Recent Publications

Dong Y, Richards JA, Gupta R, Aung PP, Emley A, Kluger Y, Dogra SK, Mahalingam M and Wajapeyee N: PTEN functions as a melanoma tumor suppressor by promoting host immune response. Oncogene. 2014 Sep 18;33 (38) :4632-42. Epub 2013 Oct 21. PMID: 24141770


Bhatnagar S, Zhu X, Ou J, Lin L, Chamberlain L, Zhu LJ, Wajapeyee N and Green MR: Genetic and pharmacological reactivation of the mammalian inactive X chromosome. Proc Natl Acad Sci U S A. 2014 Sep 2;111 (35) :12591-8. Epub 2014 Aug 18. PMID: 25136103


Gupta R, Dong Y, Solomon PD, Wettersten HI, Cheng CJ, Min JN, Henson J, Dogra SK, Hwang SH, Hammock BD, Zhu LJ, Reddel RR, Saltzman WM, Weiss RH, Chang S, Green MR and Wajapeyee N: Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proc Natl Acad Sci U S A. 2014 Jul 29;111 (30) :E3062-71. Epub 2014 Jul 14. PMID: 25024194


Lu Y, Wajapeyee N, Turker MS and Glazer PM: Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1. Cell Rep. 2014 Jul 24;8 (2) :501-13. Epub 2014 Jul 17. PMID: 25043185


Lin L, Chamberlain L, Pak ML, Nagarajan A, Gupta R, Zhu LJ, Wright CM, Fong KM, Wajapeyee N and Green MR: A Large-Scale RNAi-Based Mouse Tumorigenesis Screen Identifies New Lung Cancer Tumor Suppressors That Repress FGFR Signaling. Cancer Discov. 2014 Jul 11; Epub 2014 Jul 11. PMID: 25015643


Nagarajan A, Dogra SK, Liu AY, Green MR and Wajapeyee N: PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation. Mol Cell Biol. 2014 Jun;34 (12) :2264-82. Epub 2014 Apr 7. PMID: 24710276


Forloni M, Dogra SK, Dong Y, Conte D Jr, Ou J, Zhu LJ, Deng A, Mahalingam M, Green MR and Wajapeyee N: miR-146a promotes the initiation and progression of melanoma by activating Notch signaling. Elife. 2014 Feb 18;3 :e01460. Epub 2014 Feb 18. PMID: 24550252


Nagarajan A, Roden C and Wajapeyee N: Reduced representation bisulfite sequencing to identify global alteration of DNA methylation. Methods Mol Biol. 2014;1176 :23-31. PMID: 25030916

Wajapeyee N, Malonia SK, Palakurthy RK and Green MR: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 2013 Oct 15;27 (20) :2221-6. Epub 2013 Oct 8. PMID: 24105743


Fang M, Xia F, Mahalingam M, Virbasius CM, Wajapeyee N and Green MR: MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair. Mol Cell Biol. 2013 Jul;33 (13) :2635-47. Epub 2013 May 6. PMID: 23648481


Gupta R and Wajapeyee N: Induction of cellular senescence by oncogenic RAS. Methods Mol Biol. 2013;1048 :127-33. PMID: 23929102


Wajapeyee N, Deibler SK and Green MR: Genome-wide RNAi screening to identify regulators of oncogene-induced cellular senescence. Methods Mol Biol. 2013;965 :373-82. PMID: 23296672

Lizardi PM, Forloni M and Wajapeyee N: Genome-wide approaches for cancer gene discovery. Trends Biotechnol. 2011 Nov;29 (11) :558-68. Epub 2011 Jul 13. PMID: 21757246


Wajapeyee N and Green MR: Induction of senescence in melanoma: thinking outside the cell. Pigment Cell Melanoma Res. 2011 Oct;24 (5) :874-5. PMID: 22081810

Gupta R, Nagarajan A and Wajapeyee N: Advances in genome-wide DNA methylation analysis. Biotechniques. 2010 Oct;49 (4) :iii-xi. PMID: 20964631


Muthusamy V, Bosenberg M and Wajapeyee N: Redefining regulation of DNA methylation by RNA interference. Genomics. 2010 Oct;96 (4) :191-8. Epub 2010 Jul 8. PMID: 20620207


Wajapeyee N, Wang SZ, Serra RW, Solomon PD, Nagarajan A, Zhu X and Green MR: Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins. Blood. 2010 Jun 17;115 (24) :5057-60. Epub 2010 Apr 26. PMID: 20421454


Decarlo K, Yang S, Emley A, Wajapeyee N, Green M and Mahalingam M: Oncogenic BRAF-positive dysplastic nevi and the tumor suppressor IGFBP7--challenging the concept of dysplastic nevi as precursor lesions? Hum Pathol. 2010 Jun;41 (6) :886-94. Epub 2010 Mar 16. PMID: 20233623


Wajapeyee N, Serra RW, Zhu X, Mahalingam M and Green MR: Role for IGFBP7 in senescence induction by BRAF. Cell. 2010 May 28;141 (5) :746-7. PMID: 20510919


Nguyen LP, Emley A, Wajapeyee N, Green MR and Mahalingam M: BRAF V600E mutation and the tumour suppressor IGFBP7 in atypical genital naevi. Br J Dermatol. 2010 Mar;162 (3) :677-80. Epub 2009 Nov 16. PMID: 19919630


Emley A, Yang S, Wajapeyee N, Green MR and Mahalingam M: Oncogenic BRAF and the tumor suppressor IGFBP7 in the genesis of atypical spitzoid nevomelanocytic proliferations. J Cutan Pathol. 2010 Mar;37 (3) :344-9. Epub 2009 Sep 24. PMID: 19788444


Yan Q and Wajapeyee N: Exploiting cellular senescence to treat cancer and circumvent drug resistance. Cancer Biol Ther. 2010 Feb;9 (3) :166-75. Epub 2010 Feb 11. PMID: 20118655

Wajapeyee N, Kapoor V, Mahalingam M and Green MR: Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines. Mol Cancer Ther. 2009 Nov;8 (11) :3009-14. Epub 2009 Oct 27. PMID: 19861408


Palakurthy RK, Wajapeyee N, Santra MK, Gazin C, Lin L, Gobeil S and Green MR: Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. Mol Cell. 2009 Oct 23;36 (2) :219-30. PMID: 19854132


Santra MK, Wajapeyee N and Green MR: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature. 2009 Jun 4;459 (7247) :722-5. Epub 2009 May 3. PMID: 19412162

Wajapeyee N, Serra RW, Zhu X, Mahalingam M and Green MR: Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. 2008 Feb 8;132 (3) :363-74. PMID: 18267069

Gazin C, Wajapeyee N, Gobeil S, Virbasius CM and Green MR: An elaborate pathway required for Ras-mediated epigenetic silencing. Nature. 2007 Oct 25;449 (7165) :1073-7. PMID: 17960246

Wajapeyee N, Britto R, Ravishankar HM and Somasundaram K: Apoptosis induction by activator protein 2alpha involves transcriptional repression of Bcl-2. J Biol Chem. 2006 Jun 16;281 (24) :16207-19. Epub 2006 Mar 13. PMID: 16533807

Wajapeyee N, Raut CG and Somasundaram K: Activator protein 2alpha status determines the chemosensitivity of cancer cells: implications in cancer chemotherapy. Cancer Res. 2005 Oct 1;65 (19) :8628-34. PMID: 16204029


Joseph J, Wajapeyee N and Somasundaram K: Role of p53 status in chemosensitivity determination of cancer cells against histone deacetylase inhibitor sodium butyrate. Int J Cancer. 2005 May 20;115 (1) :11-8. PMID: 15688418

Wajapeyee N and Somasundaram K: Pharmacogenomics in breast cancer: current trends and future directions. Curr Opin Mol Ther. 2004 Jun;6 (3) :296-301. PMID: 15264432

Wajapeyee N and Somasundaram K: Cell cycle arrest and apoptosis induction by activator protein 2alpha (AP-2alpha) and the role of p53 and p21WAF1/CIP1 in AP-2alpha-mediated growth inhibition. J Biol Chem. 2003 Dec 26;278 (52) :52093-101. Epub 2003 Oct 9. PMID: 14551210


Somasundaram K, Das S, Lakhotia S and Wajapeyee N: Analysis of gene promoter regulation by tumor suppressor genes. Methods Mol Biol. 2003;223 :101-16. PMID: 12777723