Publications

Wang X, Yigitkanli K, Kim CY, Sekine-Komo T, Wirak D, Frieden E, Bhargava A, Maynard G, Cafferty WB and Strittmatter SM: Human NgR-Fc Decoy Protein via Lumbar Intrathecal Bolus Administration Enhances Recovery from Rat Spinal Cord Contusion. J Neurotrauma. 2014 Oct 16; Epub 2014 Oct 16. PMID: 24964223


Haas LT, Kostylev MA and Strittmatter SM: Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5). J Biol Chem. 2014 Oct 10;289 (41) :28460-77. Epub 2014 Aug 22. PMID: 25148681


Hafler BP, Klein ZA, Jimmy Zhou Z and Strittmatter SM: Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice. Brain Res. 2014 Sep 16; Epub 2014 Sep 16. PMID: 25234724


Schwab ME and Strittmatter SM: Nogo limits neural plasticity and recovery from injury. Curr Opin Neurobiol. 2014 Aug;27 :53-60. Epub 2014 Mar 12. PMID: 24632308


Kelley BJ, Harel NY, Kim CY, Papademetris X, Coman D, Wang X, Hasan O, Kaufman A, Globinsky R, Staib LH, Cafferty WB, Hyder F and Strittmatter SM: Diffusion tensor imaging as a predictor of locomotor function after experimental spinal cord injury and recovery. J Neurotrauma. 2014 Aug 1;31 (15) :1362-73. Epub 2014 Jul 8. PMID: 24779685


Stagi M, Klein ZA, Gould TJ, Bewersdorf J and Strittmatter SM: Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B. Mol Cell Neurosci. 2014 Jul;61 :226-40. Epub 2014 Jul 24. PMID: 25066864


Konopka-Anstadt JL, Mainou BA, Sutherland DM, Sekine Y, Strittmatter SM and Dermody TS: The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe. 2014 Jun 11;15 (6) :681-91. PMID: 24922571


Strittmatter SM: Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks. Nat Med. 2014 Jun;20 (6) :590-1. PMID: 24901567


Nygaard HB, van Dyck CH and Strittmatter SM: Fyn kinase inhibition as a novel therapy for Alzheimer's disease. Alzheimers Res Ther. 2014;6 (1) :8. Epub 2014 Feb 5. PMID: 24495408


Wheeler-Kingshott CA, Stroman PW, Schwab JM, Bacon M, Bosma R, Brooks J, Cadotte DW, Carlstedt T, Ciccarelli O, Cohen-Adad J, Curt A, Evangelou N, Fehlings MG, Filippi M, Kelley BJ, Kollias S, Mackay A, Porro CA, Smith S, Strittmatter SM, Summers P, Thompson AJ and Tracey I: The current state-of-the-art of spinal cord imaging: applications. Neuroimage. 2014 Jan 1;84 :1082-93. Epub 2013 Jul 14. PMID: 23859923


Stroman PW, Wheeler-Kingshott C, Bacon M, Schwab JM, Bosma R, Brooks J, Cadotte D, Carlstedt T, Ciccarelli O, Cohen-Adad J, Curt A, Evangelou N, Fehlings MG, Filippi M, Kelley BJ, Kollias S, Mackay A, Porro CA, Smith S, Strittmatter SM, Summers P and Tracey I: The current state-of-the-art of spinal cord imaging: methods. Neuroimage. 2014 Jan 1;84 :1070-81. Epub 2013 May 14. PMID: 23685159

Harel NY, Yigitkanli K, Fu Y, Cafferty WB and Strittmatter SM: Multimodal exercises simultaneously stimulating cortical and brainstem pathways after unilateral corticospinal lesion. Brain Res. 2013 Nov 13;1538 :17-25. Epub 2013 Sep 18. PMID: 24055330


Um JW, Kaufman AC, Kostylev M, Heiss JK, Stagi M, Takahashi H, Kerrisk ME, Vortmeyer A, Wisniewski T, Koleske AJ, Gunther EC, Nygaard HB and Strittmatter SM: Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron. 2013 Sep 4;79 (5) :887-902. PMID: 24012003


Couch BA, Kerrisk ME, Kaufman AC, Nygaard HB, Strittmatter SM and Koleske AJ: Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice. J Comp Neurol. 2013 Apr 15;521 (6) :1395-408. PMID: 23047754


Akbik FV, Bhagat SM, Patel PR, Cafferty WB and Strittmatter SM: Anatomical plasticity of adult brain is titrated by Nogo Receptor 1. Neuron. 2013 Mar 6;77 (5) :859-66. PMID: 23473316


Voikar V, Kulesskaya N, Laakso T, Lauren J, Strittmatter SM and Airaksinen MS: LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour. Behav Brain Res. 2013 Feb 1;238 :69-78. Epub 2012 Oct 23. PMID: 23089646


Um JW and Strittmatter SM: Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease. Prion. 2013 Jan-Feb;7 (1) :37-41. Epub 2012 Sep 17. PMID: 22987042

Lane RF, St George-Hyslop P, Hempstead BL, Small SA, Strittmatter SM and Gandy S: Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes. J Neurosci. 2012 Oct 10;32 (41) :14080-6. PMID: 23055476


Wang X, Hasan O, Arzeno A, Benowitz LI, Cafferty WB and Strittmatter SM: Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways. Exp Neurol. 2012 Sep;237 (1) :55-69. Epub 2012 Jun 21. PMID: 22728374


Um JW, Nygaard HB, Heiss JK, Kostylev MA, Stagi M, Vortmeyer A, Wisniewski T, Gunther EC and Strittmatter SM: Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat Neurosci. 2012 Sep;15 (9) :1227-35. Epub 2012 Jul 22. PMID: 22820466


Kopp MA, Liebscher T, Niedeggen A, Laufer S, Brommer B, Jungehulsing GJ, Strittmatter SM, Dirnagl U and Schwab JM: Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury. Cell Tissue Res. 2012 Jul;349 (1) :119-32. Epub 2012 Feb 21. PMID: 22350947


Petratos S, Ozturk E, Azari MF, Kenny R, Lee JY, Magee KA, Harvey AR, McDonald C, Taghian K, Moussa L, Mun Aui P, Siatskas C, Litwak S, Fehlings MG, Strittmatter SM and Bernard CC: Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation. Brain. 2012 Jun;135 (Pt 6) :1794-818. Epub 2012 Apr 28. PMID: 22544872


Shim SO, Cafferty WB, Schmidt EC, Kim BG, Fujisawa H and Strittmatter SM: PlexinA2 limits recovery from corticospinal axotomy by mediating oligodendrocyte-derived Sema6A growth inhibition. Mol Cell Neurosci. 2012 Jun;50 (2) :193-200. Epub 2012 Apr 26. PMID: 22564823


Akbik F, Cafferty WB and Strittmatter SM: Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity. Exp Neurol. 2012 May;235 (1) :43-52. Epub 2011 Jun 15. PMID: 21699896


Duffy P, Wang X, Siegel CS, Tu N, Henkemeyer M, Cafferty WB and Strittmatter SM: Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury. Proc Natl Acad Sci U S A. 2012 Mar 27;109 (13) :5063-8. Epub 2012 Mar 12. PMID: 22411787

Wang X, Duffy P, McGee AW, Hasan O, Gould G, Tu N, Harel NY, Huang Y, Carson RE, Weinzimmer D, Ropchan J, Benowitz LI, Cafferty WB and Strittmatter SM: Recovery from chronic spinal cord contusion after Nogo receptor intervention. Ann Neurol. 2011 Nov;70 (5) :805-21. PMID: 22162062


Ferraro GB, Morrison CJ, Overall CM, Strittmatter SM and Fournier AE: Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage. J Biol Chem. 2011 Sep 9;286 (36) :31418-24. Epub 2011 Jul 18. PMID: 21768085


Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, Arie Y, Kawasaki T, Hirata T, Abe T, Kiyonari H, Strittmatter SM, Goshima Y and Takei K: Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Science. 2011 Aug 5;333 (6043) :769-73. PMID: 21817055


Matsushita H, Endo S, Kobayashi E, Sakamoto Y, Kobayashi K, Kitaguchi K, Kuroki K, Söderhäll A, Maenaka K, Nakamura A, Strittmatter SM and Takai T: Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells. J Biol Chem. 2011 Jul 22;286 (29) :25739-47. Epub 2011 Jun 2. PMID: 21636572


Huebner EA, Kim BG, Duffy PJ, Brown RH and Strittmatter SM: A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. J Biol Chem. 2011 May 20;286 (20) :18026-36. Epub 2011 Mar 24. PMID: 21454605


Zai L, Ferrari C, Dice C, Subbaiah S, Havton LA, Coppola G, Geschwind D, Irwin N, Huebner E, Strittmatter SM and Benowitz LI: Inosine augments the effects of a Nogo receptor blocker and of environmental enrichment to restore skilled forelimb use after stroke. J Neurosci. 2011 Apr 20;31 (16) :5977-88. PMID: 21508223

Higley MJ and Strittmatter SM: Neuroscience. Lynx for braking plasticity. Science. 2010 Nov 26;330 (6008) :1189-90. PMID: 21109660


Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A and Strittmatter SM: Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron. 2010 Nov 18;68 (4) :654-67. PMID: 21092856


Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC and Lombroso PJ: Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2010 Nov 2;107 (44) :19014-9. Epub 2010 Oct 18. PMID: 20956308


Harel NY, Song KH, Tang X and Strittmatter SM: Nogo receptor deletion and multimodal exercise improve distinct aspects of recovery in cervical spinal cord injury. J Neurotrauma. 2010 Nov;27 (11) :2055-66. PMID: 20809785


Chung E, Ji Y, Sun Y, Kascsak RJ, Kascsak RB, Mehta PD, Strittmatter SM and Wisniewski T: Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci. 2010 Oct 14;11 :130. Epub 2010 Oct 14. PMID: 20946660


Hånell A, Clausen F, Björk M, Jansson K, Philipson O, Nilsson LN, Hillered L, Weinreb PH, Lee D, McIntosh TK, Gimbel DA, Strittmatter SM and Marklund N: Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice. J Neurotrauma. 2010 Jul;27 (7) :1297-309. PMID: 20486800


Cafferty WB, Duffy P, Huebner E and Strittmatter SM: MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma. J Neurosci. 2010 May 19;30 (20) :6825-37. PMID: 20484625


Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Laurén J, Gimbel ZA and Strittmatter SM: Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J Neurosci. 2010 May 5;30 (18) :6367-74. PMID: 20445063


Gunther EC and Strittmatter SM: Beta-amyloid oligomers and cellular prion protein in Alzheimer's disease. J Mol Med (Berl). 2010 Apr;88 (4) :331-8. Epub 2009 Dec 4. PMID: 19960174


Fang PC, Barbay S, Plautz EJ, Hoover E, Strittmatter SM and Nudo RJ: Combination of NEP 1-40 treatment and motor training enhances behavioral recovery after a focal cortical infarct in rats. Stroke. 2010 Mar;41 (3) :544-9. Epub 2010 Jan 14. PMID: 20075346

Duffy P, Schmandke A, Schmandke A, Sigworth J, Narumiya S, Cafferty WB and Strittmatter SM: Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord. J Neurosci. 2009 Dec 2;29 (48) :15266-76. PMID: 19955379


Owuor K, Harel NY, Englot DJ, Hisama F, Blumenfeld H and Strittmatter SM: LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology. Mol Cell Neurosci. 2009 Dec;42 (4) :448-57. Epub 2009 Sep 29. PMID: 19796686


Yang YS, Harel NY and Strittmatter SM: Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. J Neurosci. 2009 Nov 4;29 (44) :13850-9. PMID: 19889996


Nygaard HB and Strittmatter SM: Cellular prion protein mediates the toxicity of beta-amyloid oligomers: implications for Alzheimer disease. Arch Neurol. 2009 Nov;66 (11) :1325-8. PMID: 19901162


Marklund N, Morales D, Clausen F, Hånell A, Kiwanuka O, Pitkänen A, Gimbel DA, Philipson O, Lannfelt L, Hillered L, Strittmatter SM and McIntosh TK: Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice. Neuroscience. 2009 Oct 6;163 (2) :540-51. Epub 2009 Jun 23. PMID: 19555742


Harel NY, Cudkowicz ME, Brown RH and Strittmatter SM: Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients. Biomarkers. 2009 Sep;14 (6) :414-7. PMID: 19548774


Ellenberg D, Shi J, Jain S, Chang JH, Ripps H, Brady S, Melhem ER, Lakkis F, Adamis A, Chen DF, Ellis-Behnke R, Langer RS, Strittmatter SM and Azar DT: Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation. Br J Ophthalmol. 2009 Sep;93 (9) :1134-40. Epub 2009 Mar 13. PMID: 19286686


Linhoff MW, Laurén J, Cassidy RM, Dobie FA, Takahashi H, Nygaard HB, Airaksinen MS, Strittmatter SM and Craig AM: An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron. 2009 Mar 12;61 (5) :734-49. PMID: 19285470


Laurén J, Gimbel DA, Nygaard HB, Gilbert JW and Strittmatter SM: Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature. 2009 Feb 26;457 (7233) :1128-32. PMID: 19242475


Wang X, Budel S, Baughman K, Gould G, Song KH and Strittmatter SM: Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth. J Neurotrauma. 2009 Jan;26 (1) :81-95. PMID: 19125588


Huebner EA and Strittmatter SM: Axon regeneration in the peripheral and central nervous systems. Results Probl Cell Differ. 2009;48 :339-51. PMID: 19582408

Budel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S, Lauren J, Park JH, McGee AW, Liao J, Stillman A, Kim JE, Yang BZ, Sodi S, Gelernter J, Zhao H, Hisama F, Arnsten AF and Strittmatter SM: Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci. 2008 Dec 3;28 (49) :13161-72. PMID: 19052207


Harel NY and Strittmatter SM: Functional MRI and other non-invasive imaging technologies: providing visual biomarkers for spinal cord structure and function after injury. Exp Neurol. 2008 Jun;211 (2) :324-8. Epub 2008 Mar 5. PMID: 18396280


Cafferty WB, McGee AW and Strittmatter SM: Axonal growth therapeutics: regeneration or sprouting or plasticity? Trends Neurosci. 2008 May;31 (5) :215-20. Epub 2008 Apr 7. PMID: 18395807


Schmidt EF, Shim SO and Strittmatter SM: Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein. J Neurosci. 2008 Feb 27;28 (9) :2287-97. PMID: 18305261


Budel S, Shim SO, Feng Z, Zhao H, Hisama F and Strittmatter SM: No association between schizophrenia and polymorphisms of the PlexinA2 gene in Chinese Han Trios. Schizophr Res. 2008 Feb;99 (1-3) :365-6. Epub 2007 Dec 21. PMID: 18096369


Hu F and Strittmatter SM: The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism. J Neurosci. 2008 Jan 30;28 (5) :1262-9. PMID: 18234903

Park JH and Strittmatter SM: Nogo receptor interacts with brain APP and Abeta to reduce pathologic changes in Alzheimer's transgenic mice. Curr Alzheimer Res. 2007 Dec;4 (5) :568-70. PMID: 18220524


Francks C, Maegawa S, Laurén J, Abrahams BS, Velayos-Baeza A, Medland SE, Colella S, Groszer M, McAuley EZ, Caffrey TM, Timmusk T, Pruunsild P, Koppel I, Lind PA, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson AJ, Riley BP, Martin NG, Strittmatter SM, Möller HJ, Rujescu D, St Clair D, Muglia P, Roos JL, Fisher SE, Wade-Martins R, Rouleau GA, Stein JF, Karayiorgou M, Geschwind DH, Ragoussis J, Kendler KS, Airaksinen MS, Oshimura M, DeLisi LE and Monaco AP: LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry. 2007 Dec;12 (12) :1129-39, 1057. Epub 2007 Jul 31. PMID: 17667961


Cameron JS, Alexopoulou L, Sloane JA, DiBernardo AB, Ma Y, Kosaras B, Flavell R, Strittmatter SM, Volpe J, Sidman R and Vartanian T: Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J Neurosci. 2007 Nov 21;27 (47) :13033-41. PMID: 18032677


Schmandke A, Schmandke A and Strittmatter SM: ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist. 2007 Oct;13 (5) :454-69. PMID: 17901255


Harel NY and Strittmatter SM: Nogo-A marks motor neuron disease. Ann Neurol. 2007 Jul;62 (1) :1-2. PMID: 17474106


Cafferty WB, Kim JE, Lee JK and Strittmatter SM: Response to correspondence: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B." Neuron 38, 187-199. Neuron. 2007 Apr 19;54 (2) :195-9. PMID: 17442242


Cafferty WB, Yang SH, Duffy PJ, Li S and Strittmatter SM: Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans. J Neurosci. 2007 Feb 28;27 (9) :2176-85. PMID: 17329414


Laurén J, Hu F, Chin J, Liao J, Airaksinen MS and Strittmatter SM: Characterization of myelin ligand complexes with neuronal Nogo-66 receptor family members. J Biol Chem. 2007 Feb 23;282 (8) :5715-25. Epub 2006 Dec 21. PMID: 17189258


Schmidt EF and Strittmatter SM: The CRMP family of proteins and their role in Sema3A signaling. Adv Exp Med Biol. 2007;600 :1-11. PMID: 17607942


Yang YS and Strittmatter SM: The reticulons: a family of proteins with diverse functions. Genome Biol. 2007;8 (12) :234. PMID: 18177508

Park JH, Widi GA, Gimbel DA, Harel NY, Lee DH and Strittmatter SM: Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice. J Neurosci. 2006 Dec 20;26 (51) :13279-86. PMID: 17182778


Cafferty WB and Strittmatter SM: The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth. J Neurosci. 2006 Nov 22;26 (47) :12242-50. PMID: 17122049


Wang X, Baughman KW, Basso DM and Strittmatter SM: Delayed Nogo receptor therapy improves recovery from spinal cord contusion. Ann Neurol. 2006 Nov;60 (5) :540-9. PMID: 16958113


Liu BP, Cafferty WB, Budel SO and Strittmatter SM: Extracellular regulators of axonal growth in the adult central nervous system. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361 (1473) :1593-610. PMID: 16939977


Harel NY and Strittmatter SM: Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. 2006 Aug;7 (8) :603-16. PMID: 16858389


Miao RQ, Gao Y, Harrison KD, Prendergast J, Acevedo LM, Yu J, Hu F, Strittmatter SM and Sessa WC: Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proc Natl Acad Sci U S A. 2006 Jul 18;103 (29) :10997-1002. Epub 2006 Jul 11. PMID: 16835300


Togashi H, Schmidt EF and Strittmatter SM: RanBPM contributes to Semaphorin3A signaling through plexin-A receptors. J Neurosci. 2006 May 3;26 (18) :4961-9. PMID: 16672672


Park JH, Gimbel DA, GrandPre T, Lee JK, Kim JE, Li W, Lee DH and Strittmatter SM: Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci. 2006 Feb 1;26 (5) :1386-95. PMID: 16452662


Marklund N, Fulp CT, Shimizu S, Puri R, McMillan A, Strittmatter SM and McIntosh TK: Selective temporal and regional alterations of Nogo-A and small proline-rich repeat protein 1A (SPRR1A) but not Nogo-66 receptor (NgR) occur following traumatic brain injury in the rat. Exp Neurol. 2006 Jan;197 (1) :70-83. PMID: 16321384

McGee AW, Yang Y, Fischer QS, Daw NW and Strittmatter SM: Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor. Science. 2005 Sep 30;309 (5744) :2222-6. PMID: 16195464


Ji B, Li M, Budel S, Pepinsky RB, Walus L, Engber TM, Strittmatter SM and Relton JK: Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury. Eur J Neurosci. 2005 Aug;22 (3) :587-94. PMID: 16101740


Hu F, Liu BP, Budel S, Liao J, Chin J, Fournier A and Strittmatter SM: Nogo-A interacts with the Nogo-66 receptor through multiple sites to create an isoform-selective subnanomolar agonist. J Neurosci. 2005 Jun 1;25 (22) :5298-304. PMID: 15930377


Li S, Kim JE, Budel S, Hampton TG and Strittmatter SM: Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury. Mol Cell Neurosci. 2005 May;29 (1) :26-39. PMID: 15866044

Hu F and Strittmatter SM: Regulating axon growth within the postnatal central nervous system. Semin Perinatol. 2004 Dec;28 (6) :371-8. PMID: 15693393


Li S, Liu BP, Budel S, Li M, Ji B, Walus L, Li W, Jirik A, Rabacchi S, Choi E, Worley D, Sah DW, Pepinsky B, Lee D, Relton J and Strittmatter SM: Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. J Neurosci. 2004 Nov 17;24 (46) :10511-20. PMID: 15548666


Kim JE, Liu BP, Park JH and Strittmatter SM: Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron. 2004 Oct 28;44 (3) :439-51. PMID: 15504325


Li W, Walus L, Rabacchi SA, Jirik A, Chang E, Schauer J, Zheng BH, Benedetti NJ, Liu BP, Choi E, Worley D, Silvian L, Mo W, Mullen C, Yang W, Strittmatter SM, Sah DW, Pepinsky B and Lee DH: A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin. J Biol Chem. 2004 Oct 15;279 (42) :43780-8. Epub 2004 Aug 5. PMID: 15297463


Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P and Chédotal A: RGM and its receptor neogenin regulate neuronal survival. Nat Cell Biol. 2004 Aug;6 (8) :749-55. Epub 2004 Jul 18. PMID: 15258591


Rajagopalan S, Deitinghoff L, Davis D, Conrad S, Skutella T, Chedotal A, Mueller BK and Strittmatter SM: Neogenin mediates the action of repulsive guidance molecule. Nat Cell Biol. 2004 Aug;6 (8) :756-62. Epub 2004 Jul 18. PMID: 15258590


Lee JK, Kim JE, Sivula M and Strittmatter SM: Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci. 2004 Jul 7;24 (27) :6209-17. PMID: 15240813


Acevedo L, Yu J, Erdjument-Bromage H, Miao RQ, Kim JE, Fulton D, Tempst P, Strittmatter SM and Sessa WC: A new role for Nogo as a regulator of vascular remodeling. Nat Med. 2004 Apr;10 (4) :382-8. Epub 2004 Mar 21. PMID: 15034570


Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK and Strittmatter SM: Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J. 2004 Jan 14;23 (1) :9-22. Epub 2003 Dec 18. PMID: 14685275

Lee DH, Strittmatter SM and Sah DW: Targeting the Nogo receptor to treat central nervous system injuries. Nat Rev Drug Discov. 2003 Nov;2 (11) :872-8. PMID: 14668808


Tanabe K, Bonilla I, Winkles JA and Strittmatter SM: Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth. J Neurosci. 2003 Oct 22;23 (29) :9675-86. PMID: 14573547


Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM and Nikolov DB: Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. EMBO J. 2003 Jul 1;22 (13) :3291-302. PMID: 12839991


Kim JE, Bonilla IE, Qiu D and Strittmatter SM: Nogo-C is sufficient to delay nerve regeneration. Mol Cell Neurosci. 2003 Jul;23 (3) :451-9. PMID: 12837628


Li S and Strittmatter SM: Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J Neurosci. 2003 May 15;23 (10) :4219-27. PMID: 12764110


Kim JE, Li S, GrandPré T, Qiu D and Strittmatter SM: Axon regeneration in young adult mice lacking Nogo-A/B. Neuron. 2003 Apr 24;38 (2) :187-99. PMID: 12718854


McGee AW and Strittmatter SM: The Nogo-66 receptor: focusing myelin inhibition of axon regeneration. Trends Neurosci. 2003 Apr;26 (4) :193-8. PMID: 12689770


Fournier AE, Takizawa BT and Strittmatter SM: Rho kinase inhibition enhances axonal regeneration in the injured CNS. J Neurosci. 2003 Feb 15;23 (4) :1416-23. PMID: 12598630

Fournier AE, Gould GC, Liu BP and Strittmatter SM: Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin. J Neurosci. 2002 Oct 15;22 (20) :8876-83. PMID: 12388594


Fournier AE and Strittmatter SM: Regenerating nerves follow the road more traveled. Nat Neurosci. 2002 Sep;5 (9) :821-2. PMID: 12196804


Liu BP, Fournier A, GrandPré T and Strittmatter SM: Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science. 2002 Aug 16;297 (5584) :1190-3. Epub 2002 Jun 27. PMID: 12089450


Strittmatter SM: Modulation of axonal regeneration in neurodegenerative disease: focus on Nogo. J Mol Neurosci. 2002 Aug-Oct;19 (1-2) :117-21. PMID: 12212768


Wang X, Chun SJ, Treloar H, Vartanian T, Greer CA and Strittmatter SM: Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synaptic contact. J Neurosci. 2002 Jul 1;22 (13) :5505-15. PMID: 12097502


GrandPré T, Li S and Strittmatter SM: Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature. 2002 May 30;417 (6888) :547-51. PMID: 12037567


Bonilla IE, Tanabe K and Strittmatter SM: Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth. J Neurosci. 2002 Feb 15;22 (4) :1303-15. PMID: 11850458


Fournier AE, GrandPré T, Gould G, Wang X and Strittmatter SM: Nogo and the Nogo-66 receptor. Prog Brain Res. 2002;137 :361-9. PMID: 12440378

Liu BP and Strittmatter SM: Semaphorin-mediated axonal guidance via Rho-related G proteins. Curr Opin Cell Biol. 2001 Oct;13 (5) :619-26. PMID: 11544032


Grandpré T and Strittmatter SM: Nogo: a molecular determinant of axonal growth and regeneration. Neuroscientist. 2001 Oct;7 (5) :377-86. PMID: 11597097


Fournier AE and Strittmatter SM: Repulsive factors and axon regeneration in the CNS. Curr Opin Neurobiol. 2001 Feb;11 (1) :89-94. PMID: 11179877


Takahashi T and Strittmatter SM: Plexina1 autoinhibition by the plexin sema domain. Neuron. 2001 Feb;29 (2) :429-39. PMID: 11239433


Fournier AE, GrandPre T and Strittmatter SM: Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature. 2001 Jan 18;409 (6818) :341-6. PMID: 11201742

Nakamura F, Kalb RG and Strittmatter SM: Molecular basis of semaphorin-mediated axon guidance. J Neurobiol. 2000 Aug;44 (2) :219-29. PMID: 10934324


Fournier AE, Nakamura F, Kawamoto S, Goshima Y, Kalb RG and Strittmatter SM: Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse. J Cell Biol. 2000 Apr 17;149 (2) :411-22. PMID: 10769032


Strittmatter SM: Dendrites go up, axons go down. Nature. 2000 Apr 6;404 (6778) :557, 559. PMID: 10766224


Fryer HJ, Wolf DH, Knox RJ, Strittmatter SM, Pennica D, O'Leary RM, Russell DS and Kalb RG: Brain-derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3-kinase pathway. J Neurochem. 2000 Feb;74 (2) :582-95. PMID: 10646509


GrandPré T, Nakamura F, Vartanian T and Strittmatter SM: Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature. 2000 Jan 27;403 (6768) :439-44. PMID: 10667797


Fournier AE, Kalb RG and Strittmatter SM: Rho GTPases and axonal growth cone collapse. Methods Enzymol. 2000;325 :473-82. PMID: 11036628

Tanaka M, Treloar H, Kalb RG, Greer CA and Strittmatter SM: G(o) protein-dependent survival of primary accessory olfactory neurons. Proc Natl Acad Sci U S A. 1999 Nov 23;96 (24) :14106-11. PMID: 10570206


Takahashi T, Fournier A, Nakamura F, Wang LH, Murakami Y, Kalb RG, Fujisawa H and Strittmatter SM: Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell. 1999 Oct 1;99 (1) :59-69. PMID: 10520994


Yen L, Strittmatter SM and Kalb RG: Sequence-specific cleavage of Huntingtin mRNA by catalytic DNA. Ann Neurol. 1999 Sep;46 (3) :366-73. PMID: 10482267


Goshima Y, Hori H, Sasaki Y, Yang T, Kagoshima-Maezono M, Li C, Takenaka T, Nakamura F, Takahashi T, Strittmatter SM, Misu Y and Kawakami T: Growth cone neuropilin-1 mediates collapsin-1/Sema III facilitation of antero- and retrograde axoplasmic transport. J Neurobiol. 1999 Jun 15;39 (4) :579-89. PMID: 10380079


Wang LH, Kalb RG and Strittmatter SM: A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF. J Biol Chem. 1999 May 14;274 (20) :14137-46. PMID: 10318831


Fryer HJ, Knox RJ, Strittmatter SM and Kalb RG: Excitotoxic death of a subset of embryonic rat motor neurons in vitro. J Neurochem. 1999 Feb;72 (2) :500-13. PMID: 9930721


Nakamura F, Goshima Y, Strittmatter SM and Kawamoto S: Isolation of receptor clones by expression screening in Xenopus oocytes. Methods Mol Biol. 1999;128 :1-18. PMID: 10320969

Inglis FM, Furia F, Zuckerman KE, Strittmatter SM and Kalb RG: The role of nitric oxide and NMDA receptors in the development of motor neuron dendrites. J Neurosci. 1998 Dec 15;18 (24) :10493-501. PMID: 9852587


Nakamura F, Tanaka M, Takahashi T, Kalb RG and Strittmatter SM: Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse. Neuron. 1998 Nov;21 (5) :1093-100. PMID: 9856464


Takahashi T, Nakamura F, Jin Z, Kalb RG and Strittmatter SM: Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. Nat Neurosci. 1998 Oct;1 (6) :487-93. PMID: 10196546


Nakamura F, Strittmatter P and Strittmatter SM: GAP-43 augmentation of G protein-mediated signal transduction is regulated by both phosphorylation and palmitoylation. J Neurochem. 1998 Mar;70 (3) :983-92. PMID: 9489717

Wang LH and Strittmatter SM: Brain CRMP forms heterotetramers similar to liver dihydropyrimidinase. J Neurochem. 1997 Dec;69 (6) :2261-9. PMID: 9375656


Takahashi T, Nakamura F and Strittmatter SM: Neuronal and non-neuronal collapsin-1 binding sites in developing chick are distinct from other semaphorin binding sites. J Neurosci. 1997 Dec 1;17 (23) :9183-93. PMID: 9364065


Goshima Y, Kawakami T, Hori H, Sugiyama Y, Takasawa S, Hashimoto Y, Kagoshima-Maezono M, Takenaka T, Misu Y and Strittmatter SM: A novel action of collapsin: collapsin-1 increases antero- and retrograde axoplasmic transport independently of growth cone collapse. J Neurobiol. 1997 Sep;33 (3) :316-28. PMID: 9298768


Jin Z and Strittmatter SM: Rac1 mediates collapsin-1-induced growth cone collapse. J Neurosci. 1997 Aug 15;17 (16) :6256-63. PMID: 9236236

Wang LH and Strittmatter SM: A family of rat CRMP genes is differentially expressed in the nervous system. J Neurosci. 1996 Oct 1;16 (19) :6197-207. PMID: 8815901


Nakamura F and Strittmatter SM: P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation. Proc Natl Acad Sci U S A. 1996 Sep 17;93 (19) :10465-70. PMID: 8816824

Goshima Y, Nakamura F, Strittmatter P and Strittmatter SM: Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. Nature. 1995 Aug 10;376 (6540) :509-14. PMID: 7637782


Xie R, Li L, Goshima Y and Strittmatter SM: An activated mutant of the alpha subunit of G(o) increases neurite outgrowth via protein kinase C. Brain Res Dev Brain Res. 1995 Jun 27;87 (1) :77-86. PMID: 7554235


Strittmatter SM, Fankhauser C, Huang PL, Mashimo H and Fishman MC: Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell. 1995 Feb 10;80 (3) :445-52. PMID: 7859286

Strittmatter SM, Igarashi M and Fishman MC: GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth. J Neurosci. 1994 Sep;14 (9) :5503-13. PMID: 8083750


Okamoto T, Murayama Y, Strittmatter SM, Katada T, Asano S, Ogata E and Nishimoto I: An intrinsic guanine nucleotide exchange inhibitor in Gi2 alpha. Significance of G-protein self-suppression which antagonizes receptor signal. J Biol Chem. 1994 May 13;269 (19) :13756-9. PMID: 8188651


Strittmatter SM, Fishman MC and Zhu XP: Activated mutants of the alpha subunit of G(o) promote an increased number of neurites per cell. J Neurosci. 1994 Apr;14 (4) :2327-38. PMID: 8158271


Strittmatter SM, Valenzuela D and Fishman MC: An amino-terminal domain of the growth-associated protein GAP-43 mediates its effects on filopodial formation and cell spreading. J Cell Sci. 1994 Jan;107 ( Pt 1) :195-204. PMID: 8175908

Strittmatter SM, Cannon SC, Ross EM, Higashijima T and Fishman MC: GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes. Proc Natl Acad Sci U S A. 1993 Jun 1;90 (11) :5327-31. PMID: 7685122


Cannon SC and Strittmatter SM: Functional expression of sodium channel mutations identified in families with periodic paralysis. Neuron. 1993 Feb;10 (2) :317-26. PMID: 8382500


Igarashi M, Strittmatter SM, Vartanian T and Fishman MC: Mediation by G proteins of signals that cause collapse of growth cones. Science. 1993 Jan 1;259 (5091) :77-9. PMID: 8418498

Strittmatter SM, Vartanian T and Fishman MC: GAP-43 as a plasticity protein in neuronal form and repair. J Neurobiol. 1992 Jul;23 (5) :507-20. PMID: 1431834


Sudo Y, Valenzuela D, Beck-Sickinger AG, Fishman MC and Strittmatter SM: Palmitoylation alters protein activity: blockade of G(o) stimulation by GAP-43. EMBO J. 1992 Jun;11 (6) :2095-102. PMID: 1534749


Strittmatter SM: GAP-43 as a modulator of G protein transduction in the growth cone. Perspect Dev Neurobiol. 1992;1 (1) :13-9. PMID: 1364285

Strittmatter SM, Valenzuela D, Sudo Y, Linder ME and Fishman MC: An intracellular guanine nucleotide release protein for G0. GAP-43 stimulates isolated alpha subunits by a novel mechanism. J Biol Chem. 1991 Nov 25;266 (33) :22465-71. PMID: 1834672


Strittmatter SM and Fishman MC: The neuronal growth cone as a specialized transduction system. Bioessays. 1991 Mar;13 (3) :127-34. PMID: 1831353


Strittmatter SM, Valenzuela D, Vartanian T, Sudo Y, Zuber MX and Fishman MC: Growth cone transduction: Go and GAP-43. J Cell Sci Suppl. 1991;15 :27-33. PMID: 1840457

Strittmatter SM, Valenzuela D, Kennedy TE, Neer EJ and Fishman MC: G0 is a major growth cone protein subject to regulation by GAP-43. Nature. 1990 Apr 26;344 (6269) :836-41. PMID: 2158629

Strittmatter SM, Braas KM and Snyder SH: Localization of angiotensin converting enzyme in the ciliary epithelium of the rat eye. Invest Ophthalmol Vis Sci. 1989 Oct;30 (10) :2209-14. PMID: 2551838


Zuber MX, Strittmatter SM and Fishman MC: A membrane-targeting signal in the amino terminus of the neuronal protein GAP-43. Nature. 1989 Sep 28;341 (6240) :345-8. PMID: 2797153

Supattapone S, Strittmatter SM, Fricker LD and Snyder SH: Characterization of a neutral, divalent cation-sensitive endopeptidase: a possible role in neuropeptide processing. Brain Res. 1988 Apr;427 (2) :173-81. PMID: 3382941


Lynch DR, Venable JC, Strittmatter SM and Snyder SH: Enkephalin convertase: characterization and localization using [3H]guanidinoethylmercaptosuccinic acid. Biochimie. 1988 Jan;70 (1) :57-64. PMID: 3135843

Strittmatter SM, Lynch DR and Snyder SH: Differential ontogeny of rat brain peptidases: prenatal expression of enkephalin convertase and postnatal development of angiotensin-converting enzyme. Brain Res. 1986 Oct;394 (2) :207-15. PMID: 3021286


Lynch DR, Strittmatter SM, Venable JC and Snyder SH: Enkephalin convertase: localization to specific neuronal pathways. J Neurosci. 1986 Jun;6 (6) :1662-75. PMID: 3086516


Strittmatter SM, De Souza EB, Lynch DR and Snyder SH: Angiotensin-converting enzyme localized in the rat pituitary and adrenal glands by [3H]captopril autoradiography. Endocrinology. 1986 Apr;118 (4) :1690-9. PMID: 3004925


Strittmatter SM and Snyder SH: Characterization of angiotensin converting enzyme by [3H]captopril binding. Mol Pharmacol. 1986 Feb;29 (2) :142-8. PMID: 3005826

Strittmatter SM, Lynch DR, De Souza EB and Snyder SH: Enkephalin convertase demonstrated in the pituitary and adrenal gland by [3H]guanidinoethylmercaptosuccinic acid autoradiography: dehydration decreases neurohypophyseal levels. Endocrinology. 1985 Oct;117 (4) :1667-74. PMID: 3928337


Strittmatter SM, Thiele EA, De Souza EB and Snyder SH: Angiotensin-converting enzyme in the testis and epididymis: differential development and pituitary regulation of isozymes. Endocrinology. 1985 Oct;117 (4) :1374-9. PMID: 2992911


Strittmatter SM, Thiele EA, Kapiloff MS and Snyder SH: A rat brain isozyme of angiotensin-converting enzyme. Unique specificity for amidated peptide substrates. J Biol Chem. 1985 Aug 15;260 (17) :9825-32. PMID: 2991265


Javitch JA, Strittmatter SM and Snyder SH: Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography. J Neurosci. 1985 Jun;5 (6) :1513-21. PMID: 4009243


Pevsner J, Trifiletti RR, Strittmatter SM and Snyder SH: Isolation and characterization of an olfactory receptor protein for odorant pyrazines. Proc Natl Acad Sci U S A. 1985 May;82 (9) :3050-4. PMID: 2986147


Thiele EA, Strittmatter SM and Snyder SH: Substance K and substance P as possible endogenous substrates of angiotensin converting enzyme in the brain. Biochem Biophys Res Commun. 1985 Apr 16;128 (1) :317-24. PMID: 2580530


Javitch JA, D'Amato RJ, Strittmatter SM and Snyder SH: Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci U S A. 1985 Apr;82 (7) :2173-7. PMID: 3872460

Strittmatter SM and Snyder SH: Angiotensin-converting enzyme in the male rat reproductive system: autoradiographic visualization with [3H]captopril. Endocrinology. 1984 Dec;115 (6) :2332-41. PMID: 6094156


Strittmatter SM, Lynch DR and Snyder SH: [3H]guanidinoethylmercaptosuccinic acid binding to tissue homogenates. Selective labeling of enkephalin convertase. J Biol Chem. 1984 Oct 10;259 (19) :11812-7. PMID: 6434531


Lynch DR, Strittmatter SM and Snyder SH: Enkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons. Proc Natl Acad Sci U S A. 1984 Oct;81 (20) :6543-7. PMID: 6436816


Lo MM, Tsong TY, Conrad MK, Strittmatter SM, Hester LD and Snyder SH: Monoclonal antibody production by receptor-mediated electrically induced cell fusion. Nature. 1984 Aug 30-Sep 5;310 (5980) :792-4. PMID: 6088990


Kapiloff MS, Strittmatter SM, Fricker LD and Snyder SH: A fluorometric assay for angiotensin-converting enzyme activity. Anal Biochem. 1984 Jul;140 (1) :293-302. PMID: 6091493


Strittmatter SM, Lo MM, Javitch JA and Snyder SH: Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway. Proc Natl Acad Sci U S A. 1984 Mar;81 (5) :1599-603. PMID: 6324207

Strittmatter SM, Kapiloff MS and Snyder SH: [3H]Captopril binding to membrane associated angiotensin converting enzyme. Biochem Biophys Res Commun. 1983 May 16;112 (3) :1027-33. PMID: 6303332

Lo MM, Strittmatter SM and Snyder SH: Physical separation and characterization of two types of benzodiazepine receptors. Proc Natl Acad Sci U S A. 1982 Jan;79 (2) :680-4. PMID: 6281778