Recent Publications

Marenco LN, Bahl G, Hyland L, Shi J, Wang R, Lai PC, Miller PL, Shepherd GM and Crasto CJ: Databases in SenseLab for the genomics, proteomics, and function of olfactory receptors. Methods Mol Biol. 2013;1003 :3-22. PMID: 23585030

Phillips ME, Sachdev RN, Willhite DC and Shepherd GM: Respiration drives network activity and modulates synaptic and circuit processing of lateral inhibition in the olfactory bulb. J Neurosci. 2012 Jan 4;32 (1) :85-98. PMID: 22219272


McTavish TS, Migliore M, Shepherd GM and Hines ML: Mitral cell spike synchrony modulated by dendrodendritic synapse location. Front Comput Neurosci. 2012;6 :3. Epub 2012 Jan 30. PMID: 22319487

Shepherd GM, Greer CA, Mazzarello P and Sassoè-Pognetto M: The first images of nerve cells: Golgi on the olfactory bulb 1875. Brain Res Rev. 2011 Jan 7;66 (1-2) :92-105. Epub 2010 Nov 13. PMID: 20940020


Shepherd GM: The microcircuit concept applied to cortical evolution: from three-layer to six-layer cortex. Front Neuroanat. 2011;5 :30. Epub 2011 May 23. PMID: 21647397

Marenco L, Wang R, Shepherd GM and Miller PL: The NIF DISCO Framework: facilitating automated integration of neuroscience content on the web. Neuroinformatics. 2010 Jun;8 (2) :101-12. PMID: 20387131


Morse TM, Carnevale NT, Mutalik PG, Migliore M and Shepherd GM: Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Front Neural Circuits. 2010;4 Epub 2010 May 31. PMID: 20725509

Shepherd GM: Symposium overview and historical perspective: dendrodendritic synapses: past, present, and future. Ann N Y Acad Sci. 2009 Jul;1170 :215-23. PMID: 19686140


Cheung KH, Lim E, Samwald M, Chen H, Marenco L, Holford ME, Morse TM, Mutalik P, Shepherd GM and Miller PL: Approaches to neuroscience data integration. Brief Bioinform. 2009 Jul;10 (4) :345-53. PMID: 19505888

Marenco L, Ascoli GA, Martone ME, Shepherd GM and Miller PL: The NIF LinkOut broker: a web resource to facilitate federated data integration using NCBI identifiers. Neuroinformatics. 2008 Sep;6 (3) :219-27. Epub 2008 Oct 31. PMID: 18975149


Marenco L, Li Y, Martone ME, Sternberg PW, Shepherd GM and Miller PL: Issues in the design of a pilot concept-based query interface for the neuroinformatics information framework. Neuroinformatics. 2008 Sep;6 (3) :229-39. Epub 2008 Oct 25. PMID: 18953674


Shepherd GM and Charpak S: The olfactory glomerulus: a model for neuro-glio-vascular biology. Neuron. 2008 Jun 26;58 (6) :827-9. PMID: 18579073


Migliore M and Shepherd GM: Dendritic action potentials connect distributed dendrodendritic microcircuits. J Comput Neurosci. 2008 Apr;24 (2) :207-21. Epub 2007 Aug 3. PMID: 17674173

Shepherd GM: Perspectives on olfactory processing, conscious perception, and orbitofrontal cortex. Ann N Y Acad Sci. 2007 Dec;1121 :87-101. Epub 2007 Sep 13. PMID: 17872397


Shepherd GM, Chen WR, Willhite D, Migliore M and Greer CA: The olfactory granule cell: from classical enigma to central role in olfactory processing. Brain Res Rev. 2007 Oct;55 (2) :373-82. Epub 2007 Mar 16. PMID: 17434592


Liu N, Xu F, Miller PL and Shepherd GM: OdorMapComparer: an application for quantitative analyses and comparisons of fMRI brain odor maps. Neuroinformatics. 2007 Summer;5 (2) :105-14. PMID: 17873372


Laska M and Shepherd GM: Olfactory discrimination ability of CD-1 mice for a large array of enantiomers. Neuroscience. 2007 Jan 5;144 (1) :295-301. Epub 2006 Oct 11. PMID: 17045753


Migliore M, Inzirillo C and Shepherd GM: Learning mechanism for column formation in the olfactory bulb. Front Integr Neurosci. 2007;1 :12. Epub 2007 Dec 30. PMID: 18958240


Crasto CJ and Shepherd GM: Managing knowledge in neuroscience. Methods Mol Biol. 2007;401 :3-21. PMID: 18368357

Shepherd GM: Smell images and the flavour system in the human brain. Nature. 2006 Nov 16;444 (7117) :316-21. PMID: 17108956


Zhou Z, Xiong W, Masurkar AV, Chen WR and Shepherd GM: Dendritic calcium plateau potentials modulate input-output properties of juxtaglomerular cells in the rat olfactory bulb. J Neurophysiol. 2006 Nov;96 (5) :2354-63. Epub 2006 Jul 19. PMID: 16855116


Joshi D, Völkl M, Shepherd GM and Laska M: Olfactory sensitivity for enantiomers and their racemic mixtures--a comparative study in CD-1 mice and spider monkeys. Chem Senses. 2006 Sep;31 (7) :655-64. Epub 2006 Jun 22. PMID: 16793858


Zhou Z, Xiong W, Zeng S, Xia A, Shepherd GM, Greer CA and Chen WR: Dendritic excitability and calcium signalling in the mitral cell distal glomerular tuft. Eur J Neurosci. 2006 Sep;24 (6) :1623-32. PMID: 17004926


Willhite DC, Nguyen KT, Masurkar AV, Greer CA, Shepherd GM and Chen WR: Viral tracing identifies distributed columnar organization in the olfactory bulb. Proc Natl Acad Sci U S A. 2006 Aug 15;103 (33) :12592-7. Epub 2006 Aug 8. PMID: 16895993


Laska M, Joshi D and Shepherd GM: Olfactory sensitivity for aliphatic aldehydes in CD-1 mice. Behav Brain Res. 2006 Feb 28;167 (2) :349-54. Epub 2005 Oct 25. PMID: 16253352


Lam HY, Marenco L, Shepherd GM, Miller PL and Cheung KH: Using web ontology language to integrate heterogeneous databases in the neurosciences. AMIA Annu Symp Proc. 2006; :464-8. PMID: 17238384

Migliore M and Shepherd GM: Opinion: an integrated approach to classifying neuronal phenotypes. Nat Rev Neurosci. 2005 Oct;6 (10) :810-8. PMID: 16276357


Xu F, Schaefer M, Kida I, Schafer J, Liu N, Rothman DL, Hyder F, Restrepo D and Shepherd GM: Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones. J Comp Neurol. 2005 Sep 5;489 (4) :491-500. PMID: 16025460


Chen WR and Shepherd GM: The olfactory glomerulus: a cortical module with specific functions. J Neurocytol. 2005 Sep;34 (3-5) :353-60. Epub 2006 Jul 13. PMID: 16841172


Shepherd GM: Perception without a thalamus how does olfaction do it? Neuron. 2005 Apr 21;46 (2) :166-8. PMID: 15848795


Migliore M, Hines ML and Shepherd GM: The role of distal dendritic gap junctions in synchronization of mitral cell axonal output. J Comput Neurosci. 2005 Mar-Apr;18 (2) :151-61. PMID: 15714267


Shepherd GM: Outline of a theory of olfactory processing and its relevance to humans. Chem Senses. 2005 Jan;30 Suppl 1 :i3-5. PMID: 15738168

Hines ML, Morse T, Migliore M, Carnevale NT and Shepherd GM: ModelDB: A Database to Support Computational Neuroscience. J Comput Neurosci. 2004 Jul-Aug;17 (1) :7-11. PMID: 15218350


Shepherd GM: The human sense of smell: are we better than we think? PLoS Biol. 2004 May;2 (5) :E146. Epub 2004 May 11. PMID: 15138509


Liu N, Xu F, Marenco L, Hyder F, Miller P and Shepherd GM: Informatics approaches to functional MRI odor mapping of the rodent olfactory bulb: OdorMapBuilder and OdorMapDB. Neuroinformatics. 2004;2 (1) :3-18. PMID: 15067166

Shepherd GM: The single capillary and the active brain. Proc Natl Acad Sci U S A. 2003 Oct 28;100 (22) :12535-6. Epub 2003 Oct 20. PMID: 14569016


Xu F, Liu N, Kida I, Rothman DL, Hyder F and Shepherd GM: Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb. Proc Natl Acad Sci U S A. 2003 Sep 16;100 (19) :11029-34. Epub 2003 Sep 8. PMID: 12963819


Crasto CJ, Morse TM, Migliore M, Nadkarni P, Hines M, Brash DE, Miller PL and Shepherd GM: Creating knowledgebases to text-mine PUBMED articles using clustering techniques. AMIA Annu Symp Proc. 2003; :821. PMID: 14728326


Ma M, Grosmaitre X, Iwema CL, Baker H, Greer CA and Shepherd GM: Olfactory signal transduction in the mouse septal organ. J Neurosci. 2003 Jan 1;23 (1) :317-24. PMID: 12514230


Crasto CJ, Marenco LN, Migliore M, Mao B, Nadkarni PM, Miller P and Shepherd GM: Text mining neuroscience journal articles to populate neuroscience databases. Neuroinformatics. 2003;1 (3) :215-37. PMID: 15046245


Shepherd GM: Sharing the mighty mouse. Neuroinformatics. 2003;1 (4) :411-3. PMID: 15043224

Chen WR, Shen GY, Shepherd GM, Hines ML and Midtgaard J: Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol. 2002 Nov;88 (5) :2755-64. PMID: 12424310


Migliore M and Shepherd GM: Emerging rules for the distributions of active dendritic conductances. Nat Rev Neurosci. 2002 May;3 (5) :362-70. PMID: 11988775

Crasto C, Singer MS and Shepherd GM: The olfactory receptor family album. Genome Biol. 2001;2 (10) :REVIEWS1027. Epub 2001 Sep 14. PMID: 11597337

Ma M and Shepherd GM: Functional mosaic organization of mouse olfactory receptor neurons. Proc Natl Acad Sci U S A. 2000 Nov 7;97 (23) :12869-74. PMID: 11050155


Xu F, Greer CA and Shepherd GM: Odor maps in the olfactory bulb. J Comp Neurol. 2000 Jul 10;422 (4) :489-95. PMID: 10861521


Chen WR, Xiong W and Shepherd GM: Analysis of relations between NMDA receptors and GABA release at olfactory bulb reciprocal synapses. Neuron. 2000 Mar;25 (3) :625-33. PMID: 10774730


Skoufos E, Marenco L, Nadkarni PM, Miller PL and Shepherd GM: Olfactory receptor database: a sensory chemoreceptor resource. Nucleic Acids Res. 2000 Jan 1;28 (1) :341-3. PMID: 10592268

Shen GY, Chen WR, Midtgaard J, Shepherd GM and Hines ML: Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol. 1999 Dec;82 (6) :3006-20. PMID: 10601436


Ma M, Chen WR and Shepherd GM: Electrophysiological characterization of rat and mouse olfactory receptor neurons from an intact epithelial preparation. J Neurosci Methods. 1999 Oct 15;92 (1-2) :31-40. PMID: 10595701


Jia C, Chen WR and Shepherd GM: Synaptic organization and neurotransmitters in the rat accessory olfactory bulb. J Neurophysiol. 1999 Jan;81 (1) :345-55. PMID: 9914294


Skoufos E, Healy MD, Singer MS, Nadkarni PM, Miller PL and Shepherd GM: Olfactory Receptor Database: a database of the largest eukaryotic gene family. Nucleic Acids Res. 1999 Jan 1;27 (1) :343-5. PMID: 9847223

Leinders-Zufall T, Greer CA, Shepherd GM and Zufall F: Visualizing odor detection in olfactory cilia by calcium imaging. Ann N Y Acad Sci. 1998 Nov 30;855 :205-7. PMID: 9929606


Singer MS, Hughes TE, Shepherd GM and Greer CA: Identification of olfactory receptor mRNA sequences from the rat olfactory bulb glomerular layer. Neuroreport. 1998 Nov 16;9 (16) :3745-8. PMID: 9858390


Shepherd GM, Mirsky JS, Healy MD, Singer MS, Skoufos E, Hines MS, Nadkarni PM and Miller PL: The Human Brain Project: neuroinformatics tools for integrating, searching and modeling multidisciplinary neuroscience data. Trends Neurosci. 1998 Nov;21 (11) :460-8. PMID: 9829685


Mirsky JS, Nadkarni PM, Healy MD, Miller PL and Shepherd GM: Database tools for integrating and searching membrane property data correlated with neuronal morphology. J Neurosci Methods. 1998 Jul 1;82 (1) :105-21. PMID: 10223520


Yang X, Renken R, Hyder F, Siddeek M, Greer CA, Shepherd GM and Shulman RG: Dynamic mapping at the laminar level of odor-elicited responses in rat olfactory bulb by functional MRI. Proc Natl Acad Sci U S A. 1998 Jun 23;95 (13) :7715-20. PMID: 9636216

Chen WR, Midtgaard J and Shepherd GM: Forward and backward propagation of dendritic impulses and their synaptic control in mitral cells. Science. 1997 Oct 17;278 (5337) :463-7. PMID: 9334305


Shepherd GM and Erulkar SD: Centenary of the synapse: from Sherrington to the molecular biology of the synapse and beyond. Trends Neurosci. 1997 Sep;20 (9) :385-92. PMID: 9292963


Healy MD, Smith JE, Singer MS, Nadkarni PM, Skoufos E, Miller PL and Shepherd GM: Olfactory receptor database (ORDB): a resource for sharing and analyzing published and unpublished data. Chem Senses. 1997 Jun;22 (3) :321-6. PMID: 9218144


Zufall F, Shepherd GM and Barnstable CJ: Cyclic nucleotide gated channels as regulators of CNS development and plasticity. Curr Opin Neurobiol. 1997 Jun;7 (3) :404-12. PMID: 9232810


Leinders-Zufall T, Rand MN, Shepherd GM, Greer CA and Zufall F: Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics. J Neurosci. 1997 Jun 1;17 (11) :4136-48. PMID: 9151731


Chen WR and Shepherd GM: Membrane and synaptic properties of mitral cells in slices of rat olfactory bulb. Brain Res. 1997 Jan 16;745 (1-2) :189-96. PMID: 9037409

Peterson BE, Healy MD, Nadkarni PM, Miller PL and Shepherd GM: ModelDB: an environment for running and storing computational models and their results applied to neuroscience. J Am Med Inform Assoc. 1996 Nov-Dec;3 (6) :389-98. PMID: 8930855


Chen WR, Lee S, Kato K, Spencer DD, Shepherd GM and Williamson A: Long-term modifications of synaptic efficacy in the human inferior and middle temporal cortex. Proc Natl Acad Sci U S A. 1996 Jul 23;93 (15) :8011-5. PMID: 8755594


Leinders-Zufall T, Shepherd GM and Zufall F: Modulation by cyclic GMP of the odour sensitivity of vertebrate olfactory receptor cells. Proc Biol Sci. 1996 Jun 22;263 (1371) :803-11. PMID: 8763798


Shepherd GM: The dendritic spine: a multifunctional integrative unit. J Neurophysiol. 1996 Jun;75 (6) :2197-210. PMID: 8793734


Singer MS, Weisinger-Lewin Y, Lancet D and Shepherd GM: Positive selection moments identify potential functional residues in human olfactory receptors. Receptors Channels. 1996;4 (3) :141-7. PMID: 9014237

Leinders-Zufall T, Shepherd GM and Zufall F: Regulation of cyclic nucleotide-gated channels and membrane excitability in olfactory receptor cells by carbon monoxide. J Neurophysiol. 1995 Oct;74 (4) :1498-508. PMID: 8989388


Leinders-Zufall T, Rosenboom H, Barnstable CJ, Shepherd GM and Zufall F: A calcium-permeable cGMP-activated cation conductance in hippocampal neurons. Neuroreport. 1995 Sep 11;6 (13) :1761-5. PMID: 8541476


Miller PL, Nadkarni PM, Kucherlapati R, Krauter KS, Kidd KK, Ward DC, Shepherd GM and Berkowicz D: Network-based informatics support of research collaborations in the Human Genome Project and the Human Brain Project. Medinfo. 1995;8 Pt 2 :1541-4. PMID: 8591495


Singer MS, Oliveira L, Vriend G and Shepherd GM: Potential ligand-binding residues in rat olfactory receptors identified by correlated mutation analysis. Receptors Channels. 1995;3 (2) :89-95. PMID: 8581404

Shepherd GM: Discrimination of molecular signals by the olfactory receptor neuron. Neuron. 1994 Oct;13 (4) :771-90. PMID: 7946328


Singer MS and Shepherd GM: Molecular modeling of ligand-receptor interactions in the OR5 olfactory receptor. Neuroreport. 1994 Jun 2;5 (10) :1297-300. PMID: 7919185


Berkowicz DA, Trombley PQ and Shepherd GM: Evidence for glutamate as the olfactory receptor cell neurotransmitter. J Neurophysiol. 1994 Jun;71 (6) :2557-61. PMID: 7931535


Trombley PQ and Shepherd GM: Glycine exerts potent inhibitory actions on mammalian olfactory bulb neurons. J Neurophysiol. 1994 Feb;71 (2) :761-7. PMID: 8176438


Zufall F, Firestein S and Shepherd GM: Cyclic nucleotide-gated ion channels and sensory transduction in olfactory receptor neurons. Annu Rev Biophys Biomol Struct. 1994;23 :577-607. PMID: 7522666


Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F and Barnstable CJ: Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron. 1994 Jan;12 (1) :155-65. PMID: 7507337

Williamson A, Spencer DD and Shepherd GM: Comparison between the membrane and synaptic properties of human and rodent dentate granule cells. Brain Res. 1993 Sep 17;622 (1-2) :194-202. PMID: 8242356


Trombley PQ and Shepherd GM: Synaptic transmission and modulation in the olfactory bulb. Curr Opin Neurobiol. 1993 Aug;3 (4) :540-7. PMID: 8219719


Pongrácz F, McClintock TS, Ache BW and Shepherd GM: Signal transmission in lobster olfactory receptor cells: functional significance of electrotonic structure analysed by a compartmental model. Neuroscience. 1993 Jul;55 (2) :325-38. PMID: 8377928


Shepherd GM: Principles of specificity and redundancy underlying the organization of the olfactory system. Microsc Res Tech. 1993 Feb 1;24 (2) :106-12. PMID: 8457723

Pongrácz F, Poolos NP, Kocsis JD and Shepherd GM: A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons. J Neurophysiol. 1992 Dec;68 (6) :2248-59. PMID: 1337105


Trombley PQ and Shepherd GM: Noradrenergic inhibition of synaptic transmission between mitral and granule cells in mammalian olfactory bulb cultures. J Neurosci. 1992 Oct;12 (10) :3985-91. PMID: 1328562


Firestein S and Shepherd GM: Neurotransmitter antagonists block some odor responses in olfactory receptor neurons. Neuroreport. 1992 Aug;3 (8) :661-4. PMID: 1355670


Strowbridge BW, Masukawa LM, Spencer DD and Shepherd GM: Hyperexcitability associated with localizable lesions in epileptic patients. Brain Res. 1992 Jul 31;587 (1) :158-63. PMID: 1525645


Strowbridge BW, Bean AJ, Spencer DD, Roth RH, Shepherd GM and Robbins RJ: Low levels of somatostatin-like immunoreactivity in neocortex resected from presumed seizure foci in epileptic patients. Brain Res. 1992 Jul 31;587 (1) :164-8. PMID: 1356061


Shepherd GM: Toward a consensus working model for olfactory transduction. Soc Gen Physiol Ser. 1992;47 :19-37. PMID: 1369762

Shepherd GM: Sensory transduction: entering the mainstream of membrane signaling. Cell. 1991 Nov 29;67 (5) :845-51. PMID: 1959132


Firestein S, Zufall F and Shepherd GM: Single odor-sensitive channels in olfactory receptor neurons are also gated by cyclic nucleotides. J Neurosci. 1991 Nov;11 (11) :3565-72. PMID: 1719165


Shepherd GM and Firestein S: Toward a pharmacology of odor receptors and the processing of odor images. J Steroid Biochem Mol Biol. 1991 Oct;39 (4B) :583-92. PMID: 1892789


Firestein S and Shepherd GM: A kinetic model of the odor response in single olfactory receptor neurons. J Steroid Biochem Mol Biol. 1991 Oct;39 (4B) :615-20. PMID: 1654077


Shepherd GM and Firestein S: Making scents of olfactory transduction. Curr Biol. 1991 Aug;1 (4) :204-6. PMID: 15336119


Woolf TB, Shepherd GM and Greer CA: Local information processing in dendritic trees: subsets of spines in granule cells of the mammalian olfactory bulb. J Neurosci. 1991 Jun;11 (6) :1837-54. PMID: 2045889


Firestein S, Darrow B and Shepherd GM: Activation of the sensory current in salamander olfactory receptor neurons depends on a G protein-mediated cAMP second messenger system. Neuron. 1991 May;6 (5) :825-35. PMID: 1709025


Pongracz F, Firestein S and Shepherd GM: Electrotonic structure of olfactory sensory neurons analyzed by intracellular and whole cell patch techniques. J Neurophysiol. 1991 Mar;65 (3) :747-58. PMID: 2051202


Woolf TB, Shepherd GM and Greer CA: Serial reconstructions of granule cell spines in the mammalian olfactory bulb. Synapse. 1991 Mar;7 (3) :181-92. PMID: 1882328

Firestein S, Shepherd GM and Werblin FS: Time course of the membrane current underlying sensory transduction in salamander olfactory receptor neurones. J Physiol. 1990 Nov;430 :135-58. PMID: 2086763

Shepherd GM, Woolf TB and Carnevale NT: Comparisons between Active Properties of Distal Dendritic Branches and Spines: Implications for Neuronal Computations. J Cogn Neurosci. 1989 Summer;1 (3) :273-86. PMID: 23968510

Shepherd GM: Studies of development and plasticity in the olfactory sensory neuron. J Physiol (Paris). 1988-1989;83 (3) :240-5. PMID: 3078439

Shepherd GM: A molecular vocabulary for olfaction. Ann N Y Acad Sci. 1987;510 :98-103. PMID: 3324884

Shepherd GM: The neuron doctrine: a revision of functional concepts. Yale J Biol Med. 1972 Dec;45 (6) :584-99. PMID: 4347887