PDFs are available under the Resources tab.

Publications

Lennington JB, Coppola G, Kataoka-Sasaki Y, Fernandez TV, Palejev D, Li Y, Huttner A, Pletikos M, Sestan N, Leckman JF and Vaccarino FM: Transcriptome Analysis of the Human Striatum in Tourette Syndrome. Biol Psychiatry. 2014 Jul 24; Epub 2014 Jul 24. PMID: 25199956


Zhu Y, Li M, Sousa AM and Sestan N: XSAnno: a framework for building ortholog models in cross-species transcriptome comparisons. BMC Genomics. 2014 May 7;15 :343. Epub 2014 May 7. PMID: 24884593


Ercan-Sencicek AG, Jambi S, Franjic D, Nishimura S, Li M, El-Fishawy P, Morgan TM, Sanders SJ, Bilguvar K, Suri M, Johnson MH, Gupta AR, Yuksel Z, Mane S, Grigorenko E, Picciotto M, Alberts AS, Gunel M, Sestan N and State MW: Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans. Eur J Hum Genet. 2014 Apr 30; Epub 2014 Apr 30. PMID: 24781755


Miller JA, Ding SL, Sunkin SM, Smith KA, Ng L, Szafer A, Ebbert A, Riley ZL, Royall JJ, Aiona K, Arnold JM, Bennet C, Bertagnolli D, Brouner K, Butler S, Caldejon S, Carey A, Cuhaciyan C, Dalley RA, Dee N, Dolbeare TA, Facer BA, Feng D, Fliss TP, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Howard RE, Jochim JM, Kuan CL, Lau C, Lee CK, Lee F, Lemon TA, Lesnar P, McMurray B, Mastan N, Mosqueda N, Naluai-Cecchini T, Ngo NK, Nyhus J, Oldre A, Olson E, Parente J, Parker PD, Parry SE, Stevens A, Pletikos M, Reding M, Roll K, Sandman D, Sarreal M, Shapouri S, Shapovalova NV, Shen EH, Sjoquist N, Slaughterbeck CR, Smith M, Sodt AJ, Williams D, Zöllei L, Fischl B, Gerstein MB, Geschwind DH, Glass IA, Hawrylycz MJ, Hevner RF, Huang H, Jones AR, Knowles JA, Levitt P, Phillips JW, Sestan N, Wohnoutka P, Dang C, Bernard A, Hohmann JG and Lein ES: Transcriptional landscape of the prenatal human brain. Nature. 2014 Apr 10;508 (7495) :199-206. Epub 2014 Apr 2. PMID: 24695229


Tebbenkamp AT, Willsey AJ, State MW and Sestan N: The developmental transcriptome of the human brain: implications for neurodevelopmental disorders. Curr Opin Neurol. 2014 Apr;27 (2) :149-56. PMID: 24565942


Carlyle BC, Nairn AC, Wang M, Yang Y, Jin LE, Simen AA, Ramos BP, Bordner KA, Craft GE, Davies P, Pletikos M, Šestan N, Arnsten AF and Paspalas CD: cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Proc Natl Acad Sci U S A. 2014 Apr 1;111 (13) :5036-41. Epub 2014 Mar 18. PMID: 24707050


Fertuzinhos S, Li M, Kawasawa YI, Ivic V, Franjic D, Singh D, Crair M and Sestan N: Laminar and temporal expression dynamics of coding and noncoding RNAs in the mouse neocortex. Cell Rep. 2014 Mar 13;6 (5) :938-50. Epub 2014 Feb 20. PMID: 24561256


Liu L, Lei J, Sanders SJ, Willsey AJ, Kou Y, Cicek AE, Klei L, Lu C, He X, Li M, Muhle RA, Ma'ayan A, Noonan JP, Sestan N, McFadden KA, State MW, Buxbaum JD, Devlin B and Roeder K: DAWN: a framework to identify autism genes and subnetworks using gene expression and genetics. Mol Autism. 2014 Mar 6;5 (1) :22. Epub 2014 Mar 6. PMID: 24602502


Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Šestan N, Chang BS, Barkovich AJ, Grant PE, Topçu M, Politsky J, Okano H, Piao X and Walsh CA: Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14;343 (6172) :764-8. PMID: 24531968


Robichaux MA, Chenaux G, Ho HY, Soskis MJ, Dravis C, Kwan KY, Šestan N, Greenberg ME, Henkemeyer M and Cowan CW: EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding. Proc Natl Acad Sci U S A. 2014 Feb 11;111 (6) :2188-93. Epub 2014 Jan 22. PMID: 24453220


Pletikos M, Sousa AM, Sedmak G, Meyer KA, Zhu Y, Cheng F, Li M, Kawasawa YI and Sestan N: Temporal specification and bilaterality of human neocortical topographic gene expression. Neuron. 2014 Jan 22;81 (2) :321-32. Epub 2013 Dec 26. PMID: 24373884


Gupta AR, Pirruccello M, Cheng F, Kang HJ, Fernandez TV, Baskin JM, Choi M, Liu L, Ercan-Sencicek AG, Murdoch JD, Klei L, Neale BM, Franjic D, Daly MJ, Lifton RP, De Camilli P, Zhao H, Sestan N and State MW: Rare deleterious mutations of the gene EFR3A in autism spectrum disorders. Mol Autism. 2014;5 :31. Epub 2014 Apr 29. PMID: 24860643

Xie M, Li M, Vilborg A, Lee N, Shu MD, Yartseva V, Šestan N and Steitz JA: Mammalian 5'-capped microRNA precursors that generate a single microRNA. Cell. 2013 Dec 19;155 (7) :1568-80. PMID: 24360278


Han W and Sestan N: Cortical projection neurons: sprung from the same root. Neuron. 2013 Dec 4;80 (5) :1103-5. PMID: 24314721


Willsey AJ, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA, Reilly SK, Lin L, Fertuzinhos S, Miller JA, Murtha MT, Bichsel C, Niu W, Cotney J, Ercan-Sencicek AG, Gockley J, Gupta AR, Han W, He X, Hoffman EJ, Klei L, Lei J, Liu W, Liu L, Lu C, Xu X, Zhu Y, Mane SM, Lein ES, Wei L, Noonan JP, Roeder K, Devlin B, Sestan N and State MW: Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell. 2013 Nov 21;155 (5) :997-1007. PMID: 24267886


Huang H, Jeon T, Sedmak G, Pletikos M, Vasung L, Xu X, Yarowsky P, Richards LJ, Kostovic I, Sestan N and Mori S: Coupling diffusion imaging with histological and gene expression analysis to examine the dynamics of cortical areas across the fetal period of human brain development. Cereb Cortex. 2013 Nov;23 (11) :2620-31. Epub 2012 Aug 28. PMID: 22933464


Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Šestan N, Gage FH and Lein ES: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140 (22) :4633-44. Epub 2013 Oct 23. PMID: 24154525


Li H, Fertuzinhos S, Mohns E, Hnasko TS, Verhage M, Edwards R, Sestan N and Crair MC: Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron. 2013 Sep 4;79 (5) :970-86. PMID: 24012009


Ruusuvuori E, Huebner AK, Kirilkin I, Yukin AY, Blaesse P, Helmy M, Kang HJ, El Muayed M, Hennings JC, Voipio J, Šestan N, Hübner CA and Kaila K: Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J. 2013 Aug 14;32 (16) :2275-86. Epub 2013 Jul 23. PMID: 23881097


Radmanesh F, Caglayan AO, Silhavy JL, Yilmaz C, Cantagrel V, Omar T, Rosti B, Kaymakcalan H, Gabriel S, Li M, Sestan N, Bilguvar K, Dobyns WB, Zaki MS, Gunel M and Gleeson JG: Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities. Am J Hum Genet. 2013 Mar 7;92 (3) :468-74. PMID: 23472759

Miller DJ, Duka T, Stimpson CD, Schapiro SJ, Baze WB, McArthur MJ, Fobbs AJ, Sousa AM, Sestan N, Wildman DE, Lipovich L, Kuzawa CW, Hof PR and Sherwood CC: Prolonged myelination in human neocortical evolution. Proc Natl Acad Sci U S A. 2012 Oct 9;109 (41) :16480-5. Epub 2012 Sep 24. PMID: 23012402


State MW and Šestan N: Neuroscience. The emerging biology of autism spectrum disorders. Science. 2012 Sep 14;337 (6100) :1301-3. PMID: 22984058


Shim S, Kwan KY, Li M, Lefebvre V and Sestan N: Cis-regulatory control of corticospinal system development and evolution. Nature. 2012 May 30;486 (7401) :74-9. Epub 2012 May 30. PMID: 22678282


Kwan KY, Lam MM, Johnson MB, Dube U, Shim S, Rašin MR, Sousa AM, Fertuzinhos S, Chen JG, Arellano JI, Chan DW, Pletikos M, Vasung L, Rowitch DH, Huang EJ, Schwartz ML, Willemsen R, Oostra BA, Rakic P, Heffer M, Kostović I, Judaš M and Sestan N: Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell. 2012 May 11;149 (4) :899-911. PMID: 22579290


Kwan KY, Sestan N and Anton ES: Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex. Development. 2012 May;139 (9) :1535-46. PMID: 22492350


Sanders SJ, Murtha MT, Gupta AR, Murdoch JD, Raubeson MJ, Willsey AJ, Ercan-Sencicek AG, DiLullo NM, Parikshak NN, Stein JL, Walker MF, Ober GT, Teran NA, Song Y, El-Fishawy P, Murtha RC, Choi M, Overton JD, Bjornson RD, Carriero NJ, Meyer KA, Bilguvar K, Mane SM, Sestan N, Lifton RP, Günel M, Roeder K, Geschwind DH, Devlin B and State MW: De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature. 2012 Apr 4;485 (7397) :237-41. Epub 2012 Apr 4. PMID: 22495306

Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, Sousa AM, Pletikos M, Meyer KA, Sedmak G, Guennel T, Shin Y, Johnson MB, Krsnik Z, Mayer S, Fertuzinhos S, Umlauf S, Lisgo SN, Vortmeyer A, Weinberger DR, Mane S, Hyde TM, Huttner A, Reimers M, Kleinman JE and Sestan N: Spatio-temporal transcriptome of the human brain. Nature. 2011 Oct 26;478 (7370) :483-9. Epub 2011 Oct 26. PMID: 22031440


Barak T, Kwan KY, Louvi A, Demirbilek V, Saygı S, Tüysüz B, Choi M, Boyacı H, Doerschner K, Zhu Y, Kaymakçalan H, Yılmaz S, Bakırcıoğlu M, Cağlayan AO, Oztürk AK, Yasuno K, Brunken WJ, Atalar E, Yalçınkaya C, Dinçer A, Bronen RA, Mane S, Ozçelik T, Lifton RP, Sestan N, Bilgüvar K and Günel M: Recessive LAMC3 mutations cause malformations of occipital cortical development. Nat Genet. 2011 Jun;43 (6) :590-4. Epub 2011 May 15. PMID: 21572413


Han W, Kwan KY, Shim S, Lam MM, Shin Y, Xu X, Zhu Y, Li M and Sestan N: TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract. Proc Natl Acad Sci U S A. 2011 Feb 15;108 (7) :3041-6. Epub 2011 Feb 1. PMID: 21285371

Bilgüvar K, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoğlu D, Tüysüz B, Cağlayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioğlu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MH, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandaş S, Topçu M, Ozmen M, Sestan N, Lifton RP, State MW and Günel M: Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature. 2010 Sep 9;467 (7312) :207-10. Epub 2010 Aug 22. PMID: 20729831

Fertuzinhos S, Krsnik Z, Kawasawa YI, Rasin MR, Kwan KY, Chen JG, Judas M, Hayashi M and Sestan N: Selective depletion of molecularly defined cortical interneurons in human holoprosencephaly with severe striatal hypoplasia. Cereb Cortex. 2009 Sep;19 (9) :2196-207. Epub 2009 Feb 20. PMID: 19234067


Ros H, Sachdev RN, Yu Y, Sestan N and McCormick DA: Neocortical networks entrain neuronal circuits in cerebellar cortex. J Neurosci. 2009 Aug 19;29 (33) :10309-20. PMID: 19692605


Johnson MB, Kawasawa YI, Mason CE, Krsnik Z, Coppola G, Bogdanović D, Geschwind DH, Mane SM, State MW and Sestan N: Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron. 2009 May 28;62 (4) :494-509. PMID: 19477152


Stillman AA, Krsnik Z, Sun J, Rasin MR, State MW, Sestan N and Louvi A: Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome. J Comp Neurol. 2009 Mar 1;513 (1) :21-37. PMID: 19105198

Hashimoto-Torii K, Torii M, Sarkisian MR, Bartley CM, Shen J, Radtke F, Gridley T, Sestan N and Rakic P: Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron. 2008 Oct 23;60 (2) :273-84. PMID: 18957219


Kwan KY, Lam MM, Krsnik Z, Kawasawa YI, Lefebvre V and Sestan N: SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. Proc Natl Acad Sci U S A. 2008 Oct 14;105 (41) :16021-6. Epub 2008 Oct 7. PMID: 18840685


Britanova O, de Juan Romero C, Cheung A, Kwan KY, Schwark M, Gyorgy A, Vogel T, Akopov S, Mitkovski M, Agoston D, Sestan N, Molnár Z and Tarabykin V: Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron. 2008 Feb 7;57 (3) :378-92. PMID: 18255031

Breunig JJ, Silbereis J, Vaccarino FM, Sestan N and Rakic P: Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A. 2007 Dec 18;104 (51) :20558-63. Epub 2007 Dec 11. PMID: 18077357


Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P and Sestan N: Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 2007 Jul;10 (7) :819-27. Epub 2007 Jun 24. PMID: 17589506


Brandt N, Franke K, Rasin MR, Baumgart J, Vogt J, Khrulev S, Hassel B, Pohl EE, Sestan N, Nitsch R and Schumacher S: The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. EMBO J. 2007 May 2;26 (9) :2371-86. Epub 2007 Apr 12. PMID: 17431398

Kuo CT, Mirzadeh Z, Soriano-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY and Jan YN: Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell. 2006 Dec 15;127 (6) :1253-64. PMID: 17174898


Smith KM, Ohkubo Y, Maragnoli ME, Rasin MR, Schwartz ML, Sestan N and Vaccarino FM: Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci. 2006 Jun;9 (6) :787-97. Epub 2006 May 21. PMID: 16715082

Chen JG, Rasin MR, Kwan KY and Sestan N: Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex. Proc Natl Acad Sci U S A. 2005 Dec 6;102 (49) :17792-7. Epub 2005 Nov 28. PMID: 16314561


Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N and State MW: Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science. 2005 Oct 14;310 (5746) :317-20. PMID: 16224024

Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M and Horvitz HR: Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol. 2004;5 (9) :R68. Epub 2004 Aug 31. PMID: 15345052

Schmid RS, McGrath B, Berechid BE, Boyles B, Marchionni M, Sestan N and Anton ES: Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc Natl Acad Sci U S A. 2003 Apr 1;100 (7) :4251-6. Epub 2003 Mar 20. PMID: 12649319

Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P and D'Adamio L: The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc Natl Acad Sci U S A. 2002 May 14;99 (10) :7102-7. PMID: 12011466

Sestan N, Rakic P and Donoghue MJ: Independent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression. Curr Biol. 2001 Jan 9;11 (1) :39-43. PMID: 11166178

Sestan N, Artavanis-Tsakonas S and Rakic P: Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science. 1999 Oct 22;286 (5440) :741-6. PMID: 10531053


Judas M, Sestan N and Kostović I: Nitrinergic neurons in the developing and adult human telencephalon: transient and permanent patterns of expression in comparison to other mammals. Microsc Res Tech. 1999 Jun 15;45 (6) :401-19. PMID: 10402267


Qi H, Rand MD, Wu X, Sestan N, Wang W, Rakic P, Xu T and Artavanis-Tsakonas S: Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science. 1999 Jan 1;283 (5398) :91-4. PMID: 9872749

Sestan N and Kostović I: Histochemical localization of nitric oxide synthase in the CNS. Trends Neurosci. 1994 Mar;17 (3) :105-6. PMID: 7515524

Sajin B, Sestan N and Dmitrović B: Compartmentalization of NADPH-diaphorase staining in the developing human striatum. Neurosci Lett. 1992 Jun 8;140 (1) :117-20. PMID: 1407689

Sestan N, Rakic P (2002) Notch signaling in the brain: More than just a developmental storyIn Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate. Fondation IPSEN. Israel A, De Strooper B, Checler F and Christen Y, Eds., Springer, Berlin, pp. 19-40.