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Geoff Attardo

Geoffrey M. Attardo

Research Scientist
Lab Phone: (203) 737-4134
Cell Phone: (203) 464-2027
Fax: (203) 785-4782
Email: geoffrey.attardo@yale.edu
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Background

My research focuses upon the reproductive biology of insect vectors of human disease. My Ph.D. thesis in Dr. Alex Raikhels lab focused upon the effects of nutritional components of blood (amino acids) upon the transcriptional regulation of yolk protein genes in the Yellow Fever mosquito (Aedes aegypti). My current work in the Aksoy lab involves the molecular characterization of reproductive processes of the viviparous Tsetse fly (Glossina morsitans morsitans). This work targets multiple aspects of reproduction in tsetse including nutrient metabolism and mobilization to the intrauterine offspring; identification and characterization of reproductive genes and regulatory mechanisms; the role of the obligatory symbiotic bacteria wigglesworthia in tsetse fertility

Education

  • Research Scientist: Yale University School of Public Health, 2012-Present
  • Associate Research Scientist: Yale University School of Public Health, 2008-2012
  • Postdoctoral Fellow: Yale University School of Public Health, 2004-2008
  • Ph.D. Genetics: Michigan State University - Genetics Program, 2004
  • B.S. Entomology: University of Massachusetts - Amherst, 1994

Awards, Honors and Grants

  • PI on R21 AI109263-01 "Expanding the toolbox for tsetse reproductive biology"
  • Co-PI on 1R01AI081774-01A1 NIH/NIAID to Serap Aksoy: "Tsetse Fecundity reduction for trypanosomiasis control"
  • Kirschstein-NRSA training fellowship to Geoffrey Attardo- 2006-2008: #F32GM077964 "Molecular Analysis of Tsetse Fly Reproduction"

Curriculum vitae

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Publications

Attardo GM, Benoit JB, Michalkova V, Yang G, Roller L, Bohova J, Takáč P, Aksoy S. Analysis of lipolysis underlying lactation in the tsetse fly, Glossina morsitans. Insect Biochem Mol Biol. 2012 May;42(5):360-70. PubMed PMID: 22509523.

Benoit JB, Attardo GM, Michalkova V, Takac P, Bohova J, Aksoy S. Sphingomyelinase Activity in Mother's Milk Is Essential for Juvenile Development: A Case from Lactating Tsetse Flies. Biol Reprod. 2012 Apr 18. [Epub ahead of print] PubMed PMID: 22517621.

Benoit JB, Yang G, Krause TB, Patrick KR, Aksoy S, Attardo GM. Lipophorin acts as a shuttle of lipids to the milk gland during tsetse fly pregnancy. J Insect Physiol. 2011 Nov;57(11):1553-61. Epub 2011 Aug 22. PubMed PMID: 21875592; PubMed Central PMCID: PMC3209505.

Hansen IA, Boudko DY, Shiao SH, Voronov DA, Meleshkevitch EA, Drake LL, Aguirre SE, Fox JM, Attardo GM, Raikhel AS. AaCAT1 of the yellow fever mosquito, Aedes aegypti: a novel histidine-specific amino acid transporter from the SLC7 family. J Biol Chem. 2011 Mar 25;286(12):10803-13. Epub 2011 Jan 24. PubMed PMID: 21262963; PubMed Central PMCID: PMC3060531.

Yang G, Attardo GM, Lohs C, Aksoy S. Molecular characterization of two novel milk proteins in the tsetse fly (Glossina morsitans morsitans). Insect Mol Biol. 2010 Apr;19(2):253-62. Epub 2010 Feb 1. PubMed PMID: 20136662; PubMed Central PMCID: PMC2862765.

Alves-Silva J, Ribeiro JM, Van Den Abbeele J, Attardo G, Hao Z, Haines LR, Soares MB, Berriman M, Aksoy S, Lehane MJ. An insight into the sialome of Glossina morsitans morsitans. BMC Genomics. 2010 Mar 30;11:213. PubMed PMID: 20353571; PubMed Central PMCID: PMC2853526.

Attardo GM, Ribeiro JM, Wu Y, Berriman M, Aksoy S. Transcriptome analysis of reproductive tissue and intrauterine developmental stages of the tsetse fly (Glossina morsitans morsitans). BMC Genomics. 2010 Mar 9;11:160. PubMed PMID: 20214793; PubMed Central PMCID: PMC2846916.

Attardo GM, Lohs C, Heddi A, Alam UH, Yildirim S, Aksoy S. Analysis of milk gland structure and function in Glossina morsitans: milk protein production, symbiont populations and fecundity. J Insect Physiol. 2008 Aug;54(8):1236-42. Epub 2008 Jul 4. PubMed PMID: 18647605; PubMed Central PMCID: PMC2613686.

Hu C, Rio RV, Medlock J, Haines LR, Nayduch D, Savage AF, Guz N, Attardo GM, Pearson TW, Galvani AP, Aksoy S. Infections with immunogenic trypanosomes reduce tsetse reproductive fitness: potential impact of different parasite strains on vector population structure. PLoS Negl Trop Dis. 2008 Mar 12;2(3):e192. PubMed PMID: 18335067; PubMed Central PMCID: PMC2265429.

Aksoy S, Weiss B, Attardo G. Paratransgenesis applied for control of tsetse transmitted sleeping sickness. Adv Exp Med Biol. 2008;627:35-48. Review. PubMed PMID: 18510012.

Guz N, Attardo GM, Wu Y, Aksoy S. Molecular aspects of transferrin expression in the tsetse fly (Glossina morsitans morsitans). J Insect Physiol. 2007 Jul;53(7):715-23. Epub 2007 Apr 1. PubMed PMID: 17498733; PubMed Central PMCID: PMC2065764.

Strickler-Dinglasan PM, Guz N, Attardo G, Aksoy S. Molecular characterization of iron binding proteins from Glossina morsitans morsitans (Diptera: Glossinidae). Insect Biochem Mol Biol. 2006 Dec;36(12):921-33. Epub 2006 Sep 26. PubMed PMID: 17098167; PubMed Central PMCID: PMC1698469.

Attardo GM, Guz N, Strickler-Dinglasan P, Aksoy S. Molecular aspects of viviparous reproductive biology of the tsetse fly (Glossina morsitans morsitans): regulation of yolk and milk gland protein synthesis. J Insect Physiol. 2006 Nov-Dec;52(11-12):1128-36. Epub 2006 Sep 5. PubMed PMID: 17046784; PubMed Central PMCID: PMC1779500.

Attardo GM, Hansen IA, Shiao SH, Raikhel AS. Identification of two cationic amino acid transporters required for nutritional signaling during mosquito reproduction. J Exp Biol. 2006 Aug;209(Pt 16):3071-8. PubMed PMID: 16888056.

Park JH, Attardo GM, Hansen IA, Raikhel AS. GATA factor translation is the final downstream step in the amino acid/target-of-rapamycin-mediated vitellogenin gene expression in the anautogenous mosquito Aedes aegypti. J Biol Chem. 2006 Apr 21;281(16):11167-76. Epub 2006 Feb 20. PubMed PMID: 16490782.

Attardo GM, Hansen IA, Raikhel AS. Nutritional regulation of vitellogenesis in mosquitoes: implications for anautogeny. Insect Biochem Mol Biol. 2005 Jul;35(7):661-75. Epub 2005 Mar 28. Review. PubMed PMID: 15894184.

Hansen IA, Attardo GM, Roy SG, Raikhel AS. Target of rapamycin-dependent activation of S6 kinase is a central step in the transduction of nutritional signals during egg development in a mosquito. J Biol Chem. 2005 May 27;280(21):20565-72. Epub 2005 Mar 23. PubMed PMID: 15788394.

Hansen IA, Attardo GM, Park JH, Peng Q, Raikhel AS. Target of rapamycin-mediated amino acid signaling in mosquito anautogeny. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10626-31. Epub 2004 Jun 30. PubMed PMID: 15229322; PubMed Central PMCID: PMC489984.

Attardo GM, Higgs S, Klingler KA, Vanlandingham DL, Raikhel AS. RNA interference-mediated knockdown of a GATA factor reveals a link to anautogeny in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13374-9. Epub 2003 Oct 31. PubMed PMID: 14595016; PubMed Central PMCID: PMC263821.





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