Ray S, Breuer G, DeVeaux M, Zelterman D, Bindra R, Sweasy JB: DNA polymerase beta participates in DNA End-joining. Nucleic Acids Res. 2017 Nov 17; 2017 Nov 17. PMID: 29161447

Mahmoud MM, Schechter A, Alnajjar KS, Huang J, Towle-Weicksel J, Eckenroth BE, Doublié S, Sweasy JB: Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity. Biochemistry. 2017 Oct 17; 2017 Oct 2. PMID: 28945359

Alnajjar KS, Negahbani A, Nakhjiri M, Krylov IS, Kashemirov BA, McKenna CE, Goodman MF, Sweasy JB: DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP. Biochemistry. 2017 Oct 10; 2017 Sep 20. PMID: 28862868

Galick HA, Marsden CG, Kathe S, Dragon JA, Volk L, Nemec AA, Wallace SS, Prakash A, Doublié S, Sweasy JB: The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation. Oncotarget. 2017 Oct 17; 2017 Sep 8. PMID: 29156764

Maher RL, Marsden CG, Averill AM, Wallace SS, Sweasy JB, Pederson DS: Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes. DNA Repair (Amst). 2017 Sep; 2017 Jul 5. PMID: 28709015

Meas R, Burak MJ, Sweasy JB: DNA repair and systemic lupus erythematosus. DNA Repair (Amst). 2017 Aug; 2017 Jun 9. PMID: 28623091

Eckenroth BE, Towle-Weicksel JB, Nemec AA, Murphy DL, Sweasy JB, Doublié S: Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β. Biochemistry. 2017 May 9; 2017 Apr 21. PMID: 28402631

Alnajjar KS, Garcia-Barboza B, Negahbani A, Nakhjiri M, Kashemirov B, McKenna C, Goodman MF, Sweasy JB: A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant. Biochemistry. 2017 Apr 18; 2017 Apr 6. PMID: 28326765

Nemec AA, Abriola L, Merkel JS, de Stanchina E, DeVeaux M, Zelterman D, Glazer PM, Sweasy JB: DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy. Mol Cancer Res. 2017 Mar; 2017 Jan 10. PMID: 28074003

Marsden CG, Dragon JA, Wallace SS, Sweasy JB: Base Excision Repair Variants in Cancer. Methods Enzymol. 2017; 2017 May 5. PMID: 28645367

Nemec AA, Bush KB, Towle-Weicksel JB, Taylor BF, Schulz V, Weidhaas JB, Tuck DP, Sweasy JB: Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein. Mol Cancer Res. 2016 Nov; 2016 Sep 12. PMID: 27621267

Marsden CG, Jensen RB, Zagelbaum J, Rothenberg E, Morrical SW, Wallace SS, Sweasy JB: The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype. PLoS Genet. 2016 Aug; 2016 Aug 11. PMID: 27513445

Sweasy JB, Lieberman HB, Volkert M, George D: Evelyn Witkin and the coordinated response to DNA damage. DNA Repair (Amst). 2015 Nov; 2015 Oct 21. PMID: 26529061

Rozacky J, Nemec AA, Sweasy JB, Kidane D: Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks. Oncotarget. 2015 Sep 15. PMID: 26090616

Sizova DV, Keh A, Taylor BF, Sweasy JB: The R280H X-ray cross-complementing 1 germline variant induces genomic instability and cellular transformation. DNA Repair (Amst). 2015 Jul; 2015 May 14. PMID: 26011397

Sohl CD, Ray S, Sweasy JB: Pools and Pols: Mechanism of a mutator phenotype. Proc Natl Acad Sci U S A. 2015 May 12; 2015 Apr 30. PMID: 25931524

Lokanga RA, Senejani AG, Sweasy JB, Usdin K: Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders. PLoS Genet. 2015 Apr; 2015 Apr 17. PMID: 25886163

Chen J, Morrical MD, Donigan KA, Weidhaas JB, Sweasy JB, Averill AM, Tomczak JA, Morrical SW: Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase. Nucleic Acids Res. 2015 Jan; 2014 Dec 24. PMID: 25539919

Kidane D, Murphy DL, Sweasy JB: Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection. Oncogenesis. 2014 Nov 24; 2014 Nov 24. PMID: 25417725

Sjolund A, Nemec AA, Paquet N, Prakash A, Sung P, Doublié S, Sweasy JB: A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. PLoS Genet. 2014 Nov; 2014 Nov 6. PMID: 25375110

Towle-Weicksel JB, Dalal S, Sohl CD, Doublié S, Anderson KS, Sweasy JB: Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection. J Biol Chem. 2014 Jun 6; 2014 Apr 24. PMID: 24764311

Nemec AA, Murphy DL, Donigan KA, Sweasy JB: The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency. J Biol Chem. 2014 May 16; 2014 Mar 25. PMID: 24668809

Lamb KL, Liu Y, Ishiguro K, Kwon Y, Paquet N, Sartorelli AC, Sung P, Rockwell S, Sweasy JB: Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality. Mol Carcinog. 2014 Mar; 2012 Oct 12. PMID: 23065697

Prakash A, Carroll BL, Sweasy JB, Wallace SS, Doublié S: Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing. DNA Repair (Amst). 2014 Feb; 2013 Dec 29. PMID: 24382305

Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB: Mutation of POLB causes lupus in mice. Cell Rep. 2014 Jan 16; 2014 Jan 2. PMID: 24388753

Ray S, Menezes MR, Senejani A, Sweasy JB: Cellular roles of DNA polymerase beta. Yale J Biol Med. 2013 Dec 13; 2013 Dec 13. PMID: 24348210

Sweasy JB, Glazer PM: Introduction. Yale J Biol Med. 2013 Dec. PMID: 24498669

Sjolund AB, Senejani AG, Sweasy JB: MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles. Mutat Res. 2013 Mar-Apr; 2012 Nov 26. PMID: 23195996

Kidane D, Sakkas D, Nottoli T, McGrath J, Sweasy JB: Kinesin 5B (KIF5B) is required for progression through female meiosis and proper chromosomal segregation in mitotic cells. PLoS One. 2013; 2013 Apr 1. PMID: 23560038

Menezes MR, Sweasy JB: Mouse models of DNA polymerases. Environ Mol Mutagen. 2012 Dec; 2012 Sep 22. PMID: 23001998

Kidane D, Ayora S, Sweasy JB, Graumann PL, Alonso JC: The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery. Crit Rev Biochem Mol Biol. 2012 Nov-Dec; 2012 Oct 9. PMID: 23046409

Donigan KA, Tuck D, Schulz V, Sweasy JB: DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation. Mutagenesis. 2012 Nov; 2012 Aug 21. PMID: 22914675

Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM: Targeting cancer with a lupus autoantibody. Sci Transl Med. 2012 Oct 24. PMID: 23100628

Donigan KA, Sun KW, Nemec AA, Murphy DL, Cong X, Northrup V, Zelterman D, Sweasy JB: Human POLB gene is mutated in high percentage of colorectal tumors. J Biol Chem. 2012 Jul 6; 2012 May 10. PMID: 22577134

Nemec AA, Donigan KA, Murphy DL, Jaeger J, Sweasy JB: Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation. J Biol Chem. 2012 Jul 6; 2012 May 9. PMID: 22573322

Murphy DL, Donigan KA, Jaeger J, Sweasy JB: The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator. Biochemistry. 2012 Jul 3; 2012 Jun 19. PMID: 22650412

Berlow RB, Swain M, Dalal S, Sweasy JB, Loria JP: Substrate-dependent millisecond domain motions in DNA polymerase β. J Mol Biol. 2012 Jun 8; 2012 Mar 23. PMID: 22446382

Senejani AG, Dalal S, Liu Y, Nottoli TP, McGrath JM, Clairmont CS, Sweasy JB: Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates. Proc Natl Acad Sci U S A. 2012 Apr 24; 2012 Apr 9. PMID: 22493258

Donigan KA, Hile SE, Eckert KA, Sweasy JB: The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation. DNA Repair (Amst). 2012 Apr 1; 2012 Feb 15. PMID: 22341651

Yamtich J, Nemec AA, Keh A, Sweasy JB: A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation. PLoS Genet. 2012; 2012 Nov 8. PMID: 23144635

Kidane D, Sweasy JB: Tipping the balance in the powerhouse of the cell to "protect" colorectal cancer. PLoS Genet. 2012; 2012 Jun 7. PMID: 22685422

Murphy DL, Jaeger J, Sweasy JB: A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity. J Am Chem Soc. 2011 Apr 27; 2011 Mar 31. PMID: 21452873

Kidane D, Dalal S, Keh A, Liu Y, Zelterman D, Sweasy JB: DNA polymerase beta is critical for genomic stability of sperm cells. DNA Repair (Amst). 2011 Apr 3; 2011 Feb 18. PMID: 21333614

Li SX, Sjolund A, Harris L, Sweasy JB: DNA repair and personalized breast cancer therapy. Environ Mol Mutagen. 2010 Oct-Dec. PMID: 20872853

Senejani AG, Sweasy JB: Eukaryotic gene invasion by a bacterial mobile insertion sequence element IS2 during cloning into a plasmid vector. Genome Integr. 2010 May 26; 2010 May 26. PMID: 20678256

Yamtich J, Sweasy JB: DNA polymerase family X: function, structure, and cellular roles. Biochim Biophys Acta. 2010 May; 2009 Jul 23. PMID: 19631767

Yamtich J, Starcevic D, Lauper J, Smith E, Shi I, Rangarajan S, Jaeger J, Sweasy JB: Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta. Biochemistry. 2010 Mar 23. PMID: 20108981

Kidane D, Jonason AS, Gorton TS, Mihaylov I, Pan J, Keeney S, de Rooij DG, Ashley T, Keh A, Liu Y, Banerjee U, Zelterman D, Sweasy JB: DNA polymerase beta is critical for mouse meiotic synapsis. EMBO J. 2010 Jan 20; 2009 Dec 17. PMID: 20019666

Stachelek GC, Dalal S, Donigan KA, Campisi Hegan D, Sweasy JB, Glazer PM: Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Cancer Res. 2010 Jan 1; 2009 Dec 22. PMID: 20028873

Yamtich J, Speed WC, Straka E, Kidd JR, Sweasy JB, Kidd KK: Population-specific variation in haplotype composition and heterozygosity at the POLB locus. DNA Repair (Amst). 2009 May 1; 2009 Jan 23. PMID: 19167932

Donigan KA, Sweasy JB: Sequence context-specific mutagenesis and base excision repair. Mol Carcinog. 2009 Apr. PMID: 19306280

Lin GC, Jaeger J, Eckert KA, Sweasy JB: Loop II of DNA polymerase beta is important for discrimination during substrate binding. DNA Repair (Amst). 2009 Feb 1; 2008 Dec 5. PMID: 19013261

Dalal S, Starcevic D, Jaeger J, Sweasy JB: The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates. Biochemistry. 2008 Nov 18; 2008 Oct 21. PMID: 18937502

Murphy DL, Kosa J, Jaeger J, Sweasy JB: The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding. Biochemistry. 2008 Aug 5; 2008 Jul 11. PMID: 18616290

Dalal S, Chikova A, Jaeger J, Sweasy JB: The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient. Nucleic Acids Res. 2008 Feb; 2007 Nov 26. PMID: 18039710

Lang T, Dalal S, Chikova A, DiMaio D, Sweasy JB: The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation. Mol Cell Biol. 2007 Aug; 2007 May 25. PMID: 17526740

Lin GC, Jaeger J, Sweasy JB: Loop II of DNA polymerase beta is important for polymerization activity and fidelity. Nucleic Acids Res. 2007; 2007 Apr 16. PMID: 17439962

Sweasy JB, Lauper JM, Eckert KA: DNA polymerases and human diseases. Radiat Res. 2006 Nov. PMID: 17067213

Sweasy JB, Lang T, DiMaio D: Is base excision repair a tumor suppressor mechanism? Cell Cycle. 2006 Feb; 2006 Feb 14. PMID: 16418580

Sterling CH, Sweasy JB: DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage. Genetics. 2006 Jan; 2005 Oct 11. PMID: 16219787

Dalal S, Hile S, Eckert KA, Sun KW, Starcevic D, Sweasy JB: Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator. Biochemistry. 2005 Dec 6. PMID: 16313169

Sweasy JB, Lang T, Starcevic D, Sun KW, Lai CC, Dimaio D, Dalal S: Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation. Proc Natl Acad Sci U S A. 2005 Oct 4; 2005 Sep 22. PMID: 16179390

Starcevic D, Dalal S, Jaeger J, Sweasy JB: The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry. J Biol Chem. 2005 Aug 5; 2005 May 17. PMID: 15901725

Starcevic D, Dalal S, Sweasy JB: Is there a link between DNA polymerase beta and cancer? Cell Cycle. 2004 Aug; 2004 Aug 29. PMID: 15280658

Fotiadou P, Henegariu O, Sweasy JB: DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. Cancer Res. 2004 Jun 1. PMID: 15172990

Lang T, Maitra M, Starcevic D, Li SX, Sweasy JB: A DNA polymerase beta mutant from colon cancer cells induces mutations. Proc Natl Acad Sci U S A. 2004 Apr 20; 2004 Apr 9. PMID: 15075389

Sweasy JB: Evelyn M. Witkin awarded the National Medal of Science. Radiat Res. 2004 Apr. PMID: 15038781

Dalal S, Kosa JL, Sweasy JB: The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site. J Biol Chem. 2004 Jan 2; 2003 Oct 16. PMID: 14563842

Shah AM, Maitra M, Sweasy JB: Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate. Biochemistry. 2003 Sep 16. PMID: 12962495

Sweasy JB: Fidelity mechanisms of DNA polymerase beta. Prog Nucleic Acid Res Mol Biol. 2003. PMID: 12882517

Maitra M, Gudzelak A Jr, Li SX, Matsumoto Y, Eckert KA, Jager J, Sweasy JB: Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. J Biol Chem. 2002 Sep 20; 2002 Jul 16. PMID: 12121998

Jonason AS, Baker SM, Sweasy JB: Interaction of DNA polymerase beta with GRIP1 during meiosis. Chromosoma. 2001 Nov; 2001 Sep 12. PMID: 11734998

Shah AM, Conn DA, Li SX, Capaldi A, Jäger J, Sweasy JB: A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability. Biochemistry. 2001 Sep 25. PMID: 11560485

Shah AM, Li SX, Anderson KS, Sweasy JB: Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity. J Biol Chem. 2001 Apr 6; 2001 Jan 11. PMID: 11154692

Plug AW, Clairmont CA, Sapi E, Ashley T, Sweasy JB: Evidence for a role for DNA polymerase beta in mammalian meiosis. Proc Natl Acad Sci U S A. 1997 Feb 18. PMID: 9037052

Washington SL, Yoon MS, Chagovetz AM, Li SX, Clairmont CA, Preston BD, Eckert KA, Sweasy JB: A genetic system to identify DNA polymerase beta mutator mutants. Proc Natl Acad Sci U S A. 1997 Feb 18. PMID: 9037051