Publications

Kusne Y, Carrera-Silva EA, Perry AS, Rushing EJ, Mandell EK, Dietrich JD, Errasti AE, Gibbs D, Berens ME, Loftus JC, Hulme C, Yang W, Lu Z, Aldape K, Sanai N, Rothlin CV and Ghosh S: Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma. Sci Signal. 2014 Aug 12;7 (338) :ra75. Epub 2014 Aug 12. PMID: 25118327


Rothlin CV, Leighton JA and Ghosh S: Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer. Inflamm Bowel Dis. 2014 Aug;20 (8) :1472-80. PMID: 24846720

Bhattacharyya S, Zagórska A, Lew ED, Shrestha B, Rothlin CV, Naughton J, Diamond MS, Lemke G and Young JA: Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors. Cell Host Microbe. 2013 Aug 14;14 (2) :136-47. PMID: 23954153


Bosurgi L, Bernink JH, Delgado Cuevas V, Gagliani N, Joannas L, Schmid ET, Booth CJ, Ghosh S and Rothlin CV: Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Proc Natl Acad Sci U S A. 2013 Aug 6;110 (32) :13091-6. Epub 2013 Jul 22. PMID: 23878224


Carrera Silva EA, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S and Rothlin CV: T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity. 2013 Jul 25;39 (1) :160-70. Epub 2013 Jul 11. PMID: 23850380


van den Brand BT, Abdollahi-Roodsaz S, Vermeij EA, Bennink MB, Arntz OJ, Rothlin CV, van den Berg WB and van de Loo FA: Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis. Arthritis Rheum. 2013 Mar;65 (3) :671-80. PMID: 23203851

Rothlin CV and Lemke G: TAM receptor signaling and autoimmune disease. Curr Opin Immunol. 2010 Dec;22 (6) :740-6. Epub 2010 Oct 26. PMID: 21030229

Lemke G and Rothlin CV: Immunobiology of the TAM receptors. Nat Rev Immunol. 2008 May;8 (5) :327-36. PMID: 18421305

Rothlin CV, Ghosh S, Zuniga EI, Oldstone MB and Lemke G: TAM receptors are pleiotropic inhibitors of the innate immune response. Cell. 2007 Dec 14;131 (6) :1124-36. PMID: 18083102


Roth C, Rothlin C, Riou S, Raulet DH and Lemke G: Stromal-cell regulation of natural killer cell differentiation. J Mol Med (Berl). 2007 Oct;85 (10) :1047-56. Epub 2007 Apr 11. PMID: 17426948

Ghosh S, Tergaonkar V, Rothlin CV, Correa RG, Bottero V, Bist P, Verma IM and Hunter T: Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell. 2006 Sep;10 (3) :215-26. PMID: 16959613


Prasad D, Rothlin CV, Burrola P, Burstyn-Cohen T, Lu Q, Garcia de Frutos P and Lemke G: TAM receptor function in the retinal pigment epithelium. Mol Cell Neurosci. 2006 Sep;33 (1) :96-108. Epub 2006 Aug 9. PMID: 16901715


Sharif MN, Sosic D, Rothlin CV, Kelly E, Lemke G, Olson EN and Ivashkiv LB: Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med. 2006 Aug 7;203 (8) :1891-901. Epub 2006 Jul 10. PMID: 16831897

Ballestero JA, Plazas PV, Kracun S, Gómez-Casati ME, Taranda J, Rothlin CV, Katz E, Millar NS and Elgoyhen AB: Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors. Mol Pharmacol. 2005 Sep;68 (3) :822-9. Epub 2005 Jun 13. PMID: 15955868

Rothlin CV, Lioudyno MI, Silbering AF, Plazas PV, Casati ME, Katz E, Guth PS and Elgoyhen AB: Direct interaction of serotonin type 3 receptor ligands with recombinant and native alpha 9 alpha 10-containing nicotinic cholinergic receptors. Mol Pharmacol. 2003 May;63 (5) :1067-74. PMID: 12695535

Elgoyhen AB, Vetter DE, Katz E, Rothlin CV, Heinemann SF and Boulter J: alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc Natl Acad Sci U S A. 2001 Mar 13;98 (6) :3501-6. Epub 2001 Mar 6. PMID: 11248107

Rothlin CV, Katz E, Verbitsky M, Vetter DE, Heinemann SF and Elgoyhen AB: Block of the alpha9 nicotinic receptor by ototoxic aminoglycosides. Neuropharmacology. 2000 Oct;39 (13) :2525-32. PMID: 11044724


Verbitsky M, Rothlin CV, Katz E and Elgoyhen AB: Mixed nicotinic-muscarinic properties of the alpha9 nicotinic cholinergic receptor. Neuropharmacology. 2000 Oct;39 (13) :2515-24. PMID: 11044723


Katz E, Verbitsky M, Rothlin CV, Vetter DE, Heinemann SF and Elgoyhen AB: High calcium permeability and calcium block of the alpha9 nicotinic acetylcholine receptor. Hear Res. 2000 Mar;141 (1-2) :117-28. PMID: 10713500