Publications

Nemec AA, Murphy DL, Donigan KA and Sweasy JB: The S229L Colon Tumor-Associated Variant of DNA Polymerase Beta Induces Cellular Transformation As A Result Of Decreased Polymerization Efficiency. J Biol Chem. 2014 Mar 25; Epub 2014 Mar 25. PMID: 24668809


Lamb KL, Liu Y, Ishiguro K, Kwon Y, Paquet N, Sartorelli AC, Sung P, Rockwell S and Sweasy JB: Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality. Mol Carcinog. 2014 Mar;53 (3) :201-10. Epub 2012 Oct 12. PMID: 23065697


Prakash A, Carroll BL, Sweasy JB, Wallace SS and Doublié S: Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing. DNA Repair (Amst). 2014 Feb;14 :17-26. Epub 2013 Dec 29. PMID: 24382305


Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL and Sweasy JB: Mutation of POLB causes lupus in mice. Cell Rep. 2014 Jan 16;6 (1) :1-8. Epub 2014 Jan 2. PMID: 24388753

Ray S, Menezes MR, Senejani A and Sweasy JB: Cellular roles of DNA polymerase beta. Yale J Biol Med. 2013 Dec 13;86 (4) :463-9. Epub 2013 Dec 13. PMID: 24348210


Sweasy JB and Glazer PM: Introduction. Yale J Biol Med. 2013 Dec;86 (4) :441-2. PMID: 24498669


Sjolund AB, Senejani AG and Sweasy JB: MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles. Mutat Res. 2013 Mar-Apr;743-744 :12-25. Epub 2012 Nov 26. PMID: 23195996


Kidane D, Sakkas D, Nottoli T, McGrath J and Sweasy JB: Kinesin 5B (KIF5B) is required for progression through female meiosis and proper chromosomal segregation in mitotic cells. PLoS One. 2013;8 (4) :e58585. Epub 2013 Apr 1. PMID: 23560038

Menezes MR and Sweasy JB: Mouse models of DNA polymerases. Environ Mol Mutagen. 2012 Dec;53 (9) :645-65. Epub 2012 Sep 22. PMID: 23001998


Kidane D, Ayora S, Sweasy JB, Graumann PL and Alonso JC: The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery. Crit Rev Biochem Mol Biol. 2012 Nov-Dec;47 (6) :531-55. Epub 2012 Oct 9. PMID: 23046409


Donigan KA, Tuck D, Schulz V and Sweasy JB: DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation. Mutagenesis. 2012 Nov;27 (6) :683-91. Epub 2012 Aug 21. PMID: 22914675


Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH and Glazer PM: Targeting cancer with a lupus autoantibody. Sci Transl Med. 2012 Oct 24;4 (157) :157ra142. PMID: 23100628


Donigan KA, Sun KW, Nemec AA, Murphy DL, Cong X, Northrup V, Zelterman D and Sweasy JB: Human POLB gene is mutated in high percentage of colorectal tumors. J Biol Chem. 2012 Jul 6;287 (28) :23830-9. Epub 2012 May 10. PMID: 22577134


Nemec AA, Donigan KA, Murphy DL, Jaeger J and Sweasy JB: Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation. J Biol Chem. 2012 Jul 6;287 (28) :23840-9. Epub 2012 May 9. PMID: 22573322


Murphy DL, Donigan KA, Jaeger J and Sweasy JB: The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator. Biochemistry. 2012 Jul 3;51 (26) :5269-75. Epub 2012 Jun 19. PMID: 22650412


Berlow RB, Swain M, Dalal S, Sweasy JB and Loria JP: Substrate-dependent millisecond domain motions in DNA polymerase β. J Mol Biol. 2012 Jun 8;419 (3-4) :171-82. Epub 2012 Mar 23. PMID: 22446382


Senejani AG, Dalal S, Liu Y, Nottoli TP, McGrath JM, Clairmont CS and Sweasy JB: Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates. Proc Natl Acad Sci U S A. 2012 Apr 24;109 (17) :6632-7. Epub 2012 Apr 9. PMID: 22493258


Donigan KA, Hile SE, Eckert KA and Sweasy JB: The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation. DNA Repair (Amst). 2012 Apr 1;11 (4) :381-90. Epub 2012 Feb 15. PMID: 22341651


Yamtich J, Nemec AA, Keh A and Sweasy JB: A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation. PLoS Genet. 2012;8 (11) :e1003052. Epub 2012 Nov 8. PMID: 23144635


Kidane D and Sweasy JB: Tipping the balance in the powerhouse of the cell to "protect" colorectal cancer. PLoS Genet. 2012;8 (6) :e1002758. Epub 2012 Jun 7. PMID: 22685422

Murphy DL, Jaeger J and Sweasy JB: A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity. J Am Chem Soc. 2011 Apr 27;133 (16) :6279-87. Epub 2011 Mar 31. PMID: 21452873


Kidane D, Dalal S, Keh A, Liu Y, Zelterman D and Sweasy JB: DNA polymerase beta is critical for genomic stability of sperm cells. DNA Repair (Amst). 2011 Apr 3;10 (4) :390-7. Epub 2011 Feb 18. PMID: 21333614

Li SX, Sjolund A, Harris L and Sweasy JB: DNA repair and personalized breast cancer therapy. Environ Mol Mutagen. 2010 Oct-Dec;51 (8-9) :897-908. PMID: 20872853


Senejani AG and Sweasy JB: Eukaryotic gene invasion by a bacterial mobile insertion sequence element IS2 during cloning into a plasmid vector. Genome Integr. 2010 May 26;1 (1) :2. Epub 2010 May 26. PMID: 20678256


Yamtich J and Sweasy JB: DNA polymerase family X: function, structure, and cellular roles. Biochim Biophys Acta. 2010 May;1804 (5) :1136-50. Epub 2009 Jul 23. PMID: 19631767


Yamtich J, Starcevic D, Lauper J, Smith E, Shi I, Rangarajan S, Jaeger J and Sweasy JB: Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Biochemistry. 2010 Mar 23;49 (11) :2326-34. PMID: 20108981


Kidane D, Jonason AS, Gorton TS, Mihaylov I, Pan J, Keeney S, de Rooij DG, Ashley T, Keh A, Liu Y, Banerjee U, Zelterman D and Sweasy JB: DNA polymerase beta is critical for mouse meiotic synapsis. EMBO J. 2010 Jan 20;29 (2) :410-23. Epub 2009 Dec 17. PMID: 20019666


Stachelek GC, Dalal S, Donigan KA, Campisi Hegan D, Sweasy JB and Glazer PM: Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Cancer Res. 2010 Jan 1;70 (1) :409-17. Epub 2009 Dec 22. PMID: 20028873

Yamtich J, Speed WC, Straka E, Kidd JR, Sweasy JB and Kidd KK: Population-specific variation in haplotype composition and heterozygosity at the POLB locus. DNA Repair (Amst). 2009 May 1;8 (5) :579-84. Epub 2009 Jan 23. PMID: 19167932


Donigan KA and Sweasy JB: Sequence context-specific mutagenesis and base excision repair. Mol Carcinog. 2009 Apr;48 (4) :362-8. PMID: 19306280


Lin GC, Jaeger J, Eckert KA and Sweasy JB: Loop II of DNA polymerase beta is important for discrimination during substrate binding. DNA Repair (Amst). 2009 Feb 1;8 (2) :182-9. Epub 2008 Dec 5. PMID: 19013261

Dalal S, Starcevic D, Jaeger J and Sweasy JB: The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates. Biochemistry. 2008 Nov 18;47 (46) :12118-25. Epub 2008 Oct 21. PMID: 18937502


Murphy DL, Kosa J, Jaeger J and Sweasy JB: The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding. Biochemistry. 2008 Aug 5;47 (31) :8048-57. Epub 2008 Jul 11. PMID: 18616290


Dalal S, Chikova A, Jaeger J and Sweasy JB: The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. Nucleic Acids Res. 2008 Feb;36 (2) :411-22. Epub 2007 Nov 26. PMID: 18039710

Lang T, Dalal S, Chikova A, DiMaio D and Sweasy JB: The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol. 2007 Aug;27 (15) :5587-96. Epub 2007 May 25. PMID: 17526740


Lin GC, Jaeger J and Sweasy JB: Loop II of DNA polymerase beta is important for polymerization activity and fidelity. Nucleic Acids Res. 2007;35 (9) :2924-35. Epub 2007 Apr 16. PMID: 17439962

Sweasy JB, Lauper JM and Eckert KA: DNA polymerases and human diseases. Radiat Res. 2006 Nov;166 (5) :693-714. PMID: 17067213


Sweasy JB, Lang T and DiMaio D: Is base excision repair a tumor suppressor mechanism? Cell Cycle. 2006 Feb;5 (3) :250-9. Epub 2006 Feb 14. PMID: 16418580


Sterling CH and Sweasy JB: DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage. Genetics. 2006 Jan;172 (1) :89-98. Epub 2005 Oct 11. PMID: 16219787

Dalal S, Hile S, Eckert KA, Sun KW, Starcevic D and Sweasy JB: Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator. Biochemistry. 2005 Dec 6;44 (48) :15664-73. PMID: 16313169


Sweasy JB, Lang T, Starcevic D, Sun KW, Lai CC, Dimaio D and Dalal S: Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation. Proc Natl Acad Sci U S A. 2005 Oct 4;102 (40) :14350-5. Epub 2005 Sep 22. PMID: 16179390


Starcevic D, Dalal S, Jaeger J and Sweasy JB: The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry. J Biol Chem. 2005 Aug 5;280 (31) :28388-93. Epub 2005 May 17. PMID: 15901725

Starcevic D, Dalal S and Sweasy JB: Is there a link between DNA polymerase beta and cancer? Cell Cycle. 2004 Aug;3 (8) :998-1001. Epub 2004 Aug 29. PMID: 15280658


Fotiadou P, Henegariu O and Sweasy JB: DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. Cancer Res. 2004 Jun 1;64 (11) :3830-7. PMID: 15172990


Lang T, Maitra M, Starcevic D, Li SX and Sweasy JB: A DNA polymerase beta mutant from colon cancer cells induces mutations. Proc Natl Acad Sci U S A. 2004 Apr 20;101 (16) :6074-9. Epub 2004 Apr 9. PMID: 15075389


Sweasy JB: Evelyn M. Witkin awarded the National Medal of Science. Radiat Res. 2004 Apr;161 (4) :493-4. PMID: 15038781


Dalal S, Kosa JL and Sweasy JB: The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site. J Biol Chem. 2004 Jan 2;279 (1) :577-84. Epub 2003 Oct 16. PMID: 14563842

Shah AM, Maitra M and Sweasy JB: Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate. Biochemistry. 2003 Sep 16;42 (36) :10709-17. PMID: 12962495


Sweasy JB: Fidelity mechanisms of DNA polymerase beta. Prog Nucleic Acid Res Mol Biol. 2003;73 :137-69. PMID: 12882517

Maitra M, Gudzelak A Jr, Li SX, Matsumoto Y, Eckert KA, Jager J and Sweasy JB: Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. J Biol Chem. 2002 Sep 20;277 (38) :35550-60. Epub 2002 Jul 16. PMID: 12121998

Jonason AS, Baker SM and Sweasy JB: Interaction of DNA polymerase beta with GRIP1 during meiosis. Chromosoma. 2001 Nov;110 (6) :402-10. Epub 2001 Sep 12. PMID: 11734998


Shah AM, Conn DA, Li SX, Capaldi A, Jäger J and Sweasy JB: A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability. Biochemistry. 2001 Sep 25;40 (38) :11372-81. PMID: 11560485


Shah AM, Li SX, Anderson KS and Sweasy JB: Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity. J Biol Chem. 2001 Apr 6;276 (14) :10824-31. Epub 2001 Jan 11. PMID: 11154692

Kosa JL and Sweasy JB: The E249K mutator mutant of DNA polymerase beta extends mispaired termini. J Biol Chem. 1999 Dec 10;274 (50) :35866-72. PMID: 10585471


Li SX, Vaccaro JA and Sweasy JB: Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates. Biochemistry. 1999 Apr 13;38 (15) :4800-8. PMID: 10200168


Kosa JL and Sweasy JB: 3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection. J Biol Chem. 1999 Feb 5;274 (6) :3851-8. PMID: 9920940

Plug AW, Clairmont CA, Sapi E, Ashley T and Sweasy JB: Evidence for a role for DNA polymerase beta in mammalian meiosis. Proc Natl Acad Sci U S A. 1997 Feb 18;94 (4) :1327-31. PMID: 9037052


Washington SL, Yoon MS, Chagovetz AM, Li SX, Clairmont CA, Preston BD, Eckert KA and Sweasy JB: A genetic system to identify DNA polymerase beta mutator mutants. Proc Natl Acad Sci U S A. 1997 Feb 18;94 (4) :1321-6. PMID: 9037051

Sweasy JB and Yoon MS: Characterization of DNA polymerase beta mutants with amino acid substitutions located in the C-terminal portion of the enzyme. Mol Gen Genet. 1995 Jul 28;248 (2) :217-24. PMID: 7651344


Sweasy JB, Chen M and Loeb LA: DNA polymerase beta can substitute for DNA polymerase I in the initiation of plasmid DNA replication. J Bacteriol. 1995 May;177 (10) :2923-5. PMID: 7751308