Publications

Hatzis C, Bedard PL, Birkbak NJ, Beck AH, Aerts HJ, Stern DF, Shi L, Clarke R, Quackenbush J and Haibe-Kains B: Enhancing reproducibility in cancer drug screening: how do we move forward? Cancer Res. 2014 Aug 1;74 (15) :4016-23. Epub 2014 Jul 11. PMID: 25015668


Wali VB, Haskins JW, Gilmore-Hebert M, Platt JT, Liu Z and Stern DF: Convergent and Divergent Cellular Responses by ErbB4 Isoforms in Mammary Epithelial Cells. Mol Cancer Res. 2014 Aug;12 (8) :1140-55. Epub 2014 May 14. PMID: 24829397

Breindel JL, Haskins JW, Cowell EP, Zhao M, Nguyen DX and Stern DF: EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res. 2013 Aug 15;73 (16) :5053-65. Epub 2013 Jun 21. PMID: 23794705


Tworkoski KA, Platt JT, Bacchiocchi A, Bosenberg M, Boggon TJ and Stern DF: MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL. Pigment Cell Melanoma Res. 2013 Jul;26 (4) :527-41. Epub 2013 May 21. PMID: 23617806


Held MA, Langdon CG, Platt JT, Graham-Steed T, Liu Z, Chakraborty A, Bacchiocchi A, Koo A, Haskins JW, Bosenberg MW and Stern DF: Genotype-selective combination therapies for melanoma identified by high-throughput drug screening. Cancer Discov. 2013 Jan;3 (1) :52-67. Epub 2012 Dec 13. PMID: 23239741


Bai Y, Cheng H, Bordeaux J, Neumeister V, Kumar S, Rimm DL and Stern DF: Comparison of HER2 and phospho-HER2 expression between biopsy and resected breast cancer specimens using a quantitative assessment method. PLoS One. 2013;8 (11) :e79901. Epub 2013 Nov 21. PMID: 24278211

Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ and Halaban R: Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet. 2012 Sep;44 (9) :1006-14. Epub 2012 Jul 29. PMID: 22842228


Liu J, Luo S, Zhao H, Liao J, Li J, Yang C, Xu B, Stern DF, Xu X and Ye K: Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain. Nucleic Acids Res. 2012 May;40 (9) :3898-912. Epub 2012 Jan 10. PMID: 22234877

Wilson KA, Colavito SA, Schulz V, Wakefield PH, Sessa W, Tuck D and Stern DF: NFBD1/MDC1 regulates Cav1 and Cav2 independently of DNA damage and p53. Mol Cancer Res. 2011 Jun;9 (6) :766-81. Epub 2011 May 6. PMID: 21551225


Tworkoski K, Singhal G, Szpakowski S, Zito CI, Bacchiocchi A, Muthusamy V, Bosenberg M, Krauthammer M, Halaban R and Stern DF: Phosphoproteomic screen identifies potential therapeutic targets in melanoma. Mol Cancer Res. 2011 Jun;9 (6) :801-12. Epub 2011 Apr 26. PMID: 21521745


Stern DF: "Competence" progress. Mol Cell. 2011 May 20;42 (4) :411-2. PMID: 21596307

Stern DF: EGFs and ERBBs--brief history and prospects. Semin Cell Dev Biol. 2010 Dec;21 (9) :917-21. Epub 2010 Oct 21. PMID: 20970513


Gilmore-Hebert M, Ramabhadran R and Stern DF: Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. Mol Cancer Res. 2010 Oct;8 (10) :1388-98. Epub 2010 Sep 21. PMID: 20858735


Golan A, Pick E, Tsvetkov L, Nadler Y, Kluger H and Stern DF: Centrosomal Chk2 in DNA damage responses and cell cycle progression. Cell Cycle. 2010 Jul 1;9 (13) :2647-56. PMID: 20581449


Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, Sheu YJ, Sassi HE, Sopko R, Chan CS, De Virgilio C, Hollingsworth NM, Lim WA, Stern DF, Stillman B, Andrews BJ, Gerstein MB, Snyder M and Turk BE: Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal. 2010 Feb 16;3 (109) :ra12. Epub 2010 Feb 16. PMID: 20159853

Stern DF: BRCTing up is hard to do. Mol Cell. 2009 Jan 30;33 (2) :137-8. PMID: 19187753

Wilson KA and Stern DF: NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway. Cell Cycle. 2008 Nov 15;7 (22) :3584-94. Epub 2008 Nov 29. PMID: 19001859


Zito CI, Riches D, Kolmakova J, Simons J, Egholm M and Stern DF: Direct resequencing of the complete ERBB2 coding sequence reveals an absence of activating mutations in ERBB2 amplified breast cancer. Genes Chromosomes Cancer. 2008 Jul;47 (7) :633-8. PMID: 18418848


Stern DF: ERBB3/HER3 and ERBB2/HER2 duet in mammary development and breast cancer. J Mammary Gland Biol Neoplasia. 2008 Jun;13 (2) :215-23. Epub 2008 May 3. PMID: 18454306


DiGiovanna MP, Stern DF, Edgerton S, Broadwater G, Dressler LG, Budman DR, Henderson IC, Norton L, Liu ET, Muss HB, Berry DA, Hayes DF and Thor AD: Influence of activation state of ErbB-2 (HER-2) on response to adjuvant cyclophosphamide, doxorubicin, and fluorouracil for stage II, node-positive breast cancer: study 8541 from the Cancer and Leukemia Group B. J Clin Oncol. 2008 May 10;26 (14) :2364-72. Epub 2008 Apr 7. PMID: 18390970


Jia-Lin Ma N and Stern DF: Regulation of the Rad53 protein kinase in signal amplification by oligomer assembly and disassembly. Cell Cycle. 2008 Mar 15;7 (6) :808-17. Epub 2008 Jan 8. PMID: 18239457


Jackson-Fisher AJ, Bellinger G, Breindel JL, Tavassoli FA, Booth CJ, Duong JK and Stern DF: ErbB3 is required for ductal morphogenesis in the mouse mammary gland. Breast Cancer Res. 2008;10 (6) :R96. Epub 2008 Nov 18. PMID: 19019207

Arbiser JL, Govindarajan B, Battle TE, Lynch R, Frank DA, Ushio-Fukai M, Perry BN, Stern DF, Bowden GT, Liu A, Klein E, Kolodziejski PJ, Eissa NT, Hossain CF and Nagle DG: Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar. J Invest Dermatol. 2006 Jun;126 (6) :1396-402. PMID: 16614726


Ma JL, Lee SJ, Duong JK and Stern DF: Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1. J Biol Chem. 2006 Feb 17;281 (7) :3954-63. Epub 2005 Dec 19. PMID: 16365046

Li J, Young CS, Lizardi PM and Stern DF: In situ detection of specific DNA double strand breaks using rolling circle amplification. Cell Cycle. 2005 Dec;4 (12) :1767-73. Epub 2005 Dec 27. PMID: 16294038


Ptacek J, Devgan G, Michaud G, Zhu H, Zhu X, Fasolo J, Guo H, Jona G, Breitkreutz A, Sopko R, McCartney RR, Schmidt MC, Rachidi N, Lee SJ, Mah AS, Meng L, Stark MJ, Stern DF, De Virgilio C, Tyers M, Andrews B, Gerstein M, Schweitzer B, Predki PF and Snyder M: Global analysis of protein phosphorylation in yeast. Nature. 2005 Dec 1;438 (7068) :679-84. PMID: 16319894


Li J and Stern DF: DNA damage regulates Chk2 association with chromatin. J Biol Chem. 2005 Nov 11;280 (45) :37948-56. Epub 2005 Sep 8. PMID: 16150728


Amin DN, Tuck D and Stern DF: Neuregulin-regulated gene expression in mammary carcinoma cells. Exp Cell Res. 2005 Sep 10;309 (1) :12-23. PMID: 15963498


Stern DF: Phosphoproteomics for oncology discovery and treatment. Expert Opin Ther Targets. 2005 Aug;9 (4) :851-60. PMID: 16083347


Tsvetkov LM, Tsekova RT, Xu X and Stern DF: The Plk1 Polo box domain mediates a cell cycle and DNA damage regulated interaction with Chk2. Cell Cycle. 2005 Apr;4 (4) :609-17. Epub 2005 Apr 9. PMID: 15876876


Li J and Stern DF: Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem. 2005 Mar 25;280 (12) :12041-50. Epub 2005 Jan 24. PMID: 15668230


Tsvetkov L and Stern DF: Interaction of chromatin-associated Plk1 and Mcm7. J Biol Chem. 2005 Mar 25;280 (12) :11943-7. Epub 2005 Jan 15. PMID: 15654075


DiGiovanna MP, Stern DF, Edgerton SM, Whalen SG, Moore D 2nd and Thor AD: Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients. J Clin Oncol. 2005 Feb 20;23 (6) :1152-60. PMID: 15718311


Modi S, DiGiovanna MP, Lu Z, Moskowitz C, Panageas KS, Van Poznak C, Hudis CA, Norton L, Tan L, Stern DF, Carter D and Seidman AD: Phosphorylated/activated HER2 as a marker of clinical resistance to single agent taxane chemotherapy for metastatic breast cancer. Cancer Invest. 2005;23 (6) :483-7. PMID: 16203655


Tsvetkov L and Stern DF: Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage. Cell Cycle. 2005 Jan;4 (1) :166-71. Epub 2005 Jan 5. PMID: 15611664

Jackson-Fisher AJ, Bellinger G, Ramabhadran R, Morris JK, Lee KF and Stern DF: ErbB2 is required for ductal morphogenesis of the mammary gland. Proc Natl Acad Sci U S A. 2004 Dec 7;101 (49) :17138-43. Epub 2004 Nov 29. PMID: 15569931


Lee SJ, Duong JK and Stern DF: A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation. Mol Biol Cell. 2004 Dec;15 (12) :5443-55. Epub 2004 Sep 29. PMID: 15456903


Stern DF: More than a marker... Phosphorylated Akt in prostate carcinoma. Clin Cancer Res. 2004 Oct 1;10 (19) :6407-10. PMID: 15475426


Xu X, Lee J and Stern DF: Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J Biol Chem. 2004 Aug 13;279 (33) :34091-4. Epub 2004 Jun 25. PMID: 15220350


Amin DN, Perkins AS and Stern DF: Gene expression profiling of ErbB receptor and ligand-dependent transcription. Oncogene. 2004 Feb 19;23 (7) :1428-38. PMID: 14973552


Xu X and Stern DF: Establishment of a cell-free system to study the activation of Chk2. Methods Mol Biol. 2004;280 :165-74. PMID: 15187252

Xu X and Stern DF: NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 2003 Oct;17 (13) :1842-8. PMID: 14519663


Lee SJ, Schwartz MF, Duong JK and Stern DF: Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling. Mol Cell Biol. 2003 Sep;23 (17) :6300-14. PMID: 12917350


Tidcombe H, Jackson-Fisher A, Mathers K, Stern DF, Gassmann M and Golding JP: Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality. Proc Natl Acad Sci U S A. 2003 Jul 8;100 (14) :8281-6. Epub 2003 Jun 24. PMID: 12824469


Schwartz MF, Lee SJ, Duong JK, Eminaga S and Stern DF: FHA domain-mediated DNA checkpoint regulation of Rad53. Cell Cycle. 2003 Jul-Aug;2 (4) :384-96. PMID: 12851493


Stern DF: ErbBs in mammary development. Exp Cell Res. 2003 Mar 10;284 (1) :89-98. PMID: 12648468


Xu X and Stern DF: NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways. J Biol Chem. 2003 Mar 7;278 (10) :8795-803. Epub 2002 Dec 23. PMID: 12499369


Tsvetkov L, Xu X, Li J and Stern DF: Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem. 2003 Mar 7;278 (10) :8468-75. Epub 2002 Dec 18. PMID: 12493754

DiGiovanna MP, Chu P, Davison TL, Howe CL, Carter D, Claus EB and Stern DF: Active signaling by HER-2/neu in a subpopulation of HER-2/neu-overexpressing ductal carcinoma in situ: clinicopathological correlates. Cancer Res. 2002 Nov 15;62 (22) :6667-73. PMID: 12438265


Digiovanna MP, Stern DF and Roussel RR: Production of antibodies that recognize specific tyrosine-phosphorylated peptides. Curr Protoc Immunol. 2002 Nov;Chapter 11 :Unit 11.6. PMID: 18432869


Xu X, Tsvetkov LM and Stern DF: Chk2 activation and phosphorylation-dependent oligomerization. Mol Cell Biol. 2002 Jun;22 (12) :4419-32. PMID: 12024051


Schwartz MF, Duong JK, Sun Z, Morrow JS, Pradhan D and Stern DF: Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell. 2002 May;9 (5) :1055-65. PMID: 12049741


DiGiovanna MP, Roussel RR and Stern DF: Production of antibodies that recognize specific tyrosine-phosphorylated peptides. Curr Protoc Cell Biol. 2002 Feb;Chapter 16 :Unit 16.6. PMID: 18228399