In situ hybridization showing reduced expression after prenatal stress of key transcription factors for inhibitory neuron development.
Prenatal stress mechanisms and embryonic development of inhibitory neurons
Our lab has shown that prenatal stress delays inhibitory neuron migration and downregulates the expression of key transcription factors involved in inhibitory progenitor development. We are currently examining how much of these effects may be due to glucocorticoids, immune activation and other maternal factors.
Supported by a Patterson Trust Award Program in Clinical Research
Postnatal neurobiological and behavioral trajectories after prenatal stress
We are currently examining the relationship between alterations in the neurobiology of inhibitory neurons, glial cells and behavior in prenatally-stressed mice.
Supported by a NIMH Career Development Award
Gene-environment interaction and ADHD: translation between rodent and human models of prenatal stress, genetic risk, and postnatal environment
In an extension of our work in fibroblast growth factor receptors and prenatal stress as above, we are currently collaborating with David Reiss and the Early Growth and Development Study. We are examining adopted children in order to understand the interaction of different risk factors for attention-deficit disorder.
Supported by a Klingenstein Third Generation Foundation Fellowship in Attention Deficit Hyperactivity Disorder
The role of Fibroblast Growth Factor 2 in the impact of prenatal stress
Growth factors play important roles in early developmental processes in the CNS. Interactions between genes and environment are significant in the etiology of psychiatric disorders. In collaboration with the Vaccarino lab, we are exploring the interaction between growth factor genes and prenatal stress as risk factors for behavioral changes in activity level and working memory.
Supported by a Klingenstein Third Generation Foundation Fellowship in Attention Deficit Hyperactivity Disorder & a Brain and Behavior Research Foundation Young Investigator Program award
Adult BCKDK KO female (left) and male (right) mice showing reduced fur and whiskers on snout.