Current Lab Members
- Serap Aksoy, Ph.D.
- Geoffrey Attardo, Ph.D.
- Michelle Bailly, M.S.
- Josh Benoit, Ph.D.
- Oleg Kruglov
- Laura Cronin
- Michele Maltz, Ph.D.
- Veronika Michalkova
- Amy Savage, Ph.D.
- Thiago Luiz Alves e Silva
- Erich Telleria, Ph.D.
- Jingwen Wang, Ph.D.
- Brian Weiss, Ph.D.
- Xin Zhao, Ph.D.
- Yineng Wu, M.Sc.
Past Lab Members
- Leyla Akman, Ph.D.
- Uzma Alam, Ph.D.
- Corey Brelsfoard, Ph.D.
- Xiao-ai Chen, Ph.D.
- Quing Cheng, Ph.D.
- Nurper Guz
- Zhengrong Hao, Ph.D.
- Changyun Hu, Ph.D.
- Youjia Hu, Ph.D.
- Song Li, Ph.D.
- Claudia Lohs
- Dana Nayduch, Ph.D.
- Roshan Pais, Ph.D.
- Sarah Perkin, Ph.D.
- Sandesh Regmi, Ph.D.
- Rita Rio, Ph.D.
- Patricia Strickler-Dinglasan Ph.D.
- Guangxiao Yang, Ph.D.
- Jian Yang, Ph.D.
- Suleyman Yildirim, Ph.D.
Jingwen Wang
Postdoctoral fellow
Lab Phone: (203) 737-4134
Fax: (203) 785-4782
Email: jingwen.wang@yale.edu
Background
My project focuses on understanding the molecular aspects of the tsetse fly host immune responses to protozoan African trypanosomes and to its mutualistic bacterial flora. Insects appear to rely on innate immune system to differentiate between self and non-self microbes by use of pattern recognition receptors (PRRs). I investigate different PRRs and other component of immune pathway in tsetse and find a family of structurally highly conserved proteins, peptidoglycan recognition proteins (PGRPs) which play a very important role in regulation of symbiotic microorganisms, while impacting transmission on parasites.
Publications
Jingwen Wang, Corey Brelsfoard, Yineng Wu, Serap Aksoy. Intercommunity effects on microbiome and GpSGHV density regulation in tsetse flies. Journal of Invertebrate Pathology, Available online 18 April 2012, ISSN 0022-2011, 10.1016/j.jip.2012.03.028.
Alam U, Hyseni C, Symula RE, Brelsfoard C, Wu Y, Kruglov O, Wang J, Echodu R, Alioni V, Okedi LM, Caccone A, Aksoy S. Microfauna-host interactions: implications for trypanosome transmission dynamics in Glossina fuscipes fuscipes in Uganda. Appl Environ Microbiol. 2012 Apr 27. [Epub ahead of print] PubMed PMID: 22544247.
Rio RV, Symula RE, Wang J, Lohs C, Wu YN, Snyder AK, Bjornson RD, Oshima K, Biehl BS, Perna NT, Hattori M, Aksoy S. Insight into the transmission biology and species-specific functional capabilities of tsetse (Diptera: glossinidae) obligate symbiont wigglesworthia. MBio. 2012 Feb 14;3(1). pii: e00240-11. doi: 10.1128/mBio.00240-11. Print 2012. PubMed PMID: 22334516; PubMed Central PMCID: PMC3280448.
Weiss BL, Wang J, Aksoy S. Tsetse immune system maturation requires the presence of obligate symbionts in larvae. PLoS Biol. 2011 May;9(5):e1000619. Epub 2011 May 31. PubMed PMID: 21655301; PubMed Central PMCID: PMC3104962.
Wang J, Wu Y, Yang G, Aksoy S. Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12133-8. Epub 2009 Jul 8. PubMed PMID: 19587241; PubMed Central PMCID: PMC2715537.
Pais R, Lohs C, Wu Y, Wang J, Aksoy S. The obligate mutualist Wigglesworthia glossinidia influences reproduction, digestion, and immunity processes of its host, the tsetse fly. Appl Environ Microbiol. 2008 Oct;74(19):5965-74. Epub 2008 Aug 8. PubMed PMID: 18689507; PubMed Central PMCID: PMC2565960.
Wang J, Hu C, Wu Y, Stuart A, Amemiya C, Berriman M, Toyoda A, Hattori M, Aksoy S. Characterization of the antimicrobial peptide attacin loci from Glossina morsitans. Insect Mol Biol. 2008 Jun;17(3):293-302. PubMed PMID: 18477243; PubMed Central PMCID: PMC2656931.