Lombroso Lab - Development and Neurobiology Columns

Development and Neurobiology Columns

Our understanding of the biological and environmental factors that influence brain development has grown dramatically over recent years. Advances in genetics have begun to clarify the molecular basis of not only single gene disorders, such as fragile X syndrome, but also more complex phenotypes such as dyslexia and schizophrenia. New neuroimaging techniques show us the shapes and sizes of brain nuclei, the concentrations of neurotransmitters, and the changes in neuronal activity within the brain while it is actually completing tasks. I have worked more recently with Dr. Marilee Ogren to expand on the original columns and we now present all of the columns below. These are complex topics that we have tried to make available to the general public as well as scientists interested in areas they may not have explored before. Happy reading, and let us know if you would like to see more of these columns at this site.

Click on a column to view it as a PDF.

1. Development of the Cerebral Cortex, part 1 Pasko Rakic, MD/ScD Paul Lombroso, MD	27. Genetics of Childhood Disorders: 12. Genomic Imprinting, part 1 David Everman, MD Suzanne Cassidy, MD	53. Stem Cell: part 2: Reconstructing the Brain Fiona Doetsch, PhD

2. Development of the Cerebral Cortex, part 2: Lissencephaly Orly Reiner, PhD Paul Lombroso, MD	28. Genetics of Childhood Disorders: 13. Genomic Imprinting, part 2 John Greally PhD Matthew State, MD/PhD	54. Stem Cell: part 3: Regulation of Neurogenesis by Stress and Antidepressant Treatment Ronald Duman, PhD

3. Development of the Cerebral Cortex, part 3: The Reeler Mutation Paul Lombroso, MD	29. Genetics of Childhood Disorders: 14. News Flash: A Gene for Rett Syndrome Paul Lombroso, MD	55. Stem Cell: part 4: Neural Horticulture Magdalena Chechlacz, MS Janice Naegele, PhD

4. Development of the Cerebral Cortex, part 4: Transcription Factors James Leckman, MD, Paul Lombroso, MD	30. Genetics of Childhood Disorders: 15. Prader-Willi Syndrome Matthew State, MD Elisabeth Dykens, PhD	56. Stem Cell: part 5: Ethical Questions Gene Outka, PhD

5. Development of the Cerebral Cortex, part 5: Transcription Factors and Brain Development John Rubenstein, MD/PhD	31. Genetics of Childhood Disorders: 16. Angelman Syndrome Paul Lombroso, MD	57. Autism, part 1: Diagnosis and Assessment in Autistic Spectrum Disorders Catherine Lord, PhD Fred Volkmar, MD

6. Development of the Cerebral Cortex, part 6: Growth Factors: I Paul Lombroso, MD	32. ADHD, part 1: The Executive Functions and ADHD Russell Barkley, PhD	58. Autism, part 2: Neural Foundations Robert Schultz, PhD Ami Klin, PhD

7. Development of the Cerebral Cortex, part 7: Growth Factors: II Flora Vaccarino, MD Paul Lombroso, MD	33. ADHD, part 2: Norepinephrine has a Critical Influence on Prefrontal Cortical Function Amy Arnsten, PhD	59. Autism, part 3: Psychopharmacology of Autism Christopher McDougle, MD David Posey, MD

8. Development of the Cerebral Cortex, part 8: Apoptosis: Neuronal Hari-Kari Janice Naegele, PhD Paul Lombroso, MD	34. ADHD, part 3: Is ADHD a Noradrenergic Disorder? Joseph Biederman, MD Thomas Spencer, MD	60. Autism, part 4: Serotonin in Autism George Anderson, PhD

9. Development of the Cerebral Cortex, part 9: Cortical Development and Experience: I Susan Hockfield, PhD Paul Lombroso, MD	35. ADHD, part 4: Is ADHD Genetically Heterogenous? Stephen Faraone, PhD	61. Autism, part 5: Genetics of Autism Jeremy Veenstra-Vanderweele, MD Edwin Cook, MD

10. Development of the Cerebral Cortex, part 10: Cortical Development and Experience: II Susan Hockfield, PhD Paul Lombroso, MD	36. ADHD, part 5: A Behavioral Genetic Prespective Richard Todd, MD/PhD	62. Autism, part 6: Duplication and Inherited Susceptibility of Chromosome 15q11-q13 Genes in Autism James Sutcliffe, PhD Erika Nurmi, BS

11. Development of the Cerebral Cortex, part 11: Sexual Dimorphism in the Brain John Kirn, PhD Paul Lombroso, MD	37. ADHD, part 6: Dopamine D4 Receptor Gene Cathy Barr, PhD	63. Learning and Memory, part 1: Fragile X Syndrome Update Paul Lombroso, MD

12. Development of the Cerebral Cortex, part 12: Stress and Brain Development: I Paul Lombroso, MD Robert Sapolsky, PhD	38. ADHD, part 7: The Serotonin System Jennifer Quist, BS James Kennedy, MD	64. Learning and Memory, part 2: Multiple Memory Systems Stuart Zola, PhD Larry Squire, PhD

13. Development of the Cerebral Cortex, part 13: Stress and Brain Development: II Bruce McEwen, PhD	39. ADHD, part 8: Hyperdopaminergic Mice as an Animal Model of ADHD Raul Gainetdinov, MD/PhD Marc Caron, PhD	65. Learning and Memory, part 3: Fear Conditioning Kerry Ressler, MD/PhD Michael Davis, PhD

14. Development of the Cerebral Cortex, part 14: Stress Impairs Prefrontal Cortical Function Amy Arnsten, PhD	40. Velocardiofacial Syndrome Doron Gothelf, MD Paul Lombroso, MD	66. Learning and Memory, part 4: Human Cognitive Disorders and the ras/ERK/CREB Pathway J. David Sweatt, PhD Edwin Weeber, PhD Paul Lombroso, MD

15. Development of the Cerebral Cortex, part 15: Sexual Differentiation of the Central Nervous System Roger Gorski, PhD	41. Williams Syndrome, part 1: Williams Syndrome and Brain-Behavior Relationships Robert Schultz, PhD David Grelotti, BA Barbara Pober, MD	67. Learning and Memory, part 5: Human Cognitive Disorders and the ras/ERK/CREB Pathway J. David Sweatt, PhD Edwin Weeber, PhD

16. Genetics of Childhood Disorders 1: Genetics and Intelligence Robert Sternberg, PhD Elena Grigorenko, PhD	42. Williams Syndrome, part 2: Genes and Cognition in Williams Syndrome Lucy Osborne, PhD Barbara Pober, MD	68. Learning and Memory, part 6: Induction of Long-Term Potentiation Robert Blitzer, PhD Paul Lombroso, MD

17. Genetics of Childhood Disorders 2: Genetics and Intelligence Alan Kaufman, PhD	43. Autoimmunity, part 1 Syed Morshed, MD/PhD Marcos Mercadante, MD/PhD Paul Lombroso, MD	69. Learning and Memory, part 7: Maintenance of Long-Term Potentiation Robert Blitzer, PhD

18. Genetics of Childhood Disorders 3: Genetics and Intelligence Robert Plomin, PhD	44. Autoimmunity, part 2: Molecular Mimicry Martin Stocks, PhD	70. Prenatal Drug Exposure: Prenatal Drug Exposure Linda Mayes, MD

19. Genetics of Childhood Disorders 4: Linkage Analysis David Pauls, PhD	45. Autoimmunity, part 3: Myasthenia gravis and Rasmussen's encephalitis Paul Lombroso, MD Marcos Mercadante, MD/PhD	71. Epigenetics, part 1: Maternal Behavior Permanently Affects Adult Behavior in Offspring Marilee Ogren, PhD Paul Lombroso, MD

20. Genetics of Childhood Disorders 5: Nonparametric Methods of Genetics Analysis Yoav Kohn, MD Paul Lombroso, MD	46. Autoimmunity, part 4: Is Sydenham Chorea an Autoimmune Disorder? Christopher Loiselle, BS Harvey Singer, MD	72. Epigenetics, part 2: Molecular Mechanisms Marilee Ogren, PhD Paul Lombroso, MD

21. Genetics of Childhood Disorders 6: FISH, FISH, and More FISH David Ward, PhD Patricia Bray-Ward, PhD Paul Lombroso, MD	47. Autoimmunity, part 5: Streptococcal Infection and Autoimmunity, an Epidemiological Perspective Debra Bessen, PhD	73. Fragile X Syndrome, part 1: Keys to the Molecular Genetics of Synaptic Plasticity Paul Lombroso, MD Marilee Ogren, PhD

22. Genetics of Childhood Disorders 7: Cloning Genes of Interest Rachel Sparks, BA Paul Lombroso, MD Jeffrey Gruen, MD	48. Autoimmunity, part 6: Poststreptococcal Autoimmunity Susan Swedo, MD	74. Fragile X Syndrome, part 2: Reversing the Effects of Fragile X Syndrome Marilee Ogren, PhD Paul Lombroso, MD

23. Genetics of Childhood Disorders 8: Making Sense Out of Nonsense John Greally, PhD Paul Lombroso MD	49. Autoimmunity, part 7: D8/17 Reactivity as an Immunological Marker of susceptibility to Neuropsychiatric disorders Tanya Murphy, MD Wayne Goodman, MD	75. Learning and Memory, part 1: Brain Regions Involved in Two Types of Learning and Memory Paul Lombroso, MD Marilee Ogren, PhD

24. Genetics of Childhood Disorders 9: Triplet Repeat Disorders Russell Margolis, MD Christopher Ross, MD/PhD	50. Autoimmunity, part 8: Animal models of Noninflammatory Autoimmune Disorders of the Brain Joseph Hallett, MD Louise Kiessling, MD	76. Learning and Memory, part 2: Molecular Mechanisms of Synaptic Plasticity Paul Lombroso, MD Marilee Ogren, PhD

25. Genetics of Childhood Disorders 10: Huntington Disease Marian DiFiglia, PhD	51. A Gene for Expressive Language Paul Lombroso, MD	77. Heterogeneity and Homogeneity across the Autism Spectrum Warren Jones, PhD Ami Klin, PhD

26. Genetics of Childhood Disorders 11: Fragile X Syndrome Stephan Eliez, MD Allan Reiss, MD	52. Stem Cell, part 1: New Neurons in the Adult Brian Henriette van Praag, PhD Fred Gage, PhD	78. Conceptualizing Autism: The Role for Emergence George Anderson, PhD