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DiMaio Laboratory

Yale University
School of Medicine
Department of Genetics
Department of Therapeutic Radiology
Department of Molecular Biophysics & Biochemistry

Daniel DiMaio
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Lisa Petti
Associate Research Scientist

B.A. 1982 Wellesley College
Ph.D. 1988 University of Chicago

lisa.petti@yale.edu
telephone: 203-785-2685

LP


Project
Molecular mechanism of small transmembrane proteins

Publications

Petti, L.M., Ricciardi, E.C., Page, H., and Porter, K.A. (2008) Transforming signals resulting from sustained activation of the PDGF beta receptor in mortal human fibroblasts. J. Cell Sci.121:1172-1182.

Lin, H.Y., Michtalk, H.J., Zhang, S.L., Andersen, T.T., Van Riper, D.A., Davies, K., Ermak, G., Petti, L.M., Nachod, S., Narayan, A.V., Bhatt, N., and Crawford, D.R. (2003) Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein. Free Radical Biol. Med.35:528-539.

Nappi, V.M., Schaefer, J.A., and Petti, L.M. (2002) Molecular examination of the transmembrane requirements of the platelet-derived growth factor beta receptor for a productive interaction with the bovine papillomavirus E5 oncoprotein. J. Biol. Chem.277:47149-47159.

Zhang, Y., Lehman, J.M., and Petti, L.M. (2002) Apoptosis of mortal human diploid fibroblasts transformed by the bovine papillomavirus E5 oncoprotein. Mol. Cancer Res.1:122-136.

Nappi, V.M. and Petti, L.M. (2002) Multiple transmembrane requirements suggets a highly specific interaction between the platelet-derived growth factor beta receptor and the bovine papillomavirus E5 oncoprotein. J. Virol.76:7976-7986.

Petti, L.M. and Ray, F.A. (2000) Transformation of mortal human fibroblasts and activation of a growth inhibitory pathway by the BPV E5 oncoprotein. Cell Growth Differ.11:395-408.

Petti, L.M., Irusta, P., and DiMaio, D. (1998) Oncogenic activationi of the PDGF beta receptor by the transmembrane domain of p185(neu*). Oncogene16:843-851.

Petti, L., Reddy, V., Smith, S.O., and DiMaio, D. (1997) Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein. J. Virol.71:7318-7327.

Nilson, L.A., Petti, L., Drummond-Barbosa, D., Riese, D.J. II, Hwang, E.S., Nottoli, T., Henningson, C., Polack, G.W., Kegler-Ebo, D.M., and DiMaio, D. (1996) The role of the cellular platelet-derived growth factor receptor in cell transformation by the bovine papillomavirus E5 protein. In: Current Developments in Animal Virology, Oxford & IBH Publishing Co., pp. 313-323.

DiMaio, D., Petti, L., and Hwang, E-S. (1994) The E5 transforming proteins of the papillomaviruses. Sem. Virol.5:369-379.

Petti, L. and DiMaio, D. (1994) Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transformed cells. J. Virol.68:3582-3592.

Maunders, M.J., Petti, L., and Rowe, M. (1994) Precipitation of the Epstein-Barr virus (EBV) protein EBNA 2 by an EBNA 3c specific monoclonal antibody. J. Gen. Virol.75:769-778.

Petti, L. and DiMaio, D. (1992) Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells. Proc. Natl. Acad. Sci. USA89:6736-6740.

Petti, L., Nilson, L., Kulke, R., Leptak, C., Riese, D., Zibello, T., and DiMaio, D. (1991) The E5 mini-oncogene of bovine papillomavirus: biological activities, genetic analysis, and proposed mechanism of action. In: Origins of Human Cancer, A Comprehensive Review, CSHL Press, pp. 707-713.

Petti, L., Nilson, L., and DiMaio, D. (1991) Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein. EMBO J.10:845-855.

Petti, L., Sample, C., and Kieff, E. (1990) Subnuclear localization and phosphorylation of Epstein-Barr virus latent infection nuclear proteins. Virology176:563-574.

Rowe, M., Young, L.S., Cadwallader, K., Petti, L., Kieff, E., and Rickinson, A.B. (1989) Distinction between Epstein-Barr virus type A (EBNA 2A) and type B (EBNA 2B) isolates extends to the EBNA 3 family of nuclear proteins. J. Virol.63:1031-1039.

Hendricks, D., Patick, A., Petti, L., and Hall, A. (1988) Biochemical and biophysical characteristics of Rio Bravo virus (flaviviridae). J. Gen. Virol.69:337-347.

Petti, L. and Kieff, E. (1988) A sixth Epstein-Barr virus nuclear protein (EBNA3B) is expressed in latently infected growth transformed lymphocytes. J. Virol.62:2173-2178.

Petti, L., Sample, J., Wang, F., and Kieff, E. (1988) A fifth Epstein-Barr virus nuclear protein (EBNA3C) is expressed in latently infected growth-transformed lymphocytes. J. Virol.62:1330-1338.

Pearson, G., Luka, J., Petti, L., Sample, J., Birkenbach, M., Braun, D., and Kieff, E. (1987) Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex. Virology160:151-161.

Wang, F., Petti, L., Braun, D., Seung, S., and Kieff, E. (1987) A bicistronic Epstein-Barr virus mRNA encodes two nuclear proteins in latently infected growth-transformed lymphocytes. J. Virol.61:945-954.

 


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Updated March 1, 2010