Dr. Harry M. Zimmerman and Dr. Nicholas and Viola Spinelli Professor of Neurology and Professor of Neurosurgery; Vice Chairman, Department of Neurology; Director, Stroke Service; Director of Medical Studies

Research Interests

Brain; Coma; Heart Arrest; Hypothermia, Induced; Nervous System Diseases; Neurology; Neurosurgery; Stroke; Neuroimaging

Research Organizations



Faculty Research

Office of Cooperative Research

Research Summary

My research focuses on improving the ability for doctors to give an accurate prognosis for patients in coma, particularly after suffering a cardiac arrest. I am also interested in the use of hypothermia to improve neurological outcomes for various brain injuries. Ongoing projects include the appropriate training of clinicians to pronounce brain death, and differences between subspecialties who do so; a study of the use of clot-dissolving medications for patients with bleeding in the drainage system of the brain, and study looking at the use of induced hypothermia (cooling) for treating patients with large strokes.

Specialized Terms: Coma; Neurocritical care; Stroke; Neuroimaging

Extensive Research Description

My research to this point has focused on the arenas of stroke and neurocritical care. I have had a strong interest in stroke prevention studies, such as the multi-national antiplatelet trial, PROFESS. I have taken part in multiple trials comparing carotid stenting and endarterectomy. I have also studied neuroimaging features of both ischemic and hemorrhagic stroke for prediction of outcome.

My neurocritical care studies in the past have included coma, brain death, hypothermia and extubation. I have a stroke interest in features that may predict outcome from coma and cardiac arrest, including neuroimaging, electrophysiology, biomarkers and the clinical examination. I have studied the variability in brain death determination, with a goal of providing standardization in this field. I have also studied the use of hypothermia in cardiac arrest and stroke, showing the safety of combined hypothermia and cardiac catheterization. I also studied a large neurocritical care population for predictors of failure or success after attempted extubation.

My ongoing studies at Yale include a study to look at how physicians are trained to perform brain death determination, including variability between different specialties. I am the principle investigator for the CLEAR III trial, evaluating the safety and efficacy of intraventricular TPA for patients with intraventricular hemorrhage. I am the principle investigator for the ICTUS 2/3 study of induced hypothermia for large ischemic stroke. I am the principle investigator for the ATACH 2 trial, evaluating acute blood pressure lowering in acute intracerebral hemorrhage.

CLEAR III - study of intraventricular TPA for acute intraventricular hemorrhage

ATACH 2 - study of blood pressure lowering in acute intracerebral hemorrhage

ICTUS 2/3 - study of the use of induced hypothermia in acute ischemic stroke

Selected Publications

Full List of PubMed Publications

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Contact Info

Patient Care Locations
Yale NeurologyYale Physicians Building
800 Howard Avenue, Ste Lower Level

New Haven, CT 06519
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Yale NeurologyYale New Haven Hospital Saint Raphael Campus
1450 Chapel Street

New Haven, CT 06511
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Office Location
Lippard Laboratory of Clinical Investigation (LLCI)
15 York Street, Ste Room 912

New Haven, CT 06510
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Mailing Address
LLCI 912, Department of Neurology
15 York Street

New Haven, CT 06520-8018