Edward Goodwin
Research Scientist

B.A. 1983 Oberlin College
Ph.D. 1993 Case Western Reserve University
edward.goodwin@yale.edu
telephone: 203-785-2685

Publications

Woychik, R.P., Camper, S.C., Lyons, R.H., Horowitz, S., Goodwin, E.C., and Rottman, F.M. (1982) Cloning and nucleotide sequencing of the bovine growth hormone gene. Nucl. Acids Res. 10:7197-7212.

Rottman, F.M., Campers, S.C., Goodwin, E.C., Hampson, R.K., Lyons, R.L., Sakai, D., Woychik, R.P., and Yao, Y. (1986) Structure and Regulation of the Bovine Prolactin and Bovine Growth Hormone Genes. In: Molecular and Cellular Aspects of Reproduction, Dhindsa, D.S., and Bahl, O.P., eds. Plenum Publishing Corp., pp. 281-299.

Goodwin, E.C. and Rottman, F.M. (1992) The use of Rnase H and poly(A) junction oligonucleotides in the analysis of in vitro polyadenylation reaction products. Nucl. Acids Res. 20:916.

Goodwin, E.C. and Rotman, F.M. (1992) The 3’-flanking sequence of the bovine growth hormone gene contains novel elements required for efficient and accurate polyadenylation. J. Biol. Chem. 267:16330-16334.

Narayan, P., Ludwiczak, R.L., Goodwin, E.C., and Rottman, F.M. (1994) Context effects on N6-adenosine methylation sites in prolactin mRNA. Nucl. Acids Res. 22:419-426.

Goodwin, E.C., Naeger, L.K., Breiding, D.E., Androphy, E.J., and DiMaio, D. (1998) Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J. Virol. 72:3925-3934.

Naeger, L.K., Goodwin, E.C., Hwang, E.S., DeFilippis, R.A., Zhang, H., and DiMaio, D. (1999) Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. Cell Growth & Differ. 10: 413-422.

Wu, L., Goodwin, E.C., Naeger, L.K., Vigo, E., Galaktionov, K., Helin, K., & DiMaio, D. (2000) E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression. Mol. Cell. Biol. 20:7059-7067.

Goodwin, E.C., Yang, E., Lee, C.-J., Lee, H.-W., DiMaio, D., and Hwang, E.-S. (2000) Rapid induction of senescence in human cervical carcinoma cells. Proc. Natl. Acad. Sci. USA 97:10978-10983.

Goodwin, E.C. and DiMaio, D. (2000) Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc. Natl. Acad. Sci. USA 97:12513-12518.

Goodwin, E.C. and DiMaio, D. (2001) Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Cell Growth & Differ. 12:525-534.

DeFilippis, R.A., Goodwin, E.C., Wu, L., and DiMaio, D. (2003) Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence and apoptosis in HeLa cervical carcinoma cells. J. Virol. 77:1551-1563.

Brandsma, J.L., Shlyankevich, M., Zhang, L., Slade, M.D., Goodwin, E.C., Peh, W., and Deisseroth, A.B. (2004) Vaccination of rabbits with an adenovirus vector expressing the papillomavirus E2 protein leads to clearance of papillomas and infection. J. Virol. 78:116-123.

Lee, B.Y., Han, J.A., Lim, J.S., Morrone, A., Johung, K., Goodwin, E.C., Keijer, W., DiMaio, D.*, and Hwang, E.-S.* (2006) Senescence-associated ß-galactosidase is lysosomal acid ß-galactosidase. Aging Cell 5: 187-195. (*corresponding authors)

Johung, K., Goodwin, E.C., and DiMaio, D. (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J. Virol. 81:2102-2116.

Nguyen, M., Kraft, R.M., Aubert, M., Goodwin, E.C., DiMaio, D., and Blaho, J. (2007) p53 and hTERT determine sensitivity to viral apoptosis. J. Virol. 81:12985-12995.

DiMaio, D., Johung, K., Goodwin, E.C., Horner, S.M., and Yates, K.E. (2008) Senescence induced by repression of human papillomavirus oncogenes in cervical cancer cells. In: Beyond Apoptosis: Cellular Outcomes of Cancer Therapy. I. Roninson, ed., pp. 209-222, MacMillan Publishing.

Goodwin, E.C., Atwood, W.J., and DiMaio, D. (2009) High-throughput cell-based screen for chemicals that inhibit infection by SV40 and human polyomaviruses. J. Virol.83:5630-5639.

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