7. Brain Biopsy - Histopathologic Interpretation

  • NO classical HSV-associated changes (inclusions), BUT:THERE IS NOTED:
  • perivascular cuffing by a mononuclear cell infiltrate
  • dead/dying neurons
  • areas consistent with glial nodules
  • neuronophagia (clusters of cells around dying neurons)


    • There are some features of HSV infection; need to rule out lymphoma
      (Booss J and Kim JH. Yale J Biol Med 57:751, 1984)

Breakpoint #6

  • What additional studies would you suggest at this time?