Recent Publications

Deng Y, Larrivée B, Zhuang ZW, Atri D, Moraes F, Prahst C, Eichmann A and Simons M: Endothelial RAF1/ERK activation regulates arterial morphogenesis. Blood. 2013 May 9;121 (19) :3988-96. Epub 2013 Mar 25. PMID: 23529931

Corti F, Finetti F, Ziche M and Simons M: The Syndecan-4/Protein Kinase Cα Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo. J Biol Chem. 2013 May 3;288 (18) :12712-21. Epub 2013 Mar 22. PMID: 23525101

Lanahan A, Zhang X, Fantin A, Zhuang Z, Rivera-Molina F, Speichinger K, Prahst C, Zhang J, Wang Y, Davis G, Toomre D, Ruhrberg C and Simons M: The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis. Dev Cell. 2013 Apr 29;25 (2) :156-68. PMID: 23639442

Deng Y and Simons M: Lymphatic fate determination: Playing RAF with ERK. Cell Cycle. 2013 Apr 15;12 (8) :1157-8. Epub 2013 Apr 2. PMID: 23549166

Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH and Tirziu D: NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest. 2013 Apr 1;123 (4) :1718-31. PMID: 23454748

Deng Y, Atri D, Eichmann A and Simons M: Endothelial ERK signaling controls lymphatic fate specification. J Clin Invest. 2013 Mar 1;123 (3) :1202-15. Epub 2013 Feb 8. PMID: 23391722

Ju R and Simons M: Syndecan 4 regulation of PDK1-dependent Akt activation. Cell Signal. 2013 Jan;25 (1) :101-5. Epub 2012 Sep 10. PMID: 22975683

Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G and Simons M: FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012 Dec 27;2 (6) :1684-96. Epub 2012 Nov 29. PMID: 23200853

Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A and Simons M: Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation. 2012 Nov 27;126 (22) :2589-600. Epub 2012 Oct 22. PMID: 23091063

Simons M: An inside view: VEGF receptor trafficking and signaling. Physiology (Bethesda). 2012 Aug;27 (4) :213-22. PMID: 22875452

Elfenbein A, Lanahan A, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M and Simons M: Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis. Sci Signal. 2012 May 8;5 (223) :ra36. Epub 2012 May 8. PMID: 22569333

Eichmann A and Simons M: VEGF signaling inside vascular endothelial cells and beyond. Curr Opin Cell Biol. 2012 Apr;24 (2) :188-93. Epub 2012 Feb 25. PMID: 22366328

Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M and Eichmann A: ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Dev Cell. 2012 Mar 13;22 (3) :489-500. PMID: 22421041

Schwartz MA and Simons M: Lymphatics thrive on stress: mechanical force in lymphatic development. EMBO J. 2012 Feb 15;31 (4) :781-2. Epub 2012 Feb 15. PMID: 22334045

Hatanaka K, Lanahan AA, Murakami M and Simons M: Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2. PLoS One. 2012;7 (5) :e37600. Epub 2012 May 22. PMID: 22629427

Zhuang ZW, Shi J, Rhodes JM, Tsapakos MJ and Simons M: Challenging the surgical rodent hindlimb ischemia model with the miniinterventional technique. J Vasc Interv Radiol. 2011 Oct;22 (10) :1437-46. Epub 2011 Apr 3. PMID: 21459613

Criscione JM, Dobrucki LW, Zhuang ZW, Papademetris X, Simons M, Sinusas AJ and Fahmy TM: Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging. Bioconjug Chem. 2011 Sep 21;22 (9) :1784-92. Epub 2011 Sep 6. PMID: 21851119

Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL and Simons M: FGF-dependent regulation of VEGF receptor 2 expression in mice. J Clin Invest. 2011 Jul;121 (7) :2668-78. PMID: 21633168

Hatanaka K, Simons M and Murakami M: Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation. Am J Physiol Heart Circ Physiol. 2011 Jan;300 (1) :H162-72. Epub 2010 Oct 29. PMID: 21037229

Tirziu D, Giordano FJ and Simons M: Cell communications in the heart. Circulation. 2010 Aug 31;122 (9) :928-37. PMID: 20805439

Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P and Simons M: VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell. 2010 May 18;18 (5) :713-24. Epub 2010 May 6. PMID: 20434959

Simons M: Diabetic monocyte and vascular endothelial growth factor signaling impairment. Circulation. 2009 Jul 14;120 (2) :104-5. Epub 2009 Jun 29. PMID: 19564554

Murakami M and Simons M: Regulation of vascular integrity. J Mol Med (Berl). 2009 Jun;87 (6) :571-82. Epub 2009 Apr 1. PMID: 19337719

Tirziu D and Simons M: Endothelium as master regulator of organ development and growth. Vascul Pharmacol. 2009 Jan-Feb;50 (1-2) :1-7. Epub 2008 Sep 5. PMID: 18804188

Tirziu D and Simons M: Endothelium-driven myocardial growth or nitric oxide at the crossroads. Trends Cardiovasc Med. 2008 Nov;18 (8) :299-305. PMID: 19345317