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DiMaio Laboratory

Yale University
School of Medicine
Department of Genetics
Department of Therapeutic Radiology
Department of Molecular Biophysics & Biochemistry

Daniel DiMaio
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Edward Goodwin
Research Scientist

B.A. 1983 Oberlin College
Ph.D. 1993 Case Western Reserve University
edward.goodwin@yale.edu
telephone: 203-785-2685

Edward Goodwin


Project
Control of Gene Expression during Senescence

Publications

Woychik, R.P., Camper, S.C., Lyons, R.H., Horowitz, S., Goodwin, E.C., and Rottman, F.M. (1982) Cloning and nucleotide sequencing of the bovine growth hormone gene. Nucl. Acids Res. 10:7197-7212.

Rottman, F.M., Campers, S.C., Goodwin, E.C., Hampson, R.K., Lyons, R.L., Sakai, D., Woychik, R.P., and Yao, Y. (1986) Structure and Regulation of the Bovine Prolactin and Bovine Growth Hormone Genes. In: Molecular and Cellular Aspects of Reproduction, Dhindsa, D.S., and Bahl, O.P., eds. Plenum Publishing Corp., pp. 281-299.

Goodwin, E.C. and Rottman, F.M. (1992) The use of Rnase H and poly(A) junction oligonucleotides in the analysis of in vitro polyadenylation reaction products. Nucl. Acids Res. 20:916.

Goodwin, E.C. and Rotman, F.M. (1992) The 3’-flanking sequence of the bovine growth hormone gene contains novel elements required for efficient and accurate polyadenylation. J. Biol. Chem. 267:16330-16334.

Narayan, P., Ludwiczak, R.L., Goodwin, E.C., and Rottman, F.M. (1994) Context effects on N6-adenosine methylation sites in prolactin mRNA. Nucl. Acids Res. 22:419-426.

Goodwin, E.C., Naeger, L.K., Breiding, D.E., Androphy, E.J., and DiMaio, D. (1998) Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J. Virol. 72:3925-3934.

Naeger, L.K., Goodwin, E.C., Hwang, E.S., DeFilippis, R.A., Zhang, H., and DiMaio, D. (1999) Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. Cell Growth & Differ. 10: 413-422.

Wu, L., Goodwin, E.C., Naeger, L.K., Vigo, E., Galaktionov, K., Helin, K., & DiMaio, D. (2000) E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression. Mol. Cell. Biol. 20:7059-7067.

Goodwin, E.C., Yang, E., Lee, C.-J., Lee, H.-W., DiMaio, D., and Hwang, E.-S. (2000) Rapid induction of senescence in human cervical carcinoma cells. Proc. Natl. Acad. Sci. USA 97:10978-10983.

Goodwin, E.C. and DiMaio, D. (2000) Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc. Natl. Acad. Sci. USA 97:12513-12518.

Goodwin, E.C. and DiMaio, D. (2001) Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Cell Growth & Differ. 12:525-534.

DeFilippis, R.A., Goodwin, E.C., Wu, L., and DiMaio, D. (2003) Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence and apoptosis in HeLa cervical carcinoma cells. J. Virol. 77:1551-1563.

Brandsma, J.L., Shlyankevich, M., Zhang, L., Slade, M.D., Goodwin, E.C., Peh, W., and Deisseroth, A.B. (2004) Vaccination of rabbits with an adenovirus vector expressing the papillomavirus E2 protein leads to clearance of papillomas and infection. J. Virol. 78:116-123.

Lee, B.Y., Han, J.A., Lim, J.S., Morrone, A., Johung, K., Goodwin, E.C., Keijer, W., DiMaio, D.*, and Hwang, E.-S.* (2006) Senescence-associated ß-galactosidase is lysosomal acid ß-galactosidase. Aging Cell 5: 187-195. (*corresponding authors)

Johung, K., Goodwin, E.C., and DiMaio, D. (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J. Virol. 81:2102-2116.

Nguyen, M., Kraft, R.M., Aubert, M., Goodwin, E.C., DiMaio, D., and Blaho, J. (2007) p53 and hTERT determine sensitivity to viral apoptosis. J. Virol. 81:12985-12995.

DiMaio, D., Johung, K., Goodwin, E.C., Horner, S.M., and Yates, K.E. (2008) Senescence induced by repression of human papillomavirus oncogenes in cervical cancer cells. In: Beyond Apoptosis: Cellular Outcomes of Cancer Therapy. I. Roninson, ed., pp. 209-222, MacMillan Publishing.

Goodwin, E.C., Atwood, W.J., and DiMaio, D. (2009) High-throughput cell-based screen for chemicals that inhibit infection by SV40 and human polyomaviruses. J. Virol.83:5630-5639.

 


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Updated August 15, 2009