Publications

Bárcena C, Stefanovic M, Tutusaus A, Joannas L, Menéndez A, García-Ruiz C, Sancho-Bru P, Marí M, Caballeria J, Rothlin CV, Fernández-Checa JC, de Frutos PG, Morales A: Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation. J Hepatol. 2015 Sep; 2015 Apr 20. PMID: 25908269

Cabezón R, Carrera-Silva EA, Flórez-Grau G, Errasti AE, Calderón-Gómez E, Lozano JJ, España C, Ricart E, Panés J, Rothlin CV, Benítez-Ribas D: MERTK as negative regulator of human T cell activation. J Leukoc Biol. 2015 Apr; 2015 Jan 26. PMID: 25624460

Rothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S: TAM receptor signaling in immune homeostasis. Annu Rev Immunol. 2015; 2015 Jan 14. PMID: 25594431

Kusne Y, Carrera-Silva EA, Perry AS, Rushing EJ, Mandell EK, Dietrich JD, Errasti AE, Gibbs D, Berens ME, Loftus JC, Hulme C, Yang W, Lu Z, Aldape K, Sanai N, Rothlin CV, Ghosh S: Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma. Sci Signal. 2014 Aug 12; 2014 Aug 12. PMID: 25118327

Rothlin CV, Leighton JA, Ghosh S: Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer. Inflamm Bowel Dis. 2014 Aug. PMID: 24846720

Bhattacharyya S, Zagórska A, Lew ED, Shrestha B, Rothlin CV, Naughton J, Diamond MS, Lemke G, Young JA: Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors. Cell Host Microbe. 2013 Aug 14. PMID: 23954153

Bosurgi L, Bernink JH, Delgado Cuevas V, Gagliani N, Joannas L, Schmid ET, Booth CJ, Ghosh S, Rothlin CV: Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Proc Natl Acad Sci U S A. 2013 Aug 6; 2013 Jul 22. PMID: 23878224

Carrera Silva EA, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S, Rothlin CV: T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity. 2013 Jul 25; 2013 Jul 11. PMID: 23850380

van den Brand BT, Abdollahi-Roodsaz S, Vermeij EA, Bennink MB, Arntz OJ, Rothlin CV, van den Berg WB, van de Loo FA: Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis. Arthritis Rheum. 2013 Mar. PMID: 23203851

Rothlin CV, Lemke G: TAM receptor signaling and autoimmune disease. Curr Opin Immunol. 2010 Dec; 2010 Oct 26. PMID: 21030229

Lemke G, Rothlin CV: Immunobiology of the TAM receptors. Nat Rev Immunol. 2008 May. PMID: 18421305

Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G: TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007 Dec 14. PMID: 18083102

Roth C, Rothlin C, Riou S, Raulet DH, Lemke G: Stromal-cell regulation of natural killer cell differentiation. J Mol Med (Berl). 2007 Oct; 2007 Apr 11. PMID: 17426948

Ghosh S, Tergaonkar V, Rothlin CV, Correa RG, Bottero V, Bist P, Verma IM, Hunter T: Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell. 2006 Sep. PMID: 16959613

Prasad D, Rothlin CV, Burrola P, Burstyn-Cohen T, Lu Q, Garcia de Frutos P, Lemke G: TAM receptor function in the retinal pigment epithelium. Mol Cell Neurosci. 2006 Sep; 2006 Aug 9. PMID: 16901715

Sharif MN, Sosic D, Rothlin CV, Kelly E, Lemke G, Olson EN, Ivashkiv LB: Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med. 2006 Aug 7; 2006 Jul 10. PMID: 16831897

Ballestero JA, Plazas PV, Kracun S, Gómez-Casati ME, Taranda J, Rothlin CV, Katz E, Millar NS, Elgoyhen AB: Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors. Mol Pharmacol. 2005 Sep; 2005 Jun 13. PMID: 15955868

Rothlin CV, Lioudyno MI, Silbering AF, Plazas PV, Casati ME, Katz E, Guth PS, Elgoyhen AB: Direct interaction of serotonin type 3 receptor ligands with recombinant and native alpha 9 alpha 10-containing nicotinic cholinergic receptors. Mol Pharmacol. 2003 May. PMID: 12695535

Elgoyhen AB, Vetter DE, Katz E, Rothlin CV, Heinemann SF, Boulter J: alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc Natl Acad Sci U S A. 2001 Mar 13; 2001 Mar 6. PMID: 11248107

Rothlin CV, Katz E, Verbitsky M, Vetter DE, Heinemann SF, Elgoyhen AB: Block of the alpha9 nicotinic receptor by ototoxic aminoglycosides. Neuropharmacology. 2000 Oct. PMID: 11044724

Verbitsky M, Rothlin CV, Katz E, Elgoyhen AB: Mixed nicotinic-muscarinic properties of the alpha9 nicotinic cholinergic receptor. Neuropharmacology. 2000 Oct. PMID: 11044723

Katz E, Verbitsky M, Rothlin CV, Vetter DE, Heinemann SF, Elgoyhen AB: High calcium permeability and calcium block of the alpha9 nicotinic acetylcholine receptor. Hear Res. 2000 Mar. PMID: 10713500