Current Lab Members
- Serap Aksoy, Ph.D.
- Geoffrey Attardo, Ph.D.
- Michelle Bailly, M.S.
- Josh Benoit, Ph.D.
- Oleg Kruglov
- Laura Cronin
- Michele Maltz, Ph.D.
- Veronika Michalkova
- Amy Savage, Ph.D.
- Thiago Luiz Alves e Silva
- Erich Telleria, Ph.D.
- Jingwen Wang, Ph.D.
- Brian Weiss, Ph.D.
- Xin Zhao, Ph.D.
- Yineng Wu, M.Sc.
Past Lab Members
- Leyla Akman, Ph.D.
- Uzma Alam, Ph.D.
- Corey Brelsfoard, Ph.D.
- Xiao-ai Chen, Ph.D.
- Quing Cheng, Ph.D.
- Nurper Guz
- Zhengrong Hao, Ph.D.
- Changyun Hu, Ph.D.
- Youjia Hu, Ph.D.
- Song Li, Ph.D.
- Claudia Lohs
- Dana Nayduch, Ph.D.
- Roshan Pais, Ph.D.
- Sarah Perkin, Ph.D.
- Sandesh Regmi, Ph.D.
- Rita Rio, Ph.D.
- Patricia Strickler-Dinglasan Ph.D.
- Guangxiao Yang, Ph.D.
- Jian Yang, Ph.D.
- Suleyman Yildirim, Ph.D.
Uzma Alam
Postdoctoral fellow
Lab Phone: (203) 737-4134
Fax: (203) 785-4782
Email: uzma.alam@yale.edu
Background
My ongoing research involves characterization of the biological significance of wolbachia infections in both laboratory and field tsetse lines. To date it was not feasible to study tsetse-wolbachia interactions given the lack of tools. However, I have developed a line of aposymbiotic flies enabling me to begin understanding cytoplasmic incompatibility (CI) in tsetse. Additionally, using varied tsetse strains trapped from across Africa I am deciphering the infection dynamics of wolbachia at a molecular level to accurately reflect evolutionary and ecological relationships between the host-parasite.
Education
- Ph.D. Microbiology & Immunology: University of Maryland, Baltimore 2006
- BS Biochemistry: University of Cardiff, Wales 1998
Awards, Honors and Grants
- Young investigator honorary mention at the 54th Annual American Society of Tropical Medicine & Hygiene Meeting 2005.
- One out of the 6 Invited speakers to the 2005 Greater Baltimore - Washington graduate research forum sponsored by the DC chapter of the Society for Experimental Biology and Medicine.
- Travel award to Cold Spring Harbor Laboratories: Immunological & Molecular approaches to vaccine design 2005.
- 3rd place for Oral presentation at the 27th Graduate Research Conference 2005.
Curriculum vitae
Publications
Attardo GM, Lohs C, Heddi A, Alam UH, Yildirim S, Aksoy S. Analysis of milk gland structure and function in Glossina morsitans: milk protein production, symbiont populations and fecundity. J Insect Physiol. 2008 Aug;54(8):1236-42. Epub 2008 Jul 4. PubMed PMID: 18647605; PubMed Central PMCID: PMC2613686.
Sacci JB Jr, Alam U, Douglas D, Lewis J, Tyrrell DL, Azad AF, Kneteman NM. Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers. Int J Parasitol. 2006 Mar;36(3):353-60. PubMed PMID: 16442544.
Porter-Kelley JM, Dinglasan RR, Alam U, Ndeta GA, Sacci JB Jr, Azad AF. Plasmodium yoelii: axenic development of the parasite mosquito stages. Exp Parasitol. 2006 Feb;112(2):99-108. Epub 2005 Nov 14. PubMed PMID: 16289466.
Sacci JB Jr, Ribeiro JM, Huang F, Alam U, Russell JA, Blair PL, Witney A, Carucci DJ, Azad AF, Aguiar JC. Transcriptional analysis of in vivo Plasmodium yoelii liver stage gene expression. Mol Biochem Parasitol. 2005 Aug;142(2):177-83. Epub 2005 Apr 26. PubMed PMID: 15876462.
Dinglasan RR, Porter-Kelley JM, Alam U, Azad AF. Peptide mimics as surrogate immunogens of mosquito midgut carbohydrate malaria transmission blocking targets. Vaccine. 2005 Apr 15;23(21):2717-24. PubMed PMID: 15780718.
Mbaisi A, Liyala P, Eyase F, Achilla R, Akala H, Wangui J, Mwangi J, Osuna F, Alam U, Smoak BL, Davis JM, Kyle DE, Coldren RL, Mason C, Waters NC. Drug susceptibility and genetic evaluation of Plasmodium falciparum isolates obtained in four distinct geographical regions of Kenya. Antimicrob Agents Chemother. 2004 Sep;48(9):3598-601. PubMed PMID: 15328137; PubMed Central PMCID: PMC514731.
Currier JR, Dowling WE, Wasunna KM, Alam U, Mason CJ, Robb ML, Carr JK, McCutchan FE, Birx DL, Cox JH. Detection of high frequencies of HIV-1 cross-subtype reactive CD8 T lymphocytes in the peripheral blood of HIV-1-infected Kenyans. AIDS. 2003 Oct 17;17(15):2149-57. PubMed PMID: 14523271.
Macaluso KR, Davis J, Alam U, Korman A, Rutherford JS, Rosenberg R, Azad AF. Spotted fever group rickettsiae in ticks from the Masai Mara region of Kenya. Am J Trop Med Hyg. 2003 May;68(5):551-3. PubMed PMID: 12812343.
Dowling WE, Kim B, Mason CJ, Wasunna KM, Alam U, Elson L, Birx DL, Robb ML, McCutchan FE, Carr JK. Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. AIDS. 2002 Sep 6;16(13):1809-20. Erratum in: AIDS 2002 Oct 18;16(15):2104. PubMed PMID: 12218394.