Our research focuses on DNA repair, genomic instability and cancer; Meiosis; Inflammation and cancer; Single Nucleotide Polymorphisms (SNPs) in DNA repair genes and human disease; Fidelity of DNA synthesis.
The Sweasy Laboratory is part of the Radiobiology Section of the Department of Therapeutic Radiology. Our works focuses on the roles of DNA repair in the prevention of human disease and genomic instability. We purify and characterize DNA polymerases using presteady-state kinetics in order to understand how these enzymes chose the correct substrate for incorporation into DNA. Errors made by DNA polymerases result in mutations.
Click on the images to see additional information about the structure of the Polymerase Beta (pol β- 1bpy.pdb).
The Sweasy lab employs tissue culture systems to study the roles of genetic variants of DNA repair genes in genomic instability, cancer, and other diseases. A strong interest also concerns the impact of genetic variants of DNA repair genes on drug responses. We have also generated a number of genetically altered mice that have specific mutations in DNA repair genes, in order to understand how aberrant DNA repair contributes to cancer and other diseases.