Publications

Porton B, Greenberg BD, Askland K, Serra LM, Gesmonde J, Rudnick G, Rasmussen SA and Kao HT: Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder. Transl Psychiatry. 2013 May 21;3 :e259. Epub 2013 May 21. PMID: 23695234

Wong A, Zhang YW, Jeschke GR, Turk BE and Rudnick G: Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. J Biol Chem. 2012 Oct 19;287 (43) :36051-8. Epub 2012 Aug 31. PMID: 22942288

Bulling S, Schicker K, Zhang YW, Steinkellner T, Stockner T, Gruber CW, Boehm S, Freissmuth M, Rudnick G, Sitte HH and Sandtner W: The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. J Biol Chem. 2012 May 25;287 (22) :18524-34. Epub 2012 Mar 26. PMID: 22451652

Schicker K, Uzelac Z, Gesmonde J, Bulling S, Stockner T, Freissmuth M, Boehm S, Rudnick G, Sitte HH and Sandtner W: Unifying concept of serotonin transporter-associated currents. J Biol Chem. 2012 Jan 2;287 (1) :438-45. Epub 2011 Nov 9. PMID: 22072712

Rudnick G: Cytoplasmic permeation pathway of neurotransmitter transporters. Biochemistry. 2011 Sep 6;50 (35) :7462-75. Epub 2011 Aug 10. PMID: 21774491

Henry LK, Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E, Rudnick G, Noskov SY, DeFelice LJ, Meiler J and Blakely RD: A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. J Biol Chem. 2011 Sep 2;286 (35) :30823-36. Epub 2011 Jul 5. PMID: 21730057

Tavoulari S, Rizwan AN, Forrest LR and Rudnick G: Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue. J Biol Chem. 2011 Jan 28;286 (4) :2834-42. Epub 2010 Nov 29. PMID: 21115480

Zhang YW and Rudnick G: Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation. J Biol Chem. 2011 Jan 28;286 (4) :2461-8. Epub 2010 Nov 19. PMID: 21097501

Tao Z, Zhang YW, Agyiri A and Rudnick G: Ligand effects on cross-linking support a conformational mechanism for serotonin transport. J Biol Chem. 2009 Dec 4;284 (49) :33807-14. Epub 2009 Oct 16. PMID: 19837674

Forrest LR and Rudnick G: The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters. Physiology (Bethesda). 2009 Dec;24 :377-86. PMID: 19996368

Tavoulari S, Forrest LR and Rudnick G: Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes. J Neurosci. 2009 Jul 29;29 (30) :9635-43. PMID: 19641126

Forrest LR, Zhang YW, Jacobs MT, Gesmonde J, Xie L, Honig BH and Rudnick G: Mechanism for alternating access in neurotransmitter transporters. Proc Natl Acad Sci U S A. 2008 Jul 29;105 (30) :10338-43. Epub 2008 Jul 22. PMID: 18647834

Rudnick G: Vesicular ATP transport is a hard (V)NUT to crack. Proc Natl Acad Sci U S A. 2008 Apr 22;105 (16) :5949-50. Epub 2008 Apr 15. PMID: 18417450

Mao Y, Mathewson L, Gesmonde J, Sato Y, Holy M, Sitte HH and Rudnick G: Involvement of serotonin transporter extracellular loop 1 in serotonin binding and transport. Mol Membr Biol. 2008 Feb;25 (2) :115-27. PMID: 18307099

Wendland JR, DeGuzman TB, McMahon F, Rudnick G, Detera-Wadleigh SD and Murphy DL: SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder. Psychiatr Genet. 2008 Feb;18 (1) :31-9. PMID: 18197083

Jacobs MT, Zhang YW, Campbell SD and Rudnick G: Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter. J Biol Chem. 2007 Oct 5;282 (40) :29441-7. Epub 2007 Aug 13. PMID: 17698848

Zhang YW, Gesmonde J, Ramamoorthy S and Rudnick G: Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder. J Neurosci. 2007 Oct 3;27 (40) :10878-86. PMID: 17913921

Castagna M, Soragna A, Mari SA, Santacroce M, Betté S, Mandela PG, Rudnick G, Peres A and Sacchi VF: Interaction between lysine 102 and aspartate 338 in the insect amino acid cotransporter KAAT1. Am J Physiol Cell Physiol. 2007 Oct;293 (4) :C1286-95. Epub 2007 Jul 11. PMID: 17626242

Rudnick G: What is an antidepressant binding site doing in a bacterial transporter? ACS Chem Biol. 2007 Sep 21;2 (9) :606-9. PMID: 17894444

Forrest LR, Tavoulari S, Zhang YW, Rudnick G and Honig B: Identification of a chloride ion binding site in Na+/Cl -dependent transporters. Proc Natl Acad Sci U S A. 2007 Jul 31;104 (31) :12761-6. Epub 2007 Jul 24. PMID: 17652169

Ramamoorthy S, Samuvel DJ, Buck ER, Rudnick G and Jayanthi LD: Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. J Biol Chem. 2007 Apr 20;282 (16) :11639-47. Epub 2007 Feb 19. PMID: 17310063

Zhang YW and Rudnick G: The cytoplasmic substrate permeation pathway of serotonin transporter. J Biol Chem. 2006 Nov 24;281 (47) :36213-20. Epub 2006 Sep 28. PMID: 17008313

Rudnick G: Structure/function relationships in serotonin transporter: new insights from the structure of a bacterial transporter. Handb Exp Pharmacol. 2006; (175) :59-73. PMID: 16722230

Rudnick G: Serotonin transporters--structure and function. J Membr Biol. 2006;213 (2) :101-10. Epub 2007 Apr 6. PMID: 17417703

Zhang YW and Rudnick G: Serotonin transporter mutations associated with obsessive-compulsive disorder and phosphorylation alter binding affinity for inhibitors. Neuropharmacology. 2005 Nov;49 (6) :791-7. Epub 2005 Aug 19. PMID: 16112691

Zhang YW and Rudnick G: Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an alpha-helical conformation. J Biol Chem. 2005 Sep 2;280 (35) :30807-13. Epub 2005 Jul 1. PMID: 15994310

Keller PC 2nd, Stephan M, Glomska H and Rudnick G: Cysteine-scanning mutagenesis of the fifth external loop of serotonin transporter. Biochemistry. 2004 Jul 6;43 (26) :8510-6. PMID: 15222762

Sato Y, Zhang YW, Androutsellis-Theotokis A and Rudnick G: Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis. J Biol Chem. 2004 May 28;279 (22) :22926-33. Epub 2004 Mar 25. PMID: 15044496

Murphy DL, Lerner A, Rudnick G and Lesch KP: Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol Interv. 2004 Apr;4 (2) :109-23. PMID: 15087484

Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G and Murphy DL: Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry. 2003 Nov;8 (11) :933-6. PMID: 14593431

Kilic F, Murphy DL and Rudnick G: A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol. 2003 Aug;64 (2) :440-6. PMID: 12869649

Visiers I, Weinstein H, Rudnick G and Stephan MM: A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P. Biochemistry. 2003 Jun 10;42 (22) :6784-93. PMID: 12779333

Kocabas AM, Rudnick G and Kilic F: Functional consequences of homo- but not hetero-oligomerization between transporters for the biogenic amine neurotransmitters. J Neurochem. 2003 Jun;85 (6) :1513-20. PMID: 12787070

Androutsellis-Theotokis A, Goldberg NR, Ueda K, Beppu T, Beckman ML, Das S, Javitch JA and Rudnick G: Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters. J Biol Chem. 2003 Apr 11;278 (15) :12703-9. Epub 2003 Feb 4. PMID: 12569103

Androutsellis-Theotokis A and Rudnick G: Accessibility and conformational coupling in serotonin transporter predicted internal domains. J Neurosci. 2002 Oct 1;22 (19) :8370-8. PMID: 12351711

Androutsellis-Theotokis A, Ghassemi F and Rudnick G: A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter. J Biol Chem. 2001 Dec 7;276 (49) :45933-8. PMID: 11592963

Gu HH, Wu X, Giros B, Caron MG, Caplan MJ and Rudnick G: The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. Mol Biol Cell. 2001 Dec;12 (12) :3797-807. PMID: 11739781

Ni YG, Chen JG, Androutsellis-Theotokis A, Huang CJ, Moczydlowski E and Rudnick G: A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109. J Biol Chem. 2001 Aug 17;276 (33) :30942-7. Epub 2001 Jun 14. PMID: 11408487

Kamdar G, Penado KM, Rudnick G and Stephan MM: Functional role of critical stripe residues in transmembrane span 7 of the serotonin transporter. Effects of Na+, Li+, and methanethiosulfonate reagents. J Biol Chem. 2001 Feb 9;276 (6) :4038-45. Epub 2000 Oct 31. PMID: 11058600

Shields JC, Rix HW, McIntosh DH, Ho LC, Rudnick G, Filippenko AV, Sargent WL and Sarzi M: Evidence for a Black Hole and Accretion Disk in the LINER NGC 4203. Astrophys J. 2000 May 1;534 (1) :L27-L30. PMID: 10790063

Kilic F and Rudnick G: Oligomerization of serotonin transporter and its functional consequences. Proc Natl Acad Sci U S A. 2000 Mar 28;97 (7) :3106-11. PMID: 10716733

Chen JG and Rudnick G: Permeation and gating residues in serotonin transporter. Proc Natl Acad Sci U S A. 2000 Feb 1;97 (3) :1044-9. PMID: 10655481