Camille Keeler PhD, Dr.

Associate Research Scientist in Laboratory Medicine

Research Interests

NMR; Protein purification; Protein Biophysics

Current Projects

We are currently developing a device for NMR spectroscopy for the purpose of in situ microscale titrations.

Selected Publications

  • Keeler C, Poon G, Kuo IY, Ehrlich BE, Hodsdon ME. An Explicit Formulation Approach for the Analysis of Calcium Binding to EF-Hand Proteins Using Isothermal Titration Calorimetry. Biophys J. 2013 Dec 17;105(12):2843-53. doi: 10.1016/j.bpj.2013.11.017. PubMed PMID: 24359756; PubMed Central PMCID: PMC3882476.
  • Keeler C, Tettamanzi MC, Meshack S, Hodsdon ME. Contribution of individual histidines to the global stability of human prolactin. Protein Sci. 2009 May;18(5):909-20. doi: 10.1002/pro.100. PubMed PMID: 19384991; PubMed Central PMCID: PMC2771294.
  • Keeler C, Jablonski EM, Albert YB, Taylor BD, Myszka DG, Clevenger CV, Hodsdon ME. The kinetics of binding human prolactin, but not growth hormone, to the prolactin receptor vary over a physiologic pH range. Biochemistry. 2007 Mar 6;46(9):2398-410. Epub 2007 Feb 6. PubMed PMID: 17279774.
  • Keeler C, Dannies PS, Hodsdon ME. The tertiary structure and backbone dynamics of human prolactin. J Mol Biol. 2003 May 16;328(5):1105-21. PubMed PMID: 12729745
  • Keeler C, Maciel GE. Quantitation in the solid-state 13C NMR analysis of soil and organic soil fractions. Anal Chem. 2003 May 15;75(10):2421-32. PubMed PMID: 12918986
  • Keeler C, Xiong J, Lock H, Dec S, Tao T, Maciel GE. A new in situ chemical reactor for studying heterogeneous catalysis by NMR: The GRASSHopper. Catalysis Today 1999 Mar 10; 49(4):377-383.

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