Stephen C Edberg PhD
Professor Emeritus of Laboratory Medicine
Bacteria; infection; metabolic activity; enzyme production; diarrhea
My research is primarily focused on which characteristics of bacteria make them virulent for human beings. In particular, I am interested in bacteria that are found in the environment that may cause infection in human beings. To determine the virulence characteristics of bacteria, my laboratory has examined a wide variety of bacterial species from the environment and from human clinical infections to determine the most important characteristics associated with invasiveness. The bacteria have been analyzed based on metabolic activity, enzyme production, the ability to attach to and to penetrate into cells and the ability to produce certain DNA sequences that are associated with virulence. My laboratory is now engaged in a major Centers for Disease Control project on the examination of the causes of diarrhea. Patient specimens and age-matched controls are examined for three groups: those which are known; those which are suspected; and those which are speculative. In addition, normal flora bacteria are screened for antibiotic resistance. The Clinical Microbiology laboratory also engages in collegial research with both basic and clinical investigators. Plus, it generates its own projects for the residents and fellows.