12. Final Identification by HPLC
Final Identification by HPLC
- Mycobacterium chelonae complex
Discussion
- Initially, M. chelonae had two subspecies
- M. chelonae subspecies chelonae
- M. chelonae subspecies abscessus
- 1992, DNA homology studies showed these were two separate species
- M. chelonae
- M. abscessus
- There are major differences between two species
- M. chelonae
- usually produces disease in setting of corticosteroid therapy
- usually disseminated skin disease
- rarely associated with nosocomial disease
- highly cefoxitin resistant
- usually produces disease in setting of corticosteroid therapy
- M. abscessus
- more virulent
- cause disease with or without immunosuppression
- common in nosocomial disease
- Susceptible to cefoxitin
- M. chelonae
Breakpoint #5
- What further information is needed from the laboratory to initiate therapy?
