Fragile X syndrome
Fragile X syndrome is a developmental disorder that is one of the translational neuroscience projects in the lab. Dr. Susan Goebel-Goody is in charge of this project and is currently writing up her results. The basic hypothesis being tested is that STEP is over-expressed in this disorder. This in turn leads to a disruption of synaptic plasticity and contributes to the cognitive deficits that are present. Here two review columns on fragile x syndrome written by Marilee Ogren, Ph.D. and myself.