Viruses are small, non-cellular life forms that must infect host cells to propagate. Many of mankind’s most dreaded diseases are caused by viral pathogens, and much virus research is focused on making discoveries to alleviate or prevent viral diseases.
The study of viruses has also played a seminal role in our understanding of molecular biology, cell biology, immunology, and cancer biology. Yale has a rich tradition in virus research that continues to thrive. Members of the Section who study viruses include:
Host factors involved in West Nile virus infection; innate antiviral responses and vaccine design.
Small animal models of human immunodeficiency virus (HIV) and flavivirus infection; siRNA-mediated clearance of viruses in vivo.
Hepatitis C virus (HCV) assembly; reverse genetics systems and live cell imaging of HCV, yellow fever virus, and other positive-strand RNA viruses.
Cell biology of retrovirus transmission; live cell imaging of human immunodeficiency virus (HIV) and other retroviruses; innate antiviral pathways.
Small animal models of HIV; cellular determinants of HIV assembly and tropism.
Beyond the Section, many other Yale researchers study viruses. Additional information can be found on the Yale Molecular Virology website.