Full Shepherd bibliography with chapters, reviews and books available here.

Publications on PubMed

Ni R, Michalski MH, Brown E, Doan N, Zinter J, Ouellette NT, Shepherd GM: Optimal directional volatile transport in retronasal olfaction. Proc Natl Acad Sci U S A. 2015 Nov 24; 2015 Nov 9. PMID: 26553982

Heuermann RJ, Jaramillo TC, Ying SW, Suter BA, Lyman KA, Han Y, Lewis AS, Hampton TG, Shepherd GM, Goldstein PA, Chetkovich DM: Reduction of thalamic and cortical Ih by deletion of TRIP8b produces a mouse model of human absence epilepsy. Neurobiol Dis. 2015 Oct 14; 2015 Oct 14. PMID: 26459112

McDougal RA, Morse TM, Hines ML, Shepherd GM: ModelView for ModelDB: Online Presentation of Model Structure. Neuroinformatics. 2015 Oct. PMID: 25896640

Migliore M, Cavarretta F, Marasco A, Tulumello E, Hines ML, Shepherd GM: Synaptic clusters function as odor operators in the olfactory bulb. Proc Natl Acad Sci U S A. 2015 Jul 7; 2015 Jun 22. PMID: 26100895

Rowe TB, Shepherd GM: Role of ortho-retronasal olfaction in mammalian cortical evolution. J Comp Neurol. 2015 May 15; 2015 May 15. PMID: 25975561

McDougal RA, Shepherd GM: 3D-printer visualization of neuron models. Front Neuroinform. 2015; 2015 Jun 30. PMID: 26175684

Rebello MR, McTavish TS, Willhite DC, Short SM, Shepherd GM, Verhagen JV: Perception of odors linked to precise timing in the olfactory system. PLoS Biol. 2014 Dec; 2014 Dec 16. PMID: 25514030

Yu Y, Migliore M, Hines ML, Shepherd GM: Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition. J Neurosci. 2014 Oct 8. PMID: 25297097

Migliore M, Cavarretta F, Hines ML, Shepherd GM: Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb. Front Comput Neurosci. 2014; 2014 Apr 29. PMID: 24808855

Marenco LN, Wang R, Bandrowski AE, Grethe JS, Shepherd GM, Miller PL: Extending the NIF DISCO framework to automate complex workflow: coordinating the harvest and integration of data from diverse neuroscience information resources. Front Neuroinform. 2014; 2014 May 28. PMID: 25018728

Marenco LN, Bahl G, Hyland L, Shi J, Wang R, Lai PC, Miller PL, Shepherd GM, Crasto CJ: Databases in SenseLab for the genomics, proteomics, and function of olfactory receptors. Methods Mol Biol. 2013. PMID: 23585030

Phillips ME, Sachdev RN, Willhite DC, Shepherd GM: Respiration drives network activity and modulates synaptic and circuit processing of lateral inhibition in the olfactory bulb. J Neurosci. 2012 Jan 4. PMID: 22219272

McTavish TS, Migliore M, Shepherd GM, Hines ML: Mitral cell spike synchrony modulated by dendrodendritic synapse location. Front Comput Neurosci. 2012; 2012 Jan 30. PMID: 22319487

Shepherd GM, Greer CA, Mazzarello P, Sassoè-Pognetto M: The first images of nerve cells: Golgi on the olfactory bulb 1875. Brain Res Rev. 2011 Jan 7; 2010 Nov 13. PMID: 20940020

Shepherd GM: The microcircuit concept applied to cortical evolution: from three-layer to six-layer cortex. Front Neuroanat. 2011; 2011 May 23. PMID: 21647397

Marenco L, Wang R, Shepherd GM, Miller PL: The NIF DISCO Framework: facilitating automated integration of neuroscience content on the web. Neuroinformatics. 2010 Jun. PMID: 20387131

Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM: Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Front Neural Circuits. 2010; 2010 May 31. PMID: 20725509

Shepherd GM: Symposium overview and historical perspective: dendrodendritic synapses: past, present, and future. Ann N Y Acad Sci. 2009 Jul. PMID: 19686140

Cheung KH, Lim E, Samwald M, Chen H, Marenco L, Holford ME, Morse TM, Mutalik P, Shepherd GM, Miller PL: Approaches to neuroscience data integration. Brief Bioinform. 2009 Jul. PMID: 19505888

Marenco L, Ascoli GA, Martone ME, Shepherd GM, Miller PL: The NIF LinkOut broker: a web resource to facilitate federated data integration using NCBI identifiers. Neuroinformatics. 2008 Sep; 2008 Oct 31. PMID: 18975149

Marenco L, Li Y, Martone ME, Sternberg PW, Shepherd GM, Miller PL: Issues in the design of a pilot concept-based query interface for the neuroinformatics information framework. Neuroinformatics. 2008 Sep; 2008 Oct 25. PMID: 18953674

Shepherd GM, Charpak S: The olfactory glomerulus: a model for neuro-glio-vascular biology. Neuron. 2008 Jun 26. PMID: 18579073

Migliore M, Shepherd GM: Dendritic action potentials connect distributed dendrodendritic microcircuits. J Comput Neurosci. 2008 Apr; 2007 Aug 3. PMID: 17674173

Shepherd GM: Perspectives on olfactory processing, conscious perception, and orbitofrontal cortex. Ann N Y Acad Sci. 2007 Dec; 2007 Sep 13. PMID: 17872397

Shepherd GM, Chen WR, Willhite D, Migliore M, Greer CA: The olfactory granule cell: from classical enigma to central role in olfactory processing. Brain Res Rev. 2007 Oct; 2007 Mar 16. PMID: 17434592

Liu N, Xu F, Miller PL, Shepherd GM: OdorMapComparer: an application for quantitative analyses and comparisons of fMRI brain odor maps. Neuroinformatics. 2007 Summer. PMID: 17873372

Laska M, Shepherd GM: Olfactory discrimination ability of CD-1 mice for a large array of enantiomers. Neuroscience. 2007 Jan 5; 2006 Oct 11. PMID: 17045753

Migliore M, Inzirillo C, Shepherd GM: Learning mechanism for column formation in the olfactory bulb. Front Integr Neurosci. 2007; 2007 Dec 30. PMID: 18958240

Crasto CJ, Shepherd GM: Managing knowledge in neuroscience. Methods Mol Biol. 2007. PMID: 18368357

Shepherd GM: Smell images and the flavour system in the human brain. Nature. 2006 Nov 16. PMID: 17108956

Zhou Z, Xiong W, Masurkar AV, Chen WR, Shepherd GM: Dendritic calcium plateau potentials modulate input-output properties of juxtaglomerular cells in the rat olfactory bulb. J Neurophysiol. 2006 Nov; 2006 Jul 19. PMID: 16855116

Joshi D, Völkl M, Shepherd GM, Laska M: Olfactory sensitivity for enantiomers and their racemic mixtures--a comparative study in CD-1 mice and spider monkeys. Chem Senses. 2006 Sep; 2006 Jun 22. PMID: 16793858

Zhou Z, Xiong W, Zeng S, Xia A, Shepherd GM, Greer CA, Chen WR: Dendritic excitability and calcium signalling in the mitral cell distal glomerular tuft. Eur J Neurosci. 2006 Sep. PMID: 17004926

Willhite DC, Nguyen KT, Masurkar AV, Greer CA, Shepherd GM, Chen WR: Viral tracing identifies distributed columnar organization in the olfactory bulb. Proc Natl Acad Sci U S A. 2006 Aug 15; 2006 Aug 8. PMID: 16895993

Laska M, Joshi D, Shepherd GM: Olfactory sensitivity for aliphatic aldehydes in CD-1 mice. Behav Brain Res. 2006 Feb 28; 2005 Oct 25. PMID: 16253352

Lam HY, Marenco L, Shepherd GM, Miller PL, Cheung KH: Using web ontology language to integrate heterogeneous databases in the neurosciences. AMIA Annu Symp Proc. 2006. PMID: 17238384

Migliore M, Shepherd GM: Opinion: an integrated approach to classifying neuronal phenotypes. Nat Rev Neurosci. 2005 Oct. PMID: 16276357

Xu F, Schaefer M, Kida I, Schafer J, Liu N, Rothman DL, Hyder F, Restrepo D, Shepherd GM: Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones. J Comp Neurol. 2005 Sep 5. PMID: 16025460

Chen WR, Shepherd GM: The olfactory glomerulus: a cortical module with specific functions. J Neurocytol. 2005 Sep; 2006 Jul 13. PMID: 16841172

Shepherd GM: Perception without a thalamus how does olfaction do it? Neuron. 2005 Apr 21. PMID: 15848795

Migliore M, Hines ML, Shepherd GM: The role of distal dendritic gap junctions in synchronization of mitral cell axonal output. J Comput Neurosci. 2005 Mar-Apr. PMID: 15714267

Shepherd GM: Outline of a theory of olfactory processing and its relevance to humans. Chem Senses. 2005 Jan. PMID: 15738168

Hines ML, Morse T, Migliore M, Carnevale NT, Shepherd GM: ModelDB: A Database to Support Computational Neuroscience. J Comput Neurosci. 2004 Jul-Aug. PMID: 15218350

Shepherd GM: The human sense of smell: are we better than we think? PLoS Biol. 2004 May; 2004 May 11. PMID: 15138509

Liu N, Xu F, Marenco L, Hyder F, Miller P, Shepherd GM: Informatics approaches to functional MRI odor mapping of the rodent olfactory bulb: OdorMapBuilder and OdorMapDB. Neuroinformatics. 2004. PMID: 15067166

Shepherd GM: The single capillary and the active brain. Proc Natl Acad Sci U S A. 2003 Oct 28; 2003 Oct 20. PMID: 14569016

Xu F, Liu N, Kida I, Rothman DL, Hyder F, Shepherd GM: Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb. Proc Natl Acad Sci U S A. 2003 Sep 16; 2003 Sep 8. PMID: 12963819

Crasto CJ, Morse TM, Migliore M, Nadkarni P, Hines M, Brash DE, Miller PL, Shepherd GM: Creating knowledgebases to text-mine PUBMED articles using clustering techniques. AMIA Annu Symp Proc. 2003. PMID: 14728326

Ma M, Grosmaitre X, Iwema CL, Baker H, Greer CA, Shepherd GM: Olfactory signal transduction in the mouse septal organ. J Neurosci. 2003 Jan 1. PMID: 12514230

Crasto CJ, Marenco LN, Migliore M, Mao B, Nadkarni PM, Miller P, Shepherd GM: Text mining neuroscience journal articles to populate neuroscience databases. Neuroinformatics. 2003. PMID: 15046245

Shepherd GM: Sharing the mighty mouse. Neuroinformatics. 2003. PMID: 15043224

Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J: Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol. 2002 Nov. PMID: 12424310

Migliore M, Shepherd GM: Emerging rules for the distributions of active dendritic conductances. Nat Rev Neurosci. 2002 May. PMID: 11988775

Crasto C, Singer MS, Shepherd GM: The olfactory receptor family album. Genome Biol. 2001; 2001 Sep 14. PMID: 11597337

Ma M, Shepherd GM: Functional mosaic organization of mouse olfactory receptor neurons. Proc Natl Acad Sci U S A. 2000 Nov 7. PMID: 11050155

Xu F, Greer CA, Shepherd GM: Odor maps in the olfactory bulb. J Comp Neurol. 2000 Jul 10. PMID: 10861521

Chen WR, Xiong W, Shepherd GM: Analysis of relations between NMDA receptors and GABA release at olfactory bulb reciprocal synapses. Neuron. 2000 Mar. PMID: 10774730

Skoufos E, Marenco L, Nadkarni PM, Miller PL, Shepherd GM: Olfactory receptor database: a sensory chemoreceptor resource. Nucleic Acids Res. 2000 Jan 1. PMID: 10592268

Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML: Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol. 1999 Dec. PMID: 10601436

Ma M, Chen WR, Shepherd GM: Electrophysiological characterization of rat and mouse olfactory receptor neurons from an intact epithelial preparation. J Neurosci Methods. 1999 Oct 15. PMID: 10595701

Jia C, Chen WR, Shepherd GM: Synaptic organization and neurotransmitters in the rat accessory olfactory bulb. J Neurophysiol. 1999 Jan. PMID: 9914294

Skoufos E, Healy MD, Singer MS, Nadkarni PM, Miller PL, Shepherd GM: Olfactory Receptor Database: a database of the largest eukaryotic gene family. Nucleic Acids Res. 1999 Jan 1. PMID: 9847223

Leinders-Zufall T, Greer CA, Shepherd GM, Zufall F: Visualizing odor detection in olfactory cilia by calcium imaging. Ann N Y Acad Sci. 1998 Nov 30. PMID: 9929606

Singer MS, Hughes TE, Shepherd GM, Greer CA: Identification of olfactory receptor mRNA sequences from the rat olfactory bulb glomerular layer. Neuroreport. 1998 Nov 16. PMID: 9858390

Shepherd GM, Mirsky JS, Healy MD, Singer MS, Skoufos E, Hines MS, Nadkarni PM, Miller PL: The Human Brain Project: neuroinformatics tools for integrating, searching and modeling multidisciplinary neuroscience data. Trends Neurosci. 1998 Nov. PMID: 9829685

Mirsky JS, Nadkarni PM, Healy MD, Miller PL, Shepherd GM: Database tools for integrating and searching membrane property data correlated with neuronal morphology. J Neurosci Methods. 1998 Jul 1. PMID: 10223520

Yang X, Renken R, Hyder F, Siddeek M, Greer CA, Shepherd GM, Shulman RG: Dynamic mapping at the laminar level of odor-elicited responses in rat olfactory bulb by functional MRI. Proc Natl Acad Sci U S A. 1998 Jun 23. PMID: 9636216

Chen WR, Midtgaard J, Shepherd GM: Forward and backward propagation of dendritic impulses and their synaptic control in mitral cells. Science. 1997 Oct 17. PMID: 9334305

Shepherd GM, Erulkar SD: Centenary of the synapse: from Sherrington to the molecular biology of the synapse and beyond. Trends Neurosci. 1997 Sep. PMID: 9292963

Healy MD, Smith JE, Singer MS, Nadkarni PM, Skoufos E, Miller PL, Shepherd GM: Olfactory receptor database (ORDB): a resource for sharing and analyzing published and unpublished data. Chem Senses. 1997 Jun. PMID: 9218144

Zufall F, Shepherd GM, Barnstable CJ: Cyclic nucleotide gated channels as regulators of CNS development and plasticity. Curr Opin Neurobiol. 1997 Jun. PMID: 9232810

Leinders-Zufall T, Rand MN, Shepherd GM, Greer CA, Zufall F: Calcium entry through cyclic nucleotide-gated channels in individual cilia of olfactory receptor cells: spatiotemporal dynamics. J Neurosci. 1997 Jun 1. PMID: 9151731

Chen WR, Shepherd GM: Membrane and synaptic properties of mitral cells in slices of rat olfactory bulb. Brain Res. 1997 Jan 16. PMID: 9037409

Peterson BE, Healy MD, Nadkarni PM, Miller PL, Shepherd GM: ModelDB: an environment for running and storing computational models and their results applied to neuroscience. J Am Med Inform Assoc. 1996 Nov-Dec. PMID: 8930855

Chen WR, Lee S, Kato K, Spencer DD, Shepherd GM, Williamson A: Long-term modifications of synaptic efficacy in the human inferior and middle temporal cortex. Proc Natl Acad Sci U S A. 1996 Jul 23. PMID: 8755594

Leinders-Zufall T, Shepherd GM, Zufall F: Modulation by cyclic GMP of the odour sensitivity of vertebrate olfactory receptor cells. Proc Biol Sci. 1996 Jun 22. PMID: 8763798

Shepherd GM: The dendritic spine: a multifunctional integrative unit. J Neurophysiol. 1996 Jun. PMID: 8793734

Singer MS, Weisinger-Lewin Y, Lancet D, Shepherd GM: Positive selection moments identify potential functional residues in human olfactory receptors. Receptors Channels. 1996. PMID: 9014237

Leinders-Zufall T, Shepherd GM, Zufall F: Regulation of cyclic nucleotide-gated channels and membrane excitability in olfactory receptor cells by carbon monoxide. J Neurophysiol. 1995 Oct. PMID: 8989388

Leinders-Zufall T, Rosenboom H, Barnstable CJ, Shepherd GM, Zufall F: A calcium-permeable cGMP-activated cation conductance in hippocampal neurons. Neuroreport. 1995 Sep 11. PMID: 8541476

Miller PL, Nadkarni PM, Kucherlapati R, Krauter KS, Kidd KK, Ward DC, Shepherd GM, Berkowicz D: Network-based informatics support of research collaborations in the Human Genome Project and the Human Brain Project. Medinfo. 1995. PMID: 8591495

Singer MS, Oliveira L, Vriend G, Shepherd GM: Potential ligand-binding residues in rat olfactory receptors identified by correlated mutation analysis. Receptors Channels. 1995. PMID: 8581404

Shepherd GM: Discrimination of molecular signals by the olfactory receptor neuron. Neuron. 1994 Oct. PMID: 7946328

Singer MS, Shepherd GM: Molecular modeling of ligand-receptor interactions in the OR5 olfactory receptor. Neuroreport. 1994 Jun 2. PMID: 7919185

Berkowicz DA, Trombley PQ, Shepherd GM: Evidence for glutamate as the olfactory receptor cell neurotransmitter. J Neurophysiol. 1994 Jun. PMID: 7931535

Trombley PQ, Shepherd GM: Glycine exerts potent inhibitory actions on mammalian olfactory bulb neurons. J Neurophysiol. 1994 Feb. PMID: 8176438

Zufall F, Firestein S, Shepherd GM: Cyclic nucleotide-gated ion channels and sensory transduction in olfactory receptor neurons. Annu Rev Biophys Biomol Struct. 1994. PMID: 7522666

Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F, Barnstable CJ: Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron. 1994 Jan. PMID: 7507337

Williamson A, Spencer DD, Shepherd GM: Comparison between the membrane and synaptic properties of human and rodent dentate granule cells. Brain Res. 1993 Sep 17. PMID: 8242356

Trombley PQ, Shepherd GM: Synaptic transmission and modulation in the olfactory bulb. Curr Opin Neurobiol. 1993 Aug. PMID: 8219719

Pongrácz F, McClintock TS, Ache BW, Shepherd GM: Signal transmission in lobster olfactory receptor cells: functional significance of electrotonic structure analysed by a compartmental model. Neuroscience. 1993 Jul. PMID: 8377928

Shepherd GM: Principles of specificity and redundancy underlying the organization of the olfactory system. Microsc Res Tech. 1993 Feb 1. PMID: 8457723

Pongrácz F, Poolos NP, Kocsis JD, Shepherd GM: A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons. J Neurophysiol. 1992 Dec. PMID: 1337105

Trombley PQ, Shepherd GM: Noradrenergic inhibition of synaptic transmission between mitral and granule cells in mammalian olfactory bulb cultures. J Neurosci. 1992 Oct. PMID: 1328562

Firestein S, Shepherd GM: Neurotransmitter antagonists block some odor responses in olfactory receptor neurons. Neuroreport. 1992 Aug. PMID: 1355670

Strowbridge BW, Masukawa LM, Spencer DD, Shepherd GM: Hyperexcitability associated with localizable lesions in epileptic patients. Brain Res. 1992 Jul 31. PMID: 1525645

Strowbridge BW, Bean AJ, Spencer DD, Roth RH, Shepherd GM, Robbins RJ: Low levels of somatostatin-like immunoreactivity in neocortex resected from presumed seizure foci in epileptic patients. Brain Res. 1992 Jul 31. PMID: 1356061

Shepherd GM: Toward a consensus working model for olfactory transduction. Soc Gen Physiol Ser. 1992. PMID: 1369762

Shepherd GM: Sensory transduction: entering the mainstream of membrane signaling. Cell. 1991 Nov 29. PMID: 1959132

Firestein S, Zufall F, Shepherd GM: Single odor-sensitive channels in olfactory receptor neurons are also gated by cyclic nucleotides. J Neurosci. 1991 Nov. PMID: 1719165

Shepherd GM, Firestein S: Toward a pharmacology of odor receptors and the processing of odor images. J Steroid Biochem Mol Biol. 1991 Oct. PMID: 1892789

Firestein S, Shepherd GM: A kinetic model of the odor response in single olfactory receptor neurons. J Steroid Biochem Mol Biol. 1991 Oct. PMID: 1654077

Shepherd GM, Firestein S: Making scents of olfactory transduction. Curr Biol. 1991 Aug. PMID: 15336119

Woolf TB, Shepherd GM, Greer CA: Local information processing in dendritic trees: subsets of spines in granule cells of the mammalian olfactory bulb. J Neurosci. 1991 Jun. PMID: 2045889

Firestein S, Darrow B, Shepherd GM: Activation of the sensory current in salamander olfactory receptor neurons depends on a G protein-mediated cAMP second messenger system. Neuron. 1991 May. PMID: 1709025

Pongracz F, Firestein S, Shepherd GM: Electrotonic structure of olfactory sensory neurons analyzed by intracellular and whole cell patch techniques. J Neurophysiol. 1991 Mar. PMID: 2051202

Woolf TB, Shepherd GM, Greer CA: Serial reconstructions of granule cell spines in the mammalian olfactory bulb. Synapse. 1991 Mar. PMID: 1882328

Shepherd GM: Studies of development and plasticity in the olfactory sensory neuron. J Physiol (Paris). 1988-1989. PMID: 3078439

Shepherd GM: A molecular vocabulary for olfaction. Ann N Y Acad Sci. 1987. PMID: 3324884

Shepherd GM: The neuron doctrine: a revision of functional concepts. Yale J Biol Med. 1972 Dec. PMID: 4347887