Bevacizumab. (in preparation)
2. Case Reports, Technical Notes, Lectures:
Becker, K.P., Huttner, A., and Baehring, J.M. Leptomeningeal
Dissemination of Low Grade Brain Tumors: A Report on Four Cases and Review of
the Medical Literature (in preparation)
Becker, K.P., Lacy, J.,
Cooper, D., and Baehring, J.M. Autologous Stem Cell Transplant in Patient with
Relapsed Central Nervous System Lymphoma: A Case Series and Review of the
Literature (in preparation)
3. Reviews, Chapters, Books
Becker, K.P., and Hannun, Y.A: The Multifaceted Role of Diacylglycerol,
in Bioactive Lipids, Vol17, A. Nicolaou and G. Kokotos
(eds).England, PJ Barnes and Associates, 2004, pp 37-61
Becker,
K.P., Hannun, Y.A. (2005) Protein kinase C and phospholipase D: intimate
interactions in intracellular signaling. Cellular and Molecular Life
Sciences 62: 1448-61.
4. Papers in Press
Becker, K.P., and Baehring, J.M. Increased Intracranial Pressure. In Cancer: Principles and Practice of Oncology,
9th edition, edited by DeVita, V.T., Lawrence, T.S., and
Rosenbery, S.A., Lippincott-Raven (in press).
Becker, K.P., and Baehring,
J.M. Spinal Cord Compression. In Cancer:
Principles and Practice of Oncology, 9th edition, edited by
DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).
Selected Publications
- Becker, K.P., and Baehring, J.M. Spinal Cord Compression. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).
- Becker, K.P., and Baehring, J.M. Increased Intracranial Pressure. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).
- Becker, K.P., Lacy, J., and Baehring, J.M. Diffusion-Weighted Imaging in Patients Treated with Bevacizumab. (in preparation)
- Idkowiak-Baldys, J., Becker, K.P., Kitatani, K., and Hannun, Y.A. (2006) Dynamic sequestration of the recycling compartment by classical Protein Kinase C. J. Biol. Chem.281: 22321-31.
- Becker, K.P., Kitani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y.A. (2005) Selective Inhibition of Juxtanuclear Translocation of PKC ßII by a Negative Feedback Mechanism Involving Ceramide Formed From the Salvage Pathway. J. Biol. Chem. 280: 2606-2612
- Becker, K.P., and Hannun, Y.A. (2004) Phospholipase D-dependent Translocation of Protein Kinase C to a Juxtanuclear Compartment. J. Biol. Chem. 279: 28251-28256.
- Becker, K.P., and Hannun, Y.A. (2003) cPKC-Dependent Sequestration of Membrane Recycling Components in a Subset of Recycling Endosomes. J. Biol. Chem. 278: 52747-52754
- Mao, C., Xu, R., Szulc, Z., Bielawski, J., Becker, K.P., Bielawski, A., Galadari, S.H., Hu, W., and Obeid, L.M. (2003) Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase: an Enzyme that Preferentially Regulates Metabolism of Very Long Chain Ceramides. J. Biol. Chem. 278: 31184-31191
- Johnson, K.R., Johnson, K.Y., Becker, K.P., Bielawski, J., Mao, C., and Obeid, L.M. (2003) Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability J. Biol. Chem. 278: 34541-34547
- Johnson, K.J., Becker, K.P., Facchinetti, M.M., Hannun, Y.A., and Obeid, L.M. (2002) PKC Dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane.Extracellular Release of Sphingosine-1-Phosphate Induced by Phorbol-12-Myristate-13-Acetate (PMA). J. Biol. Chem. 277: 35257-35262
Selected Publications
- Becker, K.P., and Baehring, J.M. Spinal Cord Compression. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).
- Becker, K.P., and Baehring, J.M. Increased Intracranial Pressure. In Cancer: Principles and Practice of Oncology, 9th edition, edited by DeVita, V.T., Lawrence, T.S., and Rosenbery, S.A., Lippincott-Raven (in press).
- Becker, K.P., Lacy, J., and Baehring, J.M. Diffusion-Weighted Imaging in Patients Treated with Bevacizumab. (in preparation)
- Idkowiak-Baldys, J., Becker, K.P., Kitatani, K., and Hannun, Y.A. (2006) Dynamic sequestration of the recycling compartment by classical Protein Kinase C. J. Biol. Chem.281: 22321-31.
- Becker, K.P., Kitani, K., Idkowiak-Baldys, J., Bielawski, J., and Hannun, Y.A. (2005) Selective Inhibition of Juxtanuclear Translocation of PKC ßII by a Negative Feedback Mechanism Involving Ceramide Formed From the Salvage Pathway. J. Biol. Chem. 280: 2606-2612
- Becker, K.P., and Hannun, Y.A. (2004) Phospholipase D-dependent Translocation of Protein Kinase C to a Juxtanuclear Compartment. J. Biol. Chem. 279: 28251-28256.
- Becker, K.P., and Hannun, Y.A. (2003) cPKC-Dependent Sequestration of Membrane Recycling Components in a Subset of Recycling Endosomes. J. Biol. Chem. 278: 52747-52754
- Mao, C., Xu, R., Szulc, Z., Bielawski, J., Becker, K.P., Bielawski, A., Galadari, S.H., Hu, W., and Obeid, L.M. (2003) Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase: an Enzyme that Preferentially Regulates Metabolism of Very Long Chain Ceramides. J. Biol. Chem. 278: 31184-31191
- Johnson, K.R., Johnson, K.Y., Becker, K.P., Bielawski, J., Mao, C., and Obeid, L.M. (2003) Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability J. Biol. Chem. 278: 34541-34547
- Johnson, K.J., Becker, K.P., Facchinetti, M.M., Hannun, Y.A., and Obeid, L.M. (2002) PKC Dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane.Extracellular Release of Sphingosine-1-Phosphate Induced by Phorbol-12-Myristate-13-Acetate (PMA). J. Biol. Chem. 277: 35257-35262
- Feng, X., Becker, K.P., Striblling, D.S., Peters, K.G. and Hannun, Y.A. (2000). Regulation of Receptor-Mediated Protein Kinase C Membrane Trafficking by Autophosphorylation. J.Biol. Chem. 272: 17024-17034
- Becker, K.P., Garnovskaya, M., Gettys, T., and Halushka, P.V. (1999). Coupling of thromboxane A2 receptor isoforms to Ga13) effects on ligand binding and signaling. Biochimica et Biophysica Acta. 1450: 288-296
- Becker, K.P., Ullian, M., and Halushka, P.V. (1998). Cloning and Characterization of an Endogenous COS-7 Cell Thromboxane A2 Receptor. Biochimica et. Biophysica Acta. 1403:109-114
- Jenco, J.M., Becker, K.P. and Morris, A.J. (1997). Membrane-binding properties of phospholipase C- ß1 and phospholipase C-ß2: role of the C-terminus effects of polyphosphoinositides, G-proteins and Ca2+. Biochem. J. 327:431- 437
