Section of Microbial Pathogenesis LinkYale School of Medicine LinkYale School of Medicine Link



Selected Publications


Review Articles/Book Chapters

Research Articles

Song J, Gao X, Galán JE.Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature. 2013 Jul 18;499(7458):350-4.
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Hicks SW, Galán JE. Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors. Nat Rev Microbiol. 2013 May;11(5):316-26.
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Chen X, Taylor DW, Fowler CC, Galan JE, Wang HW, Wolin SL. An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA. Cell. 2013 Mar 28;153(1):166-77.
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Carleton HA, Lara-Tejero M, Liu X, Galán JE. Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery. Nat Commun. 2013;4:1590.
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Hofreuter D, Mohr J, Wensel O, Rademacher S, Schreiber K, Schomburg D, Gao B, Galán JE. Contribution of Amino Acid Catabolism to the Tissue Specific Persistence of Campylobacter jejuni in a Murine Colonization Model. PLoS ONE. 2012;7(11): e50699.
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Hodak H, Galán JE. A Salmonella Typhi homologue of bacteriophage muramidases controls typhoid toxin secretion. EMBO Rep. 2012 Nov 23.
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Spanò S, Galán JE. A Rab32-dependent pathway contributes to Salmonella typhi host restriction. Science. 2012 Nov 16;338(6109):960-3.
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Zhong D, Lefebre M, Kaur K, McDowell MA, Gdowski C, Jo S, Wang Y, Benedict SH, Lea SM, Galan JE, De Guzman RN. The Salmonella type III secretion system inner rod protein PrgJ is partially folded. J Biol Chem. 2012 Jul 20;287(30):25303-11.
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Liu X, Gao B, Novik V, Galán JE. Quantitative Proteomics of Intracellular Campylobacter jejuni Reveals Metabolic Reprogramming. PLoS Pathog. 2012;8(3):e1002562.
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Spanò S, Liu X, Galán JE. Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18418-23.
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Mukherjee S, Liu X, Arasaki K, McDonough J, Galán JE, Roy CR. Modulation of Rab GTPase function by a protein phosphocholine transferase. Nature. 2011 Aug 7;477(7362):103-6.
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Button JE, Galán JE. Regulation of chaperone/effector complex synthesis in a bacterial type III secretion system. Mol Microbiol. 2011 Sep;81(6):1474-83.
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Hicks SW, Charron G, Hang HC, Galán JE. Subcellular targeting of Salmonella virulence proteins by host-mediated S-palmitoylation. Cell Host Microbe. 2011 Jul 21;10(1):9-20.
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Lara-Tejero M, Kato J, Wagner S, Liu X, Galán JE. A sorting platform determines the order of protein secretion in bacterial type III systems. Science. 2011 Mar 4;331(6021):1188-91.
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Song J, Willinger T, Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, Galán JE. A mouse model for the human pathogen Salmonella typhi. Cell Host Microbe. 2010 Oct 21;8(4):369-76.
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Wagner S, Königsmaier L, Lara-Tejero M, Lefebre M, Marlovits TC, Galan JE. Organization and coordinated assembly of the type III secretion export apparatus. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17745-50.
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Novik V, Hofreuter D, Galan JE. Identification of Campylobacter jejuni genes involved in its interaction with epithelial cells. Infect Immun. 2010 Aug;78(8):3540-53.
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Schraidt O, Lefebre MD, Brunner MJ, Schmied WH, Schmidt A, Radics J, Mechtler K, Galán JE, Marlovits TC. Topology and organization of the Salmonella typhimurium type III secretion needle complex components. PLoS Pathog. 2010 Apr 1;6(4):e1000824.
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Hicks SW, Galán JE. Hijacking the host ubiquitin pathway: structural strategies of bacterial E3 ubiquitin ligases. Curr Opin Microbiol. 2010 Feb;13(1):41-6.
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Novik V, Hofreuter D, Galán JE. Characterization of a Campylobacter jejuni VirK protein homolog as a novel virulence determinant. Infect Immun. 2009 Dec;77(12):5428-36.
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Du F, Galán JE. Selective inhibition of type III secretion activated signaling by the Salmonella effector AvrA. PLoS Pathog. 2009 Sep;5(9):e1000595.
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Bruno VM, Hannemann S, Lara-Tejero M, Flavell RA, Kleinstein SH, Galán JE. Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells. PLoS Pathog. 2009 Aug;5(8):e1000538.
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Galán JE. Common themes in the design and function of bacterial effectors. Cell Host Microbe. 2009 Jun 18;5(6):571-9.
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Patel JC, Hueffer K, Lam TT, Galán JE. Diversification of a Salmonella virulence protein function by ubiquitin-dependent differential localization. Cell. 2009 Apr 17;137(2):283-94.
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Lara-Tejero M, Galán JE. Salmonella enterica serovar typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cells. Infect Immun. 2009 Jul;77(7):2635-42.
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Quezada CM, Hicks SW, Galán JE, Stebbins CE. A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4864-9.
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Hofreuter D, Novik V, Galán JE. Metabolic diversity in Campylobacter jejuni enhances specific tissue colonization. Cell Host Microbe. 2008 Nov 13;4(5):425-33.
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Patel JC, Galán JE. Investigating the function of Rho family GTPases during Salmonella/host cell interactions. Methods Enzymol. 2008;439:145-58.
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Galán JE. Energizing type III secretion machines: what is the fuel? Nat Struct Mol Biol. 2008 Feb;15(2):127-8.
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Spanò S, Galán JE. A novel pathway for exotoxin delivery by an intracellular pathogen. Curr Opin Microbiol. 2008 Feb;11(1):15-20.
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Watson RO, Galán JE. Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes. PLoS Pathog. 2008 Jan;4(1):e14.
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Spanò S, Ugalde JE, Galán JE. Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment. Cell Host Microbe. 2008 Jan 17;3(1):30-8.
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Strachan NJ, Watson RO, Novik V, Hofreuter D, Ogden ID, Galán JE. Sexual dimorphism in campylobacteriosis. Epidemiol Infect. 2008 Nov;136(11):1492-5.
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Galan JE. SnapShot: effector proteins of type III secretion systems. Cell. 2007 Jul 13;130(1):192.
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Haghjoo E, Galan JE. Identification of a transcriptional regulator that controls intracellular gene expression in Salmonella Typhi. Mol Microbiol. 2007 Jun;64(6):1549-61.
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Watson RO, Novik V, Hofreuter D, Lara-Tejero M, Galan JE. A MyD88-deficient mouse model reveals a role for Nramp1 in Campylobacter jejuni infection. Infect Immun. 2007 Apr;75(4):1994-2003. Epub 2006 Dec 28.
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Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galan JE, Harhaj
E, Flavell RA. Expression of interleukin-10 in intestinal lymphocytes detected by an
interleukin-10 reporter knockin tiger mouse. Immunity. 2006 Dec;25(6):941-52. Epub 2006 Nov 30.
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Galan JE, Wolf-Watz H. Protein delivery into eukaryotic cells by type III secretion machines. Nature. 2006 Nov 30;444(7119):567-73. Review.
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Patel JC, Galan JE. Differential activation and function of Rho GTPases during Salmonella-host cell interactions. J Cell Biol. 2006 Nov 6;175(3):453-63. Epub 2006 Oct 30.
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Chen LM, Briones G, Donis RO, Galan JE. Optimization of the delivery of heterologous proteins by the Salmonella enterica serovar Typhimurium type III secretion system for vaccine development. Infect Immun. 2006 Oct;74(10):5826-33.
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Kotton CN, Lankowski AJ, Scott N, Sisul D, Chen LM, Raschke K, Borders G,
Boaz M, Spentzou A, Galan JE, Hohmann EL. Safety and immunogenicity of attenuated Salmonella enterica serovar Typhimurium delivering an HIV-1 Gag antigen via the Salmonella Type III secretion system. Vaccine. 2006 Sep 11;24(37-39):6216-24. Epub 2006 Jun 13.
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Feuillet V, Medjane S, Mondor I, Demaria O, Pagni PP, Galan JE, Flavell RA,
Alexopoulou L. Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12487-92. Epub 2006 Aug 4.
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Hofreuter D, Tsai J, Watson RO, Novik V, Altman B, Benitez M, Clark C,
Perbost C, Jarvie T, Du L, Galan JE. Unique features of a highly pathogenic Campylobacter jejuni strain. Infect Immun. 2006 Aug;74(8):4694-707. Erratum in: Infect Immun. 2007 Jan;75(1):542.
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Nishikawa H, Sato E, Briones G, Chen LM, Matsuo M, Nagata Y, Ritter G, Jager
E, Nomura H, Kondo S, Tawara I, Kato T, Shiku H, Old LJ, Galan JE, Gnjatic S. In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines. J Clin Invest. 2006 Jun 22
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Marlovits TC, Kubori T, Lara-Tejero M, Thomas D, Unger VM, Galan JE. Assembly of the inner rod determines needle length in the type III secretion injectisome. Nature. 2006 Jun 1;441(7093):637-40.
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Lara-Tejero M, Sutterwala FS, Ogura Y, Grant EP, Bertin J, Coyle AJ, Flavell
RA, Galan JE. Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med. 2006 Jun 12;203(6):1407-12.
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Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant
EP, Bertin J, Coyle AJ, Galan JE, Askenase PW, Flavell RA. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 2006 Mar;24(3):317-27.
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Briones G, Hofreuter D, Galan JE. Cre reporter system to monitor the translocation of type III secreted proteins into host cells. Infect Immun. 2006 Feb;74(2):1084-90.
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Akeda Y, Galan JE. Chaperone release and unfolding of substrates in type III secretion. Nature. 2005 Oct 6;437(7060):911-5.
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Patel JC, Rossanese OW, Galan JE. The functional interface between Salmonella and its host cell: opportunities for therapeutic intervention.Trends Pharmacol Sci. 2005 Nov;26(11):564-70. Review.
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Watson RO, Galan JE. Signal transduction in Campylobacter jejuni-induced cytokine production. Cell Microbiol. 2005 May;7(5):655-65.
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Galan JE. Bacterial toxins and the immune system: show me the in vivo targets. J Exp Med. 2005 Feb 7;201(3):321-3.
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Patel JC, Galan JE. Manipulation of the host actin cytoskeleton by Salmonella--all in the name of entry. Curr Opin Microbiol. 2005 Feb;8(1):10-5.
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Galan JE, Cossart P. Host-pathogen interactions: a diversity of themes, a variety of molecular machines. Curr Opin Microbiol. 2005 Feb;8(1):1-3.
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Jiang X, Rossanese OW, Brown NF, Kujat-Choy S, Galan JE, Finlay BB, Brumell JH. The related effector proteins SopD and SopD2 from Salmonella enterica serovar Typhimurium contribute to virulence during systemic infection of mice. Mol Microbiol. 2004 Dec;54(5):1186-98.
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Marlovits TC, Kubori T, Sukhan A, Thomas DR, Galan JE, Unger VM. Structural insights into the assembly of the type III secretion needle complex. Science. 2004 Nov 5;306(5698):1040-2.
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Hueffer K, Galán JE. Salmonella-induced macrophage death: multiple mechanisms, different outcomes. Cell Microbiol. 2004 Nov;6(11):1019-25.
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Lara-Tejero M, Galán JE. A new twist in the hijacking of the actin-nucleating machinery. Mol Cell. 2004 Aug 27;15(4):495-7.
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Hernandez LD, Hueffer K, Wenk MR, Galán JE. Salmonella modulates vesicular traffic by altering phosphoinositide metabolism. Science. 2004 Jun 18;304(5678):1805-7.
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Akeda Y, Galán JE. Genetic Analysis of the Salmonella enterica Type III Secretion-Associated ATPase InvC Defines Discrete Functional Domains. J Bacteriol. 2004 Apr;186(8):2402-12.
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Haghjoo E, Galán JE. Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4614-9.
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McKinney JS, Zhang H, Kubori T, Galán JE, Altman S. Disruption of type III secretion in Salmonella enterica serovar Typhimurium by external guide sequences. Nucleic Acids Res. 2004 Feb 03;32(2):848-54.
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Lee SH, Galán JE. Salmonella type III secretion-associated chaperones confer secretion-pathway specificity. Mol Microbiol. 2004 Jan;51(2):483-95.
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Hernandez LD, Pypaert M, Flavell RA, Galán JE. A Salmonella protein causes macrophage cell death by inducing autophagy. J Cell Biol. 2003 Dec 8;163(5):1123-31.
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Lee SH, Galán JE. InvB is a type III secretion-associated chaperone for the Salmonella enterica effector protein SopE. J Bacteriol. 2003 Dec;185(24):7279-84.
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Kubori T, Galán JE. Temporal regulation of salmonella virulence effector function by proteasome-dependent protein degradation. Cell. 2003 Oct 31;115(3):333-42.
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Stebbins CE, Galán JE. Priming virulence factors for delivery into the host. Nat Rev Mol Cell Biol. 2003 Sep;4(9):738-43.
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Sukhan A, Kubori T, Galán JE. Synthesis and localization of the Salmonella SPI-1 type III secretion needle complex proteins PrgI and PrgJ. J Bacteriol. 2003 Jun;185(11):3480-3.
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Evans DT, Chen LM, Gillis J, Lin KC, Harty B, Mazzara GP, Donis RO, Mansfield KG, Lifson JD, Desrosiers RC, Galán JE, Johnson RP. Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system. J Virol. 2003 Feb;77(4):2400-9.
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Russmann H, Kubori T, Sauer J, Galán JE. Molecular and functional analysis of the type III secretion signal of the Salmonella enterica InvJ protein. Mol Microbiol. 2002 Nov;46(3):769-79.
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McKinney J, Guerrier-Takada C, Galán J, Altman S. Tightly regulated gene expression system in Salmonella enterica serovar Typhimurium. J Bacteriol. 2002 Nov;184(21):6056-9.
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Kubori T, Galán JE. Salmonella type III secretion-associated protein InvE controls translocation of effector proteins into host cells. J Bacteriol. 2002 Sep;184(17):4699-708.
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Galán JE. The cell biology of microbial infections: coming of age. J Cell Biol. 2002 Aug 5;158(3):387-8. Epub 2002 Aug 05.
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Kobayashi K, Hernandez LD, Galán JE, Janeway CA Jr, Medzhitov R, Flavell RA. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 2002 Jul 26;110(2):191-202.
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Buchwald G, Friebel A, Galán JE, Hardt WD, Wittinghofer A, Scheffzek K. Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J. 2002 Jul 1;21(13):3286-95.
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Galkin VE, Orlova A, VanLoock MS, Zhou D, Galán JE, Egelman EH. The bacterial protein SipA polymerizes G-actin and mimics muscle nebulin. Nat Struct Biol. 2002 Jul;9(7):518-21.
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Kobayashi K, Inohara N, Hernandez LD, Galán JE, Nunez G, Janeway CA, Medzhitov R, Flavell RA. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 2002 Mar 14;416(6877):194-9.
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Hughes EA, Galán JE. Immune response to Salmonella: location, location, location? Immunity. 2002 Mar;16(3):325-8.
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Lara-Tejero M, Galán JE. Cytolethal distending toxin: limited damage as a strategy to modulate cellular functions. Trends Microbiol. 2002 Mar;10(3):147-52.
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Murli S, Watson RO, Galán JE. Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction
of Salmonella with host cells. Cell Microbiol. 2001 Dec;3(12):795-810.
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Shams H, Poblete F, Russmann H, Galán JE, Donis RO. Induction of specific CD8+ memory T cells and long lasting protection following immunization with Salmonella typhimurium expressing a lymphocytic choriomeningitis MHC class I-restricted epitope. Vaccine. 2001 Nov 12;20(3-4):577-85.
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Stebbins CE, Galán JE. Maintenance of an unfolded polypeptide by a cognate chaperone in bacterial type III secretion. Nature. 2001 Nov 1;414(6859):77-81.
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Stebbins CE, Galán JE. Structural mimicry in bacterial virulence. Nature. 2001 Aug 16;412(6848):701-5.
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Lara-Tejero M, Galán JE. CdtA, CdtB, and CdtC form a tripartite complex that is required for cytolethal distending toxin activity. Infect Immun. 2001 Jul;69(7):4358-65.
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Staskawicz BJ, Mudgett MB, Dangl JL, Galán JE. Common and contrasting themes of plant and animal diseases. Science. 2001 Jun 22;292(5525):2285-9.
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Pancetti A, Galán JE. Characterization of the mutS-proximal region of the Salmonella typhimurium SPI-1 identifies a group of pathogenicity island-associated genes. FEMS Microbiol Lett. 2001 Apr 13;197(2):203-8.
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Colegio OR, Griffin TJ 4th, Grindley ND, Galán JE. In vitro transposition system for efficient generation of random mutants of Campylobacter jejuni. J Bacteriol. 2001 Apr;183(7):2384-8.
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Sukhan A, Kubori T, Wilson J, Galán JE. Genetic analysis of assembly of the Salmonella enterica serovar Typhimurium type III secretion-associated needle complex. J Bacteriol. 2001 Feb;183(4):1159-67.
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Galán JE. Salmonella interactions with host cells: type III secretion at work. Annu Rev Cell Dev Biol. 2001;17:53-86.
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Zhou D, Chen LM, Hernandez L, Shears SB, Galán JE. A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization. Mol Microbiol. 2001 Jan;39(2):248-59. Erratum in: Mol Microbiol 2001 Jun;40(6):1461.
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Stebbins CE, Galán JE. Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1. Mol Cell. 2000 Dec;6(6):1449-60.
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Galán JE. Alternative strategies for becoming an insider: lessons from the bacterial world. Cell. 2000 Oct 27;103(3):363-6.
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Lara-Tejero M, Galán JE. A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science. 2000 Oct 13;290(5490):354-7.
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Mitra K, Zhou D, Galán JE. Biophysical characterization of SipA, an actin-binding protein from Salmonella enterica. FEBS Lett. 2000 Sep 29;482(1-2):81-4.
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Kubori T, Sukhan A, Aizawa SI, Galán JE. Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10225-30.
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Garrett WS, Chen LM, Kroschewski R, Ebersold M, Turley S, Trombetta S, Galán JE, Mellman I. Developmental control of endocytosis in dendritic cells by Cdc42. Cell. 2000 Aug 4;102(3):325-34.
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Galán JE, Zhou D. Striking a balance: modulation of the actin cytoskeleton by Salmonella. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8754-61.
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Eichelberg K, Galán JE. The flagellar sigma factor FliA (sigma(28)) regulates the expression of Salmonella genes associated with the centisome 63 type III secretion system. Infect Immun. 2000 May;68(5):2735-43.
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Tucker SC, Galán JE. Complex function for SicA, a Salmonella enterica serovar typhimurium type III secretion-associated chaperone. J Bacteriol. 2000 Apr;182(8):2262-8.
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Galán JE, Fu Y. Modulation of actin cytoskeleton by Salmonella GTPase activating protein SptP. Methods Enzymol. 2000;325:496-504.
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Fu Y, Galán JE. A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion. Nature. 1999 Sep 16;401(6750):293-7.
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Zhou D, Mooseker MS, Galán JE. An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10176-81.
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Eichelberg K, Galán JE. Differential regulation of Salmonella typhimurium type III secreted proteins by pathogenicity island 1 (SPI-1)-encoded transcriptional activators InvF and hilA. Infect Immun. 1999 Aug;67(8):4099-105.
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Eichelberg K, Hardt WD, Galán JE. Characterization of SprA, an AraC-like transcriptional regulator encoded within the Salmonella typhimurium pathogenicity island 1. Mol Microbiol. 1999 Jul;33(1):139-52.
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Galán JE, Collmer A. Type III secretion machines: bacterial devices for protein delivery into host cells. Science. 1999 May 21;284(5418):1322-8.
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Chen LM, Bagrodia S, Cerione RA, Galán JE. Requirement of p21-activated kinase (PAK) for Salmonella typhimurium-induced nuclear responses. J Exp Med. 1999 May 3;189(9):1479-88.
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Zhou D, Hardt WD, Galán JE. Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island. Infect Immun. 1999 Apr;67(4):1974-81.
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Zhou D, Mooseker MS, Galán JE. Role of the S. typhimurium actin-binding protein SipA in bacterial internalization. Science. 1999 Mar 26;283(5410):2092-5.
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Galán JE. Interaction of Salmonella with host cells through the centisome 63 type III secretion system. Curr Opin Microbiol. 1999 Feb;2(1):46-50.
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Galán JE. Interactions of Salmonella with host cells: encounters of the closest kind. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14006-8.
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Russmann H, Shams H, Poblete F, Fu Y, Galán JE, Donis RO. Delivery of epitopes by the Salmonella type III secretion system for vaccine development. Science. 1998 Jul 24;281(5376):565-8.
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Fu Y, Galán JE. Identification of a specific chaperone for SptP, a substrate of the centisome 63 type III secretion system of Salmonella typhimurium. J Bacteriol. 1998 Jul;180(13):3393-9.
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Hardt WD, Chen LM, Schuebel KE, Bustelo XR, Galán JE. S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell. 1998 May 29;93(5):815-26.
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Kubori T, Matsushima Y, Nakamura D, Uralil J, Lara-Tejero M, Sukhan A, Galán JE, Aizawa SI. Supramolecular structure of the Salmonella typhimurium type III protein secretion system. Science. 1998 Apr 24;280(5363):602-5.
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Hardt WD, Urlaub H, Galán JE. A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2574-9.
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Palmer LE, Hobbie S, Galán JE, Bliska JB. YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF-alpha production and downregulation of the MAP kinases p38 and JNK. Mol Microbiol. 1998 Mar;27(5):953-65.
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Fu Y, Galán JE. The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton. Mol Microbiol. 1998 Jan;27(2):359-68.
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Galán JE. 'Avirulence genes' in animal pathogens? Trends Microbiol. 1998 Jan;6(1):3-6.
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Hobbie S, Chen LM, Davis RJ, Galán JE. Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells. J Immunol. 1997 Dec 1;159(11):5550-9.
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Hardt WD, Galán JE. A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9887-92.
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Collazo CM, Galán JE. The invasion-associated type-III protein secretion system in Salmonella--a review. Gene. 1997 Jun 11;192(1):51-9.
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Collazo, C. M. and J. E. Galán (1997) The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell Mol. Microbiol. 24: 747-756.

Ginocchio, C., K. Rhan, R. Clark and J. E. Galán (1997) Naturally occuring deletion in the inv locus of environmental isolates of Salmonella lichtfield and Salmonella seftefenberg Infect. Immun. 65: 1267-1272.

Chen, L. M., S. Hobbie and J. E. Galán (1996) Requirement of CDC42 for Salmonella-induced cytoskeletal and nuclear responses Science 274: 2115-2118.

Collazo, C. and J. E. Galán (1996) Requirement of exported proteins for secretion through the type III system of Salmonella typhimurium Infect. Immun. 64: 3524-3531.

Chen, L. M., K. Kaniga and J. E. Galán (1996) Salmonella spp. are cytotoxic for cultured macrophages Molec. Microbiol. 21: 1101-1116.

Kaniga, K., J. Uralil, J. B. Bliska and J. E. Galán (1996) A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium Mol. Microbiol. 21: 633-641.

Galán, J. E. and J. B. Bliska (1996) Cross-talk between bacterial pathogens and their host cells Ann. Rev. Cell. Dev. Bio. 12: 221-255.

Galán, J. E. (1996) Molecular genetic bases of Salmonella entry into host cells Molec. Microbiol. 20: 263-271.

Clark, C. G., L. A. MacDonald, C. C. Ginocchio, J. E. Galán and R. P. Johnson (1996) Salmonella typhimurium invA expression probed with a monoclonal antibody to the C-terminal peptide of InvA FEMS Microbiology 136: 263-268.

Kaniga, K., D. Trollinger and J. E. Galán (1995) Identification of two targets of the type III protein secretion system encoded in the inv and spa loci of Salmonella typhimurium that share homology to the Shigella IpaD and IpaA proteins J. Bacteriol. 177: 7078-7085.

Zierler, M. K. and J. E. Galán (1995) Contact with cultured epithelial cells stimulates the secretion of Salmonella typhimurium invasion protein InvJ Infect. Immun. 63: 4024-4028.

Kaniga, K., S. C. Tucker, D. Trollinger and J. E. Galán (1995) Homologues of the Shigella invasins IpaB and IpaC are required for Salmonella typhimurium entry into cultured cells J. Bacteriol. 177: 3965-3971.

Ginocchio, C. and J. E. Galán (1995) Functional conservation among members of the Salmonella typhimurium InvA family of proteins Infect. Immun. 63: 729-732.

Collazo, C., M. K. Zierler and J. E. Galán (1995) Functional analysis of the Salmonella typhimurium invasion genes invI and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus Molecular Microbiol. 15: 25-38.

Galán, J. E. (1995) Molecular and cellular bases of Salmonella entry into non-phagocytic cells Current Topics Microbiol. Immunol. 209: 43-60.

Kaniga, K., J. C. Bossio and J. E. Galán (1994) The Salmonella typhimurium invasion genes invF and invG encode homologues to the PulD and AraC family of proteins Molec. Microbiol. 13: 555-568.

Galán, J. E. (1994) Interactions of bacteria with non-phagocytic cells Curr. Opin. Immunol. 6: 590-595.

Galán, J. E. and C. Ginocchio (1994) The molecular and genetic bases of Salmonella entry into mammalian cells Biochem. Soc. Transac. 22: 301-306.

Galán, J. E. (1994) Host cell signal transduction and Salmonella entry into mammalian cells: different yet converging signaling pathways? Trends Cell Bio. 4: 196-199.

Pace, J. and J. E. Galán (1994) Measurements of free intracellular calcium levels in epithelial cells as a consequence of bacterial invasion Meth. Enzymol. 236: 482-490.

Galán, J. E., V. L. Miller and D. Portnoy (1994) Discussion of in vitro assays for studying bacterial entry into and survival within eukaryotic cells Infectious Agents and Disease 2: 288-290.

Eichelberg, K., Ginocchio, C. and J. E. Galán (1994) Molecular characterization of the Salmonella typhimurium invasion genes invB and invC: homology of invC to F0F1 ATPases J. Bacteriol. 176: 4501-4510.

Ginocchio, C., S. Olmsted, C. Wells and J. E. Galán (1994) Contact with epithelial cells induces the formation of surface appendages on Salmonella typhimurium Cell 76: 717-724.

Pace, J., M. J. Hayman and J. E. Galán (1993) Signal transduction and invasion of epithelial cells by Salmonella typhimurium Cell 72: 505-514.

Altmeyer, R. M., J. K. McNern, J. C. Bossio, I. Rosenshine, B. B. Finlay and J. E. Galán (1993) Cloning and molecular characterization of a gene involved in Salmonella adherence and invasion of cultured epithelial cells Molec. Microbiol. 7: 89-98.

Bliska, J. B., J. E. Galán and S. Falkow (1993) Signal transduction in the mammalian cell during bacterial attachment and entry Cell 73: 903-920.

Rahn, K., R. Clarck, C. Ginocchio, J. E. Galán, R. Curtiss III and C. Giles (1992) Amplification of an invA gene sequence of Salmonella typhimurium by PCR as a specific method of detection of Salmonellae Molec. Cell. Probes. 6: 271-279.

Galán, J. E., J. Pace and M. J. Hayman (1992) Involvement of the epidermal growth factor receptor in the invasion of cultured epithelial cells by Salmonella typhimurium Nature 357: 588-589.

Ginocchio, C., J. Pace and J. E. Galán (1992) Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of this organism into cultured epithelial cells Proc. Natl. Acad. Sc. USA 89: 5976-5980.

Galán, J. E., C. Ginocchio and P. Costeas (1992) Molecular characterization of the Salmonella typhimurium invasion gene invA: homology to a new protein family J. Bacteriol. 174: 4338-4349 .


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Review Articles

Galán, J. E. 2002. The cell biology of microbial infections: coming of age. J. Cell Biol. 158:387-388. (pdf)

Galán J. E. 2001. Salmonella interactions with host cells: type iii secretion at work. Annu. Rev. Cell Dev. Biol. 17:53-86. Annu. Rev. Cell Dev. Biol.. 17:53-86 (pdf)

Stebbins C. E. and J. E. Galán. 2001. Structural mimicry in bacterial virulence. Nature. 412:701-5 (pdf)

Staskawicz, B. J., M. B. Mudgett, Dangl, J. L. .and J. E. Galán. 2001. Common and contrasting themes of plant and animal diseases. Science. 292:2285-2289 (pdf).

Galán, J. E. (2000) Alternative strategies for becoming an insider: lessons from the bacterial world Cell 103(3): 363-366 (pdf).

Galán, J. E. and Y. Fu (2000) Modulation of the actin cytoskeleton by the Salmonella GTPase activating protein SptP Methods Enzymol. 325: 496-504.

Galán, J. E., and D. Zhou (2000) Striking a balance: modulation of the actin cytoskeleton by Salmonella Proc. Natl. Acad. Sci. USA 97(16): 8754-8761. (pdf)

Galán, J. E. and C. Collmer (1999) Type III secretion machines: bacterial devices for protein delivery into host cells Science 284: 1322-1328. (pdf)

Galán, J. E. (1999) Interaction of Salmonella with host cells through the centisome 63 type III secretion system Curr. Opin. Microbiol. 2: 46-50.

Galán, J. E. (1999) Interaction of Salmonella with host cells: encounters of the closest kind Proc. Natl. Acad. Sci. USA 95: 14006-14008.

Galán, J. E. 1997. 'Avirulence genes' in animal pathogens? Trends Microbiol. 6: 3-6.

Collazo, C. M. and J. E. Galán (1997) Contact dependent protein secretion and Salmonella interaction with host cells Gene 192: 51-59.

Galán, J. E. and J. B. Bliska (1996) Cross-talk between bacterial pathogens and their host cells Ann. Rev. Cell. Dev. Bio. 12: 221-255.

Galán, J. E. (1996) Molecular genetic bases of Salmonella entry into host cells Molec. Microbiol. 20: 263-271.

Galán, J. E. (1995) Molecular and cellular bases of Salmonella entry into non-phagocytic cells Current Topics Microbiol. Immunol. 209: 43-60.

Galán, J. E. (1994) Interactions of bacteria with non-phagocytic cells Curr. Opin. Immunol. 6: 590-595.

Galán, J. E. and C. Ginocchio (1994) The molecular and genetic bases of Salmonella entry into mammalian cells Biochem. Soc. Transac. 22: 301-306.

Galán, J. E. (1994) Host cell signal transduction and Salmonella entry into mammalian cells: different yet converging signaling pathways? Trends Cell Bio. 4: 196-199.

Pace, J. and J. E. Galán (1994) Measurements of free intracellular calcium levels in epithelial cells as a consequence of bacterial invasion Meth. Enzymol. 236: 482-490.

Galán, J. E., V. L. Miller and D. Portnoy (1994) Discussion of in vitro assays for studying bacterial entry into and survival within eukaryotic cells Infectious Agents and Disease 2: 288-290.

Bliska, J. B., J. E. Galán and S. Falkow (1993) Signal transduction in the mammalian cell during bacterial attachment and entry Cell 73: 903-920.

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Book Chapters

Galán, J. E. and P. J. Sansonettti (1996) Molecular and cellular bases of Salmonella and Shigella interactions with host cells In: Escherichia coli and Salmonella typhimurium: Cellular and molecular biology (F. C. Neidhardt, editor-in-chief) second ed., American Society for Microbiology Press, Washington D. C. pp. 2757-2763.

Zierler, M. K. and J. E. Galán (1995) Paradigms in bacterial entry into host cells, In: Virulence Mechanisms of Bacterial Pathogens (J. Roth, editor) American Society for Microbiology Press, Washington, DC. pp. 21-31.

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