Gerald S Shadel PhD

Professor of Pathology and of Genetics; Director, Pathology Research

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and PhysiologyCancer Genetics & GenomicsIntegrative Cell Signaling & Neurobiology of Metabolism (ICSNM)Pathology: Shadel Lab; ExPath | Genetics

Research Interests

Mitochondria; Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function; Cancer; Immune System Signaling more...


  • B.S., University of Nevada, Las Vegas, 1986
  • Ph.D., Texas A & M University, 1991

Selected Publications

  • West AP, Tal MC, Staron M, Pineda CM, Lang SM, Bestwick M, Raimundo N, Khoury-Hanold W, MacDuff DA, Duguay BA, Smiley JR, Kaech SM, Means RE, Iwasaki A & Shadel GS. (2015) Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response. Nature
  • Shadel GS (2014) Live Longer on MARS: A Yeast Paradigm of Mitochondrial Adaptive ROS Signaling. Microbial Cell 1:140-144.
  • Schroeder EA, Raimundo N & Shadel GS. (2013) Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metabolism 17:954-964.



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