Recent Publications

Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N and Mukhopadhyay D: Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis. Arterioscler Thromb Vasc Biol. 2015 Jun;35 (6) :1401-12. Epub 2015 Apr 16. PMID: 25882068

Simons M and Eichmann A: Molecular Controls of Arterial Morphogenesis. Circ Res. 2015 May 8;116 (10) :1712-1724. PMID: 25953926

Ricard N and Simons M: When it is better to regress: dynamics of vascular pruning. PLoS Biol. 2015 May;13 (5) :e1002148. Epub 2015 May 15. PMID: 25978860

Eelen G, de Zeeuw P, Simons M and Carmeliet P: Endothelial cell metabolism in normal and diseased vasculature. Circ Res. 2015 Mar 27;116 (7) :1231-44. PMID: 25814684

Deng Y, Zhang X and Simons M: Molecular controls of lymphatic VEGFR3 signaling. Arterioscler Thromb Vasc Biol. 2015 Feb;35 (2) :421-9. Epub 2014 Dec 18. PMID: 25524775

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC and Kyriakides TR: Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. J Biol Chem. 2015 Jan 2;290 (1) :409-22. Epub 2014 Nov 11. PMID: 25389299

Kofler NM and Simons M: Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling. F1000Prime Rep. 2015;7 :26. Epub 2015 Mar 3. PMID: 25926977

Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M and Hla T: ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A. 2014 Dec 23;111 (51) :18309-14. Epub 2014 Nov 24. PMID: 25422430

Baeyens N, Mulligan-Kehoe MJ, Corti F, Simon DD, Ross TD, Rhodes JM, Wang TZ, Mejean CO, Simons M, Humphrey J and Schwartz MA: Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proc Natl Acad Sci U S A. 2014 Dec 2;111 (48) :17308-13. Epub 2014 Nov 17. PMID: 25404299

Yu P, Tung JK and Simons M: Lymphatic fate specification: an ERK-controlled transcriptional program. Microvasc Res. 2014 Nov;96 :10-5. Epub 2014 Aug 15. PMID: 25132472

Ricard N and Simons M: Fox(y) regulators of VEGF receptors. Circ Res. 2014 Sep 26;115 (8) :683-5. PMID: 25258399

Chen PY, Qin L, Tellides G and Simons M: Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Sci Signal. 2014 Sep 23;7 (344) :ra90. Epub 2014 Sep 23. PMID: 25249657

Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M and Bender JR: Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med. 2014 Sep 22;211 (10) :1957-68. Epub 2014 Sep 1. PMID: 25180062

Lanahan AA, Lech D, Dubrac A, Zhang J, Zhuang ZW, Eichmann A and Simons M: PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells. Circulation. 2014 Sep 9;130 (11) :902-9. Epub 2014 Jun 30. PMID: 24982127

Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M and Sessa WC: Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proc Natl Acad Sci U S A. 2014 Sep 2;111 (35) :12865-70. Epub 2014 Aug 18. PMID: 25136137

Faber JE, Chilian WM, Deindl E, van Royen N and Simons M: A brief etymology of the collateral circulation. Arterioscler Thromb Vasc Biol. 2014 Sep;34 (9) :1854-9. Epub 2014 Jul 10. PMID: 25012127

Zhang X and Simons M: Receptor tyrosine kinases endocytosis in endothelium: biology and signaling. Arterioscler Thromb Vasc Biol. 2014 Sep;34 (9) :1831-7. Epub 2014 Jun 12. PMID: 24925972

Mulligan-Kehoe MJ and Simons M: Vasa vasorum in normal and diseased arteries. Circulation. 2014 Jun 17;129 (24) :2557-66. PMID: 24934463

Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J and Simons M: The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014 Apr 15;111 (15) :5514-9. Epub 2014 Apr 2. PMID: 24706887

Cao Z, Ding BS, Guo P, Lee SB, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Rafii A, Scandura JM and Rafii S: Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer Cell. 2014 Mar 17;25 (3) :350-65. PMID: 24651014

Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC and Simons M: Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. J Biol Chem. 2014 Jan 3;289 (1) :510-9. Epub 2013 Nov 14. PMID: 24235146

Ding BS, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold ME, Shido K, Rabbany SY and Rafii S: Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature. 2014 Jan 2;505 (7481) :97-102. Epub 2013 Nov 20. PMID: 24256728

Sakurai T, Woolls MJ, Jin SW, Murakami M and Simons M: Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PLoS One. 2014;9 (6) :e90736. Epub 2014 Mar 6. PMID: 24603875

Wang Y and Simons M: Flow-regulated lymphatic vasculature development and signaling. Vasc Cell. 2014;6 :14. Epub 2014 Jul 9. PMID: 25053993

Moraes F, Paye J, Mac Gabhann F, Zhuang ZW, Zhang J, Lanahan AA and Simons M: Endothelial cell-dependent regulation of arteriogenesis. Circ Res. 2013 Oct 12;113 (9) :1076-86. Epub 2013 Jul 29. PMID: 23897694

Eichmann A and Simons M: Need glucose to sprout: local metabolic control of angiogenesis. EMBO Mol Med. 2013 Oct;5 (10) :1459-61. Epub 2013 Aug 27. PMID: 23982994

Atri D, Larrivée B, Eichmann A and Simons M: Endothelial signaling and the molecular basis of arteriovenous malformation. Cell Mol Life Sci. 2013 Sep 28; Epub 2013 Sep 28. PMID: 24077895

Elfenbein A and Simons M: Syndecan-4 signaling at a glance. J Cell Sci. 2013 Sep 1;126 (Pt 17) :3799-804. Epub 2013 Aug 22. PMID: 23970415

Simons M and Eichmann A: Physiology. Lymphatics are in my veins. Science. 2013 Aug 9;341 (6146) :622-4. PMID: 23929973

Deng Y, Larrivée B, Zhuang ZW, Atri D, Moraes F, Prahst C, Eichmann A and Simons M: Endothelial RAF1/ERK activation regulates arterial morphogenesis. Blood. 2013 May 9;121 (19) :3988-96, S1-9. Epub 2013 Mar 25. PMID: 23529931

Corti F, Finetti F, Ziche M and Simons M: The syndecan-4/protein kinase Cα pathway mediates prostaglandin E2-induced extracellular regulated kinase (ERK) activation in endothelial cells and angiogenesis in vivo. J Biol Chem. 2013 May 3;288 (18) :12712-21. Epub 2013 Mar 22. PMID: 23525101

Lanahan A, Zhang X, Fantin A, Zhuang Z, Rivera-Molina F, Speichinger K, Prahst C, Zhang J, Wang Y, Davis G, Toomre D, Ruhrberg C and Simons M: The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev Cell. 2013 Apr 29;25 (2) :156-68. PMID: 23639442

Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH and Tirziu D: NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest. 2013 Apr;123 (4) :1718-31. PMID: 23454748

Deng Y, Atri D, Eichmann A and Simons M: Endothelial ERK signaling controls lymphatic fate specification. J Clin Invest. 2013 Mar;123 (3) :1202-15. Epub 2013 Feb 8. PMID: 23391722

Ju R and Simons M: Syndecan 4 regulation of PDK1-dependent Akt activation. Cell Signal. 2013 Jan;25 (1) :101-5. Epub 2012 Sep 10. PMID: 22975683

Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G and Simons M: FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012 Dec 27;2 (6) :1684-96. Epub 2012 Nov 29. PMID: 23200853

Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A and Simons M: Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation. 2012 Nov 27;126 (22) :2589-600. Epub 2012 Oct 22. PMID: 23091063

Simons M: An inside view: VEGF receptor trafficking and signaling. Physiology (Bethesda). 2012 Aug;27 (4) :213-22. PMID: 22875452

Elfenbein A, Lanahan A, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M and Simons M: Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis. Sci Signal. 2012 May 8;5 (223) :ra36. Epub 2012 May 8. PMID: 22569333

Eichmann A and Simons M: VEGF signaling inside vascular endothelial cells and beyond. Curr Opin Cell Biol. 2012 Apr;24 (2) :188-93. Epub 2012 Feb 25. PMID: 22366328

Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M and Eichmann A: ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Dev Cell. 2012 Mar 13;22 (3) :489-500. PMID: 22421041

Schwartz MA and Simons M: Lymphatics thrive on stress: mechanical force in lymphatic development. EMBO J. 2012 Feb 15;31 (4) :781-2. Epub 2012 Feb 15. PMID: 22334045

Hatanaka K, Lanahan AA, Murakami M and Simons M: Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2. PLoS One. 2012;7 (5) :e37600. Epub 2012 May 22. PMID: 22629427

Zhuang ZW, Shi J, Rhodes JM, Tsapakos MJ and Simons M: Challenging the surgical rodent hindlimb ischemia model with the miniinterventional technique. J Vasc Interv Radiol. 2011 Oct;22 (10) :1437-46. Epub 2011 Apr 3. PMID: 21459613

Criscione JM, Dobrucki LW, Zhuang ZW, Papademetris X, Simons M, Sinusas AJ and Fahmy TM: Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging. Bioconjug Chem. 2011 Sep 21;22 (9) :1784-92. Epub 2011 Sep 6. PMID: 21851119

Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL and Simons M: FGF-dependent regulation of VEGF receptor 2 expression in mice. J Clin Invest. 2011 Jul;121 (7) :2668-78. PMID: 21633168

Hatanaka K, Simons M and Murakami M: Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation. Am J Physiol Heart Circ Physiol. 2011 Jan;300 (1) :H162-72. Epub 2010 Oct 29. PMID: 21037229

Tirziu D, Giordano FJ and Simons M: Cell communications in the heart. Circulation. 2010 Aug 31;122 (9) :928-37. PMID: 20805439

Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P and Simons M: VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell. 2010 May 18;18 (5) :713-24. Epub 2010 May 6. PMID: 20434959

Simons M: Diabetic monocyte and vascular endothelial growth factor signaling impairment. Circulation. 2009 Jul 14;120 (2) :104-5. Epub 2009 Jun 29. PMID: 19564554

Murakami M and Simons M: Regulation of vascular integrity. J Mol Med (Berl). 2009 Jun;87 (6) :571-82. Epub 2009 Apr 1. PMID: 19337719

Tirziu D and Simons M: Endothelium as master regulator of organ development and growth. Vascul Pharmacol. 2009 Jan-Feb;50 (1-2) :1-7. Epub 2008 Sep 5. PMID: 18804188

Tirziu D and Simons M: Endothelium-driven myocardial growth or nitric oxide at the crossroads. Trends Cardiovasc Med. 2008 Nov;18 (8) :299-305. PMID: 19345317