MB&B Faculty

Primary Faculty

Sung, Patrick

Chairman

Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology

Research Interests:Repair of DNA double-strand breaks; Repair by homologous recombination; Repair by DNA end-joining

Baserga, Susan J

Professor of Molecular Biophysics and Biochemistry, of Genetics and of Therapeutic Radiology

Research Interests:Ribosome biogenesis; RRNA processing; U3 RNP structure and function; RNA helicases; Polymerase I transcription and processing

Berro, Julien

Assistant Professor of Molecular Biophysics and Biochemistry

Research Interests:Endocytosis; Cytoskeleton; Cell Biology; Quantitative Microsocopy; Mathematical Modeling

De La Cruz, Enrique M.

Professor of Molecular Biophysics and Biochemistry

Research Interests:Cytoskeleton; RNA helicases; Kinetics; Thermodynamics; Polymer Mechanics; Processivity

Engelman, Donald Max

Eugene Higgins Professor of Molecular Biophysics and Biochemistry

Research Interests:Helix Interactions; Lipid Bilayers; Membranes; Physical Biochemistry; Protein Folding; Proteins

Garen, Alan

Professor of Molecular Biophysics and Biochemistry

Research Interests:Development; Genetics; Medical Sciences; Molecular Biology

Gerstein, Mark B

Albert L. Williams Professor of Biomedical Informatics
Co-Director, Yale Computational biology and Bioinformatics Program

Research Interests:Biochemistry; Bioinformatics; Biophysics; Computational Biology; DNA; Genomics; Molecular Simulation; Proteins; Sequence Alignment; Structural Biology

Hochstrasser, Mark W

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology

Research Interests:Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin

Howard, Jonathon

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Physics

Research Interests:Motor proteins and the cytoskeleton; Microtubule dynamics and motors; Cell motility; Mitosis; the Axoneme; Neuronal Morphology

Koelle, Michael R

Associate Professor of Molecular Biophysics and Biochemistry

Research Interests:C. Elegans; G Protein; Neurotransmission; RGS Protein; Serotonin; Molecular Genetics; Neurobiology; Neurotransmitters; Proteins and Macromolecules; Receptors

Koleske, Anthony J

Professor of Molecular Biophysics and Biochemistry and of Neurobiology

Research Interests:Neuronal morphogenesis and degeneration; Stress; Schizophrenia; Cell migration; Cancer; Metastasis; Adhesion receptors

Konigsberg, William H

Professor of Molecular Biophysics and Biochemistry

Research Interests:Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules

Miranker, Andrew D

Professor of Molecular Biophysics and Biochemistry

Research Interests:Conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils

Neugebauer, Karla

Professor of Molecular Biophysics and Biochemistry

Research Interests:pre-mRNA splicing, transcription, gene architecture, SR proteins, cap-binding complex, RNA-protein interactions, Cajal bodies, organization of the cell nucleus, zebrafish embryogenesis.

Regan, Lynne J

Professor of Molecular Biophysics and Biochemistry and of Chemistry

Research Interests:Mental retardation; Protein-protein interactions; Fragile X Mental Retardation Protein (FMRP); Protein-based nanomaterials

Rhoades, Elizabeth

Associate Professor of Molecular Biophysics and Biochemistry and of Physics

Research Interests:Protein-Protein Interactions; Disordered Proteins; Protein Aggregation; Protein Folding; Fluorescence Spectroscopy

Schlieker, Christian

Assistant Professor of Molecular Biophysics and Biochemistry

Research Interests:Alternative nuclear transport (nuclear egress), Membrane dynamics, Protein quality control, viral pathogenesis, DYT1 Dystonia

Simon, Matthew

Assistant Professor of Molecular Biophysics and Biochemistry and Residential College Associate Fellow in Faculty of Arts and Sciences
Assistant Professor of Molecular Biophysics and Biochemistry (starting next year)

Research Interests:Chemical biology; Large non-coding RNAs; Epigenetic regulation; Histone modifications

Sindelar, Chuck

Assistant Professor of Molecular Biophysics and Biochemistry

Soll, Dieter G

Sterling Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry

Research Interests:Aminoacyl-tRNA Synthesis; Functional Genomics; Life Science Biological; Mechanism of Translation

Solomon, Mark J

Professor of Molecular Biophysics and Biochemistry

Research Interests:Cell cycle; Ubiquitin-mediated proteolysis; Anaphase-promoting Complex

Steitz, Joan A

Sterling Professor of Molecular Biophysics and Biochemistry
Investigator, Howard Hughes Medical Institute

Research Interests:Autoantibodies; Gene Expression; RNA; RNA Processing; SnRNPs; Viral Transformation

Steitz, Thomas A

Sterling Professor of Molecular Biophysics and Biochemistry and Professor of Chemistry
Investigator, Howard Hughes Medical Institute

Research Interests:Protein Structure; Proteins and Macromolecules; Protein Nucleic Acid Complexes; X-ray Crystallography

Strobel, Scott A

Vice Pres for West Campus; Henry Ford II Prof MB&B, Prof HHMI; Prof Chemistry
Howard Hughes Medical Institute Professor
Henry Ford II Professor

Research Interests:Antibiotics; Nucleic Acid Bioorganic Chemistry; Ribosome; Ribozyme; RNA Catalysis; RNA-Protein Interaction; Translation; Riboswitches, Biofuels; Endophytes; Natural Product Discovery

Xiong, Yong

Associate Professor of Molecular Biophysics and Biochemistry

Research Interests:Innate immune systems; HIV; fatty acid synthase (FAS); polyketide synthase (PKS); Viral vectors

Emeritus Faculty (Primary)

Grindley, Nigel D. F.

Professor Emeritus of and Senior Research Scientist in Molecular Biophysics and Biochemistry

Research Interests:Serine recombinases; site specific recombination; mechanisms of protein-DNA transactions; DNA polymerases

Lengyel, Peter

Professor Emeritus of Molecular Biophysics and Biochemistry

Research Interests:p200 family proteins; mammalian differentiation; cell proliferation; interferons

Shulman, Robert G

Professor Emeritus of Molecular Biophysics and Biochemistry and Senior Research Scientist in Diagnostic Radiology
Senior Research Scientist/Scho

Research Interests:Nuclear magnetic resonance (NMR); metabolic pathways in vivo

Secondary Faculty

Anderson, Karen S

Professor of Pharmacology and of Molecular Biophysics and Biochemistry
Co-Director Therapeutics/Chemotherapy Program

Research Interests:Enzyme function; Anti-viral agents

Baxter, Richard

Assistant Professor of Chemistry

Breaker, Ronald R

Henry Ford II Prof Mol Cell & Dev Biology
Investigator, Howard Hughes Medical Institute

Research Interests:non-coding RNA; riboswitches; ribozymes; catalytic DNA; RNA and evolution; antibiotics development

Brudvig, Gary W

Benjamin Silliman Prof of Chemistry

Research Interests:photosystem II; EPR spectroscopy; metalloproteins; artificial photosynthesis

DiMaio, Daniel C.

Waldemar Von Zedtwitz Professor of Genetics and Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology
Scientific Director, Yale Cancer Center
Deputy Director, Yale Cancer Center

Research Interests:Molecular Biology of Tumor Viruses; Mechanisms of Viral Carcinogenesis; Molecular Basis of Cell Growth Regulation and Senescence; Manipulating Cells and Viruses with Artificial Transmembrane Proteins; Oncogenes; Senescence; Signal Transduction; Trans-membrane Proteins; Tumor Suppressor Genes; Virology; Virus

Loria, J Patrick

Professor of Chemistry and of Molecular Biophysics and Biochemistry

Research Interests:Protein Folding

Miller, I George, Jr

John F. Enders Professor of Pediatrics (Infectious Disease) and Professor of Epidemiology (Microbial Diseases) and of Molecular Biophysics and Biochemistry
Section Chief, Pediatric Infectious Diseases

Research Interests:Epstein-Barr Virus (EBV); Kaposi's Sarcoma-Associated Herpesvirus (KSHV); Tumor virology

Pollard, Thomas Dean

Sterling Prof MCDB
Dean of the Graduate School of Arts and Sciences

Research Interests:Cytokinesis; cellular motility; role of actin filaments and myosin motors

Schatz, David G.

Professor of Immunobiology and of Molecular Biophysics and Biochemistry
Professor of Molecular Biophysics and Biochemistry

Research Interests:Biochemical mechanism and developmental regulation of V(D)J recombination and somatic hypermutation; Lymphocyte development; Mechanisms of DNA repair; Function of the RAG1 and RAG2 proteins; Mechanisms of lymphomagenesis

Summers, William C

Professor of Therapeutic Radiology, in the History of Medicine and of Molecular Biophysics and Biochemistry
Lecturer in History

Research Interests:History of molecular biology; Development of target theory; History of Manchurian Plague, 1910-1911

Wilson, Corey J

(Leave of absence) Asst Prof Chemical Eng (SEAS)

Wolin, Sandra L

Professor of Cell Biology and of Molecular Biophysics and Biochemistry

Research Interests:Noncoding RNAs; RNA surveillance, RNA damage; Autoimmune disease; Environmental stress

Emeritus Faculty (Secondary)

Moore, Peter B

Sterling Prof. Chemistry, Prof. Mol Biophys Biochem, Emeritus

Research Interests:RNA Structures

Radding, Charles M

Professor Emeritus of Genetics

Sinanoglu, Oktay

Professor Emeritus of Chemistry
Emeritus Faculty

Professor Adjunct of Research

Williams, Kenneth R

Professor (Adjunct) of Research in Molecular Biophysics and Biochemistry
Director, W.M. Keck Foundation Biotechnology Resource Laboratory
Director, Biomedical High Performance Computing Center
Director, Yale/NHLBI Proteomics Center

Research Interests:protein profiling; phosphoproteomics; protein posttranslational modification

Adjunct Assistant Professor

Greenbaum, Dov S.

Assistant Professor (Adjunct) of Molecular Biophysics and Biochemistry

Research Interests:Genomics; Genetics; Synthetic Biology; ELSI; Intellectual Property; Patents; Privacy; Standardization; Personalized Medicine;