Publications

Geach JE, Hickox RC, Diamond-Stanic AM, Krips M, Rudnick GH, Tremonti CA, Sell PH, Coil AL, Moustakas J: Stellar feedback as the origin of an extended molecular outflow in a starburst galaxy. Nature. 2014 Dec 4. PMID: 25471881

Fenollar-Ferrer C, Stockner T, Schwarz TC, Pal A, Gotovina J, Hofmaier T, Jayaraman K, Adhikary S, Kudlacek O, Mehdipour AR, Tavoulari S, Rudnick G, Singh SK, Konrat R, Sitte HH, Forrest LR: Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter. Biochemistry. 2014 Aug 26; 2014 Aug 15. PMID: 25093911

Rudnick G, Krämer R, Blakely RD, Murphy DL, Verrey F: The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflugers Arch. 2014 Jan; 2013 Dec 13. PMID: 24337881

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M: The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol. 2013 Dec. PMID: 24528237

Rudnick G: How do transporters couple solute movements? Mol Membr Biol. 2013 Nov. PMID: 24147977

Porton B, Greenberg BD, Askland K, Serra LM, Gesmonde J, Rudnick G, Rasmussen SA, Kao HT: Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder. Transl Psychiatry. 2013 May 21; 2013 May 21. PMID: 23695234

Wong A, Zhang YW, Jeschke GR, Turk BE, Rudnick G: Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. J Biol Chem. 2012 Oct 19; 2012 Aug 31. PMID: 22942288

Bulling S, Schicker K, Zhang YW, Steinkellner T, Stockner T, Gruber CW, Boehm S, Freissmuth M, Rudnick G, Sitte HH, Sandtner W: The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters. J Biol Chem. 2012 May 25; 2012 Mar 26. PMID: 22451652

Schicker K, Uzelac Z, Gesmonde J, Bulling S, Stockner T, Freissmuth M, Boehm S, Rudnick G, Sitte HH, Sandtner W: Unifying concept of serotonin transporter-associated currents. J Biol Chem. 2012 Jan 2; 2011 Nov 9. PMID: 22072712

Rudnick G: Cytoplasmic permeation pathway of neurotransmitter transporters. Biochemistry. 2011 Sep 6; 2011 Aug 10. PMID: 21774491

Henry LK, Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E, Rudnick G, Noskov SY, DeFelice LJ, Meiler J, Blakely RD: A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. J Biol Chem. 2011 Sep 2; 2011 Jul 5. PMID: 21730057

Tavoulari S, Rizwan AN, Forrest LR, Rudnick G: Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue. J Biol Chem. 2011 Jan 28; 2010 Nov 29. PMID: 21115480

Zhang YW, Rudnick G: Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation. J Biol Chem. 2011 Jan 28; 2010 Nov 19. PMID: 21097501

Tao Z, Zhang YW, Agyiri A, Rudnick G: Ligand effects on cross-linking support a conformational mechanism for serotonin transport. J Biol Chem. 2009 Dec 4; 2009 Oct 16. PMID: 19837674

Forrest LR, Rudnick G: The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters. Physiology (Bethesda). 2009 Dec. PMID: 19996368

Tavoulari S, Forrest LR, Rudnick G: Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes. J Neurosci. 2009 Jul 29. PMID: 19641126

Forrest LR, Zhang YW, Jacobs MT, Gesmonde J, Xie L, Honig BH, Rudnick G: Mechanism for alternating access in neurotransmitter transporters. Proc Natl Acad Sci U S A. 2008 Jul 29; 2008 Jul 22. PMID: 18647834

Rudnick G: Vesicular ATP transport is a hard (V)NUT to crack. Proc Natl Acad Sci U S A. 2008 Apr 22; 2008 Apr 15. PMID: 18417450

Mao Y, Mathewson L, Gesmonde J, Sato Y, Holy M, Sitte HH, Rudnick G: Involvement of serotonin transporter extracellular loop 1 in serotonin binding and transport. Mol Membr Biol. 2008 Feb. PMID: 18307099

Wendland JR, DeGuzman TB, McMahon F, Rudnick G, Detera-Wadleigh SD, Murphy DL: SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder. Psychiatr Genet. 2008 Feb. PMID: 18197083

Jacobs MT, Zhang YW, Campbell SD, Rudnick G: Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter. J Biol Chem. 2007 Oct 5; 2007 Aug 13. PMID: 17698848

Zhang YW, Gesmonde J, Ramamoorthy S, Rudnick G: Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder. J Neurosci. 2007 Oct 3. PMID: 17913921

Castagna M, Soragna A, Mari SA, Santacroce M, Betté S, Mandela PG, Rudnick G, Peres A, Sacchi VF: Interaction between lysine 102 and aspartate 338 in the insect amino acid cotransporter KAAT1. Am J Physiol Cell Physiol. 2007 Oct; 2007 Jul 11. PMID: 17626242

Rudnick G: What is an antidepressant binding site doing in a bacterial transporter? ACS Chem Biol. 2007 Sep 21. PMID: 17894444

Forrest LR, Tavoulari S, Zhang YW, Rudnick G, Honig B: Identification of a chloride ion binding site in Na+/Cl -dependent transporters. Proc Natl Acad Sci U S A. 2007 Jul 31; 2007 Jul 24. PMID: 17652169

Ramamoorthy S, Samuvel DJ, Buck ER, Rudnick G, Jayanthi LD: Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP. J Biol Chem. 2007 Apr 20; 2007 Feb 19. PMID: 17310063

Zhang YW, Rudnick G: The cytoplasmic substrate permeation pathway of serotonin transporter. J Biol Chem. 2006 Nov 24; 2006 Sep 28. PMID: 17008313

Rudnick G: Structure/function relationships in serotonin transporter: new insights from the structure of a bacterial transporter. Handb Exp Pharmacol. 2006. PMID: 16722230

Rudnick G: Serotonin transporters--structure and function. J Membr Biol. 2006; 2007 Apr 6. PMID: 17417703

Keller PC 2nd, Stephan M, Glomska H, Rudnick G: Cysteine-scanning mutagenesis of the fifth external loop of serotonin transporter. Biochemistry. 2004 Jul 6. PMID: 15222762

Sato Y, Zhang YW, Androutsellis-Theotokis A, Rudnick G: Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis. J Biol Chem. 2004 May 28; 2004 Mar 25. PMID: 15044496

Murphy DL, Lerner A, Rudnick G, Lesch KP: Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol Interv. 2004 Apr. PMID: 15087484

Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL: Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry. 2003 Nov. PMID: 14593431

Kilic F, Murphy DL, Rudnick G: A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol. 2003 Aug. PMID: 12869649

Visiers I, Weinstein H, Rudnick G, Stephan MM: A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P. Biochemistry. 2003 Jun 10. PMID: 12779333

Kocabas AM, Rudnick G, Kilic F: Functional consequences of homo- but not hetero-oligomerization between transporters for the biogenic amine neurotransmitters. J Neurochem. 2003 Jun. PMID: 12787070

Androutsellis-Theotokis A, Goldberg NR, Ueda K, Beppu T, Beckman ML, Das S, Javitch JA, Rudnick G: Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters. J Biol Chem. 2003 Apr 11; 2003 Feb 4. PMID: 12569103

Androutsellis-Theotokis A, Rudnick G: Accessibility and conformational coupling in serotonin transporter predicted internal domains. J Neurosci. 2002 Oct 1. PMID: 12351711

Androutsellis-Theotokis A, Ghassemi F, Rudnick G: A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter. J Biol Chem. 2001 Dec 7. PMID: 11592963

Gu HH, Wu X, Giros B, Caron MG, Caplan MJ, Rudnick G: The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. Mol Biol Cell. 2001 Dec. PMID: 11739781

Ni YG, Chen JG, Androutsellis-Theotokis A, Huang CJ, Moczydlowski E, Rudnick G: A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109. J Biol Chem. 2001 Aug 17; 2001 Jun 14. PMID: 11408487

Kamdar G, Penado KM, Rudnick G, Stephan MM: Functional role of critical stripe residues in transmembrane span 7 of the serotonin transporter. Effects of Na+, Li+, and methanethiosulfonate reagents. J Biol Chem. 2001 Feb 9; 2000 Oct 31. PMID: 11058600

Shields JC, Rix HW, McIntosh DH, Ho LC, Rudnick G, Filippenko AV, Sargent WL, Sarzi M: Evidence for a Black Hole and Accretion Disk in the LINER NGC 4203. Astrophys J. 2000 May 1. PMID: 10790063

Kilic F, Rudnick G: Oligomerization of serotonin transporter and its functional consequences. Proc Natl Acad Sci U S A. 2000 Mar 28. PMID: 10716733

Chen JG, Rudnick G: Permeation and gating residues in serotonin transporter. Proc Natl Acad Sci U S A. 2000 Feb 1. PMID: 10655481