Our laboratory studies host immune responses to viral infections and cellular DNA repair pathways. We use a variety of techniques, including X-ray crystallography, electron microscopy, biochemistry, and computational biology. We also develop new structural biology methods.

Innate immune responses to HIV infection

Retroviruses employ an arsenal of viral proteins to counteract host restriction factors. The interplay between these two classes of proteins represents an ongoing molecular arms race.

T cell costimulation and coinhibition

T cell signaling—initiated by the T cell receptor (TCR) binding its ligand, peptide in complex with MHC (pMHC)—is fundamental to the normal function of the adaptive immune system.

DNA damage and repair

Damage to cellular DNA poses a constant threat to the genome, and DNA repair mechanisms have evolved to mitigate this deleterious process.