MB&B Faculty

Primary Faculty
Secondary Faculty
Faculty Emeritus

Susan Baserga

Professor of Molecular Biophysics and Biochemistry, of Genetics and of Therapeutic Radiology

Research Interests:Ribosome biogenesis; rRNA processing; U3 RNP structure and function; RNA helicases; Polymerase I transcription and processing

Thomas Biederer

Associate Professor of Molecular Biophysics and Biochemistry

Research Interests:Biochemistry of membrane proteins; molecular and cellular neuroscience; synapse formation

Office:(203) 785-5465

Enrique De La Cruz

Professor of Molecular Biophysics and Biochemistry

Research Interests:Cytoskeleton; RNA helicases; Kinetics; Thermodynamics; Polymer Mechanics; Processivity

Donald Engelman

Eugene Higgins Professor of Molecular Biophysics and Biochemistry

Research Interests:Helix Interactions; Lipid Bilayers; Membranes; Physical Biochemistry; Protein Folding; Proteins

Alan Garen

Professor of Molecular Biophysics and Biochemistry

Research Interests:Development; Genetics; Medical Sciences; Molecular Biology

Mark Gerstein

Albert L. Williams Professor of Biomedical Informatics
Co-Director, Yale Computational biology and Bioinformatics Program

Research Interests:Biochemistry; Bioinformatics; Biophysics; Computational Biology; DNA; Genomics; Molecular Simulation; Proteins; Sequence Alignment; Structural Biology

Office:(203) 432-6105

Mark Hochstrasser

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin

Michael Koelle

Associate Professor of Molecular Biophysics and Biochemistry

Research Interests:C. Elegans; G Protein; Neurotransmission; RGS Protein; Serotonin; Molecular Genetics; Neurobiology; Neurotransmitters; Proteins and Macromolecules; Receptors

Anthony Koleske

Professor of Molecular Biophysics and Biochemistry and of Neurobiology

Research Interests:Neuronal morphogenesis and degeneration; stress; schizophrenia; cell migration; cancer; metastasis; adhesion receptors

Office:(203) 785-5624
Lab:(203) 785-5631

William Konigsberg

Professor of Molecular Biophysics and Biochemistry

Research Interests:Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules

Andrew Miranker

Professor of Molecular Biophysics and Biochemistry

Research Interests:Conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils

Yorgo Modis

Associate Professor of Molecular Biophysics and Biochemistry

Research Interests:Bacterial Infections; Biochemistry; Biophysics; Disease Resistance; Immune System; Immune System Disorders; Immunology; Infectious Diseases or Agents; Inflammatory Bowel Disease; Natural Processes Health Safety Medical; Pathogenesis; Receptors; Structural Biology; Structure or Function (Health or Safety or Medical); Vaccine

Office:(203) 432-4330
Lab:(203) 432-4414

Lynne Regan

Professor of Molecular Biophysics and Biochemistry and of Chemistry

Research Interests:Mental retardation; protein-protein interactions; Fragile X Mental Retardation Protein (FMRP); protein-based nanomaterials

Elizabeth Rhoades

Associate Professor of Molecular Biophysics and Biochemistry and of Physics

Research Interests:Protein-Protein Interactions; Disordered Proteins; Protein Aggregation; Protein Folding; Fluorescence Spectroscopy

Christian Schlieker

Assistant Professor of Molecular Biophysics and Biochemistry

Research Interests:Protein folding; ubiquitin; Protein quality control and its relation to viral pathogenesis

Office:(203) 432-5035

Matthew Simon

Assistant Professor of Molecular Biophysics and Biochemistry and Residential College Associate Fellow in Faculty of Arts and Sciences
Assistant Professor of Molecular Biophysics and Biochemistry (starting next year)

Research Interests:Chemical biology; Large non-coding RNAs; Epigenetic regulation; Histone modifications

Office:(203) 737-3274

Chuck Sindelar

Assistant Professor of Molecular Biophysics and Biochemistry

Office:(203) 737-4752
Lab:(203) 737-4723

Dieter Soll

Sterling Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry

Research Interests:Aminoacyl-tRNA Synthesis; Functional Genomics; Life Science Biological; Mechanism of Translation

Mark Solomon

Professor of Molecular Biophysics and Biochemistry

Research Interests:Cell cycle; Ubiquitin-mediated proteolysis; Anaphase-promoting Complex

Office:(203) 436-9053

Joan Steitz

Sterling Professor of Molecular Biophysics and Biochemistry
Investigator, Howard Hughes Medical Institute

Research Interests:Autoantibodies; Gene Expression; RNA; RNA Processing; SnRNPs; Viral Transformation

Office:(203) 737-4418

Thomas Steitz

Sterling Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry
Investigator, Howard Hughes Medical Institute

Research Interests:Protein Structure; Proteins and Macromolecules; Protein Nucleic Acid Complexes; X-ray Crystallography

Office:(203) 432-5617
Lab:(203) 432-5627

Scott Strobel

Henry Ford II Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry
Howard Hughes Medical Institute Professor
Henry Ford II Professor

Research Interests:Antibiotics; Nucleic Acid Bioorganic Chemistry; Ribosome; Ribozyme; RNA Catalysis; RNA-Protein Interaction; Translation; Riboswitches, Biofuels; Endophytes; Natural Product Discovery

Patrick Sung

Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology

Research Interests:Repair of DNA double-strand breaks; repair by homologous recombination; repair by DNA end-joining

Office:(203) 785-4553
Lab:(203) 785-4569

Kenneth Williams

Professor (Adjunct) of Research in Molecular Biophysics and Biochemistry
Director, W.M. Keck Foundation Biotechnology Resource Laboratory
Director, Biomedical High Performance Computing Center
Director, Yale/NHLBI Proteomics Center

Research Interests:protein profiling; phosphoproteomics; protein posttranslational modification

Yong Xiong

Associate Professor of Molecular Biophysics and Biochemistry

Research Interests:Innate immune systems; HIV; fatty acid synthase (FAS); polyketide synthase (PKS); Viral vectors

Office:(203) 436-2608

Karen Anderson

Richard Baxter

Assistant Professor of Chemistry and of Molecular Biophysics and Biochemistry

Office:(203) 432-9576

Ronald Breaker

Henry Ford II Professor of Molecular, Cellular, and Developmental Biology
Investigator, Howard Hughes Medical Institute

Research Interests:non-coding RNA; riboswitches; ribozymes; catalytic DNA; RNA's role in evolution

Office:(203) 432-9389
Lab:(203) 432-6554

Gary Brudvig

Eugene Higgins Professor of Chemistry and Professor of Molecular Biophysics and Biochemistry

Research Interests:photosystem II; EPR spectroscopy; metalloproteins; artificial photosynthesis

Daniel DiMaio

Waldemar Von Zedtwitz Professor of Genetics and Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology
Scientific Director, Yale Cancer Center
Deputy Director, Yale Cancer Center

Research Interests:Molecular Biology of Tumor Viruses; Mechanisms of Viral Carcinogenesis; Molecular Basis of Cell Growth Regulation and Senescence; Manipulating Cells and Viruses with Artificial Transmembrane Proteins; Oncogenes; Senescence ; Signal Transduction; Trans-membrane Proteins; Tumor Suppressor Genes; Virology; Virus

Office:(203) 785-2684

J Patrick Loria

Professor of Chemistry and of Molecular Biophysics and Biochemistry

Research Interests:Protein Folding

I George Miller, Jr

John F. Enders Professor of Pediatrics (Infectious Disease) and Professor of Epidemiology (Microbial Diseases) and of Molecular Biophysics and Biochemistry
Section Chief, Pediatric Infectious Diseases

Research Interests:Epstein-Barr Virus (EBV); Kaposi's Sarcoma-Associated Herpesvirus (KSHV); Tumor virology

Clinical Interests:Viral diseases; Hodgkin's Disease; Kaposi's Sarcoma; Lymphoma; Multiple Myeloma

Office:(203) 785-4758
Appt:(203) 785-4730

Nancy Moran

William H. Fleming, M.D. Professor of Ecology and Evolutionary Biology

Research Interests:Symbiosis; Genomics; Evolutionary Biology; metagenomics; metabolism

Office:(203) 737-3087
Lab:(203) 737-3087

Thomas Pollard

Sterling Professor of Molecular, Cellular, and Developmental Biology and Professor of Cell Biology and of Molecular Biophysics and Biochemistry
Dean of the Graduate School of Arts and Sciences

Research Interests:Cytokinesis; cellular motility; role of actin filaments and myosin motors

Office:(203) 432-3565
Lab:(203) 432-3194

David Schatz

Professor of Immunobiology
Professor of Molecular Biophysics and Biochemistry

Research Interests:Biochemical mechanism and developmental regulation of V(D)J recombination and somatic hypermutation; lymphocyte development; mechanisms of DNA repair; function of the RAG1 and RAG2 proteins; mechanisms of lymphomagenesis

Office:(203) 737-2255
Lab:(203) 785-3247

William Summers

Professor of Therapeutic Radiology, in the History of Medicine and of Molecular Biophysics and Biochemistry
Lecturer in History

Research Interests:History of molecular biology; Development of target theory; History of Manchurian Plague, 1910-1911

Office:(203) 432-5585

Corey Wilson

Assistant Professor of Chemical Engineering, of Biomedical Engineering and of Molecular Biophysics and Biochemistry

Sandra Wolin

Professor of Cell Biology and of Molecular Biophysics and Biochemistry
Vice Chair, Department of Cell Biology

Research Interests:RNA quality control; noncoding RNAs; RNA damage; autoimmune disease

Office:(203) 737-4439
Lab:(203) 737-4426