11. Factor X Deficiency

Factor X Deficiency

Vitamin K Metabolic Pathway

 Vitamin K Metabolic Pathway Diagram

  • Duckert et al (1954)
    - Factor deficiency in pts on coumarins, distinct from factor VII and factor IX
  • Factor X named (1962)
  • Vitamin K dependent serine protease


Factor X Gene

 Factor X Gene

  • 13q34ter, 22 kb
    - 2.8 kb downstream of FVII gene
  • Structure and sequence homologous to other vitamin K dependent factors
  • Eight exons, seven introns

Factor X Protein

 Factor X Protein

  • Hepatic synthesis
  • Two chain protein in plasma, 59 kd
    - 139 AA, 16.9 kd
    - 346 AA, 42.1 kd
  • Concentration in plasma 10 mg/mL
  • Eight functional domains