John H. Krystal MD

Robert L. McNeil, Jr. Professor of Psychiatry and Professor of Neurobiology; Chair, Department of Psychiatry; Chief of Psychiatry, Yale-New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD; Director, VA Alcohol Research Center; Medical Director, Schizophrenia Biological Research Center, DVA

Departments & Organizations



NIMH Research Training Program in Childhood-onset Neuropsychiatric Disorders

Diabetes Research Center

Psychiatry: Center for the Translational Neuroscience of Alcoholism | Clinical Neuroscience Research Unit | Obsessive Compulsive Disorder Research Clinic | Adult Psychiatry | VA National Center for PTSD

Research Interests

Neurobiology; Pharmacotherapy; Genetics; Neuroimaging; Schizophrenia; Alcoholism; PTSD more...


  • B.A., University of Chicago, 1980
  • M.D., Yale University, 1984

Selected Publications

  • Krystal JH, State MW. Psychiatric Disorders: Diagnosis to Therapy. Cell. 2014 Mar 27;157(1):201-214. doi: 10.1016/j.cell.2014.02.042. Review. PubMed PMID: 24679536.
  • Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. J Clin Invest. 2013 Mar 8. doi:pii: 65153. 10.1172/JCI65153. [Epub ahead of print] PubMed PMID: 23478412.
  • Murray JD, Anticevic A, Gancsos M, Ichinose M, Corlett PR, Krystal JH, Wang XJ. Linking Microcircuit Dysfunction to Cognitive Impairment: Effects of Disinhibition Associated with Schizophrenia in a Cortical Working Memory Model. Cereb Cortex. 2012 Nov 29. [Epub ahead of print] PubMed PMID: 23203979.



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