16. Treatment Of Bleeding With FX Deficiency

Treatment Of Bleeding With FX Deficiency

• Half-life of factor X is 24-48 hrs
  
• Fresh frozen plasma
  - 10-20 cc/Kg loading dose
  - 3-6 cc/Kg twice daily
  - Aim to keep factor levels >10-20%

Selected References

• Cooper DN, Millar DS, Wacey A, Pemberton S, Tuddenham EG. "Inherited factor X deficiency: molecular genetics and pathophysiology." Thromb Haemost. 1997 Jul;78(1):161-72.
  
• Hertzberg M. "Biochemistry of factor X." Blood Rev. 1994 Mar;8(1):56-62.
  
• Peyvandi F, Menegatti M, Santagostino E, Akhavan S, Uprichard J, Perry DJ, Perkins SJ, Mannucci PM. "Gene mutations and three-dimensional structural analysis in 13 families with severe factor X deficiency." Br J Haematol. 2002 Jun;117(3):685-92.
  
• Uprichard J, Perry DJ. "Factor X deficiency." Blood Rev. 2002 Jun;16(2):97-110.

Figure acknowledgements

• Figures on pages 11 and 12 are from McClatchey's "Clinical Laboratory Medicine", 2nd ed., 2002 and from Cooper et al. Thromb Haemost. 1997 Jul;78(1):161-72.