Susan Kaech, PhD

Associate Professor of Immunobiology; HHMI Early Career Scientist

Departments & Organizations

Infectious Diseases

Immunobiology: HTI | Lymphocyte Development

Molecular Virology

Molecular Virology

Office of Student Research

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology: B and T Cell Effector and Memory Cell Differentiation; Computational Immunology; Consequences of an Immune Response; Infectious Disease and Host-Pathogen Interaction; Lymphocyte Development; Mounting an Immune Response | Microbiology: Immunology & Host Response

Biography

Education

Stanford University Ph.D., Developmental Biology 1993-1998
University of Washington, Seattle, WA B.S., Cellular and Molecular Biology 1989-1993

Professional Experience

1990-1991 Undergraduate Researcher, Div. of Basic Sciences, Fred Hutchinson Cancer Research Center
1991-1993 Undergraduate Researcher, Dept. of Zoology, University of Washington, Seattle
1993-1998 Graduate Student, Dept. of Developmental Biology, Stanford University

1999-2004 Postdoctoral Fellow, Dept. of Microbiology and Immunology and Emory Vaccine Center, Emory University
2004-2009 Assistant Professor, Department of Immunobiology, Yale University

2009-2015 Associate Professor, Department of Immunobiology, Yale University

2015-present Professor, Department of Immunobiology, Yale University

2009-2015 HHMI Early Career Scientist



Honors and Awards

National Science Foundation Predoctoral Fellowship 1993-1996

Damon Runyon-Walter Winchell Cancer Research Fellowship 1999-2002

Burroughs-Wellcome Foundation Award in Biomedical Sciences 2003-2008

Edward Mallinckrodt Jr. Foundation Award 2005-2008

Cancer Research Institute Investigator Award 2005-2009

American Asthma Foundation Investigator 2007-2010

Presidential Early Career Award for Scientists and Engineers (PECASE) 2007

Howard Hughes Early Career Scientist 2009-2015




Education & Training

PhD Stanford University (1998)
BS University of Washington, Seattle, WA, Cellular and Molecular Biology (1993)

Honors & Recognition

  • HHMI Early Career ScientistHHMI (2009)

  • Presidential Early Career Award for Scientists and Engineers (PECASE) (2007)

  • American Asthma Foundation Investigator Award (2007)

  • Cancer Research Institute Investigator AwardCRI (2005)

  • Edward Mallinckrodt Jr. Foundation Award (2005)

  • Burroughs-Wellcome Foundation Award in Biomedical Sciences (2003)

  • Damon Runyon-Walter Foundation Winchell Cancer Research Fellowship (1999)

  • National Science Foundation Predoctoral Fellowship (1993)

Professional Service

  • MSTP Student Admissions Committee Yale University (2005)

  • Immunobiology Retreat Organizer Yale University (2005)

  • Immunobiology Graduate Student Admissions Committee (2006)

  • Yale Stem Cell Center Faculty Search Committee Yale University (2007)

  • Immunobiology Faculty Search Committee Yale University (2008)

  • Immunobiology Track Director of Graduate Admissions (DGA) Yale University (2009)

International Activity

  • Co-PI: Batu Erman at Sabanci University HIV, HCV, WHO Turkey (2010 - 2012)

    Transcriptional Control of IL-7 Receptor (IL-7R) in T Cells

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Contact Info

Susan Kaech, PhD
Lab Location
Kaech LabThe Anlyan Center
300 Cedar Street, Ste S640

New Haven, CT 06519
Mailing Address
Department of ImmunobiologyPO Box 208011
300 Cedar Street

New Haven, CT 06520

Curriculum Vitae

Kaech lab

Research Image 2

Figure 1: Formation of memory T cells following infection. Upon infection, naïve T cells become activated and proliferate and differentiate into a heterogeneous population of effector T cells. Most of the effector T cells terminally differentiate into effector T cells (blue cells) that protect against the current infection, but lose potential to develop into memory T cells. A smaller subset of effector T cells persist to develop into different types of memory T cells such as effector memory T (TEM) cells (red), central memory T (TCM) cells (yellow) and resident memory T (TRM) cells (green). These different populations of memory T cells form a tiered defense system. Figure modified from: Cui W and Kaech SM. Transcriptional Regulation of Effector and Memory CD8 T cell fates. Nat Rev Immunol 12:749-61 (2012).