Current Research
We use biochemical, molecular, immunocytochemical, and behavioral techniques in animal models to address the role that STEP plays in regulating aspects of learning.
Current projects include the involvement of STEP in three disorders: Alzheimer's disease, fragile X syndrome, and schizophrenia.
We are characterizing the STEP knock-out mouse, STEP's regulation of local protein translation, STEP's regulation of glutamate receptor trafficking, as well as screening for STEP inhibitors that are tested in animal models to determine if we can rescue cognitive deficits.
In The News
Some local news stations and papers have recently shown interest in our research. We've collected the articles and videos below:
- Yale Daily News - Micah Johnson '13: Fixing the brain, 'the greatest magic show on earth" (link)
- Society For Neuroscience - Research Provides Clues to Neurodevelopmental Disorders (link)
- Society For Neuroscience - Mental Illness: Probing the Causes of Schizophrenia, Depression, & Anxiety (link)
- WTNH News 8 - Reversing the Effects of Alzheimer's (link)
- Hartford Courant - Yale Researchers Reverse Alzheimer's Effects in Mice (link)
- Yale Daily News - Yale Researchers Tackle Alzheimer's Disease (link)
- EurekAlert! (Chinese) - Respond to cognitive impairment Alzheimer's disease: one-time "Step" (link) (English translation)