Recent Publications

Hegan PS, Lanahan AA, Simons M, Mooseker MS: Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse. Cytoskeleton (Hoboken). 2015 Aug 12; 2015 Aug 12. PMID: 26265212

Wang Y, Cao Y, Yamada S, Thirunavukkarasu M, Nin V, Joshi M, Rishi MT, Bhattacharya S, Camacho-Pereira J, Sharma AK, Shameer K, Kocher JP, Sanchez JA, Wang E, Hoeppner LH, Dutta SK, Leof EB, Shah V, Claffey KP, Chini EN, Simons M, Terzic A, Maulik N, Mukhopadhyay D: Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis. Arterioscler Thromb Vasc Biol. 2015 Jun; 2015 Apr 16. PMID: 25882068

Simons M, Eichmann A: Molecular controls of arterial morphogenesis. Circ Res. 2015 May 8. PMID: 25953926

Ricard N, Simons M: When it is better to regress: dynamics of vascular pruning. PLoS Biol. 2015 May; 2015 May 15. PMID: 25978860

Eelen G, de Zeeuw P, Simons M, Carmeliet P: Endothelial cell metabolism in normal and diseased vasculature. Circ Res. 2015 Mar 27. PMID: 25814684

Deng Y, Zhang X, Simons M: Molecular controls of lymphatic VEGFR3 signaling. Arterioscler Thromb Vasc Biol. 2015 Feb; 2014 Dec 18. PMID: 25524775

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR: Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. J Biol Chem. 2015 Jan 2; 2014 Nov 11. PMID: 25389299

Kofler NM, Simons M: Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling. F1000Prime Rep. 2015; 2015 Mar 3. PMID: 25926977

Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T: ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A. 2014 Dec 23; 2014 Nov 24. PMID: 25422430

Baeyens N, Mulligan-Kehoe MJ, Corti F, Simon DD, Ross TD, Rhodes JM, Wang TZ, Mejean CO, Simons M, Humphrey J, Schwartz MA: Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling. Proc Natl Acad Sci U S A. 2014 Dec 2; 2014 Nov 17. PMID: 25404299

Yu P, Tung JK, Simons M: Lymphatic fate specification: an ERK-controlled transcriptional program. Microvasc Res. 2014 Nov; 2014 Aug 15. PMID: 25132472

Ricard N, Simons M: Fox(y) regulators of VEGF receptors. Circ Res. 2014 Sep 26. PMID: 25258399

Chen PY, Qin L, Tellides G, Simons M: Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Sci Signal. 2014 Sep 23; 2014 Sep 23. PMID: 25249657

Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR: Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med. 2014 Sep 22; 2014 Sep 1. PMID: 25180062

Lanahan AA, Lech D, Dubrac A, Zhang J, Zhuang ZW, Eichmann A, Simons M: PTP1b is a physiologic regulator of vascular endothelial growth factor signaling in endothelial cells. Circulation. 2014 Sep 9; 2014 Jun 30. PMID: 24982127

Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC: Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proc Natl Acad Sci U S A. 2014 Sep 2; 2014 Aug 18. PMID: 25136137

Faber JE, Chilian WM, Deindl E, van Royen N, Simons M: A brief etymology of the collateral circulation. Arterioscler Thromb Vasc Biol. 2014 Sep; 2014 Jul 10. PMID: 25012127

Zhang X, Simons M: Receptor tyrosine kinases endocytosis in endothelium: biology and signaling. Arterioscler Thromb Vasc Biol. 2014 Sep; 2014 Jun 12. PMID: 24925972

Mulligan-Kehoe MJ, Simons M: Vasa vasorum in normal and diseased arteries. Circulation. 2014 Jun 17. PMID: 24934463

Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M: The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014 Apr 15; 2014 Apr 2. PMID: 24706887

Cao Z, Ding BS, Guo P, Lee SB, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Rafii A, Scandura JM, Rafii S: Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistance. Cancer Cell. 2014 Mar 17. PMID: 24651014

Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M: Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways. J Biol Chem. 2014 Jan 3; 2013 Nov 14. PMID: 24235146

Ding BS, Cao Z, Lis R, Nolan DJ, Guo P, Simons M, Penfold ME, Shido K, Rabbany SY, Rafii S: Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature. 2014 Jan 2; 2013 Nov 20. PMID: 24256728

Sakurai T, Woolls MJ, Jin SW, Murakami M, Simons M: Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PLoS One. 2014; 2014 Mar 6. PMID: 24603875

Wang Y, Simons M: Flow-regulated lymphatic vasculature development and signaling. Vasc Cell. 2014; 2014 Jul 9. PMID: 25053993

Moraes F, Paye J, Mac Gabhann F, Zhuang ZW, Zhang J, Lanahan AA, Simons M: Endothelial cell-dependent regulation of arteriogenesis. Circ Res. 2013 Oct 12; 2013 Jul 29. PMID: 23897694

Eichmann A, Simons M: Need glucose to sprout: local metabolic control of angiogenesis. EMBO Mol Med. 2013 Oct; 2013 Aug 27. PMID: 23982994

Atri D, Larrivée B, Eichmann A, Simons M: Endothelial signaling and the molecular basis of arteriovenous malformation. Cell Mol Life Sci. 2013 Sep 28; 2013 Sep 28. PMID: 24077895

Elfenbein A, Simons M: Syndecan-4 signaling at a glance. J Cell Sci. 2013 Sep 1; 2013 Aug 22. PMID: 23970415

Simons M, Eichmann A: Physiology. Lymphatics are in my veins. Science. 2013 Aug 9. PMID: 23929973

Deng Y, Larrivée B, Zhuang ZW, Atri D, Moraes F, Prahst C, Eichmann A, Simons M: Endothelial RAF1/ERK activation regulates arterial morphogenesis. Blood. 2013 May 9; 2013 Mar 25. PMID: 23529931

Corti F, Finetti F, Ziche M, Simons M: The syndecan-4/protein kinase Cα pathway mediates prostaglandin E2-induced extracellular regulated kinase (ERK) activation in endothelial cells and angiogenesis in vivo. J Biol Chem. 2013 May 3; 2013 Mar 22. PMID: 23525101

Lanahan A, Zhang X, Fantin A, Zhuang Z, Rivera-Molina F, Speichinger K, Prahst C, Zhang J, Wang Y, Davis G, Toomre D, Ruhrberg C, Simons M: The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev Cell. 2013 Apr 29. PMID: 23639442

Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D: NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest. 2013 Apr. PMID: 23454748

Deng Y, Atri D, Eichmann A, Simons M: Endothelial ERK signaling controls lymphatic fate specification. J Clin Invest. 2013 Mar; 2013 Feb 8. PMID: 23391722

Ju R, Simons M: Syndecan 4 regulation of PDK1-dependent Akt activation. Cell Signal. 2013 Jan; 2012 Sep 10. PMID: 22975683

Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M: FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012 Dec 27; 2012 Nov 29. PMID: 23200853

Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M: Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation. 2012 Nov 27; 2012 Oct 22. PMID: 23091063

Simons M: An inside view: VEGF receptor trafficking and signaling. Physiology (Bethesda). 2012 Aug. PMID: 22875452

Elfenbein A, Lanahan A, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M, Simons M: Syndecan 4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis. Sci Signal. 2012 May 8; 2012 May 8. PMID: 22569333

Eichmann A, Simons M: VEGF signaling inside vascular endothelial cells and beyond. Curr Opin Cell Biol. 2012 Apr; 2012 Feb 25. PMID: 22366328

Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M, Eichmann A: ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Dev Cell. 2012 Mar 13. PMID: 22421041

Schwartz MA, Simons M: Lymphatics thrive on stress: mechanical force in lymphatic development. EMBO J. 2012 Feb 15; 2012 Feb 15. PMID: 22334045

Hatanaka K, Lanahan AA, Murakami M, Simons M: Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2. PLoS One. 2012; 2012 May 22. PMID: 22629427

Zhuang ZW, Shi J, Rhodes JM, Tsapakos MJ, Simons M: Challenging the surgical rodent hindlimb ischemia model with the miniinterventional technique. J Vasc Interv Radiol. 2011 Oct; 2011 Apr 3. PMID: 21459613

Criscione JM, Dobrucki LW, Zhuang ZW, Papademetris X, Simons M, Sinusas AJ, Fahmy TM: Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging. Bioconjug Chem. 2011 Sep 21; 2011 Sep 6. PMID: 21851119

Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL, Simons M: FGF-dependent regulation of VEGF receptor 2 expression in mice. J Clin Invest. 2011 Jul. PMID: 21633168

Hatanaka K, Simons M, Murakami M: Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation. Am J Physiol Heart Circ Physiol. 2011 Jan; 2010 Oct 29. PMID: 21037229

Tirziu D, Giordano FJ, Simons M: Cell communications in the heart. Circulation. 2010 Aug 31. PMID: 20805439

Lanahan AA, Hermans K, Claes F, Kerley-Hamilton JS, Zhuang ZW, Giordano FJ, Carmeliet P, Simons M: VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell. 2010 May 18; 2010 May 6. PMID: 20434959

Simons M: Diabetic monocyte and vascular endothelial growth factor signaling impairment. Circulation. 2009 Jul 14; 2009 Jun 29. PMID: 19564554

Murakami M, Simons M: Regulation of vascular integrity. J Mol Med (Berl). 2009 Jun; 2009 Apr 1. PMID: 19337719

Tirziu D, Simons M: Endothelium as master regulator of organ development and growth. Vascul Pharmacol. 2009 Jan-Feb; 2008 Sep 5. PMID: 18804188

Tirziu D, Simons M: Endothelium-driven myocardial growth or nitric oxide at the crossroads. Trends Cardiovasc Med. 2008 Nov. PMID: 19345317