Development and Neurobiology Columns

Lombroso PortraitOver the past decade, I have invited experts in the field of neuroscience to write a series of articles that were published in the Journal of the American Academy of Child and Adolescent Psychiatry. The goal of these columns was to provide the readership with an opportunity to share the excitement of neuroscience relevant to child development and psychopathology.

To read these columns, click here.

Selected STEP Publications

  • Gladding CM, Sepers MD, Xu J, Zhang LY, Milnerwood AJ, Lombroso PJ, Raymond LA (2012) Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Hungtindon's disease mouse model. Hum Mol Genet. [PDF]
  • Xu J, Kurup P, Nairn AC, Lombroso PJ (2012) Striatal-enriched protein tyrosine phosphatase in Alzheimer's disease. Adv Pharmacol. [PDF]
  • Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ (2012) Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity. J Biol Chem. [PDF]
  • Carty NC, Xu J, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Haroutunian V, Pittenger C, Lombroso PJ (2012)  The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Transl Psychiatry. [PDF]
  • Goebel-Goody SM, Wilson-Wallis ED, Royston S, Tagliatela SM, Naegele JR, Lombroso PJ (2012) Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model. Genes Brains Behav. [PDF]
  • Sergienko E, Xu J, Liu WE, Dahl R, Critton DA, Su Y, Brown BT, Chan X, Yang L, Bobkova EV, Vasile S, Yuan H, Rascon J, Colayco S, Sidique S, Cosford ND, Chung TD, Mustelin T, Page R, Lombroso PJ, Tautz L (2012) A specific inhibitor of hematopoietic protein tyrosine phosphatase augments ERK and p38 activation in vivo. ACS Chem Biol PMC3288537. [PDF]
  • Goebel-Goody SM, Lombroso PJ (2012) Taking STEPs Forward to Understand Fragile X Syndrome. [PDF]
  • Goebel-Goody SM, Baum M, Paspalas C, Carty NC, Fernandez S, Kurup P, Lombroso PJ (2012) Therapeutic implications for STriatal-Enriched protein tyrosine Phosphatase (STEP) in neuropsychiatric disorders. Pharmacological Reviews 64:65-87. [PDF]
  • Venkitaramani DV, Moura PJ, Picciotto MR, Lombroso PJ (2011) Striatal-Enriched protein tyrosine Phosphatase (STEP) knockout mice have enhanced hippocampal memory. European Journal of Neuroscience 33:2288-2298. [PDF]
  • Briggs S, Lombroso PJ, Janice Naegele J, Aaron G (2011) STEP regulation of epileptogenesis in the hippocampus. Epilepsia 52:497-506. [PDF]
  • Zhang YF, Kurup P, Xu J, Anderson G, Greengard P, Nairn AC, Lombroso PJ (2011) Reduced levels of the tyrosine phosphatase STEP block beta amyloid-mediated GluA1/GluA2 receptor internalization. Journal of Neurochemistry 119:664-472. [PDF]
  • Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas J, Lombroso PJ, Alberch J, Pérez-Navarro E (2011) STEP expression and activity in Huntington’s disease-a STEP in the resistance to excitotoxicity. Journal of Neuroscience 31:8150-8162. [PDF]
  • Hicklin TR, Wu PH, Radcliffe RA, Freund RK, Goebel SM, Proctor WR, Lombroso PJ, Browning MD (2011) STriatal Enriched protein tyrosine Phosphatase (STEP) mediates ethanol inhibition of NMDA receptor activity at hippocampal glutamatergic synapses. PNAS 108:6650-6655. [PDF]
  • Baum ML, Kurup P, Xu J, Lombroso PJ (2010) A STEP forward in neural function and degeneration. Communicative and Integrative Biology 3:419-422. [PDF]
  • Zhang YF, Kurup P, Xu J, Carty N, Fernandez S, Nygaard HB, Pittenger C, Greengard P, Strittmatter S, Nairn AC and Lombroso PJ (in press) Genetic reduction of STEP reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model. PNAS 107:19014-19019. [PDF]
  • Kurup P, Zhang YF, Xu J, Venkitaramani DV, Haroutunian V, Nairn A, Lombroso PJ (2010) Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. Journal of Neuroscience 30:5948-5957. [PDF]
  • Xu J, Kurup P, Zhang YF, Goebel-Goody S, Wu P, Hawasli AH, Baum M, Bibb J, Lombroso PJ (2009) Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. Journal of Neuroscience 29:9330-9343. [PDF]
  • Tashev R, Moura PJ, Venkitaramani DV, Prosperetti C, Bernardi G, Centonze C, Paul S, Lombroso PJ (2009) The tyrosine phosphatase, STEP, regulates long-term potentiation and amphetamine-induced stereotypies in the ventrolateral striatum. Biological Psychiatry 65:637-645. [PDF]
  • Paspalas CD, Perley CC, Venkitaramani DV, Goebel-Goody S, Zhang YF, Kurup P, Mattis JH, Lombroso PJ (2009) Major Vault Protein is expressed along the nucleus-neurite axis and associates with mRNAs in cortical neurons. Cerebral Cortex 19:1666-1677. [PDF]
  • Venkitaramani DV, Paul S, Ding L, Tressler L, Allen M, Sacca R, Picciotto MR, Lombroso PJ (2009) Knockout of STriatal-Enriched protein tyrosine Phosphatase (STEP) in mice results in increased ERK1/2 phosphorylation. Synapse 63:69-81. [PDF]
  • Zhang Y, Venkitaramani DV, Gladding CM, Zhang Y, Kurup P, Molnar E, Lombroso PJ (2008) The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation. Journal of Neuroscience 28:10561-10566. [PDF]
  • Venkitaramani DV, Chin J, Netzer WJ, Gouras GK, Lesne S, Malinow R, Lombroso PJ (2007) Beta amyloid modulation of synaptic transmission and plasticity. Journal of Neuroscience 27:11832-11837. [PDF]
  • Choi YS, Lin SL, Lee B, Kurup P, Naegele JR, Lombroso PJ, Obrietan K (2007) The ERK/MAPK phosphatase STEP controls seizure-induced hippocampal interneuron cell death. Journal of Neuroscience 27:2999-3009. [PDF]
  • Hu Y, Zhang Y, Venkitaramani DV, Lombroso PJ (2007) Synaptic translation of STriatal-Enriched protein tyrosine Phosphatase (STEP) after b1-adrenergic stimulation. Journal of Neurochemistry 103:531-541. [PDF]
  • Braithwaite S, Paul S, Nairn A, Lombroso, PJ (2006) Learning and  Memory: One STEP at Time. Trends in Neuroscience 29:452-458. [PDF]
  • Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, Nairn AC,  Salter MW, Lombroso PJ, Gouras GK, Greengard P (2005) Regulation of  NMDA receptor trafficking by beta-amyloid. Nature Neuroscience 8:1051-1058. [PDF]
  • Paul S, Nairn A, Wang P, Lombroso PJ (2003) NMDA-mediated activation of the PTP, STEP, regulates the duration of ERK signaling. Nature Neuroscience 6:34-42. [PDF]
  • Pelkey K, Askalan R, Paul S, Kalia LV, Nguyen T-H, Pitcher GM,  Salter MW, Lombroso PJ (2002) Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation. Neuron 34:127-138. [PDF]
  • Nguyen TH, Liu J, Lombroso PJ (2002) Striatal enriched phosphatase 61 (STEP61) dephosphorylates Fyn at phosphotyrosine 420. Journal of Biological Chemistry 277:24274-24279. [PDF]
  • Paul S, Hisayuki Y, Snider G, Picciotto M, Nairn A, Lombroso  PJ (2000) Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase, STEP, through a PKA- mediated pathway. Journal of Neuroscience 20:5630-5638. [PDF]
  • Bult A, Zhao F, Dirkx R, Sharma E, Lukacsi E, Solimena M, Naegele JR, Lombroso PJ (1996) STEP61: A new member of a family of brain-enriched PTPs is localized to the ER. Journal of Neuroscience 16:7821-7831. [PDF]