Publications

Full Shepherd bibliography with chapters, reviews and books available here.

Publications on PubMed

McDougal RA, Morse TM, Carnevale T, Marenco L, Wang R, Migliore M, Miller PL, Shepherd GM, Hines ML: Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience. J Comput Neurosci. 2016 Sep 15; 2016 Sep 15. PMID: 27629590

Rowe TB, Shepherd GM: Role of ortho-retronasal olfaction in mammalian cortical evolution. J Comp Neurol. 2016 Feb 15; 2015 Jun 11. PMID: 25975561

Sanganahalli BG, Rebello MR, Herman P, Papademetris X, Shepherd GM, Verhagen JV, Hyder F: Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping. Neuroimage. 2016 Feb 1; 2015 Nov 26. PMID: 26631819

Cavarretta F, Marasco A, Hines ML, Shepherd GM, Migliore M: Glomerular and Mitral-Granule Cell Microcircuits Coordinate Temporal and Spatial Information Processing in the Olfactory Bulb. Front Comput Neurosci. 2016; 2016 Jul 14. PMID: 27471461

DeFelipe J, Douglas RJ, Hill SL, Lein ES, Martin KA, Rockland KS, Segev I, Shepherd GM, Tamás G: Comments and General Discussion on "The Anatomical Problem Posed by Brain Complexity and Size: A Potential Solution". Front Neuroanat. 2016; 2016 Jun 10. PMID: 27375436

Ni R, Michalski MH, Brown E, Doan N, Zinter J, Ouellette NT, Shepherd GM: Optimal directional volatile transport in retronasal olfaction. Proc Natl Acad Sci U S A. 2015 Nov 24; 2015 Nov 9. PMID: 26553982

McDougal RA, Morse TM, Hines ML, Shepherd GM: ModelView for ModelDB: Online Presentation of Model Structure. Neuroinformatics. 2015 Oct. PMID: 25896640

Migliore M, Cavarretta F, Marasco A, Tulumello E, Hines ML, Shepherd GM: Synaptic clusters function as odor operators in the olfactory bulb. Proc Natl Acad Sci U S A. 2015 Jul 7; 2015 Jun 22. PMID: 26100895

McDougal RA, Shepherd GM: 3D-printer visualization of neuron models. Front Neuroinform. 2015; 2015 Jun 30. PMID: 26175684

Rebello MR, McTavish TS, Willhite DC, Short SM, Shepherd GM, Verhagen JV: Perception of odors linked to precise timing in the olfactory system. PLoS Biol. 2014 Dec; 2014 Dec 16. PMID: 25514030

Yu Y, Migliore M, Hines ML, Shepherd GM: Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition. J Neurosci. 2014 Oct 8. PMID: 25297097

Migliore M, Cavarretta F, Hines ML, Shepherd GM: Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb. Front Comput Neurosci. 2014; 2014 Apr 29. PMID: 24808855

Marenco LN, Wang R, Bandrowski AE, Grethe JS, Shepherd GM, Miller PL: Extending the NIF DISCO framework to automate complex workflow: coordinating the harvest and integration of data from diverse neuroscience information resources. Front Neuroinform. 2014; 2014 May 28. PMID: 25018728

Marenco LN, Bahl G, Hyland L, Shi J, Wang R, Lai PC, Miller PL, Shepherd GM, Crasto CJ: Databases in SenseLab for the genomics, proteomics, and function of olfactory receptors. Methods Mol Biol. 2013. PMID: 23585030

Phillips ME, Sachdev RN, Willhite DC, Shepherd GM: Respiration drives network activity and modulates synaptic and circuit processing of lateral inhibition in the olfactory bulb. J Neurosci. 2012 Jan 4. PMID: 22219272

McTavish TS, Migliore M, Shepherd GM, Hines ML: Mitral cell spike synchrony modulated by dendrodendritic synapse location. Front Comput Neurosci. 2012; 2012 Jan 30. PMID: 22319487

Shepherd GM, Greer CA, Mazzarello P, Sassoè-Pognetto M: The first images of nerve cells: Golgi on the olfactory bulb 1875. Brain Res Rev. 2011 Jan 7; 2010 Nov 13. PMID: 20940020

Shepherd GM: The microcircuit concept applied to cortical evolution: from three-layer to six-layer cortex. Front Neuroanat. 2011; 2011 May 23. PMID: 21647397

Marenco L, Wang R, Shepherd GM, Miller PL: The NIF DISCO Framework: facilitating automated integration of neuroscience content on the web. Neuroinformatics. 2010 Jun. PMID: 20387131

Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM: Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Front Neural Circuits. 2010; 2010 May 31. PMID: 20725509

Shepherd GM: Symposium overview and historical perspective: dendrodendritic synapses: past, present, and future. Ann N Y Acad Sci. 2009 Jul. PMID: 19686140

Cheung KH, Lim E, Samwald M, Chen H, Marenco L, Holford ME, Morse TM, Mutalik P, Shepherd GM, Miller PL: Approaches to neuroscience data integration. Brief Bioinform. 2009 Jul. PMID: 19505888

Marenco L, Ascoli GA, Martone ME, Shepherd GM, Miller PL: The NIF LinkOut broker: a web resource to facilitate federated data integration using NCBI identifiers. Neuroinformatics. 2008 Sep; 2008 Oct 31. PMID: 18975149

Marenco L, Li Y, Martone ME, Sternberg PW, Shepherd GM, Miller PL: Issues in the design of a pilot concept-based query interface for the neuroinformatics information framework. Neuroinformatics. 2008 Sep; 2008 Oct 25. PMID: 18953674

Shepherd GM, Charpak S: The olfactory glomerulus: a model for neuro-glio-vascular biology. Neuron. 2008 Jun 26. PMID: 18579073

Migliore M, Shepherd GM: Dendritic action potentials connect distributed dendrodendritic microcircuits. J Comput Neurosci. 2008 Apr; 2007 Aug 3. PMID: 17674173

Shepherd GM: Perspectives on olfactory processing, conscious perception, and orbitofrontal cortex. Ann N Y Acad Sci. 2007 Dec; 2007 Sep 13. PMID: 17872397

Shepherd GM, Chen WR, Willhite D, Migliore M, Greer CA: The olfactory granule cell: from classical enigma to central role in olfactory processing. Brain Res Rev. 2007 Oct; 2007 Mar 16. PMID: 17434592

Liu N, Xu F, Miller PL, Shepherd GM: OdorMapComparer: an application for quantitative analyses and comparisons of fMRI brain odor maps. Neuroinformatics. 2007 Summer. PMID: 17873372

Laska M, Shepherd GM: Olfactory discrimination ability of CD-1 mice for a large array of enantiomers. Neuroscience. 2007 Jan 5; 2006 Oct 11. PMID: 17045753

Migliore M, Inzirillo C, Shepherd GM: Learning mechanism for column formation in the olfactory bulb. Front Integr Neurosci. 2007; 2007 Dec 30. PMID: 18958240

Crasto CJ, Shepherd GM: Managing knowledge in neuroscience. Methods Mol Biol. 2007. PMID: 18368357

Shepherd GM: Smell images and the flavour system in the human brain. Nature. 2006 Nov 16. PMID: 17108956

Zhou Z, Xiong W, Masurkar AV, Chen WR, Shepherd GM: Dendritic calcium plateau potentials modulate input-output properties of juxtaglomerular cells in the rat olfactory bulb. J Neurophysiol. 2006 Nov; 2006 Jul 19. PMID: 16855116

Joshi D, Völkl M, Shepherd GM, Laska M: Olfactory sensitivity for enantiomers and their racemic mixtures--a comparative study in CD-1 mice and spider monkeys. Chem Senses. 2006 Sep; 2006 Jun 22. PMID: 16793858

Zhou Z, Xiong W, Zeng S, Xia A, Shepherd GM, Greer CA, Chen WR: Dendritic excitability and calcium signalling in the mitral cell distal glomerular tuft. Eur J Neurosci. 2006 Sep. PMID: 17004926

Willhite DC, Nguyen KT, Masurkar AV, Greer CA, Shepherd GM, Chen WR: Viral tracing identifies distributed columnar organization in the olfactory bulb. Proc Natl Acad Sci U S A. 2006 Aug 15; 2006 Aug 8. PMID: 16895993

Laska M, Joshi D, Shepherd GM: Olfactory sensitivity for aliphatic aldehydes in CD-1 mice. Behav Brain Res. 2006 Feb 28; 2005 Oct 25. PMID: 16253352

Lam HY, Marenco L, Shepherd GM, Miller PL, Cheung KH: Using web ontology language to integrate heterogeneous databases in the neurosciences. AMIA Annu Symp Proc. 2006. PMID: 17238384

Migliore M, Shepherd GM: Opinion: an integrated approach to classifying neuronal phenotypes. Nat Rev Neurosci. 2005 Oct. PMID: 16276357

Xu F, Schaefer M, Kida I, Schafer J, Liu N, Rothman DL, Hyder F, Restrepo D, Shepherd GM: Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones. J Comp Neurol. 2005 Sep 5. PMID: 16025460

Chen WR, Shepherd GM: The olfactory glomerulus: a cortical module with specific functions. J Neurocytol. 2005 Sep; 2006 Jul 13. PMID: 16841172

Shepherd GM: Perception without a thalamus how does olfaction do it? Neuron. 2005 Apr 21. PMID: 15848795

Migliore M, Hines ML, Shepherd GM: The role of distal dendritic gap junctions in synchronization of mitral cell axonal output. J Comput Neurosci. 2005 Mar-Apr. PMID: 15714267

Shepherd GM: Outline of a theory of olfactory processing and its relevance to humans. Chem Senses. 2005 Jan. PMID: 15738168

Hines ML, Morse T, Migliore M, Carnevale NT, Shepherd GM: ModelDB: A Database to Support Computational Neuroscience. J Comput Neurosci. 2004 Jul-Aug. PMID: 15218350

Shepherd GM: The human sense of smell: are we better than we think? PLoS Biol. 2004 May; 2004 May 11. PMID: 15138509

Liu N, Xu F, Marenco L, Hyder F, Miller P, Shepherd GM: Informatics approaches to functional MRI odor mapping of the rodent olfactory bulb: OdorMapBuilder and OdorMapDB. Neuroinformatics. 2004. PMID: 15067166

Shepherd GM: The single capillary and the active brain. Proc Natl Acad Sci U S A. 2003 Oct 28; 2003 Oct 20. PMID: 14569016

Xu F, Liu N, Kida I, Rothman DL, Hyder F, Shepherd GM: Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb. Proc Natl Acad Sci U S A. 2003 Sep 16; 2003 Sep 8. PMID: 12963819

Crasto CJ, Morse TM, Migliore M, Nadkarni P, Hines M, Brash DE, Miller PL, Shepherd GM: Creating knowledgebases to text-mine PUBMED articles using clustering techniques. AMIA Annu Symp Proc. 2003. PMID: 14728326

Ma M, Grosmaitre X, Iwema CL, Baker H, Greer CA, Shepherd GM: Olfactory signal transduction in the mouse septal organ. J Neurosci. 2003 Jan 1. PMID: 12514230

Crasto CJ, Marenco LN, Migliore M, Mao B, Nadkarni PM, Miller P, Shepherd GM: Text mining neuroscience journal articles to populate neuroscience databases. Neuroinformatics. 2003. PMID: 15046245

Shepherd GM: Sharing the mighty mouse. Neuroinformatics. 2003. PMID: 15043224

Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J: Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol. 2002 Nov. PMID: 12424310

Migliore M, Shepherd GM: Emerging rules for the distributions of active dendritic conductances. Nat Rev Neurosci. 2002 May. PMID: 11988775

Crasto C, Singer MS, Shepherd GM: The olfactory receptor family album. Genome Biol. 2001; 2001 Sep 14. PMID: 11597337

Ma M, Shepherd GM: Functional mosaic organization of mouse olfactory receptor neurons. Proc Natl Acad Sci U S A. 2000 Nov 7. PMID: 11050155

Xu F, Greer CA, Shepherd GM: Odor maps in the olfactory bulb. J Comp Neurol. 2000 Jul 10. PMID: 10861521

Chen WR, Xiong W, Shepherd GM: Analysis of relations between NMDA receptors and GABA release at olfactory bulb reciprocal synapses. Neuron. 2000 Mar. PMID: 10774730

Skoufos E, Marenco L, Nadkarni PM, Miller PL, Shepherd GM: Olfactory receptor database: a sensory chemoreceptor resource. Nucleic Acids Res. 2000 Jan 1. PMID: 10592268

Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML: Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol. 1999 Dec. PMID: 10601436

Ma M, Chen WR, Shepherd GM: Electrophysiological characterization of rat and mouse olfactory receptor neurons from an intact epithelial preparation. J Neurosci Methods. 1999 Oct 15. PMID: 10595701

Jia C, Chen WR, Shepherd GM: Synaptic organization and neurotransmitters in the rat accessory olfactory bulb. J Neurophysiol. 1999 Jan. PMID: 9914294

Skoufos E, Healy MD, Singer MS, Nadkarni PM, Miller PL, Shepherd GM: Olfactory Receptor Database: a database of the largest eukaryotic gene family. Nucleic Acids Res. 1999 Jan 1. PMID: 9847223

Leinders-Zufall T, Greer CA, Shepherd GM, Zufall F: Visualizing odor detection in olfactory cilia by calcium imaging. Ann N Y Acad Sci. 1998 Nov 30. PMID: 9929606

Singer MS, Hughes TE, Shepherd GM, Greer CA: Identification of olfactory receptor mRNA sequences from the rat olfactory bulb glomerular layer. Neuroreport. 1998 Nov 16. PMID: 9858390

Shepherd GM, Mirsky JS, Healy MD, Singer MS, Skoufos E, Hines MS, Nadkarni PM, Miller PL: The Human Brain Project: neuroinformatics tools for integrating, searching and modeling multidisciplinary neuroscience data. Trends Neurosci. 1998 Nov. PMID: 9829685

Mirsky JS, Nadkarni PM, Healy MD, Miller PL, Shepherd GM: Database tools for integrating and searching membrane property data correlated with neuronal morphology. J Neurosci Methods. 1998 Jul 1. PMID: 10223520

Yang X, Renken R, Hyder F, Siddeek M, Greer CA, Shepherd GM, Shulman RG: Dynamic mapping at the laminar level of odor-elicited responses in rat olfactory bulb by functional MRI. Proc Natl Acad Sci U S A. 1998 Jun 23. PMID: 9636216

Chen WR, Midtgaard J, Shepherd GM: Forward and backward propagation of dendritic impulses and their synaptic control in mitral cells. Science. 1997 Oct 17. PMID: 9334305

Shepherd GM, Erulkar SD: Centenary of the synapse: from Sherrington to the molecular biology of the synapse and beyond. Trends Neurosci. 1997 Sep. PMID: 9292963

Healy MD, Smith JE, Singer MS, Nadkarni PM, Skoufos E, Miller PL, Shepherd GM: Olfactory receptor database (ORDB): a resource for sharing and analyzing published and unpublished data. Chem Senses. 1997 Jun. PMID: 9218144

Zufall F, Shepherd GM, Barnstable CJ: Cyclic nucleotide gated channels as regulators of CNS development and plasticity. Curr Opin Neurobiol. 1997 Jun. PMID: 9232810

Leinders-Zufall T, Rand MN, Shepherd GM, Greer CA, Zufall F: Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics. J Neurosci. 1997 Jun 1. PMID: 9151731

Chen WR, Shepherd GM: Membrane and synaptic properties of mitral cells in slices of rat olfactory bulb. Brain Res. 1997 Jan 16. PMID: 9037409

Peterson BE, Healy MD, Nadkarni PM, Miller PL, Shepherd GM: ModelDB: an environment for running and storing computational models and their results applied to neuroscience. J Am Med Inform Assoc. 1996 Nov-Dec. PMID: 8930855

Chen WR, Lee S, Kato K, Spencer DD, Shepherd GM, Williamson A: Long-term modifications of synaptic efficacy in the human inferior and middle temporal cortex. Proc Natl Acad Sci U S A. 1996 Jul 23. PMID: 8755594

Leinders-Zufall T, Shepherd GM, Zufall F: Modulation by cyclic GMP of the odour sensitivity of vertebrate olfactory receptor cells. Proc Biol Sci. 1996 Jun 22. PMID: 8763798

Shepherd GM: The dendritic spine: a multifunctional integrative unit. J Neurophysiol. 1996 Jun. PMID: 8793734

Singer MS, Weisinger-Lewin Y, Lancet D, Shepherd GM: Positive selection moments identify potential functional residues in human olfactory receptors. Receptors Channels. 1996. PMID: 9014237

Leinders-Zufall T, Shepherd GM, Zufall F: Regulation of cyclic nucleotide-gated channels and membrane excitability in olfactory receptor cells by carbon monoxide. J Neurophysiol. 1995 Oct. PMID: 8989388

Leinders-Zufall T, Rosenboom H, Barnstable CJ, Shepherd GM, Zufall F: A calcium-permeable cGMP-activated cation conductance in hippocampal neurons. Neuroreport. 1995 Sep 11. PMID: 8541476

Miller PL, Nadkarni PM, Kucherlapati R, Krauter KS, Kidd KK, Ward DC, Shepherd GM, Berkowicz D: Network-based informatics support of research collaborations in the Human Genome Project and the Human Brain Project. Medinfo. 1995. PMID: 8591495

Singer MS, Oliveira L, Vriend G, Shepherd GM: Potential ligand-binding residues in rat olfactory receptors identified by correlated mutation analysis. Receptors Channels. 1995. PMID: 8581404

Shepherd GM: Discrimination of molecular signals by the olfactory receptor neuron. Neuron. 1994 Oct. PMID: 7946328

Singer MS, Shepherd GM: Molecular modeling of ligand-receptor interactions in the OR5 olfactory receptor. Neuroreport. 1994 Jun 2. PMID: 7919185

Berkowicz DA, Trombley PQ, Shepherd GM: Evidence for glutamate as the olfactory receptor cell neurotransmitter. J Neurophysiol. 1994 Jun. PMID: 7931535

Trombley PQ, Shepherd GM: Glycine exerts potent inhibitory actions on mammalian olfactory bulb neurons. J Neurophysiol. 1994 Feb. PMID: 8176438

Zufall F, Firestein S, Shepherd GM: Cyclic nucleotide-gated ion channels and sensory transduction in olfactory receptor neurons. Annu Rev Biophys Biomol Struct. 1994. PMID: 7522666

Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F, Barnstable CJ: Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron. 1994 Jan. PMID: 7507337

Williamson A, Spencer DD, Shepherd GM: Comparison between the membrane and synaptic properties of human and rodent dentate granule cells. Brain Res. 1993 Sep 17. PMID: 8242356

Trombley PQ, Shepherd GM: Synaptic transmission and modulation in the olfactory bulb. Curr Opin Neurobiol. 1993 Aug. PMID: 8219719

Pongrácz F, McClintock TS, Ache BW, Shepherd GM: Signal transmission in lobster olfactory receptor cells: functional significance of electrotonic structure analysed by a compartmental model. Neuroscience. 1993 Jul. PMID: 8377928

Shepherd GM: Principles of specificity and redundancy underlying the organization of the olfactory system. Microsc Res Tech. 1993 Feb 1. PMID: 8457723

Pongrácz F, Poolos NP, Kocsis JD, Shepherd GM: A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons. J Neurophysiol. 1992 Dec. PMID: 1337105

Trombley PQ, Shepherd GM: Noradrenergic inhibition of synaptic transmission between mitral and granule cells in mammalian olfactory bulb cultures. J Neurosci. 1992 Oct. PMID: 1328562

Firestein S, Shepherd GM: Neurotransmitter antagonists block some odor responses in olfactory receptor neurons. Neuroreport. 1992 Aug. PMID: 1355670

Strowbridge BW, Masukawa LM, Spencer DD, Shepherd GM: Hyperexcitability associated with localizable lesions in epileptic patients. Brain Res. 1992 Jul 31. PMID: 1525645

Strowbridge BW, Bean AJ, Spencer DD, Roth RH, Shepherd GM, Robbins RJ: Low levels of somatostatin-like immunoreactivity in neocortex resected from presumed seizure foci in epileptic patients. Brain Res. 1992 Jul 31. PMID: 1356061

Shepherd GM: Toward a consensus working model for olfactory transduction. Soc Gen Physiol Ser. 1992. PMID: 1369762

Shepherd GM: Sensory transduction: entering the mainstream of membrane signaling. Cell. 1991 Nov 29. PMID: 1959132

Firestein S, Zufall F, Shepherd GM: Single odor-sensitive channels in olfactory receptor neurons are also gated by cyclic nucleotides. J Neurosci. 1991 Nov. PMID: 1719165

Shepherd GM, Firestein S: Toward a pharmacology of odor receptors and the processing of odor images. J Steroid Biochem Mol Biol. 1991 Oct. PMID: 1892789

Firestein S, Shepherd GM: A kinetic model of the odor response in single olfactory receptor neurons. J Steroid Biochem Mol Biol. 1991 Oct. PMID: 1654077

Shepherd GM, Firestein S: Making scents of olfactory transduction. Curr Biol. 1991 Aug. PMID: 15336119

Woolf TB, Shepherd GM, Greer CA: Local information processing in dendritic trees: subsets of spines in granule cells of the mammalian olfactory bulb. J Neurosci. 1991 Jun. PMID: 2045889

Firestein S, Darrow B, Shepherd GM: Activation of the sensory current in salamander olfactory receptor neurons depends on a G protein-mediated cAMP second messenger system. Neuron. 1991 May. PMID: 1709025

Pongracz F, Firestein S, Shepherd GM: Electrotonic structure of olfactory sensory neurons analyzed by intracellular and whole cell patch techniques. J Neurophysiol. 1991 Mar. PMID: 2051202

Woolf TB, Shepherd GM, Greer CA: Serial reconstructions of granule cell spines in the mammalian olfactory bulb. Synapse. 1991 Mar. PMID: 1882328

Shepherd GM: Studies of development and plasticity in the olfactory sensory neuron. J Physiol (Paris). 1988-1989. PMID: 3078439

Shepherd GM: A molecular vocabulary for olfaction. Ann N Y Acad Sci. 1987. PMID: 3324884

Shepherd GM: The neuron doctrine: a revision of functional concepts. Yale J Biol Med. 1972 Dec. PMID: 4347887