Selected Publications
Lizardi PM#, Yan Q#, and Wajapeyee N#. Analysis of DNA methylation in mammalian cells. Molecular Cloning: A Laboratory Manual (Fourth Edition), in press (2012) #corresponding authors
Cao J and Yan Q. Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer. Front. Oncol. 2:26. doi: 10.3389/fonc.2012.00026 (2012) pdf
Niu X, Zhang T, Liao L, Zhou L, Zhou M, Lindner DJ, Rini B, Yan Q, and Yang H. The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumorigenesis through histone demethylase JARID1C. Oncogene, 31(6):776-86. doi: 10.1038/onc.2011.266 (2012) pdf
Lin W*, Cao J*, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG, and Yan Q. Loss of the RBP2 histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A., 108:13379-86 (2011) *equal contribution pdf
Blair LP, Cao J, Zou MR, Sayegh J, and Yan Q. Epigenetic regulation by lysine demethylase 5 (KDM5) in cancer, Cancers, 3:1383-404 (2011) pdf
Yan Q# and Wajapeyee N#. Exploiting cellular senescence to treat cancer and circumvent drug resistance. Cancer Biology and Therapy, 9:166-175 (2010) #corresponding authors pdf
Oevelen CV, Wang J, Asp P, Yan Q, Kaelin WG, Kluger Y, Dynlacht BD. A role for mammalian Sin3 in permanent gene silencing. Mol Cell 32:359-70 (2008) pdf
Klose RJ*, Yan Q*, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 128:889-900 (2007) *equal contribution pdf, Featured in Research Highlight in Nature Reviews in Molecular Cell Biology and News and Views in Nature Structural & Molecular Biology
Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, Zhang L, Kim WY, Olumi AF, Kaelin WG. pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kB agonist Card9 by CK2. Mol Cell 28:15-27 (2007) pdf
Li L, Zhang L, Zhang X, Yan Q, Minamishima YA, Olumi A, Mao M, Bartz S, Kaelin WG. HIF linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations. Mol Cell Biol., 27:5381-92 (2007) pdf
Yan Q, Bartz S, Mao M, Li L, Kaelin WG. The HIF2 alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo. Mol Cell Biol. 27:2092-102 (2007) pdf