sung (2K)
Department of Molecular Biophysics and Biochemistry
Yale University

333 Cedar Street, PO Box 208024
New Haven, CT 06520-8024
Phone Number (203) 785-4569

publicationimage (4K)
(selected from recently published)  

Flott S, Kwon Y, Pigli YZ, Rice PA, Sung P, Jackson SP. (2011) Regulation of rad51 function by phosphorylation. EMBO Rep.
Kwon Y, Zhao W, Sung P. (2011) Biochemical studies on human rad51-mediated homologous recombination. Methods Mol Biol. 745:421-35
Chi P, Kwon Y, Visnapuu ML, Lam I, Santa Maria SR, Zheng X, Epshtein A, Greene EC, Sung P, Klein HL. (2011) Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors. Nucleic Acids Res.
Say AF, Ledford LL, Sharma D, Singh AK, Leung WK, Sehorn HA, Tsubouchi H, Sung P, Sehorn MG. (2011) The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure. DNA Repair (Amst). 10:586-94.
Fukunaga K, Kwon Y, Sung P, Sugimoto K. (2011) Activation of protein kinase Tel1 through recognition of protein-bound DNA ends. Mol Cell Biol. 31:1959-71
Williams SA, Longerich S, Sung P, Vaziri C, Kupfer GM.  (2011) The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI. Blood. 117:5078-87.
Dray E, Dunlop MH, Kauppi L, San Filippo J, Wiese C, Tsai MS, Begovic S, Schild D, Jasin M, Keeney S, Sung P. (2011) Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1). Proc Natl Acad Sci U S A. 108:3560-5.
Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P. (2010) Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol. 17:1255-9.
Wang F, Yang Y, Singh TR, Busygina V, Guo R, Wan K, Wang W, Sung P, Meetei AR, Lei M. (2010) Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex.  Structure. 18:1159-70.
Niu H, Chung WH, Zhu Z, Kwon Y, Zhao W, Chi P, Prakash R, Seong C, Liu D, Lu L, Ira G, Sung P. (2010) Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature. 467:108-11. 
Altmannova V, Eckert-Boulet N, Arneric M, Kolesar P, Chaloupkova R, Damborsky J, Sung P, Zhao X, Lisby M, Krejci L. (2010) Rad52 SUMOylation affects the efficiency of the DNA repair. Nucleic Acids Res. 38:4708-21.
Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, Stark JM, Sung P, Janscak P. (2010) Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity. J Biol Chem. 285:15739-45. 
Singh TR, Saro D, Ali AM, Zheng XF, Du CH, Killen MW, Sachpatzidis A, Wahengbam K, Pierce AJ, Xiong Y, Sung P, Meetei AR. (2010) MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Mol Cell. 37:879-86.
Niu H, Wan L, Busygina V, Kwon Y, Allen JA, Li X, Kunz RC, Kubota K, Wang B, Sung P, Shokat KM, Gygi SP, Hollingsworth NM. (2009) Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. Mol Cell. 36:393-404.
Shi I, Hallwyl SC, Seong C, Mortensen U, Rothstein R, Sung P. (2009) Role of the Rad52 amino-terminal DNA binding activity in DNA strand capture in homologous recombination. J Biol Chem. 284:33275-84.
Colavito S, Macris-Kiss M, Seong C, Gleeson O, Greene EC, Klein HL, Krejci L, Sung P. (2009) Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption. Nucleic Acids Res.  37:6754-64.
Robertson RB, Moses DN, Kwon Y, Chan P, Chi P, Klein H, Sung P, Greene EC. (2009) Structural transitions within human Rad51 nucleoprotein filaments. ProcNatl Acad Sci U S A. 106:12688-93.