My lab focuses on two main areas of research with a goal to provide pertinent insights for the mechanistic understanding of human diseases.
First, we are interested in understanding the mechanisms by which the tissue or niche microenvironment regulates stem cell maintenance as well as their cell fate. We are particularly interested in regulation of cancer stem cell functions by hypoxia or oxygen deficiency.
The second area of our research concerns the role of oxygen-sensing pathway in the regulation of energy homeostasis, in the pathological progression of obesity, and in obesity-associated metabolic syndromes including type 2 diabetes and cardiovascular diseases.
Cancer Stem Cells, Tumor Hypoxia, Tumor Microenvironment, Obesity, Metabolic Diseases