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DiMaio Laboratory

Yale University
School of Medicine
Department of Genetics
Department of Therapeutic Radiology
Department of Molecular Biophysics & Biochemistry

Daniel DiMaio
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Eun Hwang
Associate Professor

University of Seoul, Korea

B.A. 1981

Seoul National University
M.S. 1984

Seoul National University
Ph.D. 1991

Johns Hopkins University
Postdoctoral Associate, DiMaio Laboratory, 1991-1994
telephone: 82-2-2210-2608

Eun Hwang


Lee, K.H., Park, K.H., Lee, H.J., Hwang, E.S., Suh, H.C., Oh, B.H., and Jang, H.D. (1984) Characteristics of two yeast strains and conditions for the protoplast formation and regeneration as a preliminary step in interspecific protoplast-fusion. Seoul Nat'l University, College of Agriculture Research 9:1-16.

Milman, G. and Hwang, E.S. (1987) Epstein-Barr virus nuclear antigen forms a complex that binds with high concentration dependence to a single DNA-binding site. J. Virol. 61:465-

Hwang, E.S. and Scocca, J.J. (1990) Interaction of integration host factor from escherichia coli with the integration region of the haemophilus influenzae bacteriophage HP1. J. Bacteriol. 172:4852-4860.

Yuan, Y., Hwang, E.S., and Altman, S. (1992) Targeted cleavage of messenger RNA by human RNaseP. Proc. Natl. Acad. Sci. USA 89:8001-8005.

Hwang, E.S. and Scocca, J.J. (1993) A method of cloning multiple direct repeats of DNA segment. Biotechniques 14:766-767.

Hwang, E.S., Riese, II, D.J., Settleman, J., Nilson, L., Honig, J., Flynn, S., and DiMaio, D. (1993) Inhibition of cervical carcinoma cell line proliferation by introduction of a bovine papillomavirus regulatory gene. J. Virol. 67:3720-3729.

DiMaio, D., Petti, L., and Hwang, E.S. (1994) The E5 transforming proteins of the papillomaviruses. Sem. Virol. 5:369-379.

Hwang, E.S., Nottoli, T., and DiMaio, D. (1995) The HPV16 E5 protein: expression, detection, and stable complex formation with trans-membrane proteins in cos cells. Virology 211:227-233.

Seo, J., Park, W., Kim, J.S., Hwang, E.S., Lee, J.-H., and Hong, S.H. (1995) Endogenous gene expression of p53 and regulatory subunits of cyclic AMP-dependent protein kinase in ovarian cancer cells. Korean J. Zool. 38:204-211.

Hwang, E.S., Naeger, L.K., and DiMaio, D. (1996) Activation of endogenous growth inhibitory pathways in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene. Oncogene 12:795-803.

Park, J.S., Hwang, E.S., Ahn, H.K., Kim, C.J., Chung, K.T., Kim, H.S., Park, S.N., Namkoong, S.E., and Kim, S.J. (1996) Seroreactivities to HPV-16 virus like particles (VLPs) using ELISA in the patients with cervical neoplasia. Korean J. Gynecol. 39:176-185.

Park, W., Choi, J.-J., Hwang, E.S., Lee, J.-H. (1996) Identification of a variant estrogen receptor lacking Exon4 and its coexpression with wild-type estrogen receptor in ovarian carcinomas. Clin. Cancer Res. 2:2029-2035.

Park, J.S., Hwang, E.S., Park, S.N., Ahn, H.K., Yang, H.K., Kim, C.J., Kim, S.J., and Namkoong, S.E. (1997) Physical status and expression of HPV genes in cervical cancers. Gynecol. Oncol. 65:121-129.

Kim, S.N., Lee, G.R., Hwang, E.S., Lee, J.-H., Park, S.D., Cho-Chung, Y.S., and Hong, S.H.. (1997) Type II protein kinase A up-regulation is sufficient to induce growth inhibition in SK-N-SH human neuroblastoma cells. Biochem. Biophy. Res. Com. 232:469-473.

Hwang, E.S., Kim, J., Kim, J.S., Ko. S.C., Chung, L., and J.-H. Lee. (1998) The effects of the adenovirus-mediated wild-type p53 delivery in human ovarian cancer cell lines in vitro and in vivo. Intl. J. Gynecol. Cancer 8:27-36.

Park, J.S., Um, S.J., Hwang, E.S., Park, S.N., Ahn, H.K., Kim, C.J., and Namkoong, S.E.. (1998) Immunresponse to p53 and HPV16 E6 proteins in patients with cervical cancer. Intl. J. Gynecol. Cancer 8:542-547.

Hwang, E.S. (1998) Induction of senescence-like state in HeLa cells by the expression of bovine papillomavirus E2 gene. Korean J. Gerontol. 8:57-65.

Kim, J., Hwang, E.S., Kim, J.S., Ryu, E.H., Lee, S.H., and Lee, J.-H. (1999) Intraperitoneal gene therapy with adenoviral-mediated p53 tumor suppressor gene for ovarian cancer model in nude mouse. Cancer Gene Ther. 6:172-178.

Kim, C.J., Um, S.J., Hwang, E.S., Park, S.N., Kim, S.J., and Namkoong, S.E. (1999) The antibody response to HPV proteins and genomic state of HPVs in patients with cervical cancer. Intl. J. Gynecol. Cancer 9:1-11.

Naeger, L.K., Goodwin, E.C., Hwang, E.S., DeFilippis, R.A., Zhang, H., and DiMaio, D. (1999) Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. Cell Growth & Differentiation 10:1-10.

Park, J.S., Hwang, E.S., Lee, C.J., Kim, C.J., Rha, J.G., Namkoong, E.S., and Um, S.J. (1999) Mutational and functional analysis of HPV16 URR derived from Korean cervical neoplasia. Gynecol. Oncol. 74:23-29.

Hwang, E.S. (1999) Cellular machineries that regulate p53 tumor suppressor activity. Biochemistry News 19:194-201.

Goodwin, E.C., Yang, E., Lee, C.J., Lee, H.W., DiMaio, D., and Hwang, E.S. (2000) Rapid Induction of senescence in human cervical carcinoma cells. Proc. Natl. Acad. Sci. USA 97:10978-10983.

Lee, C.-J., Lee, J.-Y., Song, Y.-S., and Hwang, E.S. (2000) Endothelin-1 autocrine is suppressed in HeLa cells induced to a senescent state. Korean J. Gerontol. 10:31-37.

Um, S.J., Kim, E.J., Hwang, E.S., Kim, S.J., Namkoong, S.E., and Park, J.S. (2000) Antiproliferative effects of retinoic acid/interferon in cervical carcinoma cell lines:cooperative growth suppression of IRF-1 and p53. Intl. J. Cancer. 85:416-423.

Park, J.S., Kim, E.J., Kwon, H.J., Hwang, E.S., Namkoong, S.E., and Um, S.J. (2000) Inactivation of Interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. J. Biol. Chem. 275:6764-6769.

Lee, C.J., Lee, J.-Y., Song, Y.-S., and Hwang, E.S. (2000) Endothelin-1 autocrine is suppressed in HeLa cells induced to a senescent state. Korean J. Gerontol. 10:31-37.

Moon, M.S., Lee, C.J., Um, S.J., Park, J.S., Yang, J.M., and Hwang, E.S.. (2001) Effect of BPV1 E2-mediated inhibition of E6/E7 expression in HPV16-positive cervical carcinoma cells. Gynecol. Oncol. 80:168-175.

Um, S.-J., Rhyu, J.-W., Kim, E.-J., Jeon, K.-C., Hwang, E.S., and Park, J.-S. (2002) Abrogation of IRF-1 response by high-risk HPV E7 protein in vivo. Cancer Letters 179:205-212.

Lee, C.J., E.J. Suh, Kang, H.T., Im, J.S., Um, S.J., Park, J.S., and Hwang, E.S.. (2002) Induction of senescence-like state and suppression of telomerase activity through inhibition of HPV E6/E7 gene expression in cells immortalized by HPV16 DNA. Exp. Cell Res. 77:173-82.

Shin, K.-S., Bae, S.-J., Hwang, E.S., Jeong, S., and Lee, S.-W. (2002) Ribozyme-mediated replacement of p53 RNA by targeted trans-splicing. J. Microbiol. Biotechnol. 12:844-848.

Hwang, E.S. (2002) Replicative senescence and senescence-like state induced in cancer-derived cells. Mech. Ageing Dev. 123:1681-1694.

Lee, B.Y. and Hwang, E.S. (2002) Induction of senescence phenotypes in cancer cells by an acute growth arrest followed by ROS stress. Korean J. Gerontol. 12:31-39.

Kim, J., Lee, D., Hwang, S.G., Hwang, E.S., and Choe, J. (2003) BRCA1 associates with human papillomavirus type18 E2 and stimulates E2-dependent transcription. Biochem. Biophys. Res. Comm. 305:1008-1016.

Kang, H.T., Ju, J.W., Cho, J.W., and Hwang, E.S. (2003) Downregulation of Sp1 activity through modulation of O-glycosylation by treatment with a low glucose mimetic, 2-deoxyglucose. J. Biol. Chem. 278:51223-51231.

Kang, H.T., Lee, C.J., Seo, E.J., Bahn, Y.J., Kim, H.J., and Hwang, E.S. (2004) Transition to an irreversible state of senescence in HeLa cells arrested by repression of HPV E6 and E7 genes. Mech. Ageing Dev. 125:31-40.
Hwang, E.S. (2004) Mechanism of aging and modulation of aging at cellular level. J. Korean Soc. Endocrinol. 19:90-93.

Seo, E.J., Kim, H.J., Lee, C.J., Kang, H.T., and Hwang, E.S.. (2004) The role of HPV oncoproteins and cellular factors in maintenance of hTERT expression in cervical carcinoma cells. Gynecol. Oncol. 94:40-47.

Sook, Y.S., Lee, B.Y., and Hwang, E.S. (2005) Dinstinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis. Mech. Ageing Dev. 126:580-590.

Tang, H.T. and Hwang, E.S. (2005) 2-Deoxyglucose: an anti-cancer and anti-viral therapeutic, but not any more a low-glucose mimetic. Life Sci. (In press).

Lee, B.Y., Han, J.A., Lim, J.S., Morrone, A., Johung, K., Goodwin, E.C., Keijer, W., DiMaio, D.*, and Hwang, E.-S.* (2006) Senescence-associated ß-galactosidase is lysosomal acid ß-galactosidase. Aging Cell 5: 187-195. (*corresponding authors)


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Updated January 7, 2009