Gerald S Shadel, PhD

Professor of Pathology and of Genetics; Joseph A. and Lucille K. Madri Professor of Experimental Pathology; Director, Yale Center for Research on Aging (Y-Age)

Departments & Organizations

Pathology: Experimental Pathology Graduate Program | Pathology Research | Shadel Lab


Integrative Cell Signaling & Neurobiology of Metabolism (ICSNM)

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Yale Center for Research on Aging (Y-Age)

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Genetics, Genomics and Proteomics | Immunology: Consequences of an Immune Response; Infectious Disease and Host-Pathogen Interaction; Mounting an Immune Response | Molecular Cell Biology, Genetics and Development: Cell Biology; Human Disease; Molecular Mechanisms; RNA Biology; Signal Transduction

Office of Cooperative Research


Gerald S. Shadel earned a B.S. in Chemistry from the University of Nevada, Las Vegas in 1986 and received his Ph.D. in Biochemistry from Texas A&M University in 1991. Following this, Dr. Shadel was a postdoctoral fellow with Dr. David Clayton in the Department of Developmental Biology at Stanford University. He initial faculty appointment was Assistant Professor of Biochemistry at Emory University from 1997-2003. In 2004 he joined the faculty at Yale School of Medicine, where he is currently a full Professor with tenure in the Department of Pathology with a secondary appointment in the Department of Genetics. Dr. Shadel’s research is directed toward understanding the mechanism of gene expression in human mitochondria and delineating signaling pathways that regulate mitochondrial function and biogenesis. The ultimate goal is to gain a comprehensive understanding of how defects in these processes contribute to disease and aging that might in turn lead to novel therapeutic strategies. He has made numerous contributions to this field such as identifying and characterizing key factors and mechanisms that regulate human mitochondrial gene expression, defining stress-signaling pathways that control mitochondrial homeostasis, and elucidating how mitochondria affect aging, pathology and the immune system in yeast, mouse and human cell models. In doing so, previously unappreciated roles for mitochondria in disease pathology and aging have been elucidated, including deafness, ataxia-telangiectasia, cancer, and longevity. Honors and awards include the “Damon Runyon-Walter Winchell” Postdoctoral Fellowship, the ASIP “Amgen: Outstanding Investigator Award,” the “Breakthroughs in Gerontology” Award, the “Glenn Award” for Aging Research, and Keynote Speaker at the 2015 FASEB meeting on “Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging.”

Education & Training

PhD Texas A & M University (1991)
BS University of Nevada, Las Vegas, Chemistry (1986)
Postdoctoral Fellow Stanford University

Honors & Recognition

  • Keynote Speaker: Mitochondrial Biogenesis and Dynamics in Health, Disease and AgingFASEB (2015)

  • Glenn Award for Research in Biological Mechanisms of AgingGlenn Foundation (2011)

  • Amgen Outstanding Investigator AwardAmerican Society for Investigative Pathology (2007)

Professional Service

  • American Society for Investigative Pathology (ASIP) (2005)

  • American Society for Biochemistry and Molecular Biology (ASBMB) (1998)

  • American Association for the Advancement of Science (AAAS) (1990)

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