Recent Publications

For a complete list of publications, click here.

Herbert KM, Pimienta G, Degregorio SJ, Alexandrov A, Steitz JA. Phosphorylation of DGCR8 Increases Its Intracellular Stability and Induces a Progrowth miRNA Profile. Cell Rep. 2013 Nov 13.[PDF]

Moss WN, Steitz JA. Genome-wide analyses of Epstein-Barr virus reveal conserved RNA structures and a novel stable intronic sequence RNA. BMC Genomics. 2013 Aug 9;14:543.[PDF]

Riley KJ, Steitz JA. The "Observer Effect" in genome-wide surveys of protein-RNA interactions. Mol Cell. 2013 Feb 21;49(4):601-4.[PDF]

Alexandrov A, Colognori D, Shu MD, Steitz JA. Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21313-8.[PDF]

Brown JA, Valenstein ML, Yario TA, Tycowski KT, Steitz JA. Formation of triple-helical structures by the 3'-end sequences of MALAT1 and MENβ noncoding RNAs. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19202-7.[PDF]

Lee N, Pimienta G, Steitz JA. AUF1/hnRNP D is a novel protein partner of the EBER1 noncoding RNA of Epstein-Barr virus. RNA. 2012 Nov;18(11):2073-82.[PDF]

Tycowski KT, Shu MD, Borah S, Shi M, Steitz JA. Conservation of a Triple-Helix-Forming RNA Stability Element in Noncoding and Genomic RNAs of Diverse Viruses. Cell Rep. 2012 Jul 26;2(1):26-32.[PDF]

Riley KJ, Yario TA, Steitz JA. Association of Argonaute proteins and microRNAs can occur after cell lysis. RNA. 2012 Sep;18(9):1581-5. [PDF]

Borah S, Nichols LA, Hassman LM, Kedes DH, Steitz JA. Tracking expression and subcellular localization of RNA and protein species using high-throughput single cell imaging flow cytometry. RNA. 2012 Aug;18(8):1573-9.[PDF]

Riley KJ, Rabinowitz GS, Yario TA, Luna JM, Darnell RB, Steitz JA. EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012 Mar 30;31(9):2207-21. [PDF]

Nag A, Steitz JA. Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicing. RNA Biol. 2012 Mar 1;9(3):334-42.[PDF]

Cazalla D, Xie M, Steitz JA. A primate herpesvirus uses the integrator complex to generate viral microRNAs. Mol Cell. 2011 Sep 16;43(6):982-92.

Borah S, Darricarrère N, Darnell A, Myoung J, Steitz JA. A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression.PLoS Pathog. 2011 Oct;7(10):e1002300.[PDF]

Alexandrov A, Colognori D, Steitz JA. Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex. Genes Dev. 2011 May 15;25(10):1078-90. [PDF]

Mortensen RD, Serra M, Steitz JA, Vasudevan S. Posttranscriptional activation of gene expression in Xenopus laevis oocytes by microRNA-protein complexes (microRNPs). Proc Natl Acad Sci U S A. 2011 May 17;108(20):8281-6. [PDF]

Martinez I, Cazalla D, Almstead LL, Steitz JA, DiMaio D. miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):522-7.[PDF]

Cazalla D, Steitz JA. Down-Regulation of a Host microRNA by a Viral Noncoding RNA. Cold Spring Harb Symp Quant Biol. 2010 Dec 7.[PDF]

Mitton-Fry RM, DeGregorio SJ, Wang J, Steitz TA, Steitz JA. Poly(A) tail recognition by a viral RNA element through assembly of a triple helix. Science. 2010 Nov 26;330(6008):1244-7.[PDF]

Cazalla D, Yario T, Steitz JA. Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA. Science. 2010 Jun 18;328(5985):1563-1566. [PDF]

Riley KJ, Rabinowitz GS, Steitz JA. Comprehensive Analysis of Rhesus Lymphocryptovirus MicroRNA Expression. J Virol. 2010 May;84(10):5148-57. [PDF]

Pawlicki JM, Steitz JA. Nuclear Networking fashions pre-messenger RNA and primary microRNA transcripts for function. Trends Cell Biol. 2010 Jan;20(1):52-61. [PDF]

Steitz JA, Vasudevan S. miRNPs: versatile regulators of gene expression in vertebrate cells. Biochem Soc Trans. 2009 Oct;37(Pt 5):931-5. [PDF]

Tycowski KT, Shu MD, Kukoyi A, Steitz JA. A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles. Mol Cell. 2009 Apr 10;34(1):47-57. [PDF]

Borah S, Wong AC, Steitz JA. Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron. Proc Natl Acad Sci U S A. 2009 Feb 5. [PDF]

Pawlicki JM, Steitz JA. Subnuclear compartmentalization of transiently expressed polyadenylated pri-microRNAs: processing at transcription sites or accumulation in SC35 foci. Cell Cycle. 2009 Feb 1;8(3):345-56. [PDF]

Mishler DM, Christ AB, Steitz JA. Flexibility in the site of exon junction complex deposition revealed by functional group and RNA secondary structure alterations in the splicing substrate. RNA. 2008 Dec;14(12):2657-70. [PDF]

Kolev NG, Yario TA, Benson E, Steitz JA. Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3’-end maturation. EMBO Rep. 2008 Oct;9(10):1013-8. [PDF]

Pawlicki JM, Steitz JA. Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production. J Cell Biol. 2008 Jul 14;182(1):61-76. [PDF]

Friend K, Kolev NG, Shu MD, Steitz JA. Minor-class splicing occurs in the nucleus of the Xenopus oocyte. RNA. 2008 Aug;14(8):1459-62. [PDF]

Steitz JA, Dreyfuss G, Krainer AR, Lamond AI, Matera AG, Padgett RA. Where in the cell is the minor spliceosome? Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8485-6. [PDF]

Vasudevan S, Tong Y, Steitz JA.Cell-cycle control of microRNA-mediated translation regulation. Cell Cycle. 2008 Jun;7(11):1545-9. [PDF]

Vasudevan S, Tong Y, Steitz JA. Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation. Science. 2007 Dec 21;318(5858):1931-4. [PDF]

Friend K, Lovejoy AF, Steitz JA. U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation. Mol Cell. 2007 Oct 26;28(2):240-52. [PDF]

Conrad NK, Shu MD, Uyhazi KE, Steitz JA. Mutational analysis of a viral RNA element that counteracts rapid RNA decay by interaction with the polyadenylate tail. Proc Natl Acad Sci USA. 2007 Jun 19;104(25):10412-7. [PDF]

Lytle JR, Yario TA, Steitz JA. Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR. Proc Natl Acad Sci USA. 2007 Jun 5;104(23):9667-72. [PDF]

Vasudevan S, Steitz JA. AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell. 2007 Mar 23;128(6):1105-18. [PDF]