Yale School of Medicine
Laboratory Medicine (small parent)
Laboratory Medicine - Krause Lab

Krause Laboratory
Amistad Building
214I
New Haven, CT 06519
Tel: 203-737-1678
Fax: 203-785-7095
diane.krause@yale.edu

Selected Publications

Hematopoiesis/Leukemogenesis
  • Ma X, Husain T, Peng H, Lin S, Mironenko O, Maun N, Johnson S, Tuck D, Berliner N, Krause DS, and Perkins AS. Development of a murine hematopoietic progenitor cDNA microarray using a subtracted cDNA library. Blood 100:833-44, 2002.
  • Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood 108: 2726-35, 2006.
  • Ma X, Renda M, Wang L, Cheng E, Niu C, Morris S, Chi AS, Krause DS. Rbm15 Modulates Notch-induced Transcriptional Activation and Affects Myeloid Differentiation. MCB, 27-8: 3056-3064, 2007.
  • Cheng EC, Luo Q, Bruscia EM, Renda MJ, Troy JA, Massaro SA, Tuck D, Schulz V, Mane SM, Berliner N, Sun Y, Morris SW, Qiu C, Krause DS. Role for MKL1 in megakaryocytic maturation. Blood 2009 113:2826-34.
  • Halene S, Gao Y, Hahn K, Massaro S, Italiano JE, Lin S, Kupfer GM, Krause DS. Serum Response Factor is an essential transcription factor in megakaryocytic maturation. Blood 116:1942-1950, 2010. PMID: 20525922.
  • Bruscia EM, Zhang P, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Krause DS. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunology 186: 6990-98, 2011. PMID: 21593379.
  • Gao Y, Smith E, Ker E, Campbell P, Cheng E, Zou S, Lin S, Wang L, Halene S, Krause DS. Role of RhoA specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Developmental Cell, 2012.
Differentiation of marrow-derived cells into epithelial cells
  • Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology, 31: 235-240, 2000.
  • Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, Henegariu O, Krause DS. Liver from bone marrow in humans. Hepatology, 32: 11-16, 2000.
  • Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369-77, 2001.
  • Theise ND, Henegariu O, Grove JE, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. Radiation Pneumonitis in Mice: A Severe Injury Model for Pneumocyte Engraftment from Bone Marrow, Experimental Hematology; 30:1333-1338, 2002.
  • Grove JE, Lutzko C, Priller J, Henegariu O, Theise ND, Kohn DB, Krause DS. Marrow-derived cells as vehicles for delivery of gene-therapy to pulmonary epithelium, American Journal of Respiratory Cell and Molecular Biology 27: 645-651, 2002.
  • Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Lack of a fusion requirement for development of bone marrow derived epithelia. Science 305: 90, 2004.
  • Borue X, Lee S, Grove JE, Herzog EL, Harris R, Diflo T, Glusac E, Hyman K, Theise N, Krause DS. Bone marrow derived stem cells are recruited to wounded skin, and contribute to epithelial engraftment during wound healing. Am. Journal of Pathology 165: 1767-72, 2004.
  • Bruscia E, Price J, Cheng E, Weiner S, Caputo C, Ferreira E, Egan ME, Krause DS. Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice following bone marrow transplantation. PNAS 103: 2965-70, 2006.
  • Herzog EL, Van Arnam J, Hu B, Krause DS. Threshold of lung injury required for the appearance of marrow-derived lung epithelia. Stem Cells 24: 1986-1992, 2006. PMID: 16868209
  • Bruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS. Engraftment of donor derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Stem Cells 24: 2299-2308, 2006. PMID: 16794262
  • Swenson ES, Guest I, Ilic Z, Mazzeo M, Lizardi P, Hardiman C, Sell S, Krause DS. Hepatocyte Nuclear Factor-1 as marker of epithelial phenotype reveals marrow-derived hepatocytes, but not duct cells, after liver injury in mice. Stem Cells.26:1768-1777, 2008. PMID: 18467658
  • Kassmer SH, Krause DS. Detection of bone marrow-derived lung epithelial cells. Exp Hematol. 38:564-573, 2010. PMID: 20447442
  • Kassmer SH, Bruscia EM, Zhang PX, Krause DS. Non-Hematopoietic cells are the primary source of bone marrow derived lung epithelial cells. Stem Cells (online Dec. 2011). PMID:22162244