Brian B. Koo, MD

Assistant Professor of Neurology; Director, Sleep Medicine Program at Connecticut Veterans Affairs Healthcare System

Research Interests

Research Summary

My main research interests lie in the intersection between neurology and sleep medicine. My current area of focus is on the restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) and their association with cardiovascular disease. We have compiled epidemiologic evidence that PLMS is associated with the development of cardiovascular disease such as myocardial infarction, peripheral vascular disease and stroke. We are learning from additional studies that hypertension may play a role in this association. I am currently interested in taking a closer look at the sleep physiology in individuals with RLS and PLMS, inspecting specific time domain elements of these limb movements as well as heart rate and breathing. In addition to this vein of research, I have completed work on an animal model of RLS and am currently investigating the human genetics related to this troubling disorder.

Selected Publications

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Contact Info

Brian B. Koo, MD
Office Location
VA Connecticut Healthcare
950 Campbell Avenue

West Haven, CT 06516
Mailing Address
Yale NeurologyPO Box 208018
New Haven, CT 06520-8018