News & Events
Haberman challenges current model of germinal center differentiation
In a recent article in Immunity, Ann Haberman has provided evidence for a new paradigm for germinal center differentiation. As described by Italian immunologists Marieta Caganova and Stefano Casola in their description on the "Faculty of 1000": "The authors challenge the current model of germinal center (GC) differentiation by developing a system to track antigen-specific B and T cells at their earliest moves prior to GC formation. The initial stage of GC differentiation takes place in the neutral interfollicular zone where, by induced Bcl6 expression, T follicular helper (Tfh) cell differentiation starts as early as 1 day post antigen encounter and precedes that of a B cell by 1 day. Interestingly, not only T, but also B, cell help is mutually inclusive for successful GC persistence."
Diane Krause has been selected to participate in a prestigious year-long leadership training
Diane Krause has been selected to participate in a prestigious year-long leadership training program for women in medicine called Executive Leadership in Academic Medicine (ELAM) at Drexel University.
Laboratory Medicine researchers unravel mysteries of the "germinal center", the site where long-lived immunity to infections and vaccines is formed.
Dr. Mark Shlomchik and colleagues have recently discovered previously unsuspected aspects of cellular signalling in the germinal center that may have important implications for vaccine development and for the treatment of immunologically based diseases. Their work is published in Science. http://www.sciencemag.org/content/early/2012/05/02/science.1213368
Sheldon Campbell elected as Chair of American Society for Microbiology Division
Dr. Sheldon Campbell, Associat Professor of Microbiology, has been elected as the Chair of Division C (Clinical Microbiology) of the American Society for Microbiology, to begin his term in 2012. At the current time, another of our faculty members, Carol Ann Rauch, is Chair of the Division. The Amerian Society of Microbiology is the oldest and largest single life science membership organization in the world with more than 43,000 members, one third of whom are located outside the United States.
Medical Student Receives Research Fellowship Award
Edward Snyder receives 7-year NHLBI REDS-III Contract
With Edward Snyder, MD, as PI, the Yale Department of Laboratory Medicine, collaborating with the Connecticut American Red Cross and Bridgeport Hospital, has been selected to receive the NIH grant "REDS-III" (Recipient Epidemiology and Donor Evaluation Study-III). This NHLBI initiative brings together leading researchers from the U.S. and abroad in the fields of blood banking and transfusion medicine. Continuing the efforts of REDS and REDS-II to improve blood safety and availability, REDS-III seeks to improve transfusion practices and outcomes in recipients of blood products, both in the U.S. and internationally.
The Yale-ARC-Bridgeport consortium is one of four United States centers. The REDS-III program will run for 7 years, and the award to Yale is 10.4 million dollars. One integral element of the research program will be the development of a database that collects “vein-to-vein” information on donors, component processing, and patients to allow for systematic study of the determinants of transfusion outcomes in patients.
The other U.S. centers will be the Blood Center of Wisconsin, Milwaukee, WI; the Institute for Transfusion Medicine, Pittsburgh, PA; and the University of California, San Francisco, San Francisco, CA. Three international collaborative programs involving researchers in the U.S. and Brazil, China, and South Africa will participate in REDS-III.
Yan Yun Wu appointed Chair of the International Affairs Committee for the American Society for Apheresis
Nancy Young elected President of the American Society of Cytopathology
Nancy A. Young, MD is currently President-elect of the American Society of Cytopathology, with her term as President to begin in November, 2010. Dr Young is also Chair of Pathology and Laboratory Medicine at Albert Einstein Medical Center in Philadelphia and Professor of Pathology, Anatomy, and Cell Biology at Thomas Jefferson Medical College in Philadelphia.
Alumna Kimberle Chapin appointed Chair of the American Board of Medical Microbiology
Kimberle Chapin, MD, a former resident and medical microbiology fellow in our Department, was appointed Chair of the American Board of Medical Microbiology. The American College of Microbiology oversees all certification and accreditation activities of the American Society of Microbiology. Dr. Chapin is Director, Microbiology Laboratory, Lifespan Academic Medical Centers and Associate Professor of Pathology and Medicine at Brown.
More News and Events in Laboratory Medicine
Clinical Virology Newsletter
Lab Med Faculty Publications selected for "Faculty of 1000"
Mark Shlomchik had two articles cited (Teichmann LL, Ols ML, ..., Kaplan DH, Shlomchik MJ. Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity. 2010 Dec 14; 33(6):967-78; Tomayko MM, Steinel NC, Anderson SM, Shlomchik MJ. Cutting edge: Hierarchy of maturity of murine memory B cell subsets.J Immunol. 2010 Dec 15; 185(12):7146-50).
Michael Hodsdon also had two articles cited (Petri ET, Celic A, ..., Boggon TJ, Hodsdon ME. Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9176-81; Kucera NJ, Hodsdon ME, Wolin SL. An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors. Proc Natl Acad Sci U S A. 2011)