Publications

1.

High-throughput screening to identify inhibitors of lysine demethylases.

Gale M, Yan Q.

Epigenomics. 2015 Feb;7 (1) :57-65. PMID: 25687466

3.

Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes.

Zou MR, Cao J, Liu Z, Huh SJ, Polyak K, Yan Q.

J Biol Chem. 2014 Jun 20;289 (25) :17620-33. Epub 2014 May 6. PMID: 24802759

4.

Histone demethylase RBP2 is critical for breast cancer progression and metastasis.

Cao J, Liu Z, Cheung WK, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q.

Cell Rep. 2014 Mar 13;6 (5) :868-77. Epub 2014 Feb 27. PMID: 24582965

5.

Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis.

Teng YC, Lee CF, Li YS, Chen YR, Hsiao PW, Chan MY, Lin FM, Huang HD, Chen YT, Jeng YM, Hsu CH, Yan Q, Tsai MD, Juan LJ.

Cancer Res. 2013 Aug 1;73 (15) :4711-21. Epub 2013 May 30. PMID: 23722541

6.

Histone demethylases set the stage for cancer metastasis.

Cao J, Yan Q.

Sci Signal. 2013 Apr 30;6 (273) :pe15, 1-2. Epub 2013 Apr 30. PMID: 23633674

7.

Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.

Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel JS, Yan Q.

J Biol Chem. 2013 Mar 29;288 (13) :9408-17. Epub 2013 Feb 13. PMID: 23408432

8.

Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.

Beshiri ML, Holmes KB, Richter WF, Hess S, Islam AB, Yan Q, Plante L, Litovchick L, Gévry N, Lopez-Bigas N, Kaelin WG Jr, Benevolenskaya EV.

Proc Natl Acad Sci U S A. 2012 Nov 6;109 (45) :18499-504. Epub 2012 Oct 23. PMID: 23093672

9.

Epigenetic mechanisms in commonly occurring cancers.

Blair LP, Yan Q.

DNA Cell Biol. 2012 Oct;31 Suppl 1 :S49-61. Epub 2012 Apr 20. PMID: 22519822

10.

The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.

Niu X, Zhang T, Liao L, Zhou L, Lindner DJ, Zhou M, Rini B, Yan Q, Yang H.

Oncogene. 2012 Feb 9;31 (6) :776-86. Epub 2011 Jul 4. PMID: 21725364

11.

Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer.

Cao J, Yan Q.

Front Oncol. 2012;2 :26. Epub 2012 Mar 12. PMID: 22649782

12.

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.

Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG Jr, Yan Q.

Proc Natl Acad Sci U S A. 2011 Aug 16;108 (33) :13379-86. Epub 2011 Jul 25. PMID: 21788502

13.

Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer.

Blair LP, Cao J, Zou MR, Sayegh J, Yan Q.

Cancers (Basel). 2011 Mar 1;3 (1) :1383-404. PMID: 21544224

14.

Exploiting cellular senescence to treat cancer and circumvent drug resistance.

Yan Q, Wajapeyee N.

Cancer Biol Ther. 2010 Feb;9 (3) :166-75. Epub 2010 Feb 11. PMID: 20118655

15.

A role for mammalian Sin3 in permanent gene silencing.

van Oevelen C, Wang J, Asp P, Yan Q, Kaelin WG Jr, Kluger Y, Dynlacht BD.

Mol Cell. 2008 Nov 7;32 (3) :359-70. PMID: 18995834

16.

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.

Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, Zhang L, Kim WY, Olumi AF, Kaelin WG Jr.

Mol Cell. 2007 Oct 12;28 (1) :15-27. PMID: 17936701

17.

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

Li L, Zhang L, Zhang X, Yan Q, Minamishima YA, Olumi AF, Mao M, Bartz S, Kaelin WG Jr.

Mol Cell Biol. 2007 Aug;27 (15) :5381-92. Epub 2007 May 25. PMID: 17526729

18.

The retinoblastoma binding protein RBP2 is an H3K4 demethylase.

Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr.

Cell. 2007 Mar 9;128 (5) :889-900. Epub 2007 Feb 22. PMID: 17320163

19.

The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.

Yan Q, Bartz S, Mao M, Li L, Kaelin WG Jr.

Mol Cell Biol. 2007 Mar;27 (6) :2092-102. Epub 2007 Jan 12. PMID: 17220275

20.

Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.

Blanchette P, Cheng CY, Yan Q, Ketner G, Ornelles DA, Dobner T, Conaway RC, Conaway JW, Branton PE.

Mol Cell Biol. 2004 Nov;24 (21) :9619-29. PMID: 15485928

21.

Identification of Elongin C and Skp1 sequences that determine Cullin selection.

Yan Q, Kamura T, Cai Y, Jin J, Ivan M, Mushegian A, Conaway RC, Conaway JW.

J Biol Chem. 2004 Oct 8;279 (41) :43019-26. Epub 2004 Jul 27. PMID: 15280393

22.

Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex.

Querido E, Blanchette P, Yan Q, Kamura T, Morrison M, Boivin D, Kaelin WG, Conaway RC, Conaway JW, Branton PE.

Genes Dev. 2001 Dec 1;15 (23) :3104-17. PMID: 11731475

23.

Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.

Kamura T, Burian D, Yan Q, Schmidt SL, Lane WS, Querido E, Branton PE, Shilatifard A, Conaway RC, Conaway JW.

J Biol Chem. 2001 Aug 10;276 (32) :29748-53. Epub 2001 May 30. PMID: 11384984

24.

Transcription factors TFIIF, ELL, and Elongin negatively regulate SII-induced nascent transcript cleavage by non-arrested RNA polymerase II elongation intermediates.

Elmendorf BJ, Shilatifard A, Yan Q, Conaway JW, Conaway RC.

J Biol Chem. 2001 Jun 22;276 (25) :23109-14. Epub 2001 Mar 19. PMID: 11259417

25.

Dual roles for transcription factor IIF in promoter escape by RNA polymerase II.

Yan Q, Moreland RJ, Conaway JW, Conaway RC.

J Biol Chem. 1999 Dec 10;274 (50) :35668-75. PMID: 10585446

26.

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.

Kamura T, Conrad MN, Yan Q, Conaway RC, Conaway JW.

Genes Dev. 1999 Nov 15;13 (22) :2928-33. PMID: 10579999

27.

A role for the TFIIH XPB DNA helicase in promoter escape by RNA polymerase II.

Moreland RJ, Tirode F, Yan Q, Conaway JW, Egly JM, Conaway RC.

J Biol Chem. 1999 Aug 6;274 (32) :22127-30. PMID: 10428772

28.

Mechanism of promoter escape by RNA polymerase II.

Conaway JW, Dvir A, Moreland RJ, Yan Q, Elmendorf BJ, Tan S, Conaway RC.

Cold Spring Harb Symp Quant Biol. 1998;63 :357-64. PMID: 10384300