Our laboratory is part of the Department of Cell Biology at the Yale University School of Medicine. We are located on the first floor of the Boyer Center for Molecular Medicine.
We study how cells recognize and handle damaged, unneeded and potentially harmful noncoding RNAs and how the failure to degrade these RNAs impacts mammalian cell function and human disease. We also study the functions of several noncoding RNAs that are conserved between mammalian and bacterial cells. Our experiments utilize a variety of techniques, including mouse and bacterial genetics, mammalian cell culture, biochemistry, molecular biology and cell imaging.