Recent Publications

Nagarajan A, Dogra SK, Liu AY, Green MR and Wajapeyee N: PEA15 regulates the DNA damage induced cell cycle checkpoint and oncogene-directed transformation. Mol Cell Biol. 2014 Apr 7; Epub 2014 Apr 7. PMID: 24710276


Forloni M, Dogra SK, Dong Y, Conte D Jr, Ou J, Zhu LJ, Deng A, Mahalingam M, Green MR and Wajapeyee N: miR-146a promotes the initiation and progression of melanoma by activating Notch signaling. Elife. 2014 Feb 18;3 :e01460. Epub 2014 Feb 18. PMID: 24550252

Dong Y, Richards JA, Gupta R, Aung PP, Emley A, Kluger Y, Dogra SK, Mahalingam M and Wajapeyee N: PTEN functions as a melanoma tumor suppressor by promoting host immune response. Oncogene. 2013 Oct 21; Epub 2013 Oct 21. PMID: 24141770


Wajapeyee N, Malonia SK, Palakurthy RK and Green MR: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 2013 Oct 15;27 (20) :2221-6. Epub 2013 Oct 8. PMID: 24105743


Fang M, Xia F, Mahalingam M, Virbasius CM, Wajapeyee N and Green MR: MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair. Mol Cell Biol. 2013 Jul;33 (13) :2635-47. Epub 2013 May 6. PMID: 23648481


Gupta R and Wajapeyee N: Induction of cellular senescence by oncogenic RAS. Methods Mol Biol. 2013;1048 :127-33. PMID: 23929102


Wajapeyee N, Deibler SK and Green MR: Genome-wide RNAi screening to identify regulators of oncogene-induced cellular senescence. Methods Mol Biol. 2013;965 :373-82. PMID: 23296672

Lizardi PM, Forloni M and Wajapeyee N: Genome-wide approaches for cancer gene discovery. Trends Biotechnol. 2011 Nov;29 (11) :558-68. Epub 2011 Jul 13. PMID: 21757246


Wajapeyee N and Green MR: Induction of senescence in melanoma: thinking outside the cell. Pigment Cell Melanoma Res. 2011 Oct;24 (5) :874-5. PMID: 22081810

Gupta R, Nagarajan A and Wajapeyee N: Advances in genome-wide DNA methylation analysis. Biotechniques. 2010 Oct;49 (4) :iii-xi. PMID: 20964631


Muthusamy V, Bosenberg M and Wajapeyee N: Redefining regulation of DNA methylation by RNA interference. Genomics. 2010 Oct;96 (4) :191-8. Epub 2010 Jul 8. PMID: 20620207


Wajapeyee N, Wang SZ, Serra RW, Solomon PD, Nagarajan A, Zhu X and Green MR: Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins. Blood. 2010 Jun 17;115 (24) :5057-60. Epub 2010 Apr 26. PMID: 20421454


Decarlo K, Yang S, Emley A, Wajapeyee N, Green M and Mahalingam M: Oncogenic BRAF-positive dysplastic nevi and the tumor suppressor IGFBP7--challenging the concept of dysplastic nevi as precursor lesions? Hum Pathol. 2010 Jun;41 (6) :886-94. Epub 2010 Mar 16. PMID: 20233623


Wajapeyee N, Serra RW, Zhu X, Mahalingam M and Green MR: Role for IGFBP7 in senescence induction by BRAF. Cell. 2010 May 28;141 (5) :746-7. PMID: 20510919


Nguyen LP, Emley A, Wajapeyee N, Green MR and Mahalingam M: BRAF V600E mutation and the tumour suppressor IGFBP7 in atypical genital naevi. Br J Dermatol. 2010 Mar;162 (3) :677-80. Epub 2009 Nov 16. PMID: 19919630


Emley A, Yang S, Wajapeyee N, Green MR and Mahalingam M: Oncogenic BRAF and the tumor suppressor IGFBP7 in the genesis of atypical spitzoid nevomelanocytic proliferations. J Cutan Pathol. 2010 Mar;37 (3) :344-9. Epub 2009 Sep 24. PMID: 19788444


Yan Q and Wajapeyee N: Exploiting cellular senescence to treat cancer and circumvent drug resistance. Cancer Biol Ther. 2010 Feb;9 (3) :166-75. Epub 2010 Feb 11. PMID: 20118655

Wajapeyee N, Kapoor V, Mahalingam M and Green MR: Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines. Mol Cancer Ther. 2009 Nov;8 (11) :3009-14. Epub 2009 Oct 27. PMID: 19861408


Palakurthy RK, Wajapeyee N, Santra MK, Gazin C, Lin L, Gobeil S and Green MR: Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. Mol Cell. 2009 Oct 23;36 (2) :219-30. PMID: 19854132


Santra MK, Wajapeyee N and Green MR: F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature. 2009 Jun 4;459 (7247) :722-5. Epub 2009 May 3. PMID: 19412162

Wajapeyee N, Serra RW, Zhu X, Mahalingam M and Green MR: Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. 2008 Feb 8;132 (3) :363-74. PMID: 18267069

Gazin C, Wajapeyee N, Gobeil S, Virbasius CM and Green MR: An elaborate pathway required for Ras-mediated epigenetic silencing. Nature. 2007 Oct 25;449 (7165) :1073-7. PMID: 17960246

Wajapeyee N, Britto R, Ravishankar HM and Somasundaram K: Apoptosis induction by activator protein 2alpha involves transcriptional repression of Bcl-2. J Biol Chem. 2006 Jun 16;281 (24) :16207-19. Epub 2006 Mar 13. PMID: 16533807

Wajapeyee N, Raut CG and Somasundaram K: Activator protein 2alpha status determines the chemosensitivity of cancer cells: implications in cancer chemotherapy. Cancer Res. 2005 Oct 1;65 (19) :8628-34. PMID: 16204029


Joseph J, Wajapeyee N and Somasundaram K: Role of p53 status in chemosensitivity determination of cancer cells against histone deacetylase inhibitor sodium butyrate. Int J Cancer. 2005 May 20;115 (1) :11-8. PMID: 15688418

Wajapeyee N and Somasundaram K: Pharmacogenomics in breast cancer: current trends and future directions. Curr Opin Mol Ther. 2004 Jun;6 (3) :296-301. PMID: 15264432

Wajapeyee N and Somasundaram K: Cell cycle arrest and apoptosis induction by activator protein 2alpha (AP-2alpha) and the role of p53 and p21WAF1/CIP1 in AP-2alpha-mediated growth inhibition. J Biol Chem. 2003 Dec 26;278 (52) :52093-101. Epub 2003 Oct 9. PMID: 14551210


Somasundaram K, Das S, Lakhotia S and Wajapeyee N: Analysis of gene promoter regulation by tumor suppressor genes. Methods Mol Biol. 2003;223 :101-16. PMID: 12777723