Schalper Lab Publications

Villarroel-Espindola F, Yu X, Datar I, Mani N, Sanmamed MF, Velcheti V, Syrigos KN, Toki MI, Zhao H, Chen L, Herbst RS, Schalper KA: Spatially resolved and quantitative analysis of VISTA/PD-1H as a novel immunotherapy target in human non-small cell lung cancer. Clin Cancer Res. 2017 Dec 4; 2017 Dec 4. PMID: 29203588

Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K: Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. Cancer Discov. 2017 Dec; 2017 Oct 12. PMID: 29025772

Alfaro C, Sanmamed MF, Rodríguez-Ruiz ME, Teijeira Á, Oñate C, González Á, Ponz M, Schalper KA, Pérez-Gracia JL, Melero I: Interleukin-8 in cancer pathogenesis, treatment and follow-up. Cancer Treat Rev. 2017 Nov; 2017 Aug 31. PMID: 28866366

Wang X, Janowczyk A, Zhou Y, Thawani R, Fu P, Schalper K, Velcheti V, Madabhushi A: Prediction of recurrence in early stage non-small cell lung cancer using computer extracted nuclear features from digital H&E images. Sci Rep. 2017 Oct 19; 2017 Oct 19. PMID: 29051570

Carvajal-Hausdorf DE, Mani N, Velcheti V, Schalper KA, Rimm DL: Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer. J Immunother Cancer. 2017 Oct 17; 2017 Oct 17. PMID: 29037255

Altan M, Pelekanou V, Schalper KA, Toki M, Gaule P, Syrigos K, Herbst RS, Rimm DL: B7-H3 Expression in NSCLC and Its Association with B7-H4, PD-L1 and Tumor-Infiltrating Lymphocytes. Clin Cancer Res. 2017 Sep 1; 2017 May 24. PMID: 28539467

Sanmamed MF, Perez-Gracia JL, Schalper KA, Fusco JP, Gonzalez A, Rodriguez-Ruiz ME, Oñate C, Perez G, Alfaro C, Martín-Algarra S, Andueza MP, Gurpide A, Morgado M, Wang J, Bacchiocchi A, Halaban R, Kluger H, Chen L, Sznol M, Melero I: Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients. Ann Oncol. 2017 Aug 1. PMID: 28595336

Carvajal-Hausdorf DE, Schalper KA, Bai Y, Black J, Santin AD, Rimm DL: Objective, domain-specific HER2 measurement in uterine and ovarian serous carcinomas and its clinical significance. Gynecol Oncol. 2017 Apr; 2017 Feb 11. PMID: 28196634

Rehman JA, Han G, Carvajal-Hausdorf DE, Wasserman BE, Pelekanou V, Mani NL, McLaughlin J, Schalper KA, Rimm DL: Quantitative and pathologist-read comparison of the heterogeneity of programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer. Mod Pathol. 2017 Mar; 2016 Nov 11. PMID: 27834350

Perez-Gracia JL, Sanmamed MF, Bosch A, Patiño-Garcia A, Schalper KA, Segura V, Bellmunt J, Tabernero J, Sweeney CJ, Choueiri TK, Martín M, Fusco JP, Rodriguez-Ruiz ME, Calvo A, Prior C, Paz-Ares L, Pio R, Gonzalez-Billalabeitia E, Gonzalez Hernandez A, Páez D, Piulats JM, Gurpide A, Andueza M, de Velasco G, Pazo R, Grande E, Nicolas P, Abad-Santos F, Garcia-Donas J, Castellano D, Pajares MJ, Suarez C, Colomer R, Montuenga LM, Melero I: Strategies to design clinical studies to identify predictive biomarkers in cancer research. Cancer Treat Rev. 2017 Feb; 2016 Dec 30. PMID: 28088073

Schalper KA, Carvajal-Hausdorf D, McLaughlin J, Altan M, Velcheti V, Gaule P, Sanmamed MF, Chen L, Herbst RS, Rimm DL: Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer. Clin Cancer Res. 2017 Jan 15; 2016 Jul 20. PMID: 27440266

Toki MI, Carvajal-Hausdorf DE, Altan M, McLaughlin J, Henick B, Schalper KA, Syrigos KN, Rimm DL: EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma. J Thorac Oncol. 2016 Nov; 2016 Jul 20. PMID: 27449805

Rodriguez-Ruiz ME, Rodriguez I, Garasa S, Barbes B, Solorzano JL, Perez-Gracia JL, Labiano S, Sanmamed MF, Azpilikueta A, Bolaños E, Sanchez-Paulete AR, Aznar MA, Rouzaut A, Schalper KA, Jure-Kunkel M, Melero I: Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming. Cancer Res. 2016 Oct 15; 2016 Aug 22. PMID: 27550452

Zarrella ER, Coulter M, Welsh AW, Carvajal DE, Schalper KA, Harigopal M, Rimm DL, Neumeister VM: Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement. Lab Invest. 2016 Sep; 2016 Jun 27. PMID: 27348626

Mani NL, Schalper KA, Hatzis C, Saglam O, Tavassoli F, Butler M, Chagpar AB, Pusztai L, Rimm DL: Quantitative assessment of the spatial heterogeneity of tumor-infiltrating lymphocytes in breast cancer. Breast Cancer Res. 2016 Jul 29; 2016 Jul 29. PMID: 27473061

Datar I, Schalper KA: Epithelial-Mesenchymal Transition and Immune Evasion during Lung Cancer Progression: The Chicken or the Egg? Clin Cancer Res. 2016 Jul 15; 2016 Apr 13. PMID: 27076625

Schalper KA, Kaftan E, Herbst RS: Predictive Biomarkers for PD-1 Axis Therapies: The Hidden Treasure or a Call for Research. Clin Cancer Res. 2016 May 1; 2016 Mar 8. PMID: 26957559

Velcheti V, Schalper K: Basic Overview of Current Immunotherapy Approaches in Cancer. Am Soc Clin Oncol Educ Book. 2016. PMID: 27249709

McLaughlin J, Han G, Schalper KA, Carvajal-Hausdorf D, Pelekanou V, Rehman J, Velcheti V, Herbst R, LoRusso P, Rimm DL: Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung Cancer. JAMA Oncol. 2016 Jan. PMID: 26562159

Carreño JE, Verdugo FJ, Contreras F, Montellano FA, Veloso S, Schalper KA, Sandoval M, Villanueva S, Marusic E, Irarrazabal CE: Spironolactone inhibits the activity of the Na+/H+ exchanger in the aorta of mineralocorticoid-induced hypertensive rats. J Renin Angiotensin Aldosterone Syst. 2015 Dec; 2015 May 21. PMID: 25997821

Barrera F, Azócar L, Molina H, Schalper KA, Ocares M, Liberona J, Villarroel L, Pimentel F, Pérez-Ayuso RM, Nervi F, Groen AK, Miquel JF: Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19. Ann Hepatol. 2015 Sep-Oct. PMID: 26256900

Sanmamed MF, Rodriguez I, Schalper KA, Oñate C, Azpilikueta A, Rodriguez-Ruiz ME, Morales-Kastresana A, Labiano S, Pérez-Gracia JL, Martín-Algarra S, Alfaro C, Mazzolini G, Sarno F, Hidalgo M, Korman AJ, Jure-Kunkel M, Melero I: Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice. Cancer Res. 2015 Sep 1; 2015 Jun 25. PMID: 26113085

Carvajal-Hausdorf DE, Schalper KA, Pusztai L, Psyrri A, Kalogeras KT, Kotoula V, Fountzilas G, Rimm DL: Measurement of Domain-Specific HER2 (ERBB2) Expression May Classify Benefit From Trastuzumab in Breast Cancer. J Natl Cancer Inst. 2015 Aug; 2015 May 19. PMID: 25991002

Wimberly H, Brown JR, Schalper K, Haack H, Silver MR, Nixon C, Bossuyt V, Pusztai L, Lannin DR, Rimm DL: PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer. Cancer Immunol Res. 2015 Apr; 2014 Dec 19. PMID: 25527356

Carvajal-Hausdorf DE, Schalper KA, Neumeister VM, Rimm DL: Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic. Lab Invest. 2015 Apr; 2014 Dec 15. PMID: 25502176

Schalper KA, Brown J, Carvajal-Hausdorf D, McLaughlin J, Velcheti V, Syrigos KN, Herbst RS, Rimm DL: Objective measurement and clinical significance of TILs in non-small cell lung cancer. J Natl Cancer Inst. 2015 Mar; 2015 Feb 3. PMID: 25650315

Rimm D, Schalper K, Pusztai L: Unvalidated antibodies and misleading results. Breast Cancer Res Treat. 2014 Sep; 2014 Aug 3. PMID: 25086631

Schalper KA, Carvajal-Hausdorf D, Oyarzo MP: Possible role of hemichannels in cancer. Front Physiol. 2014; 2014 Jun 27. PMID: 25018732

Schalper KA: PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer. Oncoimmunology. 2014; 2014 Jun 25. PMID: 25083339

Schalper KA, Velcheti V, Carvajal D, Wimberly H, Brown J, Pusztai L, Rimm DL: In situ tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas. Clin Cancer Res. 2014 May 15; 2014 Mar 19. PMID: 24647569

Viray H, Coulter M, Li K, Lane K, Madan A, Mitchell K, Schalper K, Hoyt C, Rimm DL: Automated objective determination of percentage of malignant nuclei for mutation testing. Appl Immunohistochem Mol Morphol. 2014 May-Jun. PMID: 24162261

Rajbhandari P, Schalper KA, Solodin NM, Ellison-Zelski SJ, Ping Lu K, Rimm DL, Alarid ET: Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation. Oncogene. 2014 Mar 13; 2013 Apr 1. PMID: 23542176

Roa I, de Toro G, Schalper K, de Aretxabala X, Churi C, Javle M: Overexpression of the HER2/neu Gene: A New Therapeutic Possibility for Patients With Advanced Gallbladder Cancer. Gastrointest Cancer Res. 2014 Mar. PMID: 24799970

Schalper KA, Kumar S, Hui P, Rimm DL, Gershkovich P: A retrospective population-based comparison of HER2 immunohistochemistry and fluorescence in situ hybridization in breast carcinomas: impact of 2007 American Society of Clinical Oncology/College of American Pathologists criteria. Arch Pathol Lab Med. 2014 Feb; 2013 Oct 28. PMID: 24164555

Velcheti V, Schalper KA, Carvajal DE, Anagnostou VK, Syrigos KN, Sznol M, Herbst RS, Gettinger SN, Chen L, Rimm DL: Programmed death ligand-1 expression in non-small cell lung cancer. Lab Invest. 2014 Jan; 2013 Nov 11. PMID: 24217091

Roa I, Game A, Bizama C, Schalper K: [BRAF gene mutation in wild-type KRAS patients with colorectal cancers]. Rev Med Chil. 2014 Jan. PMID: 24861115

Roa I, de Toro G, Sánchez T, Slater J, Ziegler AM, Game A, Arellano L, Schalper K, de Aretxabala X: [Quality of DNA from archival pathological samples of gallbladder cancer]. Rev Med Chil. 2013 Dec. PMID: 24728429

Roa I, Slater J, Carvajal D, Schalper K, de Toro G, Ares R, Game A, León J, de Aretxabala X: [HER2 gene amplification and overexpression in advanced gastric cancer]. Rev Med Chil. 2013 Nov. PMID: 24718467

Roa I, Sánchez T, Majlis A, Schalper K: [KRAS gene mutation in colorectal cancer]. Rev Med Chil. 2013 Sep. PMID: 24522420

Viray H, Bradley WR, Schalper KA, Rimm DL, Gould Rothberg BE: Marginal and joint distributions of S100, HMB-45, and Melan-A across a large series of cutaneous melanomas. Arch Pathol Lab Med. 2013 Aug. PMID: 23899062

Velcheti V, Rimm DL, Schalper KA: Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1). J Thorac Oncol. 2013 Jun. PMID: 23676558

Velcheti V, Schalper K, Yao X, Cheng H, Kocoglu M, Dhodapkar K, Deng Y, Gettinger S, Rimm DL: High SOX2 levels predict better outcome in non-small cell lung carcinomas. PLoS One. 2013; 2013 Apr 19. PMID: 23620753

Vega JL, Subiabre M, Figueroa F, Schalper KA, Osorio L, González J, Sáez JC: Role of gap junctions and hemichannels in parasitic infections. Biomed Res Int. 2013; 2013 Oct 23. PMID: 24236292

Zoroquiain P, Fernandes BF, González S, Novais GN, Schalper KA, Burnier MN Jr: p16ink4a expression in benign and malignant melanocytic conjunctival lesions. Int J Surg Pathol. 2012 Jun; 2012 Jan 26. PMID: 22287653

Schalper KA, Riquelme MA, Brañes MC, Martínez AD, Vega JL, Berthoud VM, Bennett MV, Sáez JC: Modulation of gap junction channels and hemichannels by growth factors. Mol Biosyst. 2012 Mar; 2012 Jan 4. PMID: 22218428

Orellana JA, Sánchez HA, Schalper KA, Figueroa V, Sáez JC: Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. Adv Exp Med Biol. 2012. PMID: 22453969

Orellana JA, Díaz E, Schalper KA, Vargas AA, Bennett MV, Sáez JC: Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species. Biochem Biophys Res Commun. 2011 Jun 17; 2011 May 12. PMID: 21600880

Schalper KA, Valbuena JR: [Primary cerebral lymphomatoid granulomatosis in a HIV-positive patient. Case report]. Rev Med Chil. 2011 Feb; 2011 Jul 11. PMID: 21773660

Schalper KA, Sánchez HA, Lee SC, Altenberg GA, Nathanson MH, Sáez JC: Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization. Am J Physiol Cell Physiol. 2010 Dec; 2010 Sep 29. PMID: 20881238

Sáez JC, Schalper KA, Retamal MA, Orellana JA, Shoji KF, Bennett MV: Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp Cell Res. 2010 Sep 10; 2010 Jun 2. PMID: 20595004

Schalper KA, Orellana JA, Berthoud VM, Sáez JC: Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases. Curr Vasc Pharmacol. 2009 Oct. PMID: 19485891

Orellana JA, Sáez PJ, Shoji KF, Schalper KA, Palacios-Prado N, Velarde V, Giaume C, Bennett MV, Sáez JC: Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal. 2009 Feb. PMID: 18816186

Schalper KA, Palacios-Prado N, Retamal MA, Shoji KF, Martínez AD, Sáez JC: Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Mol Biol Cell. 2008 Aug; 2008 May 21. PMID: 18495870

Schalper KA, Palacios-Prado N, Orellana JA, Sáez JC: Currently used methods for identification and characterization of hemichannels. Cell Commun Adhes. 2008 May. PMID: 18649191

Retamal MA, Schalper KA, Shoji KF, Orellana JA, Bennett MV, Sáez JC: Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. J Membr Biol. 2007 Aug; 2007 Aug 20. PMID: 17705051

Retamal MA, Schalper KA, Shoji KF, Bennett MV, Sáez JC: Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proc Natl Acad Sci U S A. 2007 May 15; 2007 May 9. PMID: 17494739

Schalper K, Harnisch S, Müller RH, Hildebrand GE: Preparation of microparticles by micromixers: characterization of oil/water process and prediction of particle size. Pharm Res. 2005 Feb. PMID: 15783076