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DiMaio Laboratory

Yale University
School of Medicine
Department of Genetics
Department of Therapeutic Radiology
Department of Molecular Biophysics & Biochemistry

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CURRICULUM VITAE


Daniel Christopher DiMaio

Department of Genetics
Yale University School of Medicine
333 Cedar Street
New Haven, CT 06510
daniel.dimaio@yale.edu (email)

DD


Education


B.S. (Biology), Yale University, New Haven, CT, 1974

M.D., Johns Hopkins University School of Medicine, Baltimore, MD, 1978

Ph.D., (Microbiology), Johns Hopkins University School of Medicine, Baltimore, MD, 1981


Academic Positions


1977-1981 Dissertation research with Daniel Nathans, Johns Hopkins University School of Medicine

1981-1983 Postdoctoral research with Tom Maniatis, Harvard University

1983-1988 Assistant Professor of Human Genetics, Yale University School of Medicine

1988-1991 Associate Professor of Human Genetics, Yale University School of Medicine

1991-1994 Associate Professor of Genetics (with tenure), Yale University School of Medicine

1994-present Professor of Genetics, Yale University School of Medicine

1997-1998 Interim Chairman, Department of Genetics, Yale University School of Medicine

1998-present Vice Chairman, Department of Genetics, Yale University School of Medicine

2003-present Waldemar Von Zedtwitz Professor of Genetics

2005-present Professor of Therapeutic Radiology

2007-present Professor of Molecular Biophysics & Biochemistry

2007-present Scientific Director, Yale Cancer Center

 

Professional Honors or Recognition


  • Yale National Scholar, 1970-1974
  • Phi Beta Kappa, 1974
  • Graduated from Yale summa cum laude with distinction in Biology, 1974
  • Medical Scientist Training Program, 1976-1981
  • Shanoff Committee Award, 1981
  • Fellow of the Jane Coffin Childs Memorial Fund for Medical Research, 1981-1983
  • Swebilius Cancer Research Award, 1983-1984
  • Mallinckrodt Scholar Award, 1983-1988
  • NIH MERIT Award, 1992-1997
  • Elected member, American Society for Clinical Investigation, 1993
  • Chairman, Division S (DNA Viruses), American Society for Microbiology, 1998-1999
  • Elected fellow, American Academy of Microbiology, 2000
  • Outstanding Graduate Mentor in the Natural Sciences Award, Yale University, 2001
  • Elected fellow, American Association for the Advancement of Science, 2003
  • Appointed Waldemar Von Zedtwitz Professor of Genetics, 2003
  • Harold S. Ginsberg Lecturer, 2006
  • Richard Klein Lecturer in Microbiology, 2008

 

Major professional activities outside of Yale (selected)


  • Scientific Review Committee, Ludwig Institute for Cancer Research, Sao Paulo Branch, 1987
  • Anna Fuller Cancer Fund Review Committee, 1988-1993
  • Virology Study Section, NIH, 1991-1994
  • Scientific Advisory Board, Damon Runyon-Walter Winchell Cancer Research Fund, 1994-1998
  • Co-organizer, Connecticut Virology Group, 1996-2002
  • External Advisory Committee, Developmental Therapeutics AIDS Program, NCI, 1998-1999
  • Eli Lilly Award Selection Committee, American Academy of Microbiology, 2002-2005
  • Gates Grand Challenges in Global Health Review Committee, 2004
  • Consulting Editor, American Scientist, 1985-1990
  • Editorial Board, Journal of Virology, 1989-1997
  • Editorial Board, Virology, 1989-1994
  • Executive Editor, Laboratory Investigation, 1996-1997
  • Editor, Journal of Virology, 1997-2006
  • Cover Editor, Journal of Virology, 2002-present
  • Editorial Advisory Board, Annual Review of Microbiology, 2006-2011

 

Major Administrative Duties at Yale (selected)


  • Principal Investigator, Molecular and Viral Oncology Postdoctoral Training Grant, 1992-2007
  • Principal Investigator, Predoctoral Training Program in Virology, 2003-2007
  • Principal Investigator, Program on the Molecular Basis of Viral Transformation, NIH Program Project Grant, 1993-present

Department of Genetics

  • Director of Graduate Studies, 1993-1997
  • Executive Committee, 1993-1998
  • Interim Chairman, 1997-1998
  • Vice Chairman, 1998-present
  • Graduate Program Steering Committee, 1999-present

Yale Comprehensive Cancer Center

  • Program Director, Molecular Virology Research Program, 1992-present
  • Chairman, Program Committee, Yale Cancer Center Symposium on Signal Transduction, 1996
  • Chairman, Selection Committee, Steven F. Degar Memorial Lecturer, 1997-present
  • Executive Committee, 1998-2004
  • Scientific Director, 2007-present

Yale University School of Medicine

  • M.D./Ph.D. Admissions Committee, 1984-1987
  • Scholar Awards Committee, 1990-1991
  • Dean's Planning Committee for a Section of Microbial Pathogenesis at Yale, 1993-1995
  • Search Committee for Chairman of the Section of Microbial Pathogenesis, 1995-1996
  • Chairman, Working Group for Virology at Yale, 1998-1999
  • Microbiology Graduate Program Steering Committee, 1999-present
  • Ad hoc Advisory Committee, Section of Comparative Medicine, 1999-2003
  • Search Committee for Chairman of Section of Comparative Medicine, 2004
  • Basic Science Strategic Planning Committee, 2004-2005
  • Advisory Committee for Section of Infectious Diseases, Department of Medicine, 2005
  • Committee on Appointments and Promotions, School of Public Health, 2005; 2008-2009
  • Search Committee for Director of the Yale Comprehensive Cancer Center, 2008

Yale University

  • Organizing Committee, Yale Science Forum, 1996, 1997
  • Graduate School Committee for the Combined Programs in Biological and
    Biomedical Sciences, 1996
  • Wilbur Cross Medal Selection Committee, 2002
  • Biological Sciences Advisory Committee, 1996-1997, 2001-2005
  • Acting Director, Division of Biological Sciences, 2003
  • Coordinator, Yale submissions to Grand Challenges in Global Health Initiative of the
    Gates Foundation, 2003-2004
  • Search Committee for Dean of the School of Medicine, 2003-2004
  • Search Committee for Dean of the School of Epidemiology and Public Health, 2005

 

Recent Teaching Responsibilities At Yale


  • Molecular Biology of Animal Viruses. Course organizer and lecturer
  • Medical Impact of Basic Science. Joan Steitz, course organizer
  • Cellular and Molecular Biology of Cancer. David Stern, course organizer
  • Microbial Pathogenesis, Craig Roys, course organizer
  • Perspectives in Science. John Carlson, course organizer
  • Molecular Mechanisms of Disease, Robert Schulman, course organizer
  • Ethical Conduct in Science, Susan Baserga, course organizer
  • Genetics Graduate Student Seminar, Joann Sweasy, course organizer
  • Seminars in Molecular Medicine, Keith Joiner, course director
  • Introduction to Microbiology, Christine Jacobs, course director
  • Seminal Papers in Microbiology, Peter Tattersall and Norma Andrews, directors
  • Medical Microbiology, Sheldon Campbell, director

Lectures in virology courses at New York University School of Medicine, Cornell University College of Medicine, Rockefeller University, Harvard Medical School, Bristol-Myers Squibb, Inc.

 

Bibliography


1. Price, S.S., DiMaio, D.C. and Englund, P.T. (1976) Kinetoplast DNA from Leishmania tarentolae. In: The Genetic Function of Mitochondrial DNA, C. Saccone and A.M. Kroon (eds.) pp 83-94. Elsevier/North Holland Publishing Co., Amsterdam.

2. Englund, P.T., DiMaio, D.C. and Price, S. (1977) A nicked form of kinetoplast DNA in Leishmania tarentolae. J. Biol. Chem.252:6208-6212.

3. Shortle, D., Pipas, J.M., Lazarowitz, S., DiMaio, D. and Nathans, D. (1979) Constructed mutants of simian virus 40. In: Genetic Engineering, Vol. 1, J.K. Setlow and A. Hollaender (eds.) pp. 73-92. Plenum Press, New York.

4. DiMaio, D. and Nathans, D. (1980) Cold-sensitive regulatory mutants of SV40. J. Mol. Biol.140:129-142.

5. McKay, R. and DiMaio, D. (1981) Binding of a SV40 T antigen-related protein to the DNA of SV40 regulatory mutants. Nature289:810-813.

6. Shortle, D., DiMaio, D., and Nathans, D. (1981) Directed mutagenesis. Ann. Rev. Genet.15:265-294.

7. DiMaio, D. and Nathans, D. (1982) Regulatory mutants of simian virus 40: Effect of mutations at a T antigen binding site on DNA replication and expression of viral genes. J. Mol. Biol.156:531-548.

8. DiMaio, D. and Maniatis, T. (1982) Intact bovine papillomavirus-human DNA recombinant plasmids that propagate as episomes in mouse cells and bacteria. In: Eucaryotic Viral Vectors, Y. Gluzman, (ed.) pp. 93-97. CSHL, Cold Spring Harbor, New York.

9. DiMaio, D., Treisman, R., and Maniatis, T. (1982) Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. Proc. Natl. Acad. Sci. USA79:4030-4034.

10. Zinn, K., DiMaio, D., and Maniatis, T. (1983) Analysis of DNA sequences controlling expression of a cloned human ß-interferon gene on a BPV vector. In: Enhancers and Eucaryotic Gene Expression, Y. Gluzman and T. Shenk (eds.) pp. 185-189. CSHL, Cold Spring Harbor, New York.

11. Zinn, K., DiMaio, D., and Maniatis, T. (1983) Identification of two distinct regulatory regions adjacent to the human beta interferon gene. Cell34:865-879.

12. DiMaio, D., Corbin, V., Sibley, E., and Maniatis, T. (1984) High level expression of a cloned HLA heavy chain gene introduced into mouse cells on a bovine papillomavirus vector. Mol. Cell. Biol.4:340-350.

13. DiMaio, D. (1984) Eucaryotic cloning vectors based on bovine papillomaviruses. BioEssays1:23-26.

14. DiMaio, D., Metherall, J., Neary, K., and Guralski, D. (1985) Genetic analysis of transformation by bovine papillomavirus. In: Papillomaviruses: Molecular and Clinical Aspects, F. Fox (ed.) pp. 437-456. Alan R. Liss, New York.

15. DiMaio, D. (1986) A nonsense mutation in open reading frame E2 of bovine papillomavirus DNA. J. Virol.57:475-480.

16. DiMaio, D., Guralski, D., and Schiller, J.T. (1986) Translation of bovine papillomavirus open reading frame E5 is required for its transforming activity. Proc. Natl. Acad. Sci. USA83:1797-1801.

17. DiMaio, D. (1987) Papillomavirus cloning vectors. In: The Papillomaviruses, P. Howley and N. Salzman (eds.) pp. 293-319. Plenum Press, New York.

18. Neary, K., Horwitz, B.H., and DiMaio, D. (1987) Mutational analysis of open reading frame E4 of bovine papillomavirus type 1. J. Virol.61:1248-1252.

19. DiMaio, D., Neary, K., Kaczmarek, L., Andrews, E., Horwitz, B., and Guralski, D. (1987) Mutational analysis of bovine papillomavirus transformation functions. Cancer Cells5:187-193.

20. Burkhardt, A., DiMaio, D., and Schlegel, R. (1987) Genetic and biochemical definition of the E5 transforming protein of bovine papillomavirus type 1. EMBO J.6:2381-2385.

21. Jaskulski, D., Kaczmarek, L., and DiMaio, D. (1987) Stimulation of cellular DNA synthesis by wildtype and mutant bovine papillomavirus DNA. Biochem. Biophy. Res. Comm.148:86-91.

22. DiMaio, D. and Settleman, J. (1988) Bovine papillomavirus mutant temperature sensitive for transformation, replication and transactivation. EMBO J.7:1197-1204.

23. Settleman, J. and DiMaio, D. (1988) Efficient trans-activation and transformation by bovine papillomavirus genes expressed from a BPV/SV40 recombinant virus. Viral Vectors, Cold Spring Harbor Press. 13-17.

24. Prakash, S.S., Horwitz, B.H., Zibello, T., Settleman, J., and DiMaio, D. (1988) Bovine papillomavirus E2 gene regulates the expression of the E5 transforming gene. J. Virol.62: 3608-3613.

25. Horwitz, B.H., Burkhardt, A.L., Schlegel, R., and DiMaio, D. (1988) 44 amino acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl terminal amino acids. Mol. Cell. Biol.8:4071-4078.

26. Settleman, J. and DiMaio, D. (1988) Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a BPV/SV40 recombinant virus. Proc. Natl. Acad. Sci. USA85:9007-9011.

27. Vasavada, H.A., Ganguly, S., Settleman, J., DiMaio, D., and Weissman, S. (1988) A model system for the rescue of cDNAs encoding transacting transcription activators by a contingent replication assay. Ind. J. Biophys. Biochem.25:488-494.

28. Neary, K. and DiMaio, D. (1989) Open reading frames E6 and E7 of bovine papillomavirus are both required for full transformation of mouse C127 cells. J. Virol.63:259-266.

29. Horwitz, B., Settleman, J., Prakash, S.S., and DiMaio, D. (1989) Structure, function, and regulation of the bovine papillomavirus E5 gene and its transforming protein product. Curr. Topics Microbiol. Immunol.144:143-151.

30. Reiss, M., DiMaio, D., and Zibello, T. (1989) Bovine papillomavirus type 1 induces resistance to calcium-induced terminal differentiation in murine keratinocytes. Cancer Comm.1:74-80.

31. Horwitz, B.H., Weinstat, D.L., and DiMaio, D. (1989) Transforming activity of a sixteen amino acid segment of the bovine papillomavirus E5 protein linked to random sequences of hydrophobic amino acids. J. Virol.63:4515-4519.

32. Settleman, J., Fazeli, A., Malicki, J., Horwitz, B.H., and DiMaio, D. (1989) Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein. Mol. Cell. Biol.9:5563-5572.

33. Riese, D.R., Settleman, J., Neary, K., and DiMaio, D. (1990) Bovine papillomavirus E2 repressor mutant displays a high copy number phenotype and enhanced transforming activity. J. Virol.64:944-949.

34. DiMaio, D. and Neary, K. (1990) The genetics of bovine papillomavirus type 1. In: Papillomaviruses and Human Cancer, H. Pfister (ed), CRC Press. pp. 113-144.

35. Parton, A., Grand, R.J., Biggs, P., Settleman, J., DiMaio, D., and Gallimore, P.H. (1990) Integrated HPV 1 genomes in a human keratinocyte cell line can be transactivated by a SV40/BPV1 recombinant virus which expresses BPV1 E2 proteins. Virology175:508-517.

36. Horwitz, B. and DiMaio, D. (1990) Saturation mutagenesis using mixed oligonucleotides and M13 templates substituted with uracil. Meth. Enzym.185:599-612.

37. DiMaio, D. (1991) Transforming activity of papillomaviruses in cultured cells. Advances in Cancer Res.56:133-159.

38. Petti, L., Nilson, L., and DiMaio, D. (1991) Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 protein. EMBO J.10:845-855.

39. Petti, L., Nilson, L., Kulke, R., Leptak, C., Riese, D.J., Zibello, T.L., and DiMaio, D. (1991) The E5 mini-oncogene of bovine papillomavirus type 1: biological activity, genetic analysis, and proposed mechanism of action. In: Origins of Human Cancer, pp. 707-714.

40. Kulke, R. and DiMaio, D. (1991) Biological activities of the E5 protein of the deer papillomavirus in mouse C127 cells: morphologic transformation, induction of cellular DNA synthesis and activation of the PDGF receptor. J. Virol.65:4943-4949.

41. Leptak, C., Ramon y Cajal, S., Kulke, R., Riese, D.R., Horwitz, B.H., Dotto, G.P., and DiMaio, D. (1991) Tumorigenic transformation of mouse keratinocytes by the E5 genes of human papillomavirus type 16 and bovine papillomavirus type 1. J. Virol.65:7078-7083. Correction: J. Virol. 66:1833.

42. Kulke, R., Horwitz, B.H., Zibello, T., and DiMaio, D. (1992) The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many random hydrophobic sequences containing a glutamine. J. Virol.66:505-511.

43. Goldstein, D., Kulke, R., DiMaio, D., and Schlegel, R. (1992) A glutamine residue in the membrane-associating domain of the BPV-1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H+-ATPase. J. Virol.66:405-413.

44. Burnett, S., Jareborg, N., and DiMaio, D. (1992) Localization of the BPV-1 E5 protein to transformed basal keratinocytes and permissive differentiated cells in fibropapilloma tissue. Proc. Natl. Acad. Sci. USA89:5665-5669.

45. Petti, L. and DiMaio, D. (1992) Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells. Proc. Natl. Acad. Sci. USA89:6736-6740.

46. Brandsma, J.L., Yang, Z., DiMaio, D., Barthold, S.W., and Xiao, W. (1992) The putative E5 open reading frame of cottontail rabbit papillomavirus is dispensible for papilloma formation in domestic rabbits. J. Virol.66:6204-6207.

47. Hwang, E., Riese, D.R., Settleman, J., Nilson, L., Honig, J., Flynn, S., and DiMaio, D. (1993) Inhibition of cervical carcinoma cell line proliferation by introduction of a bovine papillomavirus regulatory gene. J. Virol.67:3720-3729.

48. Nilson, L. and DiMaio, D. (1993) Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein. Mol. Cell. Biol.13:4137-4145.

49. Andrews, E.M. and DiMaio, D. (1993) Hierarchy of polyadenylation site usage by bovine papillomavirus in transformed mouse cells. J. Virol.67:7705-7710.

50. Petti, L. and DiMaio, D. (1994) Specific interaction between the bovine papillomavirus E5 protein and the platelet-derived growth factor receptor in stably transformed and acutely transfected cells. J. Virol.68:3582-3592.

51. Kegler-Ebo, D., Docktor, C., and DiMaio, D. (1994) Codon cassette mutagenesis: a general method to insert or replace individual codons by using universal mutagenic cassettes. Nucl. Acids Res.22:1593-1599.

52. DiMaio, D., Petti, L., and Hwang, E.-S. (1994) The E5 transforming proteins of the papillomaviruses. Sem.Virol.5:369-379.

53. Riese, D.J. II and DiMaio, D. (1995) An intact PDGF signalling pathway is required for efficient growth transformation of mouse C127 cells by the bovine papillomavirus E5 protein. Oncogene10:1431-1440.

54. Drummond-Barbosa, D., Kazlauskas, A., and DiMaio, D. (1995) Ligand-independent activation of the platelet-derived growth factor ß receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling. Mol. Cell. Biol.15:2570-2581.

55. Kegler-Ebo, D., Pollack, G.W., and DiMaio, D. (1996) Saturation mutagenesis using codon cassette mutagenesis. Methods in Molecular Biology, Vol. 57: In vitro mutagenesis protocols 297-311.

56. Hwang, E.-S., Nottoli, T., and DiMaio, D. (1995) HPV16 E5 protein: expression, detection, and complex formation with transmembrane proteins in COS cells. Virology211:227-233.

57. Nilson, L.A., Gottlieb, R.W., Polack, G.W., and DiMaio, D. (1995) Mutational analysis of the interaction between the BPV E5 transforming protein and the endogenous receptor for platelet-derived growth factor in mouse C127 cells. J. Virol.69:5869-5874.

58. Hwang, E.-S., Naeger, L.K., and DiMaio, D. (1996) Activation of the endogenous p53 growth inhibitory pathway in HeLa cells by expression of the bovine papillomavirus E2 regulatory protein. Oncogene12:795-803.

59. Drummond-Barbosa, D., and DiMaio, D. (1997) Virocrine Transformation. Biochem. Biophys. Acta1332:M1-M17.

60. Nilson, L.A., Lisa M. Petti., D. Drummond-Barbosa, Riese, D.J., Hwang, E.-S., Nottoli, T., Henningson, C., Polack, G.W., Kegler-Ebo, D., and DiMaio, D. (1997) The role of the platelet-derived growth factor receptor in cell transformation by the bovine papillomavirus E5 protein. Current Developments in Animal Virology. Oxford & IBH Publishing Co., pp. 313-323.

61. Petti, L., Reddy, V., Smith, S.O., and DiMaio, D. (1997) Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein. J. Virol.71:7318-7327.

62. Petti, L.M., Irusta, P.M., and DiMaio, D. (1998) Oncogenic activation of the platelet-derived growth factor receptor by the transmembrane domain of p185neu*. Oncogene16:843-851.

63. Goodwin, E., Naeger, L.K., Breiding, D., Androphy, E.J., and DiMaio, D. (1998) Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines. J. Virol.72:3925-3934.

64. DiMaio, D., Lai, C.C., and Klein, O. (1998) Virocrine Transformation: the intersection between viral transforming proteins and cellular signal transduction pathways. Annu. Rev. Microbiol.52:397-421.

65. Surti, T., Klein, O., Ascheim, K., DiMaio, D., and Smith, S.O. (1998) Structural models of the bovine papillomavirus E5 protein. Proteins: Structure, Function, and Genetics33:601-612.

66. Klein, O., Polack, G.W., Surti, T., Kegler-Ebo, D., Smith, S.O., and DiMaio, D. (1998) Role of glutamine 17 of the bovine papillomvirus E5 protein in platelet-derived growth factor ß receptor activation and cell transformation. J. Virol.72:8921-8932.

67. Lai, C.C., Henningson, C., and DiMaio, D. (1998) Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor receptor. Proc. Natl. Acad. Sci. USA95:15241-15246.

68. Irusta, P.M. and DiMaio, D. (1998) A point mutation in a WW-like domain of diverse members of the platelet-derived growth factor receptor family causes constitutive receptor activation. EMBO J.17:6912-6923.

69. Klein, O., Kegler-Ebo, D., Su, J., Smith, S.O., and DiMaio, D. (1999) The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the PDGF ß receptor and transformation of C127 cells. J. Virol.73:3264-3272.

70. Naeger, L.K., Goodwin, E., Hwang, E.-S., DeFilippis, R.A., Zhang, H., and DiMaio, D. (1999) Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. Cell Growth Differ.10:413-422.

71. Lai, C.C., Henningson, C., and DiMaio, D. (2000) The bovine papillomavirus E5 protein induces the formation of signal transduction complexes containing dimeric activated PDGF ß receptor and associated signaling molecules. J. Biol. Chem.275:9832-9840.

72. Wu, L., Goodwin, E., Naeger, L.K., Vigo, E., Galaktionov, K., Helin, K., and DiMaio, D. (2000) E2F/Rb repressor complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression. Mol. Cell. Biol.20:7059-7067.

73. Goodwin, E., Yang, E., Lee, C.-J., Lee, H-W., DiMaio, D., and Hwang, E.-S. (2000) Rapid induction of senescence in human cervical carcinoma cells. Proc. Natl. Acad. Sci. USA97:10978-10983.

74. DiMaio, D. and Coen, D., (2001) Replication strategies of DNA viruses. In: Field's Virology. D. Knipe and P. Howley, eds. Fourth ed.,. pp. 119-132.

75. DiMaio, D., Lai, C.C., and Mattoon, D. (2000) Platelet-derived growth factor ß receptor as a target of the bovine papillomavirus E5 protein. Cytokine Growth Factor Rev.11:283-293.

76. Goodwin, E. and DiMaio, D. (2000) Repression of human papillomavirus oncogene expression in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc. Natl. Acad. Sci. USA97:12513-12518.

77. DiMaio, D. (2001) Daniel Nathans. National Academy of Sciences Biographical Memoirs, Vol. 79. http://books.nap.edu/html/biomems/dnathans.pdf

78. Mattoon, D., Gupta, K., Doyon, J., Loll, P., and DiMaio, D. (2001) Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein. Oncogene20:3824-3834.

79. Goodwin, E. and DiMaio, D. (2001) Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and long telomeres. Cell Growth Differ.12:525-534.

80. DiMaio, D. and Mattoon, D. (2001) Mechanisms of cell transformation by papillomavirus E5 proteins. Oncogene20:7866-7873.

81. Irusta, P., Luo, Y., Bahkt, O., Lai, C.-C., Smith, S.O., and DiMaio, D. (2002) Definition of a juxtamembrane inhibitory WW-like domain in the PDGF ß receptor. J. Biol. Chem.277:38627-38634.

82. DiMaio, D. (2002) Daniel Nathans. American National Biography Online: www.anb.org.

83. DeFilippis, R., Goodwin, E., Wu, L., and DiMaio, D. (2003) Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells. J. Virol.77:1551-1563.

84. Horner, S., DeFilippis, R., Manuelidis, L., and DiMaio, D. (2004) Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells. J. Virol.78:4063-4073.

85. Psyrri, A., DeFilippis, R., Edwards, A., and DiMaio, D. (2004) Role of the retinoblastoma pathway in senescence triggered by repression of the human papillomavirus E7 protein in cervical carcinoma cells. Cancer Res.64:3079-3086.

86. Freeman-Cook, L., Dixon, A., Frank, J., Xia, Y., Ely, L., Gerstein, M., Engelman, D., and DiMaio, D. (2004) Selection and characterization of small random transmembrane proteins that bind and activate the platelet-derived growth factor ß receptor. J. Mol. Biol.338:907-920.

87. Freeman-Cook, L., Edwards, A., Dixon, A., Yates, K.E., Ely, L., Engelman, D., and DiMaio, D. (2005) Specific locations of hydrophilic residues in constructed transmembrane ligands of the platelet-derived Growth Factor ß receptor. J. Mol. Biol.345:907-921.

88. Lai, C.C., Edwards, A., and DiMaio, D. (2005) Productive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor ß receptor. J. Virol.79:1924-9.

89. Sweasy, J.B., Dalal, S., Starcevic, D., Sun, K.-W., Lai, C.-C., DiMaio, D., and Lang, T. (2005) Expression of DNA polymerase ß cancer-associated variants in mouse cells results in cellular transformation. Proc. Natl. Acad. Sci. USA102:14350-14355. Epub 2005 Sep 22.

90. Freeman-Cook, L. and DiMaio, D. (2005) Modulation of cell phenotype by small transmembrane proteins modeled on the bovine papillomavirus E5 protein. Oncogene24:7756-7762.

91. Lee, B.Y., Han, J.A., Lim, J.S., Morrone, A., Johung, K., Goodwin, E.C., Keijer, W., DiMaio, D.*, and Hwang, E.-S.* (2006) Senescence-associated ß-galactosidase is lysosomal acid ß-galactosidase. Aging Cell5:187-195. (*corresponding authors)

92. DiMaio, D. and Liao, J. (2006) Human papillomaviruses and cervical cancer. Adv. Virus Res.66:125-159. pubmed | pdf

93. Sweasy, J.B., Lang, T., and DiMaio, D. (2006) Is base excision repair a tumor suppressor mechanism? Cell Cycle5:250-259.

94. DiMaio, D. and Miller, G. (2006) Thirty years into the genomics era: Tumor viruses led the way. Yale J. Biol. Med.79:179-185.

95. Johung, K., Goodwin, E.C., and DiMaio, D. (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J. Virol.81:2102-2116.

96. Horner, S.M. and DiMaio, D. (2007) The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells. J. Virol.81:6254-6264.

97. Ptacek, J.B., Edwards, A.P.B., Freeman-Cook, L.L., and DiMaio, D. (2007) Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGF ß receptor. Proc. Nat. Acad. Sci. USA104:11945-11950.

98. Lang, T., Dalal, S., Chikova, A., DiMaio, D., and Sweasy, J.B. (2007) The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol. Cell Biol.27:5587-5596.

99. Nguyen, M., Kraft, R.M., Aubert, M., Goodwin, E.C., DiMaio, D., and Blaho, J. (2007) p53 and hTERT determine sensitivity to viral apoptosis. J. Virol.81:12985-12995.

100. Psyrri, A. and DiMaio, D. (2008) Human papillomavirus in cervical and head-and-neck cancer. Nat. Clin. Pract. Oncol.5:24-31.

101. Yates, K.E., Korbel, G.A., Shtutman, M., Roninson, I.G., and DiMaio, D. (2007) Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell7:609-621.

102. Oates, J., Hicks, M., Dafforn, T.R., DiMaio, D., and Dixon, A.M. (2008) In vitro dimerization of the bovine papillomavirus E5 protein transmembrane domain. Biochemistry47:8985-8992.

103. Liao, J. Publicover, J., Rose, J., and DiMaio, D. (2008) Single-dose therapeutic vaccination of mice with vesicular stomatitis virus expressing human papillomavirus type 16 E7 protein. Clin. Vac. Immunol.15:817-824.

104. Talbert-Slagle, K. and DiMaio, D. (2008) The bovine papillomavirus E5 protein and the PDGF ß receptor: It takes two to tango. Virology (Minireview) 384:345-351.

105. DiMaio, D., Johung, K., Goodwin, E.C., Horner, S.M., and Yates, K.E. (2008) Senescence induced by repression of human papillomavirus oncogenes in cervical cancer cells. In: Beyond Apoptosis: Cellular Outcomes of Cancer Therapy. I. Roninson, ed., pp. 209-222, MacMillan Publishing.

106. Goodwin, E.C., Atwood, W.J., and DiMaio, D. (2009) High-throughput cell-based screen for chemicals that inhibit infection by SV40 and human polyomaviruses. J. Virol.83:5630-5639.

107. Talbert-Slagle, K., Marlatt, S., Barrera, F.N., Khurana, E., Oates, J., Gerstein, M., Engelman, D.M., Dixon, A., and DiMaio, D. (2009) Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine the sequence requirements for activation of the PDGF ß receptor. J. Virol.83:9773-9785.

108. Cammett, T.J., Jun, S.J., Cohen, E.B., Barrera, F.N., Engelman, D.M., and DiMaio, D. (2010) Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor. Proc. Natl. Acad. Sci. USA107:3447-3452.


Book reviews


1. The Biology of Cell Reproduction, Renato Baserga, Harvard University Press. American Scientist 73: 586 (1985).

2. The Transforming Principle, Maclyn McCarty, W.W. Norton. American Scientist, 74: 78-79 (1986).

3. A Genetic Switch, Mark Ptashne, Cell Press and Blackwell Scientific. American Scientist, 75: 83-84 (1987).


Commentary


Sox must now avoid a new kind of ‘curse’”, Yale Daily News, October 20, 2004.

"Don't Short the War on Cancer", Hartford Courant, September 27, 2007.

 

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Updated September 13, 2010