Our Research is driven by the desire to understand how the organelles of the endomembrane system - the collection of intracellular, membrane-bounded organelles that compartmentalize the biochemical reactions that fuel life - are assembled and maintained. The endomembrane system is broadly divided into the secretory pathway, which is responsible for the production and distribution of newly synthesized molecules throughout the cell, and the endocytic system, which internalizes components of the extracellular milieu and the plasma membrane. Elucidating the mechanisms that sort molecules to various organelles is of fundamental importance for understanding cell growth, division, multi-cellular development and physiology, and it is also crucial for understanding a broad range of diseases and afflictions - cancer, neurodegenerative disease, infectious disease, and many others.
Phosphoinositide and GTPase signaling modules constitute the master regulators of organelle biogenesis. Phosphoinositides